• Women with PCOS have higher risk of multiple diseases including Infertility, type 2 diabetes mellitus (DM-2), cardiovascular risk, metabolic syndrome, obesity, impaired glucose tolerance, depression, obstructive sleep apnea (OSA), endometrial cancer, and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH). (wikipedia.org)
  • Some members of Rhododendron genus are traditionally used as medicinal plants for arthritis, acute and chronic bronchitis, asthma, pain, inflammation, rheumatism, hypertension and metabolic diseases. (medsci.org)
  • Butyrate is a main product of fermentation in the intestine, and has been shown to have anti-inflammatory and positive effects against metabolic diseases in numerous studies. (vetscite.org)
  • Mesenchymal stem/stromal cells (MSCs), a class of cells with proliferative, immunomodulatory, and reparative functions, have shown therapeutic potential in a variety of systemic diseases, including metabolic syndrome (MetS). (bvsalud.org)
  • The odds are overwhelming that you will die as a result of one of the chronic diseases of aging that I call the Four Horsemen: heart disease, cancer, neurodegenerative disease, or type 2 diabetes and related metabolic dysfunction. (sameerbajaj.com)
  • 2 Moreover, recent studies have shown that abdominal obesity, rather than obesity simply defined by BMI, is more highly correlated with cardiovascular and metabolic diseases. (jomes.org)
  • According to studies in the United States and Canada, individuals with normal BMI and abdominal obesity showed higher risks of cardiovascular diseases compared to individuals classified as obese according to BMI without abdominal obesity. (jomes.org)
  • Nonalcoholic fatty liver disease (NAFLD) is gradually becoming one of the most frequent liver diseases worldwide. (biomedcentral.com)
  • Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases. (e-dmj.org)
  • Non-alcoholic fatty liver sickness (NAFLD) is a variety of liver pathological conditions that intensely related to other chronic diseases including obesity and diabetes. (egyptianjournal.xyz)
  • Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age. (wikipedia.org)
  • Our data suggest that inhibition of AR in the T2DM db/db mice led to significant activation in hepatic PPAR α and significant reductions in serum triglycerides (TG) and hepatic TG, suggesting that under hyperglycemia, AR/the polyol pathway might be greatly upregulated to contribute significantly to the hepatic regulation of TG metabolism and the development of nonalcoholic steatohepatitis (NASH) or nonalcoholic fatty liver disease (NAFLD). (hindawi.com)
  • Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive disease that can progress to non-alcoholic steatohepatitis (NASH). (biomedcentral.com)
  • Immune activation plays a key role in liver inflammation in patients with NASH. (biomedcentral.com)
  • Many studies have confirmed the role of high trans fatty acids, high sugars, and high cholesterol in NASH models, but few studies have involved the simultaneous use of high-trans fat, high-carbohydrate, high-cholesterol, high-cholate (HFHCCC) models to induce NASH. (biomedcentral.com)
  • To the best of our knowledge, there is no report on the protective effects of R. oldhamii leaf extract on non-alcoholic fatty liver disease (NAFLD) in vivo and in vitro . (medsci.org)
  • abstract: BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the general population. (shengsci.com)
  • Abdominal obesity predisposes individuals to cardiovascular disease, but the data in adults with normal body mass index (BMI) are relatively rare. (jomes.org)
  • This study aimed to evaluate the characteristics of subjects with normal BMI and abdominal obesity and to identify the relationship between central obesity and cardiovascular risk factors in normal BMI adults in Korea. (jomes.org)
  • Abdominal obesity was defined as a waist circumference of ≥90 cm in males and ≥85 cm in females. (jomes.org)
  • Through logistic regression, we analyzed the factors influencing abdominal obesity and the relationship between abdominal obesity and cardiovascular risk factors. (jomes.org)
  • When adjusted for age and BMI, daily excessive alcohol consumption increased the risk of abdominal obesity in adults of normal weight. (jomes.org)
  • Women with lower socioeconomic status and men in need of walking exercise also had a higher risk of abdominal obesity. (jomes.org)
  • In the model adjusted for age and BMI, abdominal obesity was associated with fasting glucose intolerance and diabetes in men and hypertriglyceridemia and low high-density lipoprotein cholesterol in women. (jomes.org)
  • Cardiovascular risk factors were associated with abdominal obesity in Korean adults with normal BMI. (jomes.org)
  • These results suggest that more careful management of abdominal obesity in those with normal weight is necessary. (jomes.org)
  • 3 - 6 Mortality from coronary artery disease was also found to be higher in individuals with normal BMI and abdominal obesity. (jomes.org)
  • 7 , 8 Although quantifying visceral and subcutaneous fat by computed tomography (CT) is the most accurate diagnostic method for abdominal obesity, CT use is limited because of high cost and risk of radiation exposure. (jomes.org)
  • Because waist circumference is highly correlated with visceral fat and is easy to measure and interpret, this is used as the basic clinical tool for evaluating abdominal obesity. (jomes.org)
  • 9 Asians are known to have more severe abdominal obesity than Caucasians with identical BMIs leading to the suggestion that different diagnostic criteria should be applied to different races. (jomes.org)
  • In 2009, the American Heart Association/National Heart, Lung, and Blood Institute and International Association for the Study of Obesity defined abdominal obesity in Asians as a waist circumference of ≥90 cm for males and ≥80 cm for females. (jomes.org)
  • Among the most prevalent CMD risk factors at ages 37-54 years were abdominal obesity defined by waist-height ratio (99.6% of women and 87.3% of men), obesity defined by percent body fat (96.6% of women and 75.9% of men), low HDL-c (87.5% of women and 74.5% of men), and elevated triglycerides (78.3% of women and 73.6% of men). (cdc.gov)
  • In this study, the effects of R. oldhamii leaf extract on inhibiting the free fatty acid (FFA)-induced accumulation of fat in HepG2 cells and on improving fatty liver syndrome in mice with high fat diet (HFD)-induced NAFLD were investigated. (medsci.org)
  • In addition, the EtOAc fraction of R. oldhamii leaf significantly improved fatty liver syndrome and reduced total cholesterol (TC) and triglyceride (TG) in HFD-induced NAFLD mice at a dosage of 200 mg/kg BW. (medsci.org)
  • Due to the relatively lower levels of expression of AR in the liver under normal situations, relatively little attention had been paid to its roles in the liver in the past. (hindawi.com)
  • The liver tissue plays a major role in energy metabolism, particularly glucose and lipid homeostasis. (hindawi.com)
  • It is known that diabetes, type II diabetes mellitus (T2DM) in particular, is often associated with hepatic accumulation of triglycerides in both rodents and humans, which might eventually lead to the development of hepatic steatosis or nonalcoholic fatty liver disease (NAFLD) [ 14 - 16 ]. (hindawi.com)
  • Nonalcoholic fatty liver disease (NAFLD) is an umbrella term that comprises a large spectrum of liver injuries, varying in severity but all leading to fibrosis. (xiahepublishing.com)
  • In addition, RNA-sequencing of healthy liver tissues was performed to elucidate the molecular pathways affected by mitochondria transfer in restoring metabolic health. (bvsalud.org)
  • SIGNIFICANCE: This study, provides insights on molecular processes triggered by mitochondria transfer in fatty liver regeneration and improvement of overall metabolic health. (bvsalud.org)
  • Background Growing evidence suggests the key role of ghrelin in the onset and progression of nonalcoholic fatty liver disease (NAFLD). (unav.edu)
  • The potential participation of ghrelin and the ghrelin receptor antagonist, LEAP-2, in the onset of liver fibrosis in patients with severe obesity and NAFLD through the regulation of TGF-& beta;1-induced hepatic stellate cell (HSC) activation was investigated. (unav.edu)
  • Methods Circulating (n = 179) and hepatic expression (n = 95) of ghrelin and LEAP-2 were measured in patients with severe obesity and available liver pathology analysis undergoing Roux-en-Y gastric bypass (RYGB). (unav.edu)
  • Results Plasma and hepatic ghrelin were negatively associated, while LEAP-2 exhibited a positive association with liver fibrosis in patients with obesity and NAFLD. (unav.edu)
  • The imbalance between acylated ghrelin and ghrelin receptor antagonist LEAP-2 might contribute to maintain liver fibrosis in patients with obesity and NAFLD. (unav.edu)
  • Background: Metabolic syndrome (MetS), prediabetes (PreDM) and metabolic-associated fatty liver disease (MAFLD) share pathophysiological pathways concerning type 2 diabetes mellitus (T2DM) onset. (unav.edu)
  • What has emerged during the past 1 year is that, apart from its potentially fatal respiratory presentation from which the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) derives its name, it presents with a myriad of gastrointestinal (GI) and liver manifestations. (xiahepublishing.com)
  • Non-alcoholic fatty liver sickness (NAFLD) is a reducing steatosis (6-9) . (egyptianjournal.xyz)
  • Besides acting directly via the ACE-2 receptor, the virus triggers a potent immune response, which might have a role in pathogenesis. (xiahepublishing.com)
  • Obesity increases the risk of a number of health problems, including coronary disease, particular types of carcinoma, respiratory system complications and osteoarthritis of small and large joints [ 1 ]. (medsci.org)
  • AR/the polyol pathway have been demonstrated to play important roles in the development and progression of diabetic complications in a number of tissues including kidney, retina, lens, and peripheral neuron tissues [ 3 - 5 ]. (hindawi.com)
  • 50% of NAFLD patients could develop were specified prior to the literature search with complications as steatohepatitis, cirrhosis, fibrosis, Prospero (CRD42016032764). (egyptianjournal.xyz)
  • In 2014, an estimated 600 million adults were obesity according to the World Health Organization. (medsci.org)
  • nigrum spinosum (chayote) on gene expression related to antioxidant protection mechanisms and the inflammatory process in older adults with metabolic syndrome (MetS). (bvsalud.org)
  • Our study explored the role of body mass index (BMI) trajectories from infancy through mid-adulthood on cardio-metabolic disease (CMD) risk factors in a prospective cohort of Guatemalan adults. (cdc.gov)
  • It is also defined as the hepatic factor interventions involving eating regimen, weight for metabolic syndrome and the most long- reduction and exercise which could decrease the established etiology for international chronic activity and biomarkers of NAFLD in adults. (egyptianjournal.xyz)
  • RCTs in human adults of any gender/ethnicity changing the lifestyle and weight loss are still the with a diagnosis of NAFLD, non-alcoholic best clinical management in all guidelines (4, 5) . (egyptianjournal.xyz)
  • MRI images were obtained from wild-type mice on high- or low-fat diet, and from 20 human subjects without clinical signs of metabolic dysfunction. (biomedcentral.com)
  • Additional genetic subtypes include progeroid syndromes, autoinflammatory disorders, and SHORT syndrome. (medscape.com)
  • in a balanced diet was related to better metabolic outcomes and was linked to a favorable microbiota profile. (frontiersin.org)
  • The best-characterized syndrome is CMSE, classically presenting with chronic loose stools and failure to thrive, often beginning after an episode of gastroenteritis in a formula-fed infant. (ac.ir)
  • Compared to the lowest sex-specific SMI tertile at baseline, the highest sex-specific SMI tertile showed a significant inverse association with metabolic syndrome risk (adjusted hazard ratio [AHR] = 0.61, 95% confidence interval [CI] 0.54-0.68). (biomedcentral.com)
  • The resemblance between the metabolic abnormalities of these extreme states of adiposity underscores the importance of fat tissue in energy homeostasis. (medscape.com)
  • The polyol pathway is a glucose metabolic shunt that is defined by two enzymatic reactions catalyzed by aldose reductase (AR, AKR1B1, EC1.1.1.21) and sorbitol dehydrogenase (SDH, EC1.1.1.14), respectively [ 1 , 2 ]. (hindawi.com)
  • Glucose metabolism derangements due to aldosterone action are frequently observed not only in patients with primary aldosteronism but also in patients with obesity. (shengsci.com)
  • Estimates indicate that 50 million Americans had metabolic syndrome in 1990 and that number increased to 64 million in 2000. (biomedcentral.com)
  • These phenotypes provided independent capacity of prediction of T2DM incidence after adjustment for age, sex, tobacco and alcohol consumption, obesity and number of SMet features with a c-Harrell=0.84.Conclusions: MAFLD interplay with MetS and PreDM might help to discriminate patient risk of T2DM in the clinical setting through metabolic remodelling-based phenotypes. (unav.edu)
  • Because the phenotypic expression of the I148M PNPLA3 polymorphism has been reported to be dependent on the presence of acquired cofactors triggering steatosis, including Fluorouracil mouse obesity and alcohol, we next evaluated whether the association of the 148M allele and severe steatosis was dependent on the presence of severe overweight (BMI, ≥27.5 kg/m2) and a positive history of alcohol intake. (inhibitorkits.com)
  • Since then, the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), responsible for COVID-19, has evolved into a pandemic, involving all continents to date (i.e. 31 st January 2021). (xiahepublishing.com)
  • The non-invasive assessment of MAFLD combined with PreDM and MetS features might provide further accuracy in predicting hyperglucaemic status with the description of singular clinical phenotypes.Methods: A retrospective cohort study was performed on 2799 patients recruited in the Vascular-Metabolic CUN cohort. (unav.edu)
  • Cutaneous manifestations of cirrhosis include jaundice, spider angiomata, skin telangiectasias ("paper money skin"), palmar erythema, white nails, disappearance of lunulae, and finger clubbing, especially in the setting of hepatopulmonary syndrome. (medscape.com)
  • AIM: We investigated the effect of mitochondria transfer in high fat diet and streptozotocin (HFD + STZ) induced metabolic syndrome (MeS) in rats. (bvsalud.org)
  • The significant effect of healthy mitochondria transfer in restoration of metabolic functions was observed by the activation of PI3K-AKT, AMPK/mTOR pathways and cytokine immune regulators, suggesting that inflammatory mediators were also significantly affected after mitochondria transfer. (bvsalud.org)
  • Hanoch-Oleic (HO), on metabolic parameters and gut microbiota composition. (frontiersin.org)
  • An increase in relative skeletal muscle mass over time has a potential preventive effect on developing metabolic syndrome, independently of baseline skeletal muscle mass and glycometabolic parameters. (biomedcentral.com)
  • Therefore, practically all patients with CS have the metabolic syndrome (MetS), which represents a high CVD risk. (shengsci.com)
  • Yet people at the early stages of this metabolic derangement will often return blood test results in the"normal" range. (sameerbajaj.com)
  • Three observers classified patients into 'switch-off' and 'failed switch-off' groups by visually comparing rest-stress perfusion data acquired with PCASL and first-pass, independently. (unav.edu)
  • A low serum total testosterone level was independently associated with NAFLD. (biomedcentral.com)
  • Collecting all the studies regarding the effects of changing the diet, exercise or combination of both on the activity or markers of NAFLD during the period from 2006 to 2017. (egyptianjournal.xyz)
  • The aim of this study was to investigate the impact of baseline skeletal muscle mass and changes in skeletal muscle mass over time on the development of metabolic syndrome in a large population-based 7-year cohort study. (biomedcentral.com)
  • A considerable amount of data supports a 1.8-7.4-fold increased mortality associated with Cushing's syndrome (CS). (shengsci.com)
  • A further longitudinal study is needed to elucidate the casual relationship between low muscle mass and metabolic syndrome incidence across the full age range of the population, beyond the sarcopenia context. (biomedcentral.com)
  • Hepatorenal syndrome is diagnosed when a creatinine clearance rate of less than 40 mL/min is present or when a serum creatinine level of greater than 1.5 mg/dL, a urine volume of less than 500 mL/day, and a urine sodium level of less than 10 mEq/L are present. (medscape.com)
  • The fact that patients with a healthy weight derived a much greater benefit - a 38% reduced risk for metastatic cancer and death compared to 17% overall - suggests your body weight may play a significant role in whether vitamin D supplementation will provide you with the anticancer benefits you seek. (losethempounds.com)
  • All of these compartments are increased in volume in obesity, so the lower vitamin D likely reflects a volumetric dilution effect and whole body stores of vitamin D may be adequate … Obese people need higher loading doses of vitamin D to achieve the same serum 25-hydroxyvitamin D as normal weight. (losethempounds.com)
  • Multiple logistic regression analysis was used to explore the association of serum total testosterone levels with NAFLD. (biomedcentral.com)
  • Men in the low serum testosterone quintile were at a higher risk for NAFLD than men in the highest serum testosterone quintile. (biomedcentral.com)
  • Obesity may confer resistance to vitamin D effects. (losethempounds.com)
  • According to study co-author Dr. Paulette Chandler, assistant professor of medicine at Brigham and Women's Hospital in Boston, "Our study highlights that obesity may confer resistance to vitamin D effects. (losethempounds.com)
  • Acquired generalized lipoatrophy is in the differential diagnosis of congenital generalized lipoatrophy. (medscape.com)
  • The NAFLD diagnosis can best be made in the Items for Systematic Reviews (PRISMA) guidelines absence of high ethanol intake and the exclusion of at the 10 last years. (egyptianjournal.xyz)
  • The syndrome is named after cysts which form on the ovaries of some people with this condition, though this is not a universal symptom, and not the underlying cause of the disorder. (wikipedia.org)
  • We used logistic regression to assess the role of BMI trajectory on CMD risk factors in 510 women and 346 men (N = 856). (cdc.gov)
  • Except for obesity defined by BMI, we found no associations between BMI latent class and CMD risk factors in women. (cdc.gov)
  • For the CMD risk factors we analyzed, the role of early life BMI on adult CMD appeared to be mediated by adult BMI among men-highlighting the need to establish and maintain healthy body weight over the life course. (cdc.gov)
  • In patients, single-delay PCASL (1200 msec) and first-pass perfusion images were acquired under rest and adenosine conditions. (unav.edu)
  • ADA) Quality Criteria Checklist, while only one article showed a neutral results, i.e. 80.0% of the articles showed a positive effect of the combination of diet and exercise on the effect of NAFLD patients. (egyptianjournal.xyz)
  • Thus NAFLD patients are advised to lose about 10% of their weight and engaging in regular exercises for 5 days per week. (egyptianjournal.xyz)
  • Thus, a better management approach for NAFLD and the development of new drugs and therapeutic options are urgently needed. (xiahepublishing.com)
  • Several lines of evidence suggest a detrimental effect of aldosterone excess on the development of metabolic alterations. (shengsci.com)