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  • glycine
  • SH) residue in the tripeptide glutamate-cysteine-glycine to carbon 6 of LTA4 thereby forming LTC4 (i.e. 5S-hydroxy,6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid). (wikipedia.org)
  • histidine
  • D. melanogaster and D. discoides have truncated N-terminal extensions and therefore prevent the conserved histidine and cysteine heme ligand residues. (wikipedia.org)
  • However, the Anopheles gambiae sequence has a longer N-terminal extension than the human enzyme and contains the conserved histidine and cysteine heme ligand residues like the human heme. (wikipedia.org)
  • Escherichia
  • Awano N, Wada M, Mori H, Nakamori S, Takagi H (2005) Identification and functional analysis of Escherichia coli Cysteine Desulfhydrases. (springer.com)
  • inhibitors
  • 1OH1: Solution structure of staphostatin A form Staphylococcus aureus confirms the discovery of a novel class of cysteine proteinase inhibitors. (rcsb.org)
  • glutamicum
  • In this study, the food-grade microorganism Corynebacterium glutamicum was engineered for l -cysteine production. (springer.com)
  • Finally, the l -cysteine concentration of the engineered strain CYS-19 could produce 947.9 ± 46.5 mg/L with addition of 6 g/L Na 2 S 2 O 3 , approximately 14.1-fold higher than that of the initial strain CYS-2, which was the highest titer of l -cysteine ever reported in C. glutamicum . (springer.com)
  • These results indicated that C. glutamicum was a promising platform for l -cysteine production. (springer.com)
  • Becker J, Zelder O, Häfner S, Schröder H, Wittmann C (2011) From zero to hero--design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production. (springer.com)
  • regulation
  • Due to the toxicity and complex regulation of l -cysteine, no efficient cell factory has yet been achieved for l -cysteine industrial production. (springer.com)
  • ATP is crucial for ALOX5's metabolic activity A proline-rich region (residues 566-577), sometimes termed a SH3-binding domain, which promotes its binding to proteins with SH3 domains such as Grb2 and may thereby link the enzyme's regulation to tyrosine kinase receptors. (wikipedia.org)
  • Goldstein J.L., Brown M.S. (1990) Regulation of the mevalonate pathway. (wikipedia.org)
  • amino acids
  • Amino acids are more likely to accumulate the closer they are to the metabolic block. (allbest.ru)
  • The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives. (springer.com)
  • genes
  • Single genes of interest included I-Kappa-B Kinase-Alpha (CHUK), and a phosphorylation dependent transcription factor (CREB1), which associate with RSK2 to regulate several signaling pathways. (jove.com)
  • molecules
  • Trichochromes (formerly called trichosiderins) are pigments produced from the same metabolic pathway as the eumelanins and pheomelanins, but unlike those molecules they have low molecular weight. (wikipedia.org)
  • accumulation
  • Metabolic blocks may result in the accumulation of novel compounds that are not normally observed-for example succinylacetone accumulates in tyrosinaemia type 1. (allbest.ru)
  • Loss of hepatic Nfe2l1 has been shown to result in lipid accumulation, hepatocellular damage, cysteine accumulation, and altered fatty acid composition. (wikipedia.org)
  • strain
  • Through deletion of the l -cysteine desulfhydrases (CD) and overexpression of the native serine acetyltransferase (CysE), the initial l -cysteine-producing strain CYS-2 was constructed to produce 58.2 ± 5.1 mg/L of l -cysteine. (springer.com)
  • Becker J, Wittmann C (2012b) Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development. (springer.com)
  • Moreover
  • Moreover, rather than looking only at individual correlations (one-to-one), we adapted canonical correlation analysis and related techniques to define an ensemble of weighted pathways that maximally covaries with a combination of environmental variables (many-to-many), which we term a metabolic footprint. (pnas.org)
  • disorders
  • Feature congenital metabolic disorders due to the inability to convert phenylalanine to tyrosine. (allbest.ru)
  • All of the pyruvate dehydrogenase isozymes have been associated with various metabolic disorders, including diabetes. (wikipedia.org)
  • novel
  • On the other hand novel drugs like ticagrelor (Brilique®) and cangrelor (Kengrexal®) are non-thienopyridines and reversibly inhibit P2Y12 meaning they act directly on the receptor without the requirement of metabolic activation and display faster onset and offset of action. (wikipedia.org)
  • crucial
  • As the primary regulators of a crucial step in the central metabolic pathway, the pyruvate dehydrogenase family is tightly regulated itself by a myriad of factors. (wikipedia.org)
  • therefore
  • Therefore, we introduce an approach that employs correlation and regression to relate multiple, continuously varying factors defining an environment to the extent of particular microbial pathways present in a geographic site. (pnas.org)
  • Therefore, mitochondria-targeting metabolic modulators increase pyruvate dehydrogenase activity, and suppress angiogenesis as well, normalizing the pseudo-hypoxic signals that lead to normoxic HIF1A activation in solid tumors. (wikipedia.org)
  • composition
  • Comparative metagenomics approaches have revealed significant variation in sequence composition ( 3 ), genome size ( 4 ), evolutionary rates ( 5 ), and metabolic capabilities ( 6 - 8 ) among qualitatively dissimilar environments (e.g., terrestrial vs. marine), providing evidence for genomic adaptations. (pnas.org)
  • activity
  • this happens because the compound temporarily oxidizes the cysteine residues 45 and 392 on the enzyme, resulting in an inactive PDK2 and greater PDH activity. (wikipedia.org)
  • levels
  • Carfagna S, Salbitani G, Vona V, Esposito S (2011) Changes in cysteine and O-acetyl-L-serine levels in the microalga Chlorella sorokiniana in response to the S-nutritional status. (springer.com)
  • Cysteine in sufficient levels will bind with metals-preferentially, the heavy metals lead, mercury, and cadmium bond most strongly-thus, cysteine aids the body's elimination of them. (healthy.net)
  • form
  • The cytosolic form is the starting point of the mevalonate pathway, which leads to cholesterol and other sterolic and isoprenoid compounds). (wikipedia.org)