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CimetidineHistamine H2 AntagonistsGuanidinesRanitidineFamotidineDuodenal UlcerReceptors, Histamine H2DimapritEnergy MetabolismLipid MetabolismHistamineGastric AcidReceptors, HistaminePyrilamineAnti-Ulcer AgentsDrug InteractionsMagnesium HydroxideHistamine H1 AntagonistsStomach UlcerDiphenhydramineHistamine AntagonistsAntacidsReceptors, Histamine H1Organic Cation Transport ProteinsMetabolismHistamine AgonistsImpromidineAluminum HydroxideGastric JuiceGastric Acidity DeterminationGlucoseLiverFuransChlorpheniramineAdministration, OralMetiamidePentagastrinBiotransformationCytochrome P-450 Enzyme SystemMicrosomes, LiverKineticsGastric MucosaClonazepamAnxiety DisordersEconomics, NursingPanic DisorderLactationSeizuresAlgorithms
HepaticTagametInhibitorsAntidepressantsKetoconazoleEnzymeLiverPhenytoinInhibitInterferesToxicityPlasmaEffectEffectsBlood flowAdministrationRanitidineExcretionHepatic metabolismHistamineAbsorptionPharmacokineticsCarbamazepineAntagonistLiverRenalEnzymesCYP3A4ErythromycinEliminationPhenobarbitalMetabolitesCytochromeIncreases0.05PlaceboSystemicMedicationCaffeineProcainamideDosesInhibitionUrineDrugsConcomitantDrugConcentration2020EffectEffectsProteinUltimatelyLung
Hepatic6
  • apalutamide will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • Also inhibits cytochrome P450 enzymes and thereby inhibits hepatic estradiol metabolism and increases circulating estradiol levels. (wikipedia.org)
  • carbamazepine will decrease the level or effect of irinotecan liposomal by affecting hepatic enzyme CYP2B6 metabolism. (medscape.com)
  • apalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • enzalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • Caffeine metabolism in preterm neonates is limited due to their immature hepatic enzyme systems. (drugs.com)
Tagamet4
Inhibitors2
Antidepressants2
  • Barbiturates like butabarbital may increase the metabolism of tricyclic antidepressants like amoxipine. (genelabs.com)
  • Barbiturates such as butalbital may increase the metabolism of tricyclic antidepressants amoxapine. (genelabs.com)
Ketoconazole3
Enzyme2
  • Might niclosamide's poor solubility be just one part of the problem, with enzyme metabolism more critical? (news-medical.net)
  • The metabolising enzyme CYP2D6 is involved in the metabolism of most TCAs and drugs which inhibit this enzyme (e.g. (bpac.org.nz)
Liver5
  • 1. The inhibitory effects of cimetidine, nizatidine and omeprazole on the metabolic activity of CYP2C9, 2C19, 2D6 and 3A were investigated in human liver microsomes. (nih.gov)
  • The average CL(int) value (sum of 4- and alpha-hydroxylation) obtained using three human liver microsomal samples was 4-fold higher than that obtained using three small intestinal microsomal samples from the same donors, indicating the minor contribution of intestinal metabolism to alprazolam disposition. (nih.gov)
  • A quantitative prediction of the AUC increase by cimetidine was also successful (1.73-1.79 vs 1.58-1.64), considering the active transport of cimetidine into the liver. (nih.gov)
  • In conclusion, we have succeeded in carrying out an in vitro/in vivo scaling of alprazolam metabolism using human liver microsomes and human CYP3A4 and CYP3A5 recombinants. (nih.gov)
  • It reduces concentration of glucose in blood suppressing metabolism of glucose in the liver, reducing absorption of glucose from the gastrointestinal tract, and enhancing its utilization in tissues. (canadianokpharmacy.com)
Phenytoin1
Inhibit1
  • 3. Nizatidine did not inhibit the metabolism of cisapride, glibenclamide, benidipine and simvastatin. (nih.gov)
Interferes1
  • Travelers taking atovaquone-proguanil for malaria prophylaxis should avoid using cimetidine (an H2 receptor antagonist) because this medication interferes with proguanil metabolism. (cdc.gov)
Toxicity1
  • Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, amoxapine, by decreasing its metabolism. (genelabs.com)
Plasma1
  • SSRIs, amiodarone, cimetidine, methadone) will increase plasma concentrations of TCAs and dose related adverse effects. (bpac.org.nz)
Effect2
  • Terbinafine is an inhibitor of CYP450 2D6 isozyme and has an effect on metabolism of desipramine. (nih.gov)
  • It was designed to test if cimetidine will have effect on offspring born to mothers who took cimetidine during gestation period. (imsuinfo.com)
Effects1
  • The concern of this research was the Behovioural teratogenic effects of cimetidine on the offspring's of Albino Rats. (imsuinfo.com)
Blood flow2
  • Factors affecting duration such as protein binding, regional blood flow, metabolism and use of vasoconstrictors scored marks. (derangedphysiology.com)
  • A simple lung model (mucosal blood flow and metabolism model, MBM model) was developed to describe the uptake of organic solvents and investigate the role of mucosal blood flow and metabolism. (cdc.gov)
Administration1
  • Concomitant administration with indirect anticoagulants and Cimetidine should be done with cautiousness. (aerodisk.com)
Ranitidine8
  • A comparison of some of the pharmacological properties of etintidine, a new histamine H2-receptor antagonist, with those of cimetidine, ranitidine and tiotidine. (nih.gov)
  • Effects of cimetidine and ranitidine on halothane metabolism and hepatotoxicity in an animal model. (aspetjournals.org)
  • A pharmacokinetic and pharmacodynamic interaction study between nebivolol and the H2-receptor antagonists cimetidine and ranitidine. (ox.ac.uk)
  • AIMS: The study was designed to investigate the effects of the H2-receptor antagonists, cimetidine and ranitidine on the pharmacokinetics and pharmacodynamics of nebivolol in healthy volunteers. (ox.ac.uk)
  • Each subject received on three separate occasions placebo, cimetidine (400 mg twice daily) or ranitidine (150 mg twice daily) for 24 h before and 48 h after a single oral dose of nebivolol (5 mg). (ox.ac.uk)
  • Statistical analysis of the resting blood pressure and heart rate and exercise data did not suggest any consistent effects of ranitidine or cimetidine upon the pharmacodynamic effects of nebivolol. (ox.ac.uk)
  • Drug Interactions - Itraconazole requires an acidic environment for maximal absorption, therefore antacids , Histamine 2 -blockers (cimetidine, ranitidine, etc) or didanosine will cause marked reduction in absorption of itraconazole. (elephantcare.org)
  • It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. (bvsalud.org)
Excretion2
  • Although urinary excretion of unchanged drug decreased in the presence of cimetidine, the urinary concentrations still exceeded MIC 90 values for typical pathogens implicated in urinary tract infections (0.25 mg/L) [ 2 , 8 ] throughout the 24-hour dosage interval. (medscape.com)
  • Metformin does not undergo hepatic metabolism or biliary excretion. (empr.com)
Hepatic metabolism2
Histamine3
  • In vitro studies show that cimetidine is a specific competitive histamine H2-receptor antagonist. (nih.gov)
  • The evidence suggests that cimetidine inhibits gastric acid secretion through blockade of histamine H2-receptors in the gastric mucosa. (nih.gov)
  • Because pentagastrin-stimulated acid secretion could be completely inhibited by a histamine H2-receptor antagonist (cimetidine) and because IL-1 had no effect on histamine-stimulated acid secretion, it is possible that IL-1 exerts its antisecretory actions by inhibiting pentagastrin-stimulated histamine release. (nih.gov)
Absorption2
  • The absorption, distribution, and elimination of caffeine, 2 mg/kg by mouth, were evaluated in six smokers and six nonsmokers before and on the fourth day of administration of cimetidine, 300 mg by mouth every 6 hr. (nih.gov)
  • It reduces concentration of glucose in blood suppressing metabolism of glucose in the liver, reducing absorption of glucose from the gastrointestinal tract, and enhancing its utilization in tissues. (umc-cares.org)
Pharmacokinetics2
  • Therefore, it was possible that inhibition of active renal transport by cimetidine could significantly affect the pharmacokinetics of gemifloxacin. (medscape.com)
  • Cite this: Effect of Cimetidine on the Pharmacokinetics of Oral Gemifloxacin in Healthy Volunteers - Medscape - Jul 01, 2001. (medscape.com)
Carbamazepine1
Antagonist1
  • Travelers taking atovaquone-proguanil for malaria prophylaxis should avoid using cimetidine (an H2 receptor antagonist) because this medication interferes with proguanil metabolism. (cdc.gov)
Liver2
  • In vitro metabolism of the antimalarial agent primaquine by mouse liver enzymes and identification of a methemoglobin-forming metabolite. (aspetjournals.org)
  • liver micsrosomal enzymes are induced by a wide variety of drugs and these affect the metabolism of other drugs reducing their concentration and hence effect. (powershow.com)
Renal1
  • When coadministered with cimetidine, the renal clearance of gemifloxacin showed a modest reduction (on average, 28%), when compared with results on coadministration with placebo. (medscape.com)
Enzymes1
  • Also inhibits cytochrome P450 enzymes and thereby inhibits hepatic estradiol metabolism and increases circulating estradiol levels. (wikipedia.org)
CYP3A41
  • The development of a potentially life-threatening serotonin syndrome may occur with use of tramadol products, including ConZip™ , particularly with concomitant use of serotonergic drugs such as SSRIs, SNRIs, TCAs, MAOIs and triptans, with drugs which impair metabolism of serotonin (including MAOIs) and with drugs which impair metabolism of tramadol (CYP2D6 and CYP3A4 inhibitors). (wikidoc.org)
Erythromycin2
  • Other medication that intrude with the metabolism of sildenafil embody erythromycin and cimetidine, both of which can additionally result in extended plasma half-life levels. (haydennace.com)
  • Loratadine increasing plasma level has been reported in concomitant use with Ketoconazole, Erythromycin or Cimetidine in a controlled clinical trial, but no significant clinical change (including electrocardiographic). (bernofarm.com)
Elimination1
  • As a result of the minimal decrease in the total oral plasma clearance, gemifloxacin AUC increased by only 10% and its plasma elimination half-life was prolonged by only 0.75h when gemifloxacin was coadministered with cimetidine. (medscape.com)
Phenobarbital1
  • This medication can interact with other medications that depress the central nervous system like barbituates (including phenobarbital), tranquilizers (including Haldol®, Librium®, and Xanax ®), other narcotics, MAOI's, cimetidine, and general anesthetic. (allfiveoceans.com)
Metabolites2
  • Paroxetine metabolism is mediated in part by CYP2D6, and the metabolites are primarily excreted in the urine and to some extent in the feces. (nih.gov)
  • Cimetidine, however, resulted in a 21-23% increase in Cmax of unchanged nebivolol and of each enantiomer plus its hydroxylated metabolites. (ox.ac.uk)
Cytochrome3
  • The predominant mechanism for this interaction is the inhibition of cytochrome P -450 3A4 in the small intestine, resulting in a significant reduction of drug presystemic metabolism. (nature.com)
  • Cytochrome P450 1A2 is the principal isozyme involved in tacrine metabolism. (illumina.com)
  • Genetic Polymorphisms of Cytochrome P450 2C19 in Functional Dyspeptic Patients Treated with Cimetidine. (cdc.gov)
Increases2
  • Caffeine induced similar slight increases in blood pressure and pulse rate in smokers and nonsmokers both before and during cimetidine dosing. (nih.gov)
  • This is a condition where cells metabolism speeds up and heart rate increases, which can lead to diarrhea. (bisquelbi.com)
0.051
  • Cimetidine decreased the TBC of caffeine by 31% (to 1.73 +/- 0.28 ml/kg/min, P less than 0.05) and by 42% (to 0.92 +/- 0.11 ml/kg/min, P less than 0.01) in smokers and nonsmokers. (nih.gov)
Placebo1
  • However, oral plasma clearance of gemifloxacin was only reduced by, on average, 9% when coadministered with cimetidine compared with placebo. (medscape.com)
Systemic1
Medication1
  • OTC labeling: When used for self-medication (OTC), do not use if trouble or pain when swallowing food, vomiting with blood, or bloody or black stools, allergic to cimetidine or other acid reducers. (medicine.com)
Caffeine2
Procainamide1
  • Metabolism of procainamide to a hydroxylamine by rat and human hepatic microsomes. (aspetjournals.org)
Doses1
Inhibition1
  • Preincubation enhanced cimetidine inhibition of noroxycodone formation and rabeprazole inhibition of all pathways. (ojp.gov)
Urine1
  • Alogliptin does not undergo extensive metabolism and 60-71% of the dose is excreted as unchanged drug in the urine. (empr.com)
Drugs1
Concomitant1
  • Concomitant administration with indirect anticoagulants and Cimetidine should be done with cautiousness. (umc-cares.org)
Drug3
Concentration1
20201
  • METHODS: We searched Ovid Medline 1946-2020, Embase 1947-2020, Scopus 2004-2020, Cochrane Databases of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), and clinicaltrials.gov 1997-2020 for records including the concepts of paracetamol poisoning and cimetidine, fomepizole, calmangafodipir, and acetylcysteine. (bvsalud.org)
Effect1
  • There is no known toxic effect which would limit the usefulness of cimetidine in man. (nih.gov)
Effects1
Protein1
Ultimately2
Lung1
  • A simple lung model (mucosal blood flow and metabolism model, MBM model) was developed to describe the uptake of organic solvents and investigate the role of mucosal blood flow and metabolism. (cdc.gov)