Antimetabolites can be used in cancer treatment, as they interfere with DNA production and therefore cell division and tumor growth. (wikipedia.org)
Anthracyclines are anti-tumor antibiotics that interfere with enzymes involved in copying DNA during the cell cycle. (wikipedia.org)
Examples of anthracyclines include: Daunorubicin Doxorubicin (Adriamycin®) Epirubicin Idarubicin Anti-tumor antibiotics that are not anthracyclines include: Actinomycin-D Bleomycin Mitomycin-C Mitoxantrone Phototrexate Antimetabolites, particularly mitomycin C (MMC), are commonly used in America and Japan as an addition to trabeculectomy, a surgical procedure to treat glaucoma. (wikipedia.org)
Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)
Regimens2
All chemotherapy regimens require that the recipient be capable of undergoing the treatment. (worldsbest.rehab)
Current chemotherapy regimens apply drug treatment in cycles, with the frequency and duration of treatments limited by toxicity. (worldsbest.rehab)
Purine4
Examples of cancer drug antimetabolites include, but are not limited to the following: 5-Fluorouracil (5-FU) 6-Mercaptopurine (6-MP) Capecitabine (Xeloda®) Cytarabine (Ara-C®) Floxuridine Fludarabine Gemcitabine (Gemzar®) Hydroxycarbamide Methotrexate Pemetrexed (Alimta®) Phototrexate Anti-metabolites masquerade as a purine (azathioprine, mercaptopurine) or a pyrimidine, chemicals that become the building-blocks of DNA. (wikipedia.org)
It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. (lookformedical.com)
Antimetabolites may also be antibiotics, such as sulfanilamide drugs, which inhibit dihydrofolate synthesis in bacteria by competing with para-aminobenzoic acid (PABA). (wikipedia.org)
PABA is needed in enzymatic reactions that produce folic acid, which acts as a coenzyme in the synthesis of purines and pyrimidines, the building-blocks of DNA. (wikipedia.org)
To overcome these issues, herein, the synthesis of eight new pyrimidine-curcumin derivatives is reported. (bvsalud.org)
Nucleotides2
Antimetabolites generally impair DNA replication machinery, either by incorporation of chemically altered nucleotides or by depleting the supply of deoxynucleotides needed for DNA replication and cell proliferation. (wikipedia.org)
Examples: Azathioprine, Thiopurines, and Fludarabine pyrimidine analogues - mimic the structure of metabolic pyrimidines, the smaller bases incorporated into DNA as cytosine and thymine. (wikipedia.org)
Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (lookformedical.com)
Inhibition3
thus, competitive inhibition can occur, and the presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer. (wikipedia.org)
The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (worldsbest.rehab)
IC50 values did not significantly differ between CU428 and NP1 for the same analog at either room temperature or 37°C. To investigate the mechanism of inhibition, we used two pyrimidine bases (uracil and thymine) and three nucleosides (uridine, thymidine, and 5-methyluridine) to determine whether the inhibitory effects from the pyrimidine analogs were reversible. (bvsalud.org)
Drugs10
Antimetabolite drugs are commonly used to treat leukemia, cancers of the breast, ovary, and the gastrointestinal tract, as well as other types of cancers. (wikipedia.org)
In the Anatomical Therapeutic Chemical Classification System antimetabolite cancer drugs are classified under L01B. (wikipedia.org)
Antitumor antibiotics are a class of antimetabolite drugs that are cell cycle nonspecific. (wikipedia.org)
It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including chemotherapy. (worldsbest.rehab)
It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing chemotherapy and Weed. (worldsbest.rehab)
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx ) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (worldsbest.rehab)
Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (worldsbest.rehab)
Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (worldsbest.rehab)
Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (worldsbest.rehab)
Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)
however, the most prevalent forms of human cancer respond poorly or not at all to chemotherapy. (doctorlib.info)
Antimetabolites that are useful in cancer chemotherapy. (lookformedical.com)
Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology . (worldsbest.rehab)
Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)
The efficiency of chemotherapy depends on the type of cancer and the stage. (worldsbest.rehab)
Normal1
An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. (wikipedia.org)
Cells2
To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (worldsbest.rehab)
Sites2
Antimetabolites have been shown to decrease fibrosis of operative sites. (wikipedia.org)
Our results suggest that the five pyrimidine analogs act on different sites to inhibit T. thermophila growth and that nucleobases and nucleosides are metabolized differently in Tetrahymena. (bvsalud.org)
Results1
The results of our studies indicate that the newly discovered phenylpyrazolo[3,4-d]pyrimidine-based multitarget inhibitors have significant potential for anticancer treatment. (bvsalud.org)
Nonspecific4
Antitumor antibiotics are a class of antimetabolite drugs that are cell cycle nonspecific. (wikipedia.org)
Chemotherapy can be either "cell-cycle phase specific," targeting one specific phase of the cell cycle, or "cell-cycle phase nonspecific," targeting all proliferating cells regardless of their place in the cell cycle. (basicmedicalkey.com)
Whereas cell-cycle phase-specific chemotherapies are generally given more frequently or as continuous infusions, cell-cycle phase-nonspecific chemotherapies are usually given as a single dose. (basicmedicalkey.com)
Myelosuppression is the acute dose-limiting toxicity for most nonspecific chemotherapy. (basicmedicalkey.com)
Replication3
Antimetabolites generally impair DNA replication machinery, either by incorporation of chemically altered nucleotides or by depleting the supply of deoxynucleotides needed for DNA replication and cell proliferation. (wikipedia.org)
thus, competitive inhibition can occur, and the presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer. (wikipedia.org)
In the cell, antimetabolites are mistaken for the metabolites they resemble, and are processed in the cell in a manner analogous to the normal compounds. (cancerquest.org)
Dose3
Watch the video to hear how sarcoma survivor Ned Crystal dealt with the side effects of high dose chemotherapy. (cancerquest.org)
Prospective dose modification of some chemotherapy and targeted therapies are essential in patients with impaired organ function to reduce the risk of severe adverse events. (basicmedicalkey.com)
pegargiminase) combined with pemetrexed (Pem) and cisplatin (Cis) chemotherapy in a phase 1 dose-expansion study of patients with argininosuccinate synthetase (ASS1)-deficient metastatic UM. (bvsalud.org)
Chemicals1
Examples of cancer drug antimetabolites include, but are not limited to the following: 5-Fluorouracil (5-FU) 6-Mercaptopurine (6-MP) Capecitabine (Xeloda®) Cytarabine (Ara-C®) Floxuridine Fludarabine Gemcitabine (Gemzar®) Hydroxycarbamide Methotrexate Pemetrexed (Alimta®) Phototrexate Anti-metabolites masquerade as a purine (azathioprine, mercaptopurine) or a pyrimidine, chemicals that become the building-blocks of DNA. (wikipedia.org)
Anemia1
Death of the normal cells produces some of the common side-effects of chemotherapy, including hair loss, anemia, immune suppression and stomach/digestive problems. (cancerquest.org)
Cell division2
Antimetabolites can be used in cancer treatment, as they interfere with DNA production and therefore cell division and tumor growth. (wikipedia.org)
These agents prevent proper cell division by interfering with the cytoskeletal components that enable one cell to divide into two. (cancerquest.org)