• Hyperglycemia, glycosuria, hyperuricemia. (druglib.com)
  • Patients reporting a history of hypertension, dyslipidemia, or hyperglycemia warrant screening for metabolic syndrome. (medscape.com)
  • Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). (wikipedia.org)
  • The key sign of metabolic syndrome is central obesity, also known as visceral, male-pattern or apple-shaped adiposity. (wikipedia.org)
  • There is debate regarding whether obesity or insulin resistance is the cause of the metabolic syndrome or if they are consequences of a more far-reaching metabolic derangement. (wikipedia.org)
  • Several studies have shown that too little or too much sleep is related to poor health problems such as hyperuricemia, hyperlipidemia, hypertension, type 2 diabetes, obesity, cardiovascular disease, and even mortality. (medicalxpress.com)
  • Subgroup analyses showed that a relationship between gout and the risk of acute MI was present among nonusers of alcohol, diuretics, or aspirin and among those who did not have metabolic syndrome, diabetes mellitus, or obesity. (natap.org)
  • 26 120 180 ] Body mass index (BMI) has been widely used to indicate the level of obesity, though recent studies have found that abdominal or visceral adiposity (vs subcutaneous), as reflected in the waist-to-hip ratio or waist circumference, is a strong criteria for predicting the risk of developing metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). (surgicalneurologyint.com)
  • High blood Uric Acid levels are also associated with a wide variety of diseases including hypertension, increased cardiovascular mortality, obesity and metabolic syndrome. (salimetrics.com)
  • The physical examination is crucial in patients with metabolic syndrome, as the findings of elevated blood pressure and abdominal obesity are 2 of the 5 diagnostic criteria. (medscape.com)
  • Diabetes, metabolic syndrome and obesity : targets and therapy 2020 11 13 4311-4322. (cdc.gov)
  • The independent risk relationship between hyperuricemia and acute MI is confirmed. (natap.org)
  • Dietary patterns,tors (2005) Intense metabolic control by means of insulinmental represen-EVIDENCE OF THE RELATIONSHIP BETWEEN HYPERURICEMIA, ANDhours later at the intake of a dose of Viagra. (mwro.org)
  • Gout (urate crystal deposition disease) is characterized by hyperuricemia and manifested by recurrent attacks of acute gouty arthritis, tophaceous disease, and chronic gouty arthropathy. (mhmedical.com)
  • most often hyperuricemia is defined as serum urate concentrations exceeding 7.0 mg/dl in men and 6.0 mg/dl in women, employing enzyme-based (uricase) methods of measurement. (mhmedical.com)
  • Gout results from elevated serum urate (SU) levels, or hyperuricemia, and is a globally widespread and increasingly burdensome disease. (researchgate.net)
  • The caricature of the typical patient with hyperuricemia is an obese middle-aged man with hypertension, diabetes mellitus, and hyperlipidemia who is given to excessive drinking. (natap.org)
  • Epidemiologic studies indicate relation of serum uric acid levels with hypertension metabolic syndrome, coronary artery disease, cerebrovascular disease, vascular dementia, kidney disease and preeclampsia. (standardofcare.com)
  • While hyperuricemia is linked to adverse health outcomes from hypertension and cardiovascular disease, metabolic syndrome, and chronic kidney disease, it is controversial with the hyperuricemia has a causal role. (standardofcare.com)
  • Insulin resistance, metabolic syndrome, and prediabetes are closely related to one another and have overlapping aspects. (wikipedia.org)
  • Other signs of metabolic syndrome include high blood pressure, decreased fasting serum HDL cholesterol, elevated fasting serum triglyceride level, impaired fasting glucose, insulin resistance, or prediabetes. (wikipedia.org)
  • Rather than total adiposity, the core clinical component of the syndrome is visceral and/or ectopic fat (i.e., fat in organs not designed for fat storage) whereas the principal metabolic abnormality is insulin resistance. (wikipedia.org)
  • Metabolic syndrome (syndrome X, insulin resistance) is a multifactorial disease with multiple risk factors that arises from insulin resistance accompanying abnormal adipose deposition and function. (medscape.com)
  • Hyperuricemia is presumed to be a consequence of insulin resistance rather than its precursor. (arizonaadvancedmedicine.com)
  • Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis Study. (medscape.com)
  • Metabolic syndrome can lead to several serious and chronic complications, including type-2 diabetes, cardiovascular diseases, stroke, kidney disease and nonalcoholic fatty liver disease. (wikipedia.org)
  • citation needed] Recent research indicates prolonged chronic stress can contribute to metabolic syndrome by disrupting the hormonal balance of the hypothalamic-pituitary-adrenal axis (HPA-axis). (wikipedia.org)
  • In this study, we aimed to investigate the effects of allopurinol on metabolic acidosis and endothelial functions in hyperuricemic stage 2-4 chronic kidney disease (CKD) patients. (nih.gov)
  • 10) Furthermore, recent clinical studies revealed that hyperuricemia was an independent risk factor for cardiovascular events and the progression of chronic kidney diseases (CKD) in the general population,(19-22) which is also true for patients with CKD and kidney transplant recipients. (researchsquare.com)
  • Hyperuricemia, commonly associated with gout and kidney stones, has also been strongly correlated with many chronic conditions including cardiovascular disease, kidney disease, metabolic syndrome and diabetes. (salimetrics.com)
  • For example, sleep-related breathing disorders, such as obstructive sleep apnea, are becoming increasingly relevant and novel risk factors for metabolic syndrome. (medscape.com)
  • A new study suggests that weekend catch-up sleep may minimize the risk of hyperuricemia in postmenopausal women. (medicalxpress.com)
  • In this latest study involving nearly 1,900 participants, the researchers hypothesized that weekend catch-up sleep could be a solution to making up for lost sleep during the week and effectively lowering the risk of hyperuricemia in postmenopausal women, who often struggle to get sufficient sleep. (medicalxpress.com)
  • This is the first known study to investigate the relation between weekend catch-up sleep and hyperuricemia in postmenopausal women. (medicalxpress.com)
  • Study results suggest that weekend catch-up sleep is linked with a lower prevalence of hyperuricemia in postmenopausal women with insufficient sleep. (medicalxpress.com)
  • Further studies are required to identify the causal relationships between sleep recovery and hyperuricemia in postmenopausal women. (medicalxpress.com)
  • This study shows that weekend catch-up sleep of just 1 to 2 hours was linked with a lower prevalence of hyperuricemia in postmenopausal women with insufficient sleep. (medicalxpress.com)
  • Levels higher in postmenopausal women, blacks, hypertensives, patients with metabolic syndrome and those with renal disease. (standardofcare.com)
  • Since thiazide adverse effects may predominate (hyponatremia, metabolic alkalosis), due to variations in bioavailability, individual dose adjustment of the two drugs may be better. (pharmacology2000.com)
  • Hyperuricemia is the second most common metabolic disease after diabetes mellitus in China. (eisai.com)
  • In addition, hyperuricemia is known to be associated with various diseases in the urinary system, endocrine system, metabolic system, cardio-cerebrovascular system etc., including gout. (eisai.com)
  • Secondary gout is related to medications or conditions that cause hyperuricemia, such as myeloproliferative diseases and their treatment, hyperproliferative skin disorders, enzymatic defects, and renal failure. (medscape.com)
  • The Romanian Society of Diabetes, Nutrition and Metabolic Diseases was established to constantly provide appropriate care and treatment for all people with diabetes and/or other nutritional and metabolic diseases and to improve their quality of life. (idf.org)
  • The Romanian Society of Diabetes, Nutrition and Metabolic Diseases organizes every year a number of courses meant to increase and constantly improve the level of education of its members and specialists involved in the management of people with diabetes. (idf.org)
  • As a member of IDF, the Romanian Society of Diabetes, Nutrition and Metabolic Diseases wishes to continuously adapt the prevention, diagnosis and treatment methods of diabetes and its complications with international standards. (idf.org)
  • After sustained hyperuricemia, these MSU crystals deposit in tendons and joints to cause severe diseases including gout, kidney stones and several forms of kidney disease. (salimetrics.com)
  • As with other diseases, careful history taking is important in metabolic syndrome. (medscape.com)
  • The xanthine oxidase metabolic pathway may contribute to impaired vasodilator capacity in CHF. (nih.gov)
  • The available pathophysiologic evidence points toward inflammation, the characteristic difference between gout and hyperuricemia, as the likely pathway. (natap.org)
  • Recent studies have illuminated the pathophysiology of gout/hyperuricemia and its epidemiology, diagnosis, treatment, and complications. (researchgate.net)
  • Studies comparing ethnically similar populations exposed to different dietary environments have suggested that westernized diets are strongly associated with a higher risk of developing metabolic syndrome. (medscape.com)
  • The prevalence of hyperuricemia increases with age in all populations and especially in women after menopause. (medicalxpress.com)
  • Prevalence of metabolic syndrome compared between native Japanese and Japanese-Americans. (medscape.com)
  • These metabolic complications predispose the cancer patient to clinical toxicities including renal insufficiency, cardiac arrhythmias, neurological complications and potentially sudden death. (asn-online.org)
  • The patient's social history is important for identifying additional risks, such as tobacco use, which may exacerbate the increased cardiovascular complications associated with metabolic syndrome. (medscape.com)
  • Les paramètres d?intérêt étaient : l?âge au moment de la greffe, le type de greffe, la spécialité du médecin qui avait sélectionné le donneur et qui a fait le suivi post-greffe à Kinshasa, la régularité de prise des immunosuppresseurs et l?issue de la greffe (complications, rejet ou non, reprise ou non en dialyse). (bvsalud.org)
  • Dotinurad is a new therapeutic agent for gout and hyperuricemia discovered by FUJI YAKUHIN. (eisai.com)
  • URAT1, a molecular therapeutic target for gout/hyperuricemia, was initially derived from research into hereditary renal hypouricemia (RHUC). (researchgate.net)
  • Metabolic syndrome and related disorders 2020 04 18 (3): 121-127. (cdc.gov)
  • Furthermore, it is estimated that currently in China, the number of patients with hyperuricemia is approximately 190 million and the number of patients with gout is approximately 16 million. (eisai.com)
  • Following commercialization, Eisai will aim to contribute to patients with hyperuricemia that is unmet medical needs by utilizing the knowledge and networks that Eisai has cultivated through its China business. (eisai.com)
  • Through the development and commercialization of dotinurad, Eisai and FUJI YAKUHIN will provide new treatment options for hyperuricemia and gout in China and contribute to improving the quality of life of patients. (eisai.com)
  • Hyperuricemia and postischemic leg vascular resistance are highest in cachectic patients with CHF, and both are directly related independent of diuretic dose and kidney function. (nih.gov)
  • Garrod showed elevated SU concentration in gout patients in 1848 [14], and hyperuricemia has since been established as the cause of gout. (researchgate.net)
  • Low hepatic ATP, hyperuricemia, and hepatic lipid accumulation reported in metabolic syndrome (MetS) patients may reflect insufficient hepatic O 2 delivery, potentially accounting for the sympathetic overdrive associated with MetS. (surgicalneurologyint.com)
  • La greffe rénale n?est pas encore pratiquée en RDC, ce qui oblige les patients à se faire opérer à l?étranger. (bvsalud.org)
  • Nous avons colligé les dossiers des patients qui ont bénéficié d?une greffe rénale à l?étranger (86% en Inde) et dont le suivi post-greffe a été effectué dans les hôpitaux de Kinshasa entre 2000 et 2017. (bvsalud.org)
  • 0nze patients (38%) ont été repris en dialyse. (bvsalud.org)
  • Nonobstant un faible échantillonnage, ces donnent révèlent une moins bonne survie des greffons après la transplantation rénale chez les patients suivis à Kinshasa, notamment lorsque la prise en charge n?est pas faite en milieu spécialisé. (bvsalud.org)
  • Hyperuricemia and metabolic acidosis have emerged as important risk factors for progression of kidney disease. (nih.gov)
  • Although no statement regarding hyperuricemia was included in the Amsterdam Forum on the Care of the Live Kidney Donor published in 2005,(7) given these emerging studies on hyperuricemia for the general population and living donors, the 2017 Kidney Disease Improving Global Outcomes Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors referred to the potential impact of UA levels on living donors. (researchsquare.com)
  • Hyperuricemia is most often associated with gout, an increasingly common form of arthritis characterized by severe pain , redness, and tenderness in joints. (medicalxpress.com)
  • Changing or stopping medications associated with hyperuricemia (like diuretics) may also help. (cdc.gov)
  • Tumor lysis syndrome is a life-threatening oncological emergency characterized by metabolic abnormalities including hyperuricemia, hyperphosphatasemia, hyperkaliemia and hypocalcemia. (asn-online.org)
  • Even in the absence of chemotherapy, STLS can occur and lead to severe metabolic abnormalities and renal dysfunction. (asn-online.org)
  • Although HDL-C levels predict cardiovascular risk in the general population, the increased risk may be caused by other factors, such as accompanying lipid and metabolic abnormalities, such as hypertriglyceridemia, rather than the HDL-C level itself. (msdmanuals.com)
  • We assume that decreasing uric acid levels with allopurinol treatment seems to be helpful in restoring endothelial functions, preventing metabolic acidosis and slowing down the progression of CKD. (nih.gov)
  • Metabolic acidosis. (nih.gov)
  • Research shows that Western diet habits are a factor in development of metabolic syndrome, with high consumption of food that is not biochemically suited to humans. (wikipedia.org)
  • To determine if hyperuricemia and gouty arthritis are independent risk factors for acute myocardial infarction (MI) and, if so, whether they are independent of renal function, diuretic use, metabolic syndrome, and other established risk factors. (natap.org)
  • Hyperuricemia was an independent risk factor for acute MI in the multivariable regression models, with an odds ratio (OR) of 1.11 (95% confidence interval [95% CI] 1.08-1.15, P (natap.org)
  • In separate analyses, a relationship between gout and the risk of acute MI was evident among those with and without those hyperuricemia. (natap.org)
  • Gouty arthritis is associated with an excess risk of acute MI, and this is not explained by its well-known links with renal function, metabolic syndrome, diuretic use, and traditional cardiovascular risk factors. (natap.org)
  • The mechanisms of the complex pathways of metabolic syndrome are under investigation. (wikipedia.org)
  • Regarding ethical drugs, FUJI YAKUHIN has created two drugs with different mechanisms of action, topiroxostat and dotinurad, for gout and hyperuricemia. (eisai.com)
  • Metabolic syndrome is associated with the risk of developing cardiovascular disease and type 2 diabetes. (wikipedia.org)
  • A suggested approach to lowering the risk of hyperuricemia is adequate sleep duration that unfortunately becomes more of a challenge during the postmenopausal phase. (medicalxpress.com)
  • Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. (medscape.com)
  • Primary gout is related to underexcretion or overproduction of uric acid, which is often associated with dietary excesses or overuse of alcohol and metabolic syndrome. (medscape.com)
  • 26-28) We have also reported that preoperative hyperuricemia was strongly associated with suboptimal renal compensatory hypertrophy at 12 months after renal donation. (researchsquare.com)
  • Tasali E, Ip MS. Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation. (medscape.com)