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  • obese
  • Long-term 3% naringenin supplementation resulted in significant naringenin accumulation in plasma and tissues, associated with attenuated metabolic dysregulation and muscle loss in obese ovariectomized mice. (ovid.com)
  • Such state in human medicine is called leptin resistance , the failure, in obese individuals with elevated leptin levels, for suppressing feeding and mediating weight loss [ 17 , 18 ] due to LEPR polymorphisms associated with food preferences and obesity [ 19 ]. (hindawi.com)
  • "To our knowledge, this is the first study investigating the effects of decaffeinated green tea supplementation on biomarkers of inflammation and features of metabolic syndrome in obese population in the US," ​ wrote the researchers. (nutraingredients.com)
  • Targets
  • A down-regulation of plasminogen activator inhibitor-1 (PAI-1), said to be associated with both obesity and type 2 diabetes, was observed after incubation, "suggesting that regulation of PAI-1 expression is one of the important therapeutic targets for the metabolic syndrome," ​ states the research. (nutraingredients-usa.com)
  • Furthermore
  • Furthermore, abundant evidence, mostly derived from mouse studies, links the Wingless-type (WNT) signaling pathway to the regulation of adipogenesis ( 5 , 6 ) and inflammation ( 7 ) in obesity. (diabetesjournals.org)
  • study
  • Subclinical systolic dysfunction is one of the proposed mechanisms for increased cardiovascular risk associated with metabolic syndrome (MS). This study investigated the association between MS and impaired left ventricular global longitudinal strain (GLS) and the role of each MS criteria in this association. (revespcardiol.org)
  • 7 Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, and Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, U.K. (diabetesjournals.org)
  • After 7 days, participants will return to the metabolic unit to repeat the Day 1 and Day 2 study procedures. (clinicaltrials.gov)
  • The eight week study also supported the tolerability of both the beverage and the extracts, but the researchers note that the regime did not affect the various features of metabolic syndrome. (nutraingredients.com)
  • intake
  • This metabolically favorable state results partly from an increased metabolic rate and partly from gastrointestinal loss of dietary fat, but not from increased physical activity or decreased food intake," they said. (medicalnewstoday.com)
  • body
  • After inclusion of body mass index in the models, these associations were attenuated, suggesting that they may, at least in part, be mediated by obesity. (revespcardiol.org)
  • Obesity, defined as a body mass index (BMI) exceeding 30 kg/m 2 , is a serious health problem, which can be called an epidemic on a global scale and is one of the most important causes of preventable death. (dovepress.com)
  • People with central obesity and metabolic syndrome may have higher than normal cortisol levels that the body cannot regulate properly. (clinicaltrials.gov)