• As reported in the journal Cell Metabolism by a team of researchers from the University of Basel and colleagues, acetate supports the function of certain immune cells and thus helps to eliminate pathogens safely and efficiently. (news-medical.net)
  • New findings reported in the July issue of Cell Metabolism, a Cell Press publication, are offering new leads as to why some people might suffer from high levels of triglycerides. (redorbit.com)
  • Evidence emerging in the last years has led to the re-appreciation of the central role of altered cell metabolism in cancer. (dkfz.de)
  • Based upon the previous work, our T Cell Metabolism group will use mouse melanoma models to identify the metabolic checkpoints regulating anti-tumor T cell bioenergetics, survival and effector functions. (dkfz.de)
  • The long-term research goal of our T Cell Metabolism group is to translate our findings made using the mouse models into clinical benefits. (dkfz.de)
  • Current projects in the lab center on developing new experimental techniques to learn how genetic changes within individual genes and proteins can impair cell metabolism and cause diabetes. (mcgill.ca)
  • The role of mitochondria in cell metabolism and apoptosis are hot topics since they combine bioenergetics with mitochondria ability to rapidly respond to changes in cell function and adaption but also disease development. (biophysics.org)
  • Please help make this a valuable resource for drug metabolism scientists by expanding the content on this site. (archive.org)
  • His research interests and publications span all aspects of drug discovery and development, particularly where drug metabolism impacts on the design of more efficacious and safer drugs. (google.com)
  • He joined Pfizer in 1999, where he is currently a Research Fellow in the Drug Metabolism Group (Groton Laboratories). (google.com)
  • He worked for Pfizer for 24 years in the Pharmacokinetics, Dynamics and Metabolism Department contributing scientific leadership to the drug metabolism and pharmacokinetic evaluations on many drug discovery and development projects across a range of therapeutic areas including cardiovascular, allergy and respiratory, anti-infectives and sexual health. (google.com)
  • Review a recent study where a recombinant human AO enzyme using a mammalian cell based expression system enabled the early assessment of the liability of AO for drug metabolism and clearance. (corning.com)
  • Drug metabolism occurs in two phases: Phase I (biotransformation) involves oxidation, hydroxylation reduction, and hydrolysis. (fpnotebook.com)
  • Deterioration of mitochondria and metabolism is a common component of numerous diseases such as cancer and neurodegeneration as well as the aging process. (umassmed.edu)
  • Here, we review the cancer cell-intrinsic and cell-extrinsic mechanisms through which mitochondria influence all steps of oncogenesis, with a focus on the therapeutic potential of targeting mitochondrial metabolism for cancer therapy. (nih.gov)
  • Your mitochondria have enormous potential to influence your health, specifically cancer, and I'm starting to believe that optimizing mitochondrial metabolism may in fact be at the core of effective cancer treatment. (mercola.com)
  • Antonio Zorzano @IRBBarcelona @UniBarcelona and co-authors tell all you need know about #organelle - #mitochondria communication, and explain how deficient organelle tethering affects organelle # metabolism . (twitter.com)
  • The Bioenergetics, Mitochondria, and Metabolism Subgroup attracts participants with a wide range of interests. (biophysics.org)
  • In order to join the Bioenergetics, Mitochondria, and Metabolism Subgroup, you must be a member of the Society. (biophysics.org)
  • Ceramide, a central sphingolipid, affects cellular metabolism with important consequences on the onset and progression of metabolic diseases such as obesity, diabetes and cardiovascular disorders. (umassmed.edu)
  • The Metabolism, Energy Balance, and Obesity program supports basic and clinical studies related to energy balance and physiological mechanisms modulating weight gain, loss, and maintenance. (nih.gov)
  • The theme "Metabolism, Obesity and Diabetes" covers two fundamental lines of research detailed at the "Research and development" page. (uclouvain.be)
  • The aim of the "Hormones and Metabolism" line of research is to better understand the causes and consequences of obesity, diabetes mellitus, and other endocrine diseases with an impact on metabolism, and to identify new therapeutic targets, test new treatments and improve patient care. (uclouvain.be)
  • Welcome to CMOR, The Center for Metabolism and Obesity Research in the Institute for Basic Biomedical Research. (hopkinsmedicine.org)
  • CMOR is an interdepartmental and interdisciplinary center established to support the advancement of our understanding of the basic biological mechanisms that regulate metabolism, and how they are dysregulated in disorders such as obesity, diabetes, stroke, and cancer. (hopkinsmedicine.org)
  • Addressing topics such as nutrient sensing, bioenergetics, and endocrine regulation, the center employs both cutting edge technologies and fundamental basic science to advance our understanding of the biology that regulates metabolism and how it is dysregulated in attendant disorders such as obesity, diabetes, cancer, and stroke. (hopkinsmedicine.org)
  • To lead in the study and support of integrative research in the field of metabolism and obesity to advance our understanding of the biological mechanisms that regulate metabolism and how they are dysregulated in attendant disorders, such as obesity and diabetes. (hopkinsmedicine.org)
  • To foster interactions between CMOR and agencies that support research in metabolism and obesity. (hopkinsmedicine.org)
  • Circadian clocks play a major role in orchestrating daily metabolism and their disruption can lead to metabolic diseases such as diabetes and obesity. (weizmann.ac.il)
  • The Indirect calorimetry is well established and widely used to measure metabolism, and recommended for the treatment of obesity and management of weight by World Health Organization, American Dietetic Association and American College of Sports Medicine. (forbes.com)
  • MPC, which operates at a critical branch point in carbohydrate metabolism, counteracts the Warburg effect. (newswise.com)
  • Cancers appear to do whatever they can to get rid of MPC, a protein involved in carbohydrate metabolism, shows the study led by Jared Rutter, Ph.D., professor of biochemistry and Dee Glen and Ida W. Smith Endowed Chair for Cancer Research at the University of Utah. (newswise.com)
  • However, because normal cells and cancer cells often require the same energy sources and metabolic pathways, designing metabolism-based cancer therapies without systemic toxicity has proven challenging. (eurekalert.org)
  • This program also supports studies that explore mathematical models contributing to the understanding of whole-body energy balance and metabolism as well as the metabolic pathways in cells, tissues, and organs. (nih.gov)
  • There is also discussion of regulatory mechanisms for all these metabolic pathways, and of metabolic and genetic diseases affecting the (human) metabolism of amino acids. (indiebound.org)
  • Vision: Understanding how specific metabolic pathways influence biological outcomes and behavior is the goal of metabolism in our era, and is a common foundation for systems and behavioral biology. (hopkinsmedicine.org)
  • Purine metabolism refers to the metabolic pathways to synthesize and break down purines that are present in many organisms. (rug.nl)
  • The chemical reactions of metabolism are organized into metabolic pathways, in which one chemical is transformed through a series of steps into another chemical, by a sequence of enzymes. (wikipedia.org)
  • A striking feature of metabolism is the similarity of the basic metabolic pathways and components between even vastly different species. (wikipedia.org)
  • In addition we aim to use our expertise in monitoring cancer metabolism for the analysis of nicotinamide metabolism in brain tumors. (dkfz.de)
  • This volume details common experimental approaches in studies designed to illuminate various processes used to study cancer metabolism. (springer.com)
  • Last but not least, the third part is an overview of vital and actively researched topics in the field of cancer metabolism, as well as computational methodological approaches. (springer.com)
  • Authoritative and cutting-edge, Cancer Metabolism: Methods and Protocols aims to be an essential compilation of protocols utilized in many laboratories. (springer.com)
  • Several of the hormones of the endocrine system are involved in controlling the rate and direction of metabolism. (kidshealth.org)
  • Fatty acid metabolism consists of catabolic processes that generate energy, and anabolic processes that create biologically important molecules (triglycerides, phospholipids, second messengers, local hormones and ketone bodies). (wikipedia.org)
  • Several hormones of the endocrine system help control the rate and direction of metabolism. (kidshealth.org)
  • Insulin is one of the main hormones involved in fat metabolism. (healthline.com)
  • Identifying liver hormones that play a role in the develolpment of type 2 diabetes is among the goals of Division of Metabolism researcher Mehboob Hussain. (hopkinsmedicine.org)
  • In addition, it examines pathways used by bacteria for the degradation of organic compounds, the synthesis of cellular constituents, the regulation of bacterial metabolism and the fixation of molecular nitrogen. (springer.com)
  • INFORMATION concerning the endocrinological regulation of mineral metabolism in fishes is lacking. (nature.com)
  • Anabolism (pronounced: uh-NAB-uh-lih-zem), or constructive metabolism , is all about building and storing: It supports the growth of new cells, the maintenance of body tissues, and the storage of energy for use in the future. (kidshealth.org)
  • 4. Metabolism p 101 Anabolism  Synthesis Energy transferred commonly measured in calories: 1 cal =  1 g of H 2 O by 1 ° C 1 Kcal =  temp. (slideshare.net)
  • Anabolism (pronounced: uh-NAB-uh-liz-um), or constructive metabolism, is all about building and storing. (kidshealth.org)
  • When it comes to weight loss, a fast metabolism makes the difference between reaching your goals and spinning your wheels without seeing much progess. (ehow.com)
  • What Does Fast Metabolism Mean? (livestrong.com)
  • What Is the Difference Between Slow & Fast Metabolism? (livestrong.com)
  • A fast metabolism uses calories very quickly whereas a slow metabolism uses very few calories. (sooperarticles.com)
  • Studies using transgenic mouse models and pharmacological compounds to mimic or counter the switch of substrate preference in cardiac hypertrophy have demonstrated that increased glucose metabolism in adult heart is not harmful and can be beneficial when it provides sufficient fuel for oxidative metabolism. (nih.gov)
  • Retrieved on August 09, 2020 from https://www.news-medical.net/life-sciences/Metabolism-Thermodynamics.aspx. (news-medical.net)
  • 6. Decrease Diet Soda Although it's low in calories and seems like an easy swap for high calorie beverages, diet soda may actually have adverse effects on your metabolism. (yahoo.com)
  • Not only does a speedy metabolism help you burn more calories, but it allows you to eat more during your weight loss journey, making you more likely to stick with your new lifestyle for long-term results. (ehow.com)
  • Metabolism is defined as the series of chemical reactions that burn calories. (medicinenet.com)
  • The faster your metabolism, the more calories you burn. (womenshealthmag.com)
  • Another reason to drink your milk: Calcium plays a key role in regulating your fat metabolism, which determines whether you burn calories or store them as fat. (womenshealthmag.com)
  • A faster metabolism burns calories more quickly than a slower one, making it less likely that a person will put on weight. (medicalnewstoday.com)
  • Everybody's metabolism is slightly different, so everybody has slightly different needs when it comes to calories. (wikihow.com)
  • Slowing your metabolism can involve some pretty unpleasant things: skipping meals, eating few calories, etc. (wikihow.com)
  • While there is controversy as to whether there is an 'after-burn' effect where calories continue to be burned after exercise is finished, there's no doubt that exercising burns calories and builds muscle and that muscle increases metabolism. (jamaica-gleaner.com)
  • 7 Metabolism Boosting Moves # metabolism #weightloss Here are some specific exercises that really kick your metabolism into high-gear and torch calories, inspired by a 28-Day Fat Torch series. (twitter.com)
  • By burning extra calories of food before they are stored as fat as well as burning the existing extra fat, metabolism can be increased. (reference.com)
  • To achieve weight loss and boost metabolism, more calories need to be burned than consumed. (reference.com)
  • Exercising speeds up the metabolism, and for hours after, calories can still be burned. (reference.com)
  • Don't Only Count Calories and Steps, Your Metabolism is Key! (forbes.com)
  • Metabolism determines what our bodies need to sustain our life--and how many calories we should be eating to maintain, loose, or gain weight. (forbes.com)
  • JJL @doyonlab @SbastienLevesq4 # metabolism #autophagy . (twitter.com)
  • But when you disrupt your so-called circadian rhythm-by crossing time zones, for instance-your cells don't function the way they should and your metabolism suffers, according to researchers at the Center for Epigenetics and Metabolism at University of California - Irvine. (womenshealthmag.com)
  • Last 48 hours to send your abstract on the link of # metabolism and #epigenetics . (twitter.com)
  • Metabolism (pronounced: meh-TAB-uh-lih-zem) is a collection of chemical reactions that takes place in the body's cells. (kidshealth.org)
  • The study, carried out in yeast - which can be used to model some of the body's fundamental processes - shows that while the activity of our genes influences our metabolism, the opposite is also true and the nutrients available to cells influence our genes. (cam.ac.uk)
  • All of your body's cellular processes, including metabolism, depend on water. (womenshealthmag.com)
  • Decreasing your metabolism means you are "turning down" your body's internal furnaces, which lowers your calorie requirements. (wikihow.com)
  • Drawing on her fundamental "food as medicine" techniques, she's created the Metabolism Revolution diet, which strategically manipulates macronutrients to speed the body's metabolic rate, a guaranteed way to kick start a stalled metabolism. (harpercollins.com)
  • The staff in the Division of Metabolism at the Children's Center diagnoses and treats diseases and conditions in children that result from genetic mutations that prevent the body's natural molecules from being used properly. (hopkinsmedicine.org)
  • From mild to fiery, research shows that a compound in chiles (capsaicin) helps trigger the body's natural cooling system and revs up your metabolism. (eatingwell.com)
  • Research in several MCCB labs focuses on these different aspects of metabolism to gain a better understanding of its link to disease processes. (umassmed.edu)
  • Click on the links below to learn more details about MCCB research concerning metabolism and disease. (umassmed.edu)
  • It takes only 20 minutes in any fixed position to inhibit your metabolism, according to Carrie Schmitz, an ergonomic research manager for Ergotron. (womenshealthmag.com)
  • CMOR is an integrative and collaborative center that combines research into the molecular and cellular mechanisms of metabolism with a wide range of physiological and behavioral studies. (hopkinsmedicine.org)
  • The overall goal of CMOR is to develop an infrastructure to facilitate cutting-edge research into the fundamental basic science of metabolism. (hopkinsmedicine.org)
  • Metabolism promotes excellence in research by publishing high-quality original research papers, fast-tracking cutting-edge papers, research brief reports, mini-reviews, and other special articles related to all aspects of human metabolism . (elsevier.com)
  • The research, which appears online on Oct. 30 in Molecular Cell , implicates changes in a key step in metabolism - the way cellular fuel is utilized - as an important driver of colon cancer that is also likely to be important in many other cancer settings. (newswise.com)
  • Shekhar is in the beginning stages of his research and in theory could one day use the discovery of these protein patterns to reverse the side effects of aging and diabetes as it pertains to metabolism. (click2houston.com)
  • The traditional approach for measuring metabolism is to use a metabolic cart, which is rather bulky and expensive equipment, available only in clinic or research labs. (forbes.com)
  • Crassulacean acid metabolism , also known as CAM photosynthesis , is a carbon fixation pathway that evolved in some plants as an adaptation to arid conditions. (wikipedia.org)
  • Bone Metabolism Clinic addressing osteoporosis, calcium and mineral metabolism as well as genetic and acquired metabolic bone diseases. (mcgill.ca)
  • The aberrant metabolism of cancer cells remains a promising but elusive therapeutic target. (stanford.edu)
  • The student will gain the latest insights on how nutrition regulates metabolism and how unbalanced nutrition may lead to disease. (rug.nl)
  • Calcium speeds up metabolism, while vitamin C helps the body absorb this mineral, creating an overall win-win situation. (yahoo.com)
  • This symposium will highlight insights into tumor metabolism from leaders in the field and explore how this information is being used to design safe and effective, metabolism-targeted therapies. (eurekalert.org)
  • Our group aims at delineating the role of nicotinamide metabolism in brain tumors by targeted metabolomics and bioinformatics approaches using malignant brain tumor cells and tumor stem cells. (dkfz.de)
  • In addition, nicotinamide will be measured in biofluids of brain tumor patients and correlated with the activity of the respective enzymes in the tumor tissue with the aim of identifying biomarkers for the activity of nicotinamide metabolism for future stratification of patients to treatment with inhibitors of this pathway. (dkfz.de)
  • Amino Acid Metabolism, 3rd Edition covers all aspects of the biochemistry and nutritional biochemistry of the amino acids. (indiebound.org)
  • transport in cells is a key step in metabolism. (bartleby.com)
  • Following his retirement in 2010 he has continued to provide occasional consulting and lecturing in the field of metabolism and pharmacokinetics. (google.com)
  • Here are 10 things to avoid in order to keep your metabolism humming. (womenshealthmag.com)
  • An increase in the lean muscle will help keep your metabolism alive and kicking. (sooperarticles.com)
  • Loss of MPC seems to be a biomarker for cancer aggressiveness and patient survival," said Rutter, also co-director of the Diabetes and Metabolism Center at the University of Utah, and co-leader of the Nuclear Control of Cell Growth and Differentiation Program at the Huntsman Cancer Institute. (newswise.com)
  • as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice. (fpnotebook.com)
  • Preliminary evidence suggests that several enzymes implicated in nicotinamide metabolism are overexpressed in brain tumors. (dkfz.de)
  • If the metabolism of nicotinamide is found to be functionally relevant for the malignant phenotype or the treatment resistance of brain tumors, small molecule screens will be performed to identify inhibitors of the respective enzymes. (dkfz.de)
  • Contrary to popular belief, the way to get a faster metabolism is not through hours of cardio. (ehow.com)
  • Weight lifting is the best thing you can do if you want a faster metabolism, because it helps you build and maintain lean muscle. (ehow.com)
  • 7. Don't Forget Your ZZZ's Getting a least seven to eight hours of sleep every night is crucial to a healthy metabolism. (yahoo.com)
  • The detoxifying nature of this beverage may help your body function at an optimal level, which means a healthy metabolism. (yahoo.com)
  • 13. Vitamin B is Key Getting in all over your vitamin B, which you can do by incorporating small amounts of nuts, seeds, lean chicken, beef, and fish into your diet, helps maintain a healthy metabolism. (yahoo.com)
  • I have tried to find out if the thyroid had any control over the mineral metabolism in yearling salmonr Salmo solar L. 1,2 . (nature.com)
  • Our results show that diatoms can remodel their intermediate metabolism on environmental cues and reveal that a key signal in this remodeling is associated with nitrogen assimilation. (pnas.org)
  • Our results reveal that the accumulation of lipids is a consequence of remodeling of intermediate metabolism, especially reactions in the tricarboxylic acid and the urea cycles. (pnas.org)