• Regulation of autophagy is essential to prevent unwanted and escess activation, and several pathways and molecules, both stimulatory and inhibitory, are included. (helsinki.fi)
  • However it remains unknown which endocytic pathways are active in brain endothelial cells. (helsinki.fi)
  • As brain endothelial cells are polarized in vivo, the aim of the study was to demonstrate the cell polarization of hCMEC/D3 cells and to study the activity and functionality of different endocytic pathways as a function of cell polarization. (helsinki.fi)
  • To characterize hCMEC/D3 cells for the presence of specific endocytic pathways, proteins involved into each pathway were selected. (helsinki.fi)
  • In addition, some pathways that are typically altered during cardiac aging-induced damage, including the generation of radical oxidative species, the mitochondrial metabolic activity, the modulation of the mitochondrial calcium buffering capacity, and the regulation of estradiol and estrogen-regulated gene expression, were investigated [ 20 - 22 ]. (hindawi.com)
  • The main aim of this paper is to review the pathways that lead to cell death in plants with a purpose of identifying the anti-cell death genes. (essaywriter.org)
  • Reduced number and function of insulin-secreting beta cells underlies the progression of all forms of diabetes, underscoring the translational relevance of deciphering molecular pathways regulating the formation, growth, and function of beta cells. (upenn.edu)
  • A Warburg-like metabolic program coordinates Wnt, AMPK, and mTOR signaling pathways in epileptogenesis. (nih.gov)
  • Four metabolic pathways and one oxidative stress pathway were identified in the miPPSPC, whereas linoleic acid metabolism and the pentose phosphate pathway were identified in the mPPSPC. (aging-us.com)
  • The metabolic and oxidative stress pathways may participate in PC progression. (aging-us.com)
  • The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. (wikidata.org)
  • Strikingly, contrary to its role as a tumor suppressor, excessive SETD2 results in the upregulation of cell cycle-associated pathways. (frontiersin.org)
  • You will focus on the metabolic pathways in the cells of mammals, with some reference to microbes and plants. (manchester.ac.uk)
  • Describe the main mechanisms through which metabolic pathways are controlled and how control occurs on multiple levels. (manchester.ac.uk)
  • These health concerns have demonstrated that clearance and oxidation of single wall carbon been associated - to a large extent - with the reported long ``life- nanotubes (SWCNT) in the lungs after their pharyngeal span'' of SWCNT in the lung thus necessitating exploration of aspiration was markedly less effective whereas inflammatory possible metabolic pathways leading to their biodegradation. (cdc.gov)
  • Is There a Metabolic Requirement for Photorespiratory Enzyme Activities in Heterotrophic Tissues? (mpg.de)
  • While ROS was found to feedback on a key metabolic enzyme PKM2 to facilitate the metabolic switching, it also affected the cell cycle. (manchester.ac.uk)
  • We found that the tricarboxylic acid cycle-associated enzyme α-ketoglutarate (α-KG) dehydrogenase (KGDH) entered the nucleus, where it interacted with various JMJs to regulate α-KG-dependent histone demethylations by JMJs, and thus controlled genome-wide gene expression in plants. (bvsalud.org)
  • Rhea can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analysis. (biokeanos.com)
  • One such important histone mark is H3K36me3 which is deposited by the enzyme SETD2 in mammalian cells. (frontiersin.org)
  • long-term regulation of glucose utilisation, enzyme-level control of glycolysis and gluconeogenesis, links to fatty acid metabolism, glycogen turnover, sugar interconversions and the citric acid cycle. (manchester.ac.uk)
  • Receptors on the cell surface bind with hormones that regulate enzyme activity or affect ion channels (eg, growth hormone, thyrotropin-releasing hormone). (msdmanuals.com)
  • Blockage of a key metabolic enzyme could explain the profound lack of energy and other symptoms experienced by patients with myalgic encephalomyelitis /chronic fatigue syndrome (ME/CFS), new research suggests. (medscape.com)
  • Our findings indicate an impaired function of the PDH enzyme complex, resulting in reduced flux of pyruvate to the [tricarboxylic acid ( TCA )] cycle. (medscape.com)
  • Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis. (nature.com)
  • These high levels of proliferation may be achieved via regulation of cellular metabolism in a manner similar to the Warburg effect observed in cancer cells. (manchester.ac.uk)
  • Analysis of the metabolic oscillations suggested that the metabolic profile of early embryos was switching between a Warburg-like to a non-Warburg like metabolism. (manchester.ac.uk)
  • As the cell approached mitotic exit and into interphase, a Warburg-like metabolism dominated in the embryo, whereby only glycolysis remained highly active. (manchester.ac.uk)
  • The exploration of PDX1 partners and targets takes us into new areas including mechanistic investigations of beta cell development, metabolism and postnatal cell survival. (upenn.edu)
  • Mitra A, Vo L, Soukar I, Chaubal A, Greenberg ML, Pile LA. Isoforms of the transcriptional cofactor SIN3 differentially regulate genes necessary for energy metabolism and cell survival. (wayne.edu)
  • You will learn about diseases caused by defects in metabolism, such as diabetes, which will emphasise the importance of metabolic control. (manchester.ac.uk)
  • Diseases caused by defects in metabolism will be studied to emphasise the importance of metabolic control. (manchester.ac.uk)
  • control of protein turnover, nitrogen handling, links to nucleic acid metabolism, amino acid oxidation, integration with citric acid cycle. (manchester.ac.uk)
  • starch/sugar metabolism and fermentation for biofuels, storage lipid biosynthesis: regulation and applications. (manchester.ac.uk)
  • Biochemical genetic testing and newborn screening are essential laboratory services for the screening, detection, diagnosis, and monitoring of inborn errors of metabolism or inherited metabolic disorders. (cdc.gov)
  • Special focus is put on regulation of enzymatic activity and on absorption and metabolism of nutrients such as carbohydrates, lipids and amino acids. (lu.se)
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (cancerindex.org)
  • Soft repression: Subtle transcriptional regulation with global impact. (wayne.edu)
  • Chaubal A, Pile LA. Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms. (wayne.edu)
  • The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. (nature.com)
  • Visfatin is a novel adipokine involved in the regulation of inflammatory cytokines, however, the effects of visfatin on proliferation and collagen synthesis of CFs are unclear. (thieme-connect.com)
  • Cell cycle analysis showed that visfatin increased S-stage percentage and proliferation index in a dose- and time-dependent manner. (thieme-connect.com)
  • A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
  • Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation in human colon cancer cells. (jefferson.edu)
  • In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
  • Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
  • ROS has previously been demonstrated to interact and regulate cell cycle machinery, thus potentially controlling the rate of proliferation. (manchester.ac.uk)
  • Therefore, this coupled oscillation system can regulate the timing of cell cycle leading to the rapid proliferation required in early embryos. (manchester.ac.uk)
  • Pdx1 is mutated in monogenic forms of human diabetes and plays critical roles in early pancreas specification, regulation of organ size, and in beta cell formation, proliferation, and identity. (upenn.edu)
  • The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. (molvis.org)
  • Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
  • This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)
  • Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
  • This is also reflected in phenotypes of increased cell proliferation and migration. (frontiersin.org)
  • In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
  • H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)
  • François, J. M.: Developmental stage dependent metabolic regulation during meiotic differentiation in budding yeast. (tu-dresden.de)
  • Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. (cancerindex.org)
  • In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling , cellular differentiation , and cell death , as well as maintaining control of the cell cycle and cell growth . (wikipedia.org)
  • In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)
  • The transcriptional networks critical for the proper development, differentiation, and expansion of beta cells, work through islet enhancers, super enhancers and active promoters that form 3- dimensional hubs. (upenn.edu)
  • 3. We hypothesize that PDX1-Onecut1 (OC1) interactions, in part mediated by their intrinsically disordered protein regions (IDPRs), regulate Pdx1 stability, cell cycle progression, and pancreatic endocrine differentiation during development. (upenn.edu)
  • PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. (antikoerper-online.de)
  • Cancer stem cells are a selective clonal subset of tumour cells that have avoided various cell regulatory mechanisms, including terminal differentiation, and yet have retained the self-renewal properties and proliferative potential of adult stem cells. (who.int)
  • The Krebs cycle, also called the citric acid cycle and tricarboxylic acid cycle, is the common pathway by which organic fuel molecules of the cell are oxidized during cellular respiration. (encyclopedia.com)
  • Autophagy is a pathway for cells to degrade intracellular components that are no longer needed or are detrimental for the cells. (helsinki.fi)
  • The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation. (nih.gov)
  • Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway. (assaygenie.com)
  • Conversely, genetically promoting lactate production in HFSCs through mitochondrial pyruvate carrier 1 (Mpc1) deletion accelerated their activation and the hair cycle. (nature.com)
  • Regulation of the mitochondrial tricarboxylic acid cycle. (mpg.de)
  • In addition, cardiac markers of aging-induced damage, including radical oxidative species levels, mitochondrial metabolic activity, mitochondrial calcium buffer capacity, and estrogenic signaling functions, were also modulated by the compound. (hindawi.com)
  • Importantly, it has been suggested that mitochondrial dysfunction might precede the metabolic change. (intechopen.com)
  • The metabolic switching directly led to oscillations in the mitochondrial production of ROS. (manchester.ac.uk)
  • Heterogeneity is generated both passively, e.g. by differential gene expression in cells of a tissue, and actively, such as the generation of the immense variation for immunological recognition molecules. (researchsquare.com)
  • The late entry into the S/M phase coincides with the timing for the peak expression of PF13_0027, suggesting that the deficiency in the mutant cycle can be correlated with the gene expression pattern ( 26 ). (frontiersin.org)
  • Besides their canonical roles in translation, tRNAs also originate tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs with regulatory functions ranging from translation regulation to gene expression control and cellular stress response. (mdpi.com)
  • In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
  • Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)
  • The rat HMGCS2 gene contains elements that control its multihormonal regulation and tissue specificity ( 11 - 14 ). (aacrjournals.org)
  • Gene Ontology (GO) enrichment analysis of these genes identified an overrepresentation of genes related to the cell cycle. (biomedcentral.com)
  • Gene expression-based prognostic signatures have a significant effect on predicting the survival of patients with malignant tumors, such as non-small cell lung cancer [ 7 ] and pediatric acute myeloid leukemia [ 8 ]. (aging-us.com)
  • Recently, the work supported by GM120374 led to the discovery that mutations in components of the Krebs cycle that function as cancer driver mutations have unexpected impacts on histone demethylases and gene silencing, and identified new metabolic links to heterochromatin stability. (grantome.com)
  • The cell-cycle requirements for the creation of new cell-type-specific states of gene expression will be identified. (grantome.com)
  • We utilize a combination of biochemical, molecular and genetic techniques to understand the mechanism of SIN3 gene regulation. (wayne.edu)
  • STK11 is a tumor suppressor gene, in that its overexpression can induce a growth arrest of a cell at the G1 phase of the cell cycle and that somatic inactivation of the unaffected allele of STK11 is often observed in polyps and cancers from patients with Peutz-Jeghers syndrome. (medscape.com)
  • Receptors inside cells interact with hormones that regulate gene function (eg, corticosteroids, vitamin D , thyroid hormone). (msdmanuals.com)
  • Primig, M.: Integrated RNA- and protein profiling of fermentation and respiration in diploid budding yeast provides insight into nutrient control of cell growth and development. (tu-dresden.de)
  • Visfatin Stimulates Production of Monocyte Chemotactic Protein-1 and Interleukin-6 in Human Vein Umbilical Endothelial Cells. (thieme-connect.com)
  • This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
  • 1. The Stoffers laboratory recently identified the polyC binding protein (PCBP) family of RBPs as important players in the post-transcriptional regulatory landscape of pancreatic beta cells. (upenn.edu)
  • This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)
  • The 4E-BP1 (Phospho-Thr36) Colorimetric Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can detect 4E-BP1 protein phosphorylation and expression profile in cells. (assaygenie.com)
  • Although SETD2 is functionally important, the protein does not accumulate in human cells. (frontiersin.org)
  • We show that changing the carbon source from glucose to lactic acid alters the functions of the cyclin-dependent kinase (CDK) Cdc2 and mitogen-activated protein kinase (MAPK) Sty1, leading to unanticipated outcomes in the behavior and fate of such cells. (bvsalud.org)
  • The biologic function of LKB1 includes the regulation of downstream kinases, including adenosine monophosphate-activated protein kinase (AMPK) and the related kinases (microtube affinity-regulating kinase [MARK] 1 through MARK4 and brain-specific kinase/synapses of the amphid-defective kinase [Brsk/SAD]), which are involved in cellular metabolic regulation-stress response and cellular polarity, the latter through tubulin stabilization, tight junction formation, and E-cadherin localization. (medscape.com)
  • DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)
  • Obesity in Childhood-Adolescence Period: biochemical, hormonal, metabolic, genetic, proteomic and body-composition study in children and adolescents. (wikipedia.org)
  • Parrou, J.L.: Genetic and metabolic regulation of glycogen and trehalose in Saccharomyces cerevisiae. (tu-dresden.de)
  • Therefore, C9-M and C9-C (Rescued phenotype of wild-type growth by genetic complementation) parasites ( 26 ) showed the attenuation in PF13_0027 knock-out parasites (C9-M) growth, which in turn resulted in the irregular cell cycle. (frontiersin.org)
  • Despite this, there are adaptive characteristics and distinctive features that that distinguish the lifestyle of plants from those of animals, hence the adoption of only distantly related components in revealing the genetic regulations of plant cell death. (essaywriter.org)
  • Recent high-impact research has shown the genomic/genetic differences between cancer and normal cells using methods such as next-generation sequencing [ 1 , 2 ]. (intechopen.com)
  • Laboratories that perform biochemical genetic testing are required by CLIA regulations to meet the general quality systems requirements for nonwaived testing and the personnel requirements for high-complexity testing. (cdc.gov)
  • As the number of inherited metabolic diseases that are included in state-based newborn screening programs continues to increase, ensuring the quality of performance and delivery of testing services remains a continuous challenge not only for public health laboratories and other newborn screening facilities but also for biochemical genetic testing laboratories. (cdc.gov)
  • These recommendations are intended for laboratories that perform biochemical genetic testing to improve the quality of laboratory services and for newborn screening laboratories to ensure the quality of laboratory practices for inherited metabolic disorders. (cdc.gov)
  • From its early beginnings in the 1960s, the academic field of biochemistry of exercise has expanded beyond examining and describing metabolic responses to exercise and adaptations to training to include a wide understanding of molecular biology, cell signalling, interorgan communication, stem cell physiology, and a host of other cellular and biochemical mechanisms regulating acute responses and chronic adaptations related to exercise performance, human health/disease, nutrition, and cellular functioning. (routledge.com)
  • Cell cycle regulation in response to biochemical cues is a fundamental event associated with many diseases. (bvsalud.org)
  • We also show that the biochemical status of cells under these conditions is an important determinant of the altered molecular functions mentioned above as well as the altered behavior of these cells. (bvsalud.org)
  • CNT in biochemical models and in cells yielding the products engineered CNT represent a possible health risk due to their that did not cause pulmonary inflammation in mice [14]. (cdc.gov)
  • Anti-cell death is a technique adopted by multi-cellular organisms as a defensive and developmental mechanism (Franklin-Tong and Gourlay, pg 390). (essaywriter.org)
  • Studies indicate that there are diverse plant developmental systems and a consortium of plant cell culture models being analyzed by different research centers. (essaywriter.org)
  • Other factors have since been linked with the decision by plant cells to activate cell death, including cell survival signals, stress signals, developmental cues, pathogen recognition and metabolic state. (essaywriter.org)
  • Developmental Cell. (kcl.ac.uk)
  • Frontiers in cell and developmental biology. (lu.se)
  • Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, in the present study, the ability of naringenin to prevent cardiac cell senescence was investigated. (hindawi.com)
  • Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, together, the data have prompted us to investigate the effects of Nar in a cellular model of aged myocardial cells. (hindawi.com)
  • Information gained is critical for the development of new treatments for a variety of human health disorders, including cancer and metabolic disease. (wayne.edu)
  • In secondary carnitine deficiency, which is caused by other metabolic disorders (eg, fatty acid oxidation disorders, organic acidemias), carnitine depletion may be secondary to the formation of acylcarnitine adducts and the inhibition of carnitine transport in renal cells by acylcarnitines. (medscape.com)
  • Their in vitro effects on hypoxic cells concerning cell viability, apoptosis, migration, and angiogenesis were detected through gain- and loss-of-function assays. (hindawi.com)
  • LCN2 was increased by SOX9 and SIRT1 deacetylated SOX9 to promote its nuclear translocation, which further inhibited the viability of human retinal pigment epithelial cells and promoted cell apoptosis and angiogenesis as well as CNV-induced AMD formation. (hindawi.com)
  • In animals, morphological distinctions have since been used to distinguish different types of cell deaths, including apoptosis, necrosis and autophagy. (essaywriter.org)
  • Primarily, the aim of anti-cell death in animals is to describe the processes of autophagy and apoptosis, while necrosis is the mechanism for defining the uncontrollable or chaotic mode of death. (essaywriter.org)
  • Majority of the literature and experiments in the field of programmed cell death in plants draw heavily on comparative analysis retrieved from paradigms of animal systems such as apoptosis, necrosis and autophagy. (essaywriter.org)
  • Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)
  • GLT) and that depletion of JUND in β cells reduces oxidative stress and apoptosis caused by GLT. (upenn.edu)
  • 2. We recently identified a novel PDX1 stress inducible complex (es) positioned over CARE sites and involving ATF4 and ATF5 that regulates expression of stress and apoptosis genes to govern β cell survival. (upenn.edu)
  • Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis. (cancerindex.org)
  • Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. (wikidata.org)
  • Involved in negative regulation of lipid transport and negative regulation of reactive oxygen species biosynthetic process. (nih.gov)
  • Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)
  • Metabolite Profiling in Arabidopsisthaliana with Moderately Impaired Photorespiration Reveals Novel Metabolic Links and Compensatory Mechanisms of Photorespiration. (mpg.de)
  • Each turn of the Krebs cycle therefore begins when one of the two acetyl-CoA molecules derived from the original 6-carbon glucose molecule yields its acetyl group to the 4-carbon compound oxaloacetate to form the 6-carbon tricarboxylic acid (citrate) molecule. (encyclopedia.com)
  • Metabolic control and regulation of the tricarboxylic acid cycle in photosynthetic and heterotrophic plant tissues. (mpg.de)
  • Obesity and Cancer: role of those proteins associated with cell cycle on metabolic control and obesity development. (wikipedia.org)
  • Since rate of autophagy in cells was not detected, it is impossible to determine, if there were changes in autophagy that were not reflected as changes in colocalization of these two proteins. (helsinki.fi)
  • Our results indicate that several dozens of proteins for each cell type, are PE-lipoxidated in HT-22, MLE, and H9c2 cells and M2 macrophages after they were induced to undergo ferroptosis. (cdc.gov)
  • Pretreatment of cells with the strong nucleophile, 2-mercaptoethanol, prevented the formation of PE-lipoxidated proteins and blocked ferroptotic death. (cdc.gov)
  • Many ORs are expressed by tumor cells and tissues, suggesting that they may be associated with cancer progression or may be cancer biomarkers. (bmbreports.org)
  • SIN3 is required for viability of multi-cellular organisms and mutations in components in the complex have been linked to defects in cell cycle progression. (wayne.edu)
  • The Krebs cycle is part of the aerobic degradative process in eukaryotes known as cellular respiration, which is a process that generates adenosine triphosphate (ATP) by oxidizing energy-rich fuel molecules. (encyclopedia.com)
  • The breakdown of pyruvate irreversibly funnels the products of glycolysis into the Krebs cycle. (encyclopedia.com)
  • Thus, the transformation of pyruvate to acetyl-CoA is the link between the metabolic reactions of glycolysis and the Krebs cycle. (encyclopedia.com)
  • In eukaryotic cells, the enzymes that are reponsible for this breakdown are located in the mitochondria, while in procaryotes they are in the cytoplasm. (encyclopedia.com)
  • [20] This finding has led to general acceptance of the endosymbiotic hypothesis - that free-living prokaryotic ancestors of modern mitochondria permanently fused with eukaryotic cells in the distant past, evolving such that modern animals, plants, fungi, and other eukaryotes are able to respire to generate cellular energy . (wikipedia.org)
  • Similarly, the miRNA signature shows predictive value in adults with T-cell lymphoblastic lymphoma [ 9 ], and long noncoding RNA shows predictive value in adults with localized clear cell renal cell carcinoma [ 10 ]. (aging-us.com)
  • Although most of a eukaryotic cell's DNA is contained in the cell nucleus , the mitochondrion has its own genome ("mitogenome") that is substantially similar to bacterial genomes. (wikipedia.org)
  • BiGG Models is a knowledgebase of genome-scale metabolic network reconstructions. (biokeanos.com)
  • BiGG Models integrates more than 70 published genome-scale metabolic networks into a single database with a set of standardized identifiers called BiGG IDs. (biokeanos.com)
  • It is essential for cell homeostasis and survival and has been related to various diseases and pathophysiology. (helsinki.fi)
  • Obesity and Cardiovascular risk: hemodynamic, metabolic and inflammatory factors associated to cardiac and vascular diseases in obesity. (wikipedia.org)
  • The dominant discovery in these experiments indicates that there is a heterologous expression of certain genes in plants that can regulate cell death. (essaywriter.org)
  • By studying both metabolic and ROS profiles in early embryos of X. laevis, I uncovered a novel coupled oscillation system that works to regulate the cell cycle. (manchester.ac.uk)
  • Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo. (wikidata.org)
  • This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. (antikoerper-online.de)
  • concepts of metabolic control. (manchester.ac.uk)
  • As an outcome of the two-part signalling and/or cell-cycle control. (who.int)
  • In that context, differentiated enterocytes in villi exhibit higher guanylin expression and ligand-dependent cGMP accumulation compared to proliferating progenitor cells in crypts. (jefferson.edu)
  • Crypt expansion reflected hyperplasia of the proliferating compartment with reciprocal increases in rapidly cycling progenitor cells and reductions in differentiated cells of the secretory lineage, including Paneth and goblet, but not enteroendocrine, cells. (jefferson.edu)
  • Human embryonic kidney cells 293 (HEK-293) and hPREP knockout cell line created from them by using CRISPR/Cas9-silencing were used in the experiments. (helsinki.fi)
  • to what extent do the processes of early embryonic development and tissue regeneration share or differ in metabolic states and how are these regulated? (manchester.ac.uk)
  • The homeodomain transcription factor Pdx1 is a critical member of the beta cell transcriptional network during embryonic beta cell formation and in postnatal beta cell function. (upenn.edu)
  • Jeffrey Twum-Ampofo, Dexue Fu, Antonino Passaniti , Arif Hussain, and M. Minhaj Siddiqui (2016) Metabolic Targets for Potential Prostate Cancer Therapeutics. (umaryland.edu)
  • Finally, the results of ROC curves, immunohistochemical staining, immune cell infiltration and kinase / miRNA / transcription factor regulation showed that KCNK2, KCNK4, KCNK5 and KCNK15 levels could be used as biomarkers for PTC diagnosis. (jcancer.org)
  • It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. (cancerindex.org)
  • Thus, the regulation of SETD2 levels through its proteolysis is important to maintain its appropriate function, which in turn regulates the fidelity of transcription and splicing-related processes. (frontiersin.org)
  • Expression of SIRT1/SOX9/LCN2 in the hypoxic cells was determined, and their interactions were predicted by bioinformatics websites and followed by the verification by luciferase assay and chromatin immunoprecipitation (ChIP). (hindawi.com)
  • Together, these grants have produced a transformative technique for the locus-specific labeling of individual nucleosomes that allowed resolution of one of the longest unsolved questions regarding chromatin, showing that individual nucleosome retain their genomic addresses through multiple DNA replication cycles. (grantome.com)
  • The endocrine system coordinates functioning between different organs through hormones, which are chemicals released into the bloodstream from specific types of cells within endocrine (ductless) glands. (msdmanuals.com)
  • The recommended practices address the benefits of using a quality management system approach, factors to consider before introducing new tests, establishment and verification of test performance specifications, the total laboratory testing process (which consists of the preanalytic, analytic, and postanalytic phases), confidentiality of patient information and test results, and personnel qualifications and responsibilities for laboratory testing for inherited metabolic diseases. (cdc.gov)
  • 2/ 4 contribute to cellular function, · account for how vitamins contribute to biological function and how deficiency of these can lead to disease, · account for metabolic changes in cells in some common diseases. (lu.se)
  • While at Hopkins his work on the role of cell surface glycosylation in tumor metastasis led to a subsequent staff position at the NIH (National Institute on Aging) where he focused on tumor angiogenesis. (umaryland.edu)
  • Adipobiology: identification of new signals released by the adipose tissue which are involved in the regulation of energy homeostasis. (wikipedia.org)
  • The significance of loss of GCC ligands early in intestinal tumorigenesis remains obscure because (patho)physiological roles of GCC signaling in intestine, beyond regulation of intestinal fluid and electrolyte homeostasis, are poorly defined. (jefferson.edu)
  • The Stoffers laboratory is a basic biomedical research group, encompassing clinical and basic postdoctoral fellows, MD, MD-PhD and PhD graduate students, and undergraduates, all striving to understand the development, maintenance and regeneration of pancreatic islet beta cells that produce the hormone insulin so critically required for normal glucose homeostasis. (upenn.edu)
  • Cancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attracts interest as a therapeutic target. (lu.se)
  • In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. (lu.se)
  • Here we investigated the characteristics of a population of pancreatic cancer tumorspheres derived from different human pancreatic cancer cell lines and a primary line from a genetically engineered KPC mouse model, using flow cytometry and western blotting to analyse surface and stemness markers. (lu.se)
  • In addition, we have shown that pancreatic cancer tumorspheres have a unique metabolic profile with reduced metabolic potential. (lu.se)
  • EGCg has been scientifically demonstrated to assist in maintaining healthy tissues in the face of normal metabolic stress and to support proper cell cycle regulation. (netrition.com)
  • In addition, ORs were recently shown to be expressed in many nonolfactory tissues and cells, indicating that these receptors have physiological and pathophysiological roles beyond olfaction. (bmbreports.org)
  • Carnitine deficiency is a metabolic state in which carnitine concentrations in plasma and tissues are less than the levels required for normal function of the organism. (medscape.com)
  • The activation of cell death by plants is dependent on the decision by the plant cells based on information that these cells receive from different sources, such as the environment . (essaywriter.org)
  • Some cells in some multicellular organisms lack mitochondria (for example, mature mammalian red blood cells ). (wikipedia.org)
  • Some hormones exert an effect on cells of the organ from which they were released (paracrine effect), some even on the same cell type (autocrine effect). (msdmanuals.com)
  • Hormones bind selectively to receptors located inside or on the surface of target cells. (msdmanuals.com)
  • In addition to his research programs in angiogenesis and breast cancer biology he also directs the Advanced Cancer Biology course in the Molecular Medicine program and participates in clinical conferences for medical students in Cell and Molecular Biology. (umaryland.edu)
  • In present study we characterized human brain endothelial cells, hCMEC/D3, which are widely utilized as BBB in vitro model. (helsinki.fi)
  • In the third mode, reguland regulation, the regulated entity is the target of a regulatory shift, which is often irreversible or requires action of another regulator to return to original state. (researchsquare.com)
  • Relevant cellular senescence markers, such as X-gal staining, cell cycle regulator levels, and the percentage of cell cycle-arrested cells, were found to be reduced in the presence of naringenin. (hindawi.com)
  • This generated low ROS levels, which were not sufficient to inactivate a key cell cycle regulator, thus leading to an active Cyclin B-Cdk1 complex to allow entry into mitosis. (manchester.ac.uk)
  • The regulation of such responses in complex metabolic environments is poorly understood. (bvsalud.org)
  • Additionally, this discussion expands its mandate by analyzing the function and regulation of anti-cell death in plant development. (essaywriter.org)
  • We discovered an unprecedented burst of differential expression of cell cycle related genes at one particular point during transition to flowering. (biomedcentral.com)
  • Our results show that cross-talk between Cdc2 and Sty1, and the consequent Sty1-dependent regulation of Cdc2 activity, appears to be compromised and the relationship between Cdc2 activity and mitotic timing is also reversed in the presence of lactate. (bvsalud.org)
  • The enzymatic steps of glycolysis and the subsequent synthesis of acetyl-CoA involve a linear sequence, whereas the oxidation of acetyl-CoA in the Krebs cycle is a cyclic sequence of reactions in which the starting substrate is subsequently regenerated with each turn of the cycle. (encyclopedia.com)
  • Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. (thieme-connect.com)
  • The newly generated xxt3xxt4xxt5 mutant produces only XXGG-type XyGs, which further helps to understand the impact of structurally deficient polysaccharides on plant cell wall organization, growth, and development. (bvsalud.org)