UncouplerCardiovascular and metabolic diseaseInhibitionDehydrogenasePhosphorylationMetabolismInhibitAdaptationsHormonalLifespanCharacterizationProcessesVulnerabilitiesPeripheralResistanceGlucoseBeneficial effectsRegulationDrugsIncreasesCompoundsCellularGrowthNuclearConcentrationActiveBodySpecificSide EffectsFoundCancer cellHumanLossStudiesActionsMuscle
Uncoupler3
- BT2 is roughly five-fold less potent than the prototypical uncoupler 2,4-dinitrophenol (DNP), and phenocopies DNP in lowering de novo lipogenesis and mitochondrial superoxide production. (bvsalud.org)
- A low dose of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) remarkably extends mouse lifespan ( Cerqueira, Laurindo & Kowaltowski, 2011 ). (peerj.com)
- The peak values of delta psi and ROS generation are under succinate oxidation and delta psi is modified using either an uncoupler or complex II inhibitor, so, as so often, we are a long way from physiology here but the general principle that ROS generation rises rapidly above a threshold delta psi appears to hold good today. (blogspot.com)
Cardiovascular and metabolic disease2
- Elevated levels of branched chain amino acids (BCAAs) and branched-chain α-ketoacids (BCKAs) are associated with cardiovascular and metabolic disease, but the molecular mechanisms underlying a putative causal relationship remain unclear. (bvsalud.org)
- The data suggest the therapeutic efficacy of BT2 may be attributable to the well-documented effects of mitochondrial uncoupling in alleviating cardiovascular and metabolic disease. (biomed.news)
Inhibition3
- The metabolic response to AR inhibition is defined by reduced glycolysis, robust elongation of mitochondria, and increased reliance on mitochondrial oxidative metabolism. (bvsalud.org)
- BT2 administration is protective in various rodent models of heart failure and metabolic disease, but confoundingly, targeted ablation of Bckdk in specific tissues does not reproduce the beneficial effects conferred by pharmacologic inhibition. (bvsalud.org)
- However, baseline opening of K ATP channels and their activation induced by metabolic inhibition was suppressed by axotomy. (biomedcentral.com)
Dehydrogenase2
- The branched-chain ketoacid dehydrogenase kinase (BCKDK) inhibitor BT2 is often used in preclinical models to increase BCAA oxidation and restore steady-state BCAA and BCKA levels. (bvsalud.org)
- It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. (lookformedical.com)
Phosphorylation1
- Oxidative phosphorylation (UK /ɒkˈsɪd.ə.tɪv/, US /ˈɑːk.sɪˌdeɪ.tɪv/ ) or electron transport-linked phosphorylation or terminal oxidation is the metabolic pathway in which cells use enzymes to oxidize nutrients, thereby releasing chemical energy in order to produce adenosine triphosphate (ATP). (wikipedia.org)
Metabolism6
- Thus, ACE overexpression in myeloid lineage cells modifies the metabolic function of peripheral blood circulating monocytes which differentiate to macrophages and protect against atherosclerotic lesion progression due to better lipid metabolism. (bvsalud.org)
- Here, we comprehensively characterize the effects of AR blockade on prostate cancer metabolism using transcriptomics, metabolomics, and bioenergetics approaches. (bvsalud.org)
- 1989. Metabolism of DEHP: Effects of prefeeding and dose variation, and comparative studies in rodents and the cynomolgus monkey (CMA studies). (cdc.gov)
- 2,4-Dinitrophenol slowed the influx of only those compounds whose metabolism it blocks. (biologists.com)
- To test the first possibility, we measured the effect of UA on bacterial metabolism by measuring the growth of two Escherichia coli strains, OP50 and HT115, after treatment with UA. (lsd1receptor.com)
- Uric acid is the metabolic end product of purine metabolism. (lookformedical.com)
Inhibit3
- The enzymes carrying out this metabolic pathway are also the target of many drugs and poisons that inhibit their activities. (wikipedia.org)
- Protease inhibitors protease inhibitors inhibit the action of about 5 months 4. (revivemedicalny.com)
- The purpose of the study was to evaluate the effect of an Ayurvedic formulation Varanadi kashayam to inhibit pancreatic lipase activity in-vitro . (ijpsr.com)
Adaptations2
- Metabolic adaptations significantly contribute to tumor development and escape from tissue homeostatic defenses. (biomed.news)
- Since metabolic suppression was suggested to mitigate DNA damage ( Koubova & Guarente, 2005 ), a novel model deciphering CR-conferred DNA protection has been established, in which CR-mediated metabolic/hormonal adaptations result in cellular adaptations including reduced cell proliferation, increased autophagy or apoptosis, up-regulated DNA repair systems, and enhanced genomic stability ( Longo & Fontana, 2010 ). (peerj.com)
Hormonal2
- During PCT, users typically take medications or supplements that aid in hormonal recovery, such as Selective Estrogen Receptor Modulators (SERMs), Aromatase Inhibitors (AIs), and Human Chorionic Gonadotropin (HCG). (teletest.ca)
- These substances can help reduce the likelihood of unwanted side effects and help the body return to its normal hormonal balance. (teletest.ca)
Lifespan2
- In contrast, treatment with EA at the same concentration had no effect on lifespan (Fig. 1b). (lsd1receptor.com)
- We found a clear dose-response effect on lifespan when UA concentrations were increased from 10 to 50 µM (Fig. 1c). (lsd1receptor.com)
Characterization1
- Kiorpes TC, Hoerr D, Ho W, Weaner LE, Inman MG, Tutwiler GF (2021) Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria. (bioblast.at)
Processes3
- SUMMARY: A fractionation of sulphur isotopes was found in all metabolic processes investigated except those in which elemental sulphur was the starting substrate for growth of Thiobacillus concretivorus and Chromatium sp. (microbiologyresearch.org)
- Also, Cytomel is popular among bodybuilders due to its ability to speed up metabolic processes, effectively eliminating body fat. (24hoursppc.org)
- The growth of hormone concentration speeds up metabolic processes and, accordingly, fat loss occurs faster. (24hoursppc.org)
Vulnerabilities2
- Our study provides insight into the regulation of treatment-induced metabolic phenotypes and vulnerabilities in prostate cancer. (bvsalud.org)
- Collectively, these finding indicate that combining a GLUT1 inhibitor with a mitochondrial fusion inhibitor can work synergistically in cancer therapy and, more broadly, suggest that the incorporations of mitochondrial dynamics and metabolic regulation may become the targetable vulnerabilities bypassing the genotypic heterogeneity of multiple malignancies. (biomed.news)
Peripheral1
- Here, we show that the ACE-mediated metabolic phenotype is already triggered in peripheral blood circulating monocytes and that this functional modification is directly transferred to differentiated macrophages in ACE10/10 mice. (bvsalud.org)
Resistance3
- Cancer cells with healthy mitochondria and high SRC exhibit greater metabolic flexibility and higher resistance to GLUT1 inhibitors. (biomed.news)
- Freeze-drying from 5 % (w/v) aqueous solutions of glucose, lactose or fructose had a significant protective effect on the radiation resistance of the spores. (microbiologyresearch.org)
- Freeze-drying from aqueous suspension, or from 5 % maltose had no effect on the resistance. (microbiologyresearch.org)
Glucose4
- In this work, we identified oroxylin A (OA), a dual GLUT1/mitochondrial fusion inhibitor, which restricted glucose catabolism of hepatocellular carcinoma cells and simultaneously inhibited mitochondrial fusion by disturbing SIRT1/PDK2/PARL axis. (biomed.news)
- Based the dual action of OA in metabolic regulation and mitochondrial dynamics, further results revealed that mitochondrial functional status and spare respiratory capacity (SRC) of cancer cells had a close correlation with mitochondrial metabolic plasticity, and played important roles in the susceptibility to cancer therapy aiming at glucose restriction. (biomed.news)
- Thus, inhibiting mitochondrial fusion breaks mitochondrial metabolic plasticity and increases cancer cell susceptibility to glucose restriction therapy. (biomed.news)
- In patients with type 2 diabetes mellitus who are overweight or obese, antidiabetic medications that have additional actions to promote weight loss (such as glucagonlike peptide-1 [GLP-1] analogs or sodium-glucose-linked transporter-2 [SGLT-2] inhibitors) are suggested, in addition to the first-line agent for type 2 diabetes mellitus and obesity, metformin. (medscape.com)
Beneficial effects2
- The SIRT1 activator resveratrol has been also known to exert CR-like beneficial effects on obese humans' life quality ( Blagosklonny, 2010 ). (peerj.com)
- Maintenance strategies are required to ensure the preservation of the early beneficial effects of the TDR intervention. (blogspot.com)
Regulation1
- Those who combine T3 and clenbuterol receive synergetic effect especially because of better regulation of beta 2 receptors in fat tissue, which clen tends to deregulate. (24hoursppc.org)
Drugs6
- Drugs that typically affects individuals who consider suffering, illness, and even increase their clearance of paraquat poisoning result from local gastric irritation at 72 h 124 pesticides 879 younger than 3 months. (revivemedicalny.com)
- In the period between 1950 and 1960 there were a number of reports of the relative insensitivity of insect nerves and ganglia to various electrolytes, drugs and toxicants which affected vertebrate nervous systems. (biologists.com)
- Harm reduction testing is important for anabolic steroid users because the use of these drugs can have potential negative effects on the body, including changes in hormone levels, liver damage, and cardiovascular problems. (teletest.ca)
- Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (lookformedical.com)
- The study of the origin, nature, properties, and actions of drugs and their effects on living organisms. (lookformedical.com)
- Determination of antioxidant activity of herbal drugs is necessary because of its pharmaceutical effects. (ijpsr.com)
Increases1
- Measurements of oxygen consumption, mitochondrial membrane potential, and patch-clamp electrophysiology show BT2 increases proton conductance across the mitochondrial inner membrane independently of its inhibitory effect on BCKDK. (bvsalud.org)
Compounds1
- Some elements and compounds used in industry cause local damage in the digestive system affecting, for example, the mouth and neighbouring area, stomach, intestine, liver or pancreas. (cloudaccess.net)
Cellular1
- Because their opening is determined by the cytosolic ADP/ATP ratio, K ATP channels act as metabolic sensors, linking cytosolic energetics with cellular functions in various tissues [ 21 , 22 ]. (biomedcentral.com)
Growth4
- 1987. Growth and aggregation behavior of representative phytoplankton as affected by the environmental contaminant di-n-butyl phthalate. (cdc.gov)
- Fasting can be induced if a compound affects bacterial growth, thereby reducing the amount of food available or modifying key nutrient amounts14, or acts as repellent for the worms and prevents food intake. (lsd1receptor.com)
- We found that UA had a very modest effect on the growth of these two strains (Supplementary Fig. 1a,b). (lsd1receptor.com)
- Users stack different substances in an attempt to maximize the desired effects, such as muscle growth, while minimizing potential side effects. (teletest.ca)
Nuclear1
- The conformation of III was assigned from the examination of its derivatives IV, Va and Vb in nuclear Overhouser effect and circular dichroism. (go.jp)
Concentration1
- rapid onset of effect - the maximum concentration of active component occurs in 4-8 hours after taking drug. (24hoursppc.org)
Active1
- Cytomel (Liothyronine Sodium, L-T3) has proven to be 4-5 times more biologically active and to take effect more quickly than Levothyroxin T4. (24hoursppc.org)
Body1
- Armor tablets have a pronounced fat burning effect on the body. (24hoursppc.org)
Specific1
- Failure to block the NO-mediated amplification of K ATP currents with specific inhibitors of sGC and PKG indicated that the classical sGC/cGMP/PKG signaling pathway was not involved in the activation by SNAP. (biomedcentral.com)
Side Effects1
- What are some risks and side effects of using PEDs? (teletest.ca)
Found1
- The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries. (lsd1receptor.com)
Cancer cell1
- A few studies have documented biological effects of urolithins in vitro, including antiproliferation in cancer cell models10, anti-inflammation11 and benefits on lipid metabolism12, although a clear biological pathway has not yet been described. (lsd1receptor.com)
Human1
- Dysregulated mitochondrial dynamics respond rapidly to metabolic cues, and are linked to the initiation and progression of diverse human cancers. (biomed.news)
Loss1
- Young MP, Schug ZT, Booth DM, Yule DI, Mikoshiba K, Hajnóczky G, Joseph SK (2021) Metabolic adaptation to the chronic loss of Ca 2+ signaling induced by knockout of IP 3 receptors or the mitochondrial Ca 2+ uniporter. (bioblast.at)
Studies1
- Dinitrophenol and thyroid function tests (see urodynamic studies, opposite). (revivemedicalny.com)
Actions1
- By 288 nutritional-metabolic pattern nursing actions/interventions with rationales gerontic health actions/interventions monitor for factors contributing to hopelessness mutual goal setting with client his or her condition. (revivemedicalny.com)
Muscle1
- These effects translated to rodents, where UA improved exercise capacity in two different mouse models of age-related decline of muscle function, as well as in young rats. (lsd1receptor.com)