Metabolism from fatty. Medical search. Frequent questions

Fatty acid metabolism consists of various metabolic processes involving or closely related to fatty acids, a family of molecules classified within the lipid macronutrient category. (wikipedia.org)
In catabolism, fatty acids are metabolized to produce energy, mainly in the form of adenosine triphosphate (ATP). (wikipedia.org)
When compared to other macronutrient classes (carbohydrates and protein), fatty acids yield the most ATP on an energy per gram basis, when they are completely oxidized to CO2 and water by beta oxidation and the citric acid cycle. (wikipedia.org)
Fatty acids (mainly in the form of triglycerides) are therefore the foremost storage form of fuel in most animals, and to a lesser extent in plants. (wikipedia.org)
For example, phospholipids form the phospholipid bilayers out of which all the membranes of the cell are constructed from fatty acids. (wikipedia.org)
In another type of anabolism, fatty acids are modified to form other compounds such as second messengers and local hormones. (wikipedia.org)
Fatty acids are stored as triglycerides in the fat depots of adipose tissue. (wikipedia.org)
Once freed from glycerol, the free fatty acids enter the blood, which transports them, attached to plasma albumin, throughout the body. (wikipedia.org)
Long-chain free fatty acids enter metabolizing cells (i.e. most living cells in the body except red blood cells and neurons in the central nervous system) through specific transport proteins, such as the SLC27 family fatty acid transport protein. (wikipedia.org)
the tissues of the central nervous system cannot use fatty acids, despite containing mitochondria, because long-chain fatty acids (as opposed to medium-chain fatty acids) cannot cross the blood-brain barrier into the interstitial fluids that bathe these cells. (wikipedia.org)
Beta oxidation, in the mitochondrial matrix, then cuts the long carbon chains of the fatty acids (in the form of acyl-CoA molecules) into a series of two-carbon (acetate) units, which, combined with co-enzyme A, form molecules of acetyl CoA, which condense with oxaloacetate to form citrate at the "beginning" of the citric acid cycle. (wikipedia.org)
Researchers aim to further enrich eggs and poultry meat with omega-3 fatty acids. (feedstuffs.com)
Research in Penn State's College of Agricultural Sciences aims to fortify foods people frequently eat - eggs and chicken - with heart-healthy, long-chain omega-3 fatty acids. (feedstuffs.com)
Research has shown that the consumption of long-chain omega-3 polyunsaturated fatty acids provides a myriad of health benefits, including lowering the risk of cardiovascular disease and death, according to an announcement from The Pennsylvania State University. (feedstuffs.com)
Researchers in Penn State's College of Agricultural Sciences hope to change this deficiency by fortifying foods people frequently eat - eggs and chicken - with the heart-healthy long-chain omega-3 fatty acids. (feedstuffs.com)
it is one of two essential fatty acids that the human body cannot produce on its own but is vital for cardiovascular, cognitive and immune system health. (feedstuffs.com)
While omega-6 fatty acids can be beneficial, consuming too much - which many people do - is not good because it promotes inflammation, Elkin pointed out. (feedstuffs.com)
As a result, when the ratio of omega-6 to omega-3 fatty acids favors the former, fewer omega-3 fatty acids are produced by the liver and transported to tissues such as the brain and retina, where they have other important physiological functions, the researchers noted. (feedstuffs.com)
Unlike typical nutritionally enhanced eggs found in grocery stores, Harvatine's and Elkin's goal is to create poultry products that are richer in long-chain omega-3 fatty acids but lower in omega-6 fatty acids. (feedstuffs.com)
Humans also have a very limited ability to convert linolenic acid to the important omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). (feedstuffs.com)
The contribution of dietary trans fatty acids (TFAs) on the risk of ischemic heart disease (IHD) has recently gained further support due to the results from large, prospective, population-based studies. (karger.com)
The effect of different dietary fatty acids on lipoprotein. (cambridge.org)
While it is well established that the fatty acid composition of dietary fat is important in determining plasma lipoprotein cholesterol concentrations, the effects of changing the absolute quantities of the individual fatty acids are less clear. (cambridge.org)
Neutrophil migration inhibitory properties of polyunsaturated fatty acids. (jci.org)
The n-3 polyunsaturated fatty acids (PUFA) appear to have antiinflammatory properties that can be partly explained by their biological activity on leukocytes. (jci.org)
Arachidonic and docosahexaenoic acids were the most active fatty acids. (jci.org)
Our studies showed that ACBD5 deficiency leads to accumulation of very long-chain fatty acids (VLCFAs) due to impaired peroxisomal β-oxidation. (bmj.com)
mtFAS is required for growth of cultured skeletal myoblasts but does not significantly contribute to cellular fatty acids. (elifesciences.org)
Shown are quantitation of c16:0 and c18:0 fatty acids. (elifesciences.org)
In NAFLD, increased de novo synthesis and uptake of fatty acids led to further hepatocyte accumulation of fatty acids. (spandidos-publications.com)
Marine fish are known to have an absolute dietary requirement for C20 and C22 highly unsaturated fatty acids. (stir.ac.uk)
The evidence obtained in the SAF-1 cell line is consistent with the dietary requirement for C20 and C22 highly unsaturated fatty acids in the marine fish, the sea bream, being primarily due to a deficiency in fatty acid Δ5 desaturase activity. (stir.ac.uk)
Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and signalling molecules1. (mcmaster.ca)
A class of molecules formed when the body metabolizes omega-3 fatty acids could inhibit cancer's growth and spread, University of Illinois researchers report in a new study in mice. (illinois.edu)
Comparative biosciences professor Aditi Das and veterinary clinical medicine professor Timothy Fan found that a class of molecules that form when the body metabolizes omega-3 fatty acids may prevent cancer from migrating. (illinois.edu)
Dietary consumption of omega-3 fatty acids can lead to the formation of these substances in the body and may have some beneficial effects. (illinois.edu)
They also plan to study the effects of EDP-EAs derived from omega-3 fatty acids in other cancer types. (illinois.edu)
The simplest form of fats are fatty acids , which are grouped by length into short, medium, long, and very long chain fatty acids . (osmosis.org)
Short and medium chain fatty acids are primarily obtained from the diet, while long and very long chain fatty acids can be synthesized from acetyl-CoA by the liver and fat cells . (osmosis.org)
Fat burning makes it possible to provide energy through oxidation of fatty acids in the body. (health-site.com)
These fatty acids are provided by the conversion of fat reserves stored in the body. (health-site.com)
These fatty acids then enter the fat metabolism, where they have a comparatively good calorific value. (health-site.com)
The inverse association of cardiovascular risk with intake of omega-3 polyunsaturated fatty acids was suspected early in populations that are known to have a high consumption of fish and fish oil. (current-pharmaceutical-design.com)
To define prophylactic as well as treatment options in primary and secondary prevention, large clinical trial assessed the effect of omega-3 polyunsaturated fatty acids on end points as cardiovascular morbidity and mortality. (current-pharmaceutical-design.com)
However, so far these trials provided ambiguous data that do allow recommendations regarding the use of omega-3 polyunsaturated fatty acids in higher dosages and beyond the dietary advice of regular fish intake only in few clinical situations, such as severe hypertriglyceridemia. (current-pharmaceutical-design.com)
Fatty acids are the preferred energy source for the heart and an important energy source for skeletal muscle during prolonged exertion. (msdmanuals.com)
Epidemiological and laboratory studies have shown that increased consumption of saturated fatty acids (SFA) are associated with an increased risk of CVD, whereas consumption of polyunsaturated fatty acids (PUFA) are associated with reducing the risk of CVD. (mun.ca)
Feeding diets with varying n-6 to n-3 PUFA ratios to C57BL/6 mice led to the incorporation of dietary fatty acids in red blood cell (RBC) phospholipids (PL), and also altered the regulation of lipid and lipoprotein metabolism. (mun.ca)
Circulating odd-chain fatty acids pentadecanoic (15:0) and heptadecanoic acid (17:0) are considered to reflect dairy intake. (biomedcentral.com)
We performed cross-sectional analyses in a subsample of 869 Dutch post-MI patients of the Alpha Omega Cohort who had data on dietary intake and circulating fatty acids. (biomedcentral.com)
Circulating 15:0 and 17:0 (as % of total fatty acids) were measured in plasma phospholipids (PL) and cholesteryl esters (CE). (biomedcentral.com)
The reason is that fatty acids primarily coming from exogenous sources are usually considered good candidates as biomarkers for intake [ 3 ] and more objective than self-reported dietary assessment. (biomedcentral.com)
The objective of this meta-analysis was to investigate the effects of plant-derived polyunsaturated fatty acids (PUFAs) on glucose metabolism and insulin resistance. (bmj.com)
Eligible studies were randomized controlled feeding trials that investigated the effects of a diet high in plant-derived PUFA as compared with saturated fatty acids (SFA) or carbohydrates and measured markers of glucose metabolism and insulin resistance as outcomes. (bmj.com)
For patients with diabetes, dietary guidelines often recommend increasing the intake of foods rich in monounsaturated fatty acids (MUFA) and sometimes the intake of polyunsaturated fatty acids (PUFA). (bmj.com)
How does diet composition influence bird metabolism and fatty acids in the blood? (lu.se)
In particular, the composition of fatty acids in the food can affect many physiological parameters, including energy metabolism. (lu.se)
You will follow how a diet switch impacts the concentration of circulating fatty acids in blood plasma, before and over the course of the diet manipulation experiment, using gas chromatography-mass spectrometry (GC/MS). These results will then be related to the data on cellular- and whole-animal metabolic rate, to gain a better understanding of the mechanisms underlying observed changes in birds following diet manipulation. (lu.se)
Long chain free fatty acids (FFA) are the preferred metabolic substrates of myocardium under aerobic conditions. (elsevierpure.com)
Serum levels of free fatty acids frequently are elevated in patients with myocardial ischemia. (elsevierpure.com)
The proposed mechanisms of the detrimental effects of free fatty acids include: (1) accumulation of toxic intermediates of fatty acid metabolism, such as long chain acyl-CoA thioesters and long chain acylcarnitines, (2) inhibition of glucose utilization, particularly glycolysis, during ischemia and/or reperfusion, and (3) uncoupling of oxidative metabolism from electron transfer. (elsevierpure.com)
Omega-3 fatty acids (O3FA) have been observed to improve metabolic health and therefore might be useful in treatment of obesity. (uark.edu)
These studies were conducted to measure between-study variability of these types of experiments and assess whether dietary fatty acids are handled differently in the follicular vs. luteal phase of the menstrual cycle. (elsevierpure.com)
Leg adipose tissue uptake of meal fatty acids was 15 ± 2% in the follicular phase of the menstrual cycle and 10 ± 1% in the luteal phase (P = NS). (elsevierpure.com)
Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? (biomedcentral.com)
Early randomized controlled trials (RCTs) demonstrated the health benefits of omega-3 fatty acids (n-3), whereas recent RCTs were negative. (biomedcentral.com)
Finally, statins favor the metabolism of omega-6 fatty acids (n-6), which in turn inhibits n-3 and, contrary to n-3, they increase insulin resistance and the risk of diabetes. (biomedcentral.com)
Fatty acids intake in the Mexican population. (biomedcentral.com)
Dietary intake of individual and classes of fatty acids was computed from the dataset of the 2006 Mexican National Health and Nutrition Survey (ENSANUT2006), collected by a food frequency questionnaire. (biomedcentral.com)
the intakes of saturated fatty acids (SFA) among all age-groups (45-60%) and of trans fatty acids (TrFA) in 30% of school-age children and adolescents and 20% of adults exceeded international recommendations. (biomedcentral.com)
The mean intake of polyunsaturated fatty acids (PUFA) and particularly of n6 and n3 PUFAS, was inadequately insufficient in 50% of the sample. (biomedcentral.com)
The objective of the present analysis is to describe the distribution and adequacy of the dietary intake of individual and classes of fatty acids, representing protection or risk for cardiovascular diseases. (biomedcentral.com)
[1] It helps in the consumption and disposal of fat in the body because it is responsible for the transport of fatty acids from the cytosol into the mitochondria . (wikidoc.org)
Carnitine transports long-chain acyl groups from fatty acids into the mitochondrial matrix , so that they can be broken down through beta-oxidation to acetate to obtain usable energy via the citric acid cycle . (wikidoc.org)
Fatty acids must be activated before binding to the carnitine molecule to form acyl-carnitine . (wikidoc.org)
Some authors suggest that the accumulation of methylmalonic acid and odd-chain fatty acids may be directly toxic to neuronal and glial cells. (medscape.com)
With an unavailability of fatty acids, the body resorts to using glucose and glycogen for its energy, which then leads to hypoglycemia. (cdc.gov)
unsaturated fatty acids (n-3 HUFAs), and selenium. (cdc.gov)

Elkin has expertise in poultry nutrition and a long history of work aimed at modifying egg cholesterol content, while Harvatine has expertise in lipid (fat) nutrition and metabolism in dairy cattle. (feedstuffs.com)
In addition, reduced alcoholic steatosis was associated with reduced fatty acid synthesis in combination with increased CYP4A-catalyzed fatty acid oxidation and effects on lipid export. (nih.gov)
Body Composition and lipid metabolism are not inherently good nor bad, but rather an unstoppable force that must be comprehended and redirected for the treatment of various pathologies. (frontiersin.org)
To explore any differences in lipid metabolism between obese and non-obese patients, we determined the expression of fatty acid metabolism-related genes. (spandidos-publications.com)
CYP4F11 is a fatty acid w-hydroxylase and catalyzes the production of the lipid mediator 20-hydroxyeicosatetraenoic acid (20-HETE) from arachidonic acid. (aspetjournals.org)
One of the objectives of this thesis was to investigate the effect of various dietary n-6 to n-3 PUFA ratios on the regulation of lipid and lipoprotein metabolism using C57BL/6 mice as an animal model. (mun.ca)
Given the health benefits of maintaining a proper ratio of dietary n-6 to n-3 PUFA, it was of interest to understand the role of altered maternal dietary n-6 to n-3 PUFA ratio on the regulation of lipid and lipoprotein metabolism in the offspring of C57BL/6 mice at weaning. (mun.ca)
Offspring at weaning were selected to isolate the effects of pre-weaning diet, excluding the post weaning diet, on the offspring's lipid and lipoprotein metabolism. (mun.ca)
The C57BL/6 mice were selected for the current study as these have been already established as an animal model in our laboratory to study 'in utero' programming of lipid and lipoprotein metabolism in the offspring. (mun.ca)
In the one month feeding study, female C57BL/6 mice were fed a diet containing 20% w/w fat with n-6 to n-3 PUFA ratio of either 5:1, 15:1 or 30:1 to establish the effect on the regulation of lipid and lipoprotein metabolism. (mun.ca)
Here we have shown that neurons have abundant expression and activity of the long-chain cytoplasmic acyl coenzyme A (acyl-CoA) thioesterase 7 (ACOT7) to regulate lipid retention and metabolism. (johnshopkins.edu)
In cancer cells however, lipid metabolism is altered and is dependent on continuous de novo FA synthesis for cell proliferation and survival. (tocris.com)

They are accompanied with a range of metabolic and endocrine abnormalities involved in the pathophysiology of pancreatic cancer, including fatty acid metabolism disorder, insulin resistance, inflammatory processes, and disorders in hormonal changes and pancreatic steatosis. (frontiersin.org)
Approach to the Patient With a Suspected Inherited Disorder of Metabolism Most inherited disorders of metabolism (inborn errors of metabolism) are rare, and therefore their diagnosis requires a high index of suspicion. (msdmanuals.com)
Fatty acid metabolism plays a central role in energy homeostasis and related disorders such as the metabolic syndrome, obesity or type-II diabetes. (123dok.net)
Inborn errors of metabolism describes a class of over 1000 inherited disorders caused by mutations in genes coding for proteins that function in metabolism. (medscape.com)
Biochemical genetic testing and newborn screening are essential laboratory services for the screening, detection, diagnosis, and monitoring of inborn errors of metabolism or inherited metabolic disorders. (cdc.gov)

Most of the genes tested related to fatty acid and reactive oxygen species (ROS) elimination, were overexpressed in NAFLD and the levels were significantly higher in non-obese patients. (spandidos-publications.com)
Expression of genes related to fatty acid oxidation and ROS elimination were higher in the non-obese group than in the obese group, which contributes to the trend of more severe liver injury, insulin resistance and steatosis in obese patients. (spandidos-publications.com)

These effects on lipoprotein metabolism may be exerted through specific modulation of the expression of the LDL receptor and apolipoprotein B genes. (cambridge.org)

abstract = "Normal fatty aldehyde and alcohol metabolism is essential for epidermal differentiation and function. (nebraska.edu)

Carnitine acyltransferase I undergoes allosteric inhibition as a result of malonyl-CoA , an intermediate in fatty acid biosynthesis, in order to prevent futile cycling between beta-oxidation and fatty acid synthesis. (wikidoc.org)

Changes in dietary fat composition did not alter ethanol metabolism or CYP2E1 induction, but hepatic CYP4A levels increased markedly in rats fed the saturated fat diet. (nih.gov)
Objectives In non-alcoholic fatty liver disease (NAFLD), hepatic steatosis is intricately linked with a number of metabolic alterations. (bmj.com)
The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. (nature.com)
The alterations in brain fatty acid metabolism were concomitant with a loss of lean mass, hypermetabolism, hepatic steatosis, dyslipidemia, and behavioral hyperexcitability in Acot7 N-/- mice. (johnshopkins.edu)

After 70 d, liver pathology, serum alanine aminotransferase (ALT), biochemical markers of oxidative stress, liver fatty acid composition, cytochrome P450 2E1 (CYP2E1) expression and activity and cytochrome P450 4A (CYP4A) expression were assessed. (nih.gov)
Background and aims: Several susceptibility gene variants predisposing to nonalcoholic fatty liver disease (NAFLD) have been identified in chronic kidney disease (CKD). (lu.se)
Ingestion of the poison causes a malady referred to as Jamaican vomiting sickness, which involves a disruption of fatty acid metabolism, leading to fatty acid accumulating in the liver. (cdc.gov)

The purpose of this study was to investigate the effects of HIT and MIT on the right ventricular glucose and fat metabolism along with its structural and functional parameters. (jyu.fi)
The main finding was that the right ventricular glucose uptake was decreased (p = 0.001 for the training effect) after both HIT (-22 %) and MIT (-15 %) whereas fat metabolism remained unchanged (p = 0.96). (jyu.fi)
Hence, two weeks of training induced adaptations in right ventricular glucose metabolism and volume while its mass and stroke volume remained unchanged. (jyu.fi)
Accumulated evidence from genetic animal models suggests that the brain, particularly the hypothalamus, has a key role in the homeostatic regulation of energy and glucose metabolism. (nature.com)
Here we comprehensively review the above topics, discussing the main findings related to the role of the brain in the homeostatic regulation of energy and glucose metabolism. (nature.com)
You decide to run a blood test, which also reveals low blood glucose and ketone bodies , but unlike Dalia, he has high levels of fatty acyl-carnitine. (osmosis.org)
In dose-response analyses, a 5% increase in energy (En%) from PUFA significantly reduced insulin by 5.8 pmol/L (95% CI −10.2 to −1.3 pmol/L), but not glucose (change −0.07, 95% CI −0.17 to 0.04 mmol/L) and HOMA-IR (change − 0.24, 95% CI −0.56 to 0.07 units). (bmj.com)
OBJECTIVE: Free fatty acid (FFA) oxidation is reduced in subjects with type 2 diabetes mellitus and impaired glucose tolerance (IGT). (maastrichtuniversity.nl)

The PUFA concentration required to inhibit migration was dependent on cell number, suggesting that the fatty acid effects on leukocyte migration in vivo may be governed by the stage of the inflammatory response. (jci.org)
Barramundi (Lates calcarifer), a catadromous teleost of significant and growing commercial importance, are reported to have limited fatty acid bioconversion capability and therefore require preformed long-chain PUFA (LC-PUFA) as dietary essential fatty acid (EFA). (stir.ac.uk)

A ) Schematic of the mitochondrial fatty acid synthesis pathway and downstream lipoic acid synthesis. (elifesciences.org)
Now, keep in mind that acetyl-CoA is usually found in the mitochondrial matrix, whereas the enzymes required for fatty acid synthesis are all in the cytoplasm. (osmosis.org)
Fatty acid synthase (FASN) , EC 2.3.1.85, catalyzes the final stage of de novo fatty acid (FA) synthesis, that is the conversion of acetyl-CoA and malonyl-CoA to the 16-carbon FA palmitate. (tocris.com)

Although the chicken is able to convert the 18-carbon omega-3 fatty acid found in plants to the heart-healthy long-chain omega-3s, the process is very inefficient. (feedstuffs.com)
In 2017, the Illinois team identified a new group of omega-3 fatty-acid metabolites called endocannabinoid epoxides, or EDP-EAs. (illinois.edu)

Microarray analyses revealed that TRAF6-deficient CD8 T cells exhibit altered expression of genes that regulate fatty acid metabolism. (nih.gov)
These studies indicate that several enzymes within metabolic pathways that regulate fatty acid metabolism may serve as targets for pharmacological interventions for obesity. (eurekaselect.com)

The role of fatty acid structure, metabolism, and possible second messenger systems. (jci.org)

Long-chain aldehydes are produced by catabolism of several lipids including fatty alcohols, sphingolipids, ether glycerolipids, isoprenoid alcohols and certain aliphatic lipids that undergo α- or ω-oxidation. (nebraska.edu)

Between meals they are released as follows: Lipolysis, the removal of the fatty acid chains from the glycerol to which they are bound in their storage form as triglycerides (or fats), is carried out by lipases. (wikipedia.org)
Using fat as an energy source requires catabolizing adipose tissue into free fatty acid and glycerol. (msdmanuals.com)

We review studies that support the use of modulators of fatty acid synthase (FAS) and carnitine palmitoyltransferase-1 (CPT-1) to influence known energy sensors such as AMP-activated protein kinase (AMPK) to affect food intake and energy consumption. (eurekaselect.com)
1 Evidence-based lifestyle modification programmes to lower the risk for diabetes involve dietary changes, including reductions in saturated fatty acid (SFA) intake and increases in dietary fibre intake. (bmj.com)
Objective: The objective of this thesis was to determine if habitual intake of O3FA at breakfast improves energy metabolism, appetite, and metabolic response in overweight and obese school-aged children. (uark.edu)
The objective of the study is to describe quantitatively the intake and adequacy of fatty acid classes among the Mexican population aged 5-90 years from a probabilistic survey. (biomedcentral.com)
There is little or null information about the intake of individual or classes of fatty acid in the Mexican diet, despite their risks and benefits for the health of the population. (biomedcentral.com)
C-reactive protein level had a significant association with body mass index (r = 0.18), adiposity (r = 0.23), smoking (r = 0.20), carbohydrate intake (r = 0.19) and saturated fatty acid (r = 0.20). (who.int)

Carnitine is required for long-chain fatty acid oxidation. (msdmanuals.com)
Secondary carnitine deficiency is a secondary biochemical feature of many organic acidemias and fatty acid oxidation defects. (msdmanuals.com)
Metabolic pathway enrichment identified 41 pathways associated with benzene exposure, with altered pathways including carnitine shuttle, fatty acid metabolism, sulfur amino acid metabolism, glycolysis, gluconeogenesis and branched chain amino acid metabolism. (cdc.gov)

Energy expenditure (indirect calorimetry), meal fatty acid oxidation, and meal fatty acid uptake into upper body and lower body subcutaneous fat (biopsies) 24 h after the experimental meal were measured. (elsevierpure.com)
Variance in meal fatty acid uptake was somewhat (P = NS) greater in women than in men, although menstrual cycle factors did not contribute significantly. (elsevierpure.com)
These results suggest disruption to fatty acid uptake, energy metabolism and increased oxidative stress, and point towards pathways related to mitochondrial dysfunction, which has previously been linked to benzene exposure in animal models and human studies. (cdc.gov)

Consistent with this, activated CD8 T cells lacking TRAF6 display defective AMP-activated kinase activation and mitochondrial fatty acid oxidation (FAO) in response to growth factor withdrawal. (nih.gov)

Genetic deficiency of FALDH/FAO in patients with Sjögren-Larsson syndrome (SLS) results in accumulation of fatty aldehydes, fatty alcohols and related lipids (ether glycerolipids, wax esters) in cultured keratinocytes. (nebraska.edu)
Rizzo, WB 2014, ' Fatty aldehyde and fatty alcohol metabolism: Review and importance for epidermal structure and function ', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids , vol. 1841, no. 3, pp. 377-389. (nebraska.edu)

Oxidation and adipose tissue uptake of dietary fat can be measured by adding fatty acid tracers to meals. (elsevierpure.com)

Although lamellar bodies appear to be the pathogenic target for abnormal fatty aldehyde/alcohol metabolism in SLS, the precise biochemical mechanisms are yet to be elucidated. (nebraska.edu)

We conclude that leg uptake of dietary fat is slightly more variable in women than in men, but that there are no major effects of menstrual cycle on meal fatty acid disposal. (elsevierpure.com)

Acyl-CoA binding protein (ACBP) maintains a pool of fatty acyl-CoA molecules in the cell and plays a role in fatty acid metabolism. (rcsb.org)

The gut microbiota is currently considered a key regulator of host energy metabolism ( Sonnenburg and Bäckhed, 2016 ). (biorxiv.org)
lactis GCL2505 modulates host energy metabolism via the short-chain fatty acid receptor GPR43. (bvsalud.org)

Here we show that tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF6), an adaptor protein in the TNF-receptor and interleukin-1R/Toll-like receptor superfamily, regulates CD8 T(M)-cell development after infection by modulating fatty acid metabolism. (nih.gov)
Here we report a new level of regulation wherein LCFA-CoA esters per se allosterically activate AMP-activated protein kinase (AMPK) β1-containing isoforms to increase fatty acid oxidation through phosphorylation of acetyl-CoA carboxylase. (mcmaster.ca)
Inborn errors of metabolism (IEMs) are a large group of rare genetic diseases that generally result from a defect in an enzyme or transport protein which results in a block in a metabolic pathway. (medscape.com)

Methylmalonic acidemia is an autosomal recessive disorder of amino acid metabolism, involving a defect in the conversion of methylmalonyl-coenzyme A (CoA) to succinyl-CoA. (medscape.com)

While the metabolic pathways involved in fatty acid homeostasis are quite well understood and referenced, the genetic regulations are much less accurately described. (123dok.net)

Interluekin-6 concentration was significantly correlated with dietary carbohydrate (r = 0.15), saturated fatty acid (r = 0.15) and glycaemic load (r = 0.15). (who.int)

Once inside the cell, long-chain-fatty-acid-CoA ligase catalyzes the reaction between a fatty acid molecule with ATP (which is broken down to AMP and inorganic pyrophosphate) to give a fatty acyl-adenylate, which then reacts with free coenzyme A to give a fatty acyl-CoA molecule. (wikipedia.org)

The fatty aldehyde generated by these pathways is chiefly metabolized to fatty acid by fatty aldehyde dehydrogenase (FALDH, alternately known as ALDH3A2), which also functions to oxidize fatty alcohols as a component of the fatty alcohol:NAD oxidoreductase (FAO) enzyme complex. (nebraska.edu)
Unbiased and targeted metabolomic analysis of fasted mice with a conditional knockout of ACOT7 in the nervous system, Acot7 N-/- , revealed increased fatty acid flux into multiple long-chain acyl-CoA-dependent pathways. (johnshopkins.edu)

Based on the initial presentation, both Dalia and Luca seem to have some fatty acid metabolism disorder. (osmosis.org)

The other essential fatty acid is linoleic acid, an 18-carbon omega-6 fatty acid. (feedstuffs.com)

The up-regulation of fatty acid oxidation and the antioxidant pathway and the suppression of lipolysis seemed to be involved in this process. (spandidos-publications.com)
In the present study, the fatty acid desaturase/elongase pathway was investigated in a cell line (SAF-1) from another carnivorous marine fish, sea bream. (stir.ac.uk)
A deficiency in the desaturation/elongation pathway was clearly identified at the level of the fatty acyl Δ5 desaturase which was very low, particularly with 20:4n-3 as substrate. (stir.ac.uk)
The main pathway of methylmalonyl-CoA production involves the metabolism of isoleucine, valine, threonine, and methionine. (medscape.com)

Accordingly, ACBD5 deficiency is a novel single peroxisomal enzyme deficiency caused by impaired VLCFA metabolism, leading to retinal dystrophy and white matter disease. (bmj.com)
Previous studies using cultured cell lines indicated that underlying this requirement in marine fish was either a deficiency in fatty acyl Δ5 desaturase or C18-20 elongase activity. (stir.ac.uk)

The transcription of several genes involved in fatty acid metabolism was affected after 2 weeks of feeding, showing a rapid nutritional regulation. (stir.ac.uk)
Many genes are involved in the metabolism of warfarin and in determining the drug's effects in the body. (medlineplus.gov)
Certain common changes (polymorphisms) in the CYP2C9 and VKORC1 genes account for most of the variation in warfarin metabolism due to genetic factors. (medlineplus.gov)
Polymorphisms in other genes, some of which have not been identified, have a smaller effect on warfarin metabolism. (medlineplus.gov)

This reaction is catalyzed by the enzyme fatty acyl-CoA synthetase and driven to completion by inorganic pyrophosphatase . (wikidoc.org)
Several CYP2C9 gene polymorphisms decrease the activity of the CYP2C9 enzyme and slow the body's metabolism of warfarin. (medlineplus.gov)

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