Metabolism axin protein. Medical search. Frequent questions

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. (wikipedia.org)
First discovered in 1980 as a regulatory kinase for its namesake, glycogen synthase (GS), GSK-3 has since been identified as a protein kinase for over 100 different proteins in a variety of different pathways. (wikipedia.org)
GSK-3 is a serine/threonine protein kinase that phosphorylate either threonine or serine, and this phosphorylation controls a variety of biological activities, such as glycogen metabolism, cell signaling, cellular transport, and others. (wikipedia.org)
Outcomes Diet-induced weight problems reduced cardiac blood sugar fat PTK787 2HCl burning capacity GLUT and AMP-activated proteins kinase (AMPK) amounts which was connected with increased degrees of macrophages toll-like receptor 4 suppressor of cytokine signaling 3 (SOCS3) and cytokines in center. (cancer-ecosystem.com)
Price TJ, Das V, Dussor G. Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain. (rush.edu)
A group of cell cycle proteins that negatively regulate the activity of CYCLIN / CYCLIN-DEPENDENT KINASE complexes. (nih.gov)

There are few studies on lipid metabolism in tumor metastasis. (biomedcentral.com)
Our previous study demonstrated that after developmental seizures in rats, E-64d exerts a neuroprotective effect on the seizure-induced brain damage by modulating lipid metabolism enzymes, especially ApoE and ApoJ/clusterin. (omicsdi.org)
AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP. (rush.edu)

The inactivation of GSK3B by various protein kinases also affects the adaptive immune response by inducing cytokine production and proliferation in naïve and memory CD4+ T cells. (wikipedia.org)
AMP-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. (rush.edu)
This graph shows the total number of publications written about "AMP-Activated Protein Kinases" by people in this website by year, and whether "AMP-Activated Protein Kinases" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "AMP-Activated Protein Kinases" by people in Profiles. (rush.edu)
A family of cell cycle proteins containing ANKYRIN REPEATS that are specific inhibitors of cyclin D-dependent kinases. (nih.gov)

these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3 , adenomatous polyposis coli (APC) and axin. (tocris.com)
The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)

Phosphorylation of a protein by GSK-3 usually inhibits the activity of its downstream target. (wikipedia.org)
Among multiple downstream signalling occasions p38MAPK favorably regulates the experience of myogenic bHLH elements such as MyoD via phosphorylation of the ubiquitously indicated E-protein-binding partners of the myogenic as well as neural bHLH factors17 18 Consistently Cdo also promotes neuronal differentiation by activation of transcriptional activity of Neurogenin1 in P19 embryonal carcinoma cells19. (cell-metabolism.com)
Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)

Those two mechanisms play an important role in glycogen metabolism. (wikipedia.org)

We show that RNF146, tankyrase, and Axin form a protein complex, and that RNF146 mediates ubiquitylation of all three proteins to target them for proteasomal degradation. (omicsdi.org)
Tankyrase auto-PARsylation and PARsylation of Axin is known to lead to proteasome-mediated degradation of these proteins, and we demonstrate that, through ubiquitylation, RNF146 mediates this process to regulate Wnt signaling. (omicsdi.org)

Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). (novusbio.com)

It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
Wnt proteins regulate developmental processes, tissue regeneration and stem cell maintenance. (exeter.ac.uk)

In keeping with its appearance pattern Cdo has important assignments in myogenesis and neurogenesis12 13 In myoblasts Cdo promotes differentiation as an element of multiprotein complexes offering the cell adhesion substances N-cadherin as well as the carefully related proteins Boc and Neogenin14-16. (cell-metabolism.com)
Hamanaka, R. B. & Chandel, N. S. Mitochondrial metabolism as a regulator of keratinocyte differentiation. (nature.com)
Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways. (pfmjournal.org)
Local factors, including transcription factors such as SRY-box 9 protein (SOX9), Runt-related transcription factor 2 (RUNX2), and bone morphogenetic proteins (BMPs), along with signaling pathways such as the Wnt pathway, play critical roles in chondrocyte proliferation and differentiation. (pfmjournal.org)
Chondrocyte growth, metabolism, and differentiation are complex processes. (pfmjournal.org)

Mechanistically, how tankyrase limits Axin protein accumulation, and how tankyrase levels and activity are regulated for this function, are currently under investigation. (omicsdi.org)

MF's action increases the activity of AMPK, and consequently normalizes the energy metabolism of the target cell. (encyclopedia.pub)
At the lysosomal surface, free aldolase promotes the formation of a multiprotein complex, including the vacuolar H + -ATPase and the scaffold protein AXIN, and this complex ensures the effective binding between AMPK and LKB1, thereby activating AMPK [ 25 ] [ 26 ] . (encyclopedia.pub)
A negative regulator of AMPK is the protein phosphatase 2C (PP2C), which dephosphorylates and inactivates the α-subunit of AMPK, causing the dissociation of the αβγ-heterotrimeric complex. (encyclopedia.pub)
Acute physiological elevation of IL-6 suppressed blood sugar metabolism and triggered insulin level of resistance by raising SOCS3 and via SOCS3-mediated inhibition of insulin receptor substrate (IRS)-1 and perhaps AMPK in center. (cancer-ecosystem.com)
IL-6 reduces blood sugar fat burning capacity by suppressing AMPK and insulin PTK787 2HCl receptor substrate (IRS)-linked insulin signaling in center whereas IL-6-deficient mice are covered from diet-induced modifications in blood sugar metabolism. (cancer-ecosystem.com)

AXIN1 and AXIN2 protein levels are regulated by tankyrase-mediated poly(ADP-ribosyl)ation (PARsylation), which destabilizes Axin and promotes signaling. (omicsdi.org)

This gene and/or its encoded proteins are associated with 219 experimentally validated interaction(s) in this database. (innatedb.com)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Male mice homozygous for a gene trapped allele exhibit decreased fat pad weight, increased metabolism, hyperinsulinemia, and hypoglycemia. (utsouthwestern.edu)

SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)

Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. (omicsdi.org)
By RNAi screening, we identified the RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins. (omicsdi.org)
RNF146 also destabilizes tankyrases TNKS1 and TNKS2 proteins and, in a reciprocal relationship, tankyrase activity reduces RNF146 protein levels. (omicsdi.org)
RNF146 is a cytoplasmic protein that also prevents tankyrase protein aggregation at a centrosomal location. (omicsdi.org)

Metabolism reprogramming provides sufficient energy, amino acids, ribose, phospholipids and other macromolecules to meet demands for rapid proliferation [ 8 ], and it might play a critical role during the process of tumor metastasis. (biomedcentral.com)

ACLY could stabilize CTNNB1 (beta-catenin 1) protein by interacting, and the complex might promote CTNNB1 translocation through cytoplasm to nucleus, subsequently promote the CTNNB1 transcriptional activity and migration and invasion abilities of colon cancer cells. (biomedcentral.com)

Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)

Taxon ID: the taxon identifier of the organisms with the number of their proteins annotated by UniProt in brackets. (biomedcentral.com)

β-catenin protein is an integral part of the canonical Wnt signaling pathway. (tocris.com)
Mutations in β-catenin, axin and APC have been discovered in numerous cancers, and other members of the canonical pathway may also contribute to misregulation of Wnt signaling. (tocris.com)
SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
During the course of this review, attention is paid to the influence of intestinal microbiota on the vitamin A metabolism and the RA signaling pathway, as well as the mutual promotion relationships between them in the prevention of bladder cancer, In addition, it emphasizes the importance of intestinal microbiota for bladder cancer prevention and treatment. (bvsalud.org)
A database to provide information about the known and explored therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. (idrblab.net)

Multiprotein complexes that carry out protein SECRETION PROCESSES. (bvsalud.org)

Thus, Dab2 mediates the simultaneous attachment of clathrin-coated cargos containing transmembrane proteins with one or more NPXY motifs, such as the low density lipoprotein (LDL) receptor, megalin, and integrins, to the myosin motor, enabling endocytosis and directional trafficking. (biomedcentral.com)

Previously, researchers mainly focus on glucose and glutamine metabolism in the field of tumor metabolism and metastasis. (biomedcentral.com)
Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice. (rush.edu)

This function of Axin is counteracted through relocalization of Axin protein to the Wnt receptor complex to allow for ligand-activated Wnt signaling. (omicsdi.org)
They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. (bvsalud.org)

Species and strain information is followed by columns showing information on the 9 proteins with retained LDRs. (biomedcentral.com)
Animal models in multiple species have confirmed that early life represents a critical window of phenotypic plasticity, highly responsive to maternal behaviour, stress, metabolism and nutrition (reviewed by [1] ). (prolekarniky.cz)

Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. (bvsalud.org)

Scope includes mutations and abnormal protein expression. (cancerindex.org)

We further show that DNA methylation is predictably influenced by periconceptional maternal plasma biomarker concentrations of key micronutrients involved in one-carbon metabolism. (fertilityacupuncturistseattle.com)

Abcam: antibodies, proteins, kits. (abcam.com)

In addition to maintaining specific organelle structures, phase separation enables hub proteins to assemble signalosomes which promote the speed of signaling outputs 11 , 12 . (nature.com)
Since these intrinsically disordered regions, which are conformationally dynamic and do not adopt stable secondary or tertiary structures, are often essential for mediating the phase transition of proteins 9 , it is therefore of interest to consider if the C-terminus of IRS-1 is involved in phase separation and to further delineate such implications upon insulin/IGF signaling. (nature.com)

Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis. (nature.com)

However, Dab2 has a physiological role in the endocytosis of lipoproteins and cholesterol metabolism. (biomedcentral.com)

Disabled-2 (Dab2) is an endocytic adaptor protein involved in clathrin-mediated endocytosis and cargo trafficking. (biomedcentral.com)

Multiprotein complexes that carry out PROTEIN TRANSPORT across CELL MEMBRANES. (bvsalud.org)
The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration-dependent manner. (exeter.ac.uk)
We identified a novel way of spreading Wnt proteins in vertebrates: Wnt molecules are mobilized on specific cell protrusions known as cytonemes. (exeter.ac.uk)
In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)
Protein concentrations should be titrated based on cell type and if appropriate, passage number of the cell line. (novusbio.com)

These specialized signalling filopodia transmit signal proteins between communicating cells and allow a high degree of control of propagation speed, direction and concentration of the transmitted ligand. (exeter.ac.uk)
In wild type cells, Wnt family protein members (e.g. (biomedcentral.com)

Diet-induced irritation and flaws in blood sugar metabolism had been attenuated in IL-6 knockout mice implicating the function of IL-6 in obesity-associated cardiac irritation. (cancer-ecosystem.com)
Our latest study (7) discovered that chronic high-fat nourishing impairs myocardial blood sugar metabolism which was connected with ventricular hypertrophy and cardiac dysfunction in obese mice. (cancer-ecosystem.com)

We analyzed the correlation between ACLY and CTNNB1 protein in 78 colon cancer patients by Pearson correlation. (biomedcentral.com)
Immunohistochemical analysis of 78 colon cancer patients showed that the high expression levels of ACLY and CTNNB1 protein was positively correlated with metastasis of colon cancer. (biomedcentral.com)

Insulin receptor substrate (IRS) proteins play essential roles in mediating insulin/IGF signaling by recruiting a series of downstream effectors 23 . (nature.com)

Mechanistically, QL-007 blocked the encapsidation of pgRNA and induced aberrant polymers assembly at concentrations ≥100 nM, while having no impact on the stability of core proteins. (bvsalud.org)

Chemicals and Drugs5

Phenomena and Processes2

Information Science3

Kinase6

Lipid metabolism3

Kinases6

Adenomatous poly2

Phosphorylation3

Glycogen metabolism1

Degradation2

Lipoprotein receptor-related protein1

Regulate2

Differentiation5

Accumulation1

AMPK5

Axin11

Gene4

Cellular1

Tankyrase4

Amino acids1

Stabilize1

Binds1

UniProt1

Pathway6

Processes1

Mediates1

Glucose2

Complex2

Species2

Cytosol1

Mutations1

Maternal1

Antibodies1

Phase separation2

Lactate1

Physiological1

Adaptor1

Cell5

Cells2

Mice2

CTNNB12

Insulin1

Concentrations1