Metabolic hepatic. Medical search. Frequent questions

Likewise, the pathophysiologic mechanism that leads to hepatic encephalopathy in children with FHF has not been fully defined (see Pathophysiology and Etiology ). (medscape.com)
Decreased hepatic clearance of these neurotoxins and increased absorption may contribute to the encephalopathy. (medscape.com)
The necessity of such a system is demonstrated by what happens when the system breaks down, as seen when advanced hepatic fibrosis in cirrhosis leads to hepatic encephalopathy in the brain owing to the blood being loaded with ammonia and other substances not conducive to brain function. (wikipedia.org)
Some of these conditions are multifactorial, and some have an established cause, such as hepatic or uremic encephalopathy. (medscape.com)
To propose an alternative model of hepatic encephalopathy (HE) in mice, resembling the human features of the disease. (wjgnet.com)

Hepatocytes (liver parenchymal cells) perform the liver's metabolic functions: Formation and excretion of bile as a component of bilirubin metabolism. (merckmanuals.com)
The effects of hepatic uptake and efflux transporters on metabolism of digoxin were examined in isolated rat hepatocytes versus microsomes. (aspetjournals.org)
These results strongly suggest that the hepatic uptake and efflux transporters that are found in hepatocytes, but not in microsomes, modulate intracellular concentration of digoxin and thus affect metabolism. (aspetjournals.org)
This study aimed to elucidate hepatic events related to inflammation and lipid metabolism and their linkage with metabolic alterations during NAFLD in American lifestyle-induced obesity syndrome (ALIOS) diet-fed mice. (utu.fi)
This study proposes to describe the basal hepatic metabolism at the level of mRNA in mule duck embryos in order to reveal potential interesting programming windows in the context of foie gras production. (biomedcentral.com)
Sun B, Kudo M, Hayashi M, Qin LL, Wu LL, Liu TH, Gao M. YNCRG Alleviated Hepatic Steatosis in Metabolic Syndrome Model Rats by Improving Lipid Metabolism and Chronic Inflammatory Reaction. (lidsen.com)
We found that YNCRG can reduce the accumulation of lipids in the liver of rats with metabolic syndrome, probably by affecting lipid metabolism and the signaling pathway associated with inflammatory reactions. (lidsen.com)
These results are inconsistent with the canonical model of hepatic metabolism in which Akt is an obligate intermediate for proper insulin signaling. (nature.com)
Since physical activity potently modulates glycogen metabolism, this provides a rationale for considering nutrient-physical activity interactions in metabolic health. (healthresults.com)
CONCLUSIONS: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. (ox.ac.uk)
Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice. (theopenscholar.com)
NREP and GDF15 modulate the expression of several genes involved in the regulation of hepatic lipid metabolism. (theopenscholar.com)
The benefit of first-pass metabolism, whereby substances absorbed from food in the gut pass through the liver before entering the systemic circulation, is to use the liver as a shield (a first line of defense) between (a) the food, its toxins (whatever they may be), and its metabolic intermediates/metabolites (such as ammonia) and (b) the rest of the body's tissues, including the brain. (wikipedia.org)
Maren Laughlin, Ph.D. Energy balance, thermogenesis and mitochondria biology, whole body intermediary carbohydrate, lipid and protein metabolism, and functional and metabolic imaging in adipose, pancreas and other metabolic organs. (nih.gov)
Parenchymal liver disease severely alters the normal metabolic functions such as metabolism of ammonia to urea. (vin.com)
esomeprazole will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. (medscape.com)

Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study. (ox.ac.uk)
We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. (ox.ac.uk)
Thus, quercetin treatment attenuated most of the symptoms of metabolic syndrome, including abdominal obesity, cardiovascular remodeling, and NAFLD, with the most likely mechanisms being decreases in oxidative stress and inflammation. (edu.au)
Visceral fat and metabolic inflammation: the portal theory revisited" (PDF). (wikipedia.org)
ABSTRACT There is accumulating evidence suggesting that inflammation is the bridging link between cardiovascular disease and metabolic syndrome. (who.int)
Relevant to the studies presented in this manuscript, mitochondrial dysfunction is a key contributor to the perpetuation of metabolic inflammation caused by nutrient excess. (frontiersin.org)
Background: Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). (lu.se)

In summary, our data indicate that sepsis promotes hepatic metabolic dysfunction and that targeting the mitochondrial PDC/PDK energy homeostat rebalances transcriptional and metabolic manifestations of sepsis within the liver. (metabolon.com)
These data show that MRI-derived indexes of portal hemodynamics and hepatic mass (1) correlate well with biochemical indexes of hepatic dysfunction and (2) serve as anatomic and hemodynamic correlates to Child's functional classification. (duke.edu)
CONCLUSIONS: We conclude that MRI may serve to noninvasively delineate preoperative hepatic vascular anatomy and metabolic dysfunction in candidates undergoing examination for liver transplantation. (duke.edu)
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. (nature.com)
Fig. 1: Remote primary tumours induce metabolic dysfunction in the liver. (nature.com)
Fig. 2: Tumour-derived EVPs induce liver metabolic dysfunction. (nature.com)
Metabolic disorder caused by dysfunction of mitochondrial DNA. (wikipedia.org)

The aim of this perform was to confirm the efficacy of metreleptin for enhancing metabolic manage, hypertriglyceridemia, and hepatic steatosis in patients with genetic lipodystrophies. (hsvinhibitor.com)

So, the purpose of this study is to identify the relationship between the physical activity level and the hepatic steatosis presence, metabolic syndrome and the risk of developing type 2 diabetes mellitus in men. (scirp.org)
Because of metabolic changes resulting from HS, currently the HS is recognized as the common cause to the development of metabolic syndrome, including the Type 2 Diabetes Mellitus (DM2) development. (scirp.org)
This rare disorder is clinically similar to Dubin-Johnson syndrome, but the liver is not pigmented, and other subtle metabolic differences are present. (merckmanuals.com)
We studied its effects and mechanism of action on a rat model of non-alcoholic fatty liver with metabolic syndrome. (lidsen.com)
Although gene-environment interactions have been implicated in the etiology of several disorders, the impact of paternal and/or maternal metabolic syndrome on the clinical phenotypes of offspring and the underlying genetic and epigenetic contributors of NAFLD have not been fully explored. (theopenscholar.com)
We report that parental metabolic syndrome epigenetically reprograms members of the TGF-β family, including neuronal regeneration-related protein (NREP) and growth differentiation factor 15 (GDF15). (theopenscholar.com)
Metabolic syndrome is a risk factor for cardiovascular disease and nonalcoholic fatty liver disease (NAFLD). (edu.au)
Definition of syndrome from metabolic and enzyme studies on a 9-year-old girl. (qxmd.com)
We carried out a cross-sectional study of 195 patients with metabolic syndrome. (who.int)
The aim of the present study was to investigate if time since schizophrenia diagnosis, body mass index (BMI), sex, metabolic syndrome, alcohol use, smoking, alanine transaminase (ALT), and body fat percentage (as measured by bioelectrical impedance) were associated with HS, determined by computed tomography (CT), in a population of patients diagnosed with schizophrenia. (aau.dk)
CONCLUSION: Higher ALT and the presence of metabolic syndrome were associated with HS in patients with schizophrenia utilizing multivariable analysis. (aau.dk)
The aim of the present study was to investigate if time since schizophrenia diagnosis, body mass index (BMI), sex, metabolic syndrome, alcohol use, smoking, alanine transaminase (ALT), and body fat percentage (as measured by bioelectrical impedance) were associated with HS, determined by computed tomography (CT), in a population of patients diagnosed with schizophrenia.METHODS: Moderate to severe HS (40 CT Hounsfield units as threshold) was determined utilizing non-contrast enhanced CT. (aau.dk)

The Nonalcoholic Fatty Liver Disease (NAFLD) is the most prevalent liver disease in adults, and can progress and be characterized as hepatic steatosis (HS) which is derived from the accumulation of lipids in hepatocytes, and histopathologic condition is more than 5% of the weight of liver. (scirp.org)
NAFLD can progress and be characterized as hepatic steatosis (HS) which is derived from the accumulation of lipids in hepatocytes, and histopathologic condition is more than 5% of the weight of liver. (scirp.org)
Non-alcoholic fatty liver disease (NAFLD) pathogenesis remains poorly understood due to the complex metabolic and inflammatory changes in the liver. (utu.fi)
The combination of non-targeted metabolomics with gene expression in future studies can further identify key metabolic routes during NAFLD which could be the targets of potential novel therapeutics. (utu.fi)
Reduced hepatic expression of NREP in patients with NAFLD and substantial correlations between low serum NREP levels and the presence of steatosis and nonalcoholic steatohepatitis highlight the clinical translational relevance of our findings in the context of recent preclinical trials implicating ACLY in NAFLD progression. (theopenscholar.com)
Excessive fructose consumption exacerbates the progression of nonalcoholic fatty liver disease (NAFLD) by disrupting hepatic lipid homeostasis. (cabi.org)
Conclusions: Our results suggest that one of the mechanisms how SFA could contribute to metabolic dysregulation in NAFLD is at the level of DNA methylation. (lu.se)

Hepatic osteodystrophy is an often forgotten metabolic bone disease seen in patients with chronic liver disease, in particular cirrhosis , primary biliary cholangitis , and primary sclerosing cholangitis . (radiopaedia.org)
In hepatic cirrhosis with ascites, Amiloride Hydrochloride usually provides adequate diuresis, with diminished potassium loss and less risk of metabolic alkalosis, when used alone. (janusinfo.se)

Figure 5: Nutritional regulation of hepatic gene expression in the absence of Foxo1 alone and in the absence of both Akt and Foxo1. (nature.com)

Fructose and metabolic health: governed by hepatic glycogen status? (healthresults.com)
Hepatic de novo lipogenesis is also upregulated by the inability to synthesise glycogen, either when storage is inhibited in knock-down animal models or storage is saturated in glycogen storage disease. (healthresults.com)
Considering that fructose has the capacity to upregulate hepatic glycogen storage, and replenish these stores more readily following glycogen depleting exercise, the idea that hepatic glycogen storage and hepatic de novo lipogenesis are linked is an attractive prospect. (healthresults.com)
We propose that hepatic glycogen stores may be a key factor in determining the metabolic responses to fructose ingestion, and saturation of hepatic glycogen stores could exacerbate the negative metabolic effects of excessive fructose intake. (healthresults.com)
Hepatic glycogen synthetase deficiency. (qxmd.com)
In the 13 years since hepatic glycogen synthetase deficiency was first described in identical twins no further cases seem to have been observed. (qxmd.com)
Hepatic glycogen synthetase deficiency causing fasting hypoglycaemia has been confirmed. (qxmd.com)

Fulminant hepatic failure (FHF) is usually defined as the severe impairment of hepatic functions or severe necrosis of hepatocytes in the absence of preexisting liver disease. (medscape.com)
HA557 trade name] is contraindicated in severe hepatic impairment. (who.int)
In moderate hepatic impairment, the components of [HA557 trade name] may have to be given separately if the dose of zidovudine needs to be reduced. (who.int)

Ellagitannins-derived intestinal microbial metabolite urolithin A ameliorates fructose-driven hepatosteatosis by suppressing hepatic lipid metabolic reprogramming and inducing lipophagy. (cabi.org)

However, the metabolic clearance estimated from hepatocytes was 15.9 ± 3.0 ml/min/kg. (aspetjournals.org)
We hypothesize that hepatic transporters present in hepatocytes, but not in microsomes, are often the missing link explaining such discrepancies between microsome data and in vivo profiles. (aspetjournals.org)
Blood also flows from branches of the hepatic artery and mixes in the sinusoids to supply the hepatocytes with oxygen. (wikipedia.org)

Evaluation of the Patient With a Liver Disorder History and physical examination often suggest a cause of potential liver disorders and narrow the scope of testing for hepatic and biliary disorders. (merckmanuals.com)

Physical inactivity is considered a case of public health, and other behavioral and metabolic risk factors, according to WHO (2011), such as smoking, increased blood pressure, increased blood glucose, hypercholesterolemia, overweight and obesity. (scirp.org)
Hepatic fibrosis is a major consequence of chronic liver disease such as non-alcoholic steatohepatitis which is undergoing a dramatic evolution given the obesity progression worldwide, and has no treatment to date. (pasteur.fr)

The production of foie gras involves different metabolic pathways in the liver of overfed ducks such as lipid synthesis and carbohydrates catabolism, but the establishment of these pathways has not yet been described with precision during embryogenesis. (biomedcentral.com)
In the context of foie gras production, better knowledge of the establishment of hepatic metabolic pathways during embryogenesis could be of particular interest to modulate the individual response to force-feeding. (biomedcentral.com)
Liver fattening involves the activation of several metabolic pathways. (biomedcentral.com)
BACKGROUND: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. (ox.ac.uk)

Hepatic stellate cells (HSCs) play a key role in the fibrosis process, because in chronic liver damage, they transdifferentiate from a "quiescent" to an "activated" phenotype responsible for most the collagen deposition in liver tissue. (pasteur.fr)

The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform. (cdc.gov)

Differential diagnoses for metabolic acidosis include toxins, uremic acidosis, ketoacidosis, or organic acidosis (e.g. (vin.com)

Hepatic fat accumulation was followed using magnetic resonance imaging and confirmed with histology. (utu.fi)
Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. (mdpi.com)

It is known that metabolic diseases are strongly associated with lifestyle, especially with the nutritional habits and physical activity practice. (scirp.org)
Basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes. (nih.gov)
The Pathophysiology of Diabetes and Metabolic Disease Program supports basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes. (nih.gov)
Common metabolic diseases can be readily diagnosed on blood work. (vin.com)

In particular, we have demonstrated a significant positive correlation between the stage of liver fibrosis and HSC hypertrophy in a cohort of obese patients with hepatic fibrosis. (pasteur.fr)
These results lead us to conclude that hypertrophied HSCs are closely associated with hepatic fibrosis in a metabolic disease context and may represent a new marker of metabolic liver disease progression. (pasteur.fr)

Oral Pg administration induced gut microbiota changes, leading to entero-hepatic metabolic derangements, thus aggravating hyperglycemia in an obese type 2 diabetes mouse model. (bvsalud.org)

Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model. (bvsalud.org)
Collectively, our data indicate that MSC therapy rescues impaired mitochondrial morphology, enhances host metabolic capacity, and induces widespread host gene shifting. (frontiersin.org)

Hepatic transporters are roughly categorized into two groups: efflux transporters that are localized on the canalicular (apical) membrane and the more recently discovered uptake transporters that are found on the sinusoidal (basolateral) membrane. (aspetjournals.org)
In cats small bowel disease inhibits cobalamin uptake, and cobalamin deficiency can result in metabolic acidosis. (vin.com)

Cardiovascular disease, cancer, respiratory and metabolic disease represent 63% of all deaths worldwide and are considered the major causes of morbidity and mortality. (scirp.org)

Fructose is a commonly ingested dietary sugar which has been implicated in playing a particularly harmful role in the development of metabolic disease. (healthresults.com)
Hepatic osteodystrophy: An important matter for consideration in chronic liver disease. (radiopaedia.org)
This Program supports both basic mechanistic and clinical studies that address the effect of the intrauterine environment on subsequent metabolic disease in the offspring, as well as the role of gestational diabetes on the subsequent development of maternal diabetes. (nih.gov)
She teaches medical students and residents, and frequently lectures on metabolic disease at Cleveland Clinic, as well as regionally in the Mid-West. (clevelandclinic.org)
Metabolic or Respiratory Acidosis: Potassium-conserving therapy should be initiated only with caution in severely ill patients in whom metabolic or respiratory acidosis may occur, e.g. patients with cardiopulmonary disease or decompensated diabetes. (janusinfo.se)

Axial breath-held multiplanar spoiled-gradient echo MRI measured hepatic volume, whereas a cine phase-contrast sequence perpendicular to the portal vein measured flow. (duke.edu)
In human anatomy, the hepatic portal system or portal venous system is the system of veins comprising the portal vein and its tributaries. (wikipedia.org)
Large veins that are considered part of the portal venous system are the: Hepatic portal vein Splenic vein Superior mesenteric vein Inferior mesenteric vein The superior mesenteric vein and the splenic vein come together to form the actual hepatic portal vein. (wikipedia.org)

Notably, in the absence of both Akt and Foxo1, mice adapted appropriately to both the fasted and fed state, and insulin suppressed hepatic glucose production normally. (nature.com)

Since liver sampling was only possible from the 12th day of embryogenesis (E12), we analyzed hepatic gene expression at 7 sampling points every 4 days from this point up to 4 days post-hatch (D4) and revealed different patterns of expression depending on the cellular pathway. (biomedcentral.com)
A gene expression analysis revealed that deletion of Akt in liver led to the constitutive activation of Foxo1-dependent gene expression, but again, concomitant ablation of Foxo1 restored postprandial regulation, preventing the inhibition of the metabolic response to nutrient intake caused by deletion of Akt . (nature.com)

Our results reveal how tumour-derived EVPs dysregulate hepatic function and their targetable potential, alongside TNF inhibition, for preventing fatty liver formation and enhancing the efficacy of chemotherapy. (nature.com)

Our results showed higher hepatic steatosis, body weight, energy consumption, and liver mass in ALIOS diet-fed mice compared to control mice. (utu.fi)
Here we show that mice with hepatic deletion of Akt1 and Akt2 were glucose intolerant, insulin resistant and defective in their transcriptional response to feeding in the liver. (nature.com)

Fructose increases hepatic de novo lipogenesis via numerous mechanisms: by altering transcriptional and allosteric regulation, interfering with cellular energy sensing, and disrupting the balance between lipid synthesis and lipid oxidation. (healthresults.com)

FHF usually begins with exposure of a susceptible person to an agent capable of producing severe hepatic injury, although the exact etiology remains unidentified in many cases of FHF. (medscape.com)

The mRNA expression and enzymatic activity of cystathionine β -synthase and cystathionine γ -lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine β -synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin. (hindawi.com)
Meanwhile, hepatic ratio of S-adenosylmethionine to S-adenosylhomocysteine was significantly decreased in response to methionine supplementation and normalized after the addition of quercetin. (hindawi.com)

Metabolic acidosis develops because of impaired renal tubular ammonia production, decreased urinary excretion of hydrogen ion and reduced renal tubular reabsorption of bicarbonate. (vin.com)

Intrinsic clearances ( V max / K m ) of compounds are often calculated using microsome incubations in an effort to predict in vivo hepatic clearances. (aspetjournals.org)
Rather, they show that a major role of hepatic Akt is to restrain the activity of Foxo1 and that in the absence of Foxo1, Akt is largely dispensable for insulin- and nutrient-mediated hepatic metabolic regulation in vivo . (nature.com)

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. (nature.com)
Ed metabolic liver zonation and controls hepatic development and size during development, homeostasis, and regeneration.120 Human ZnRF3 (UniProt ID: Q9ULT6) is often a singlepass transmembrane protein containing N-terminal signal peptide ( IFN-alpha 2a Proteins Recombinant Proteins residues 15), extracellular domain (residues 5619), transmembrane helix (residues 22040), in addition to a cytoplasmic domain (residues 241936), where the zinc finger domain (RING-type, residues 29334) is embedded. (calcium-channel.com)

METHODS: To examine the role of MRI-derived indexes of hepatic hemodynamics in the preoperative assessment of liver function, 39 consecutive liver transplantation candidates were studied in a prospective manner. (duke.edu)

As normal nervous system function depends on a closely regulated environment, systemic metabolic disorders often affect the nervous system. (vin.com)

Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. (ox.ac.uk)

According to the results, it is concluded that there is a positive association between low physical activity level and the presence of Hepatic steatosis. (scirp.org)
Considering that 2002 [3], recombinant human methionyl leptin (metreleptin, Amylin Pharmaceuticals, San Diego, CA, USA) has been employed to treat the metabolic and hepatic complications of rare lipodystrophies, with reasonable results with regards to diabetes control, lowered hypertriglyceridemia, and improvement of hepatic steatosis [4]. (hsvinhibitor.com)

Fructose is primarily metabolised by the liver in humans, and increases rates of hepatic de novo lipogenesis. (healthresults.com)

The etiology of pediatric fulminant hepatic failure differs significantly from adults in developed countries. (medscape.com)

A genetic metabolic disorder involving excess production of glycine. (wikipedia.org)

Notably, tumour EVP education enhanced side effects of chemotherapy, including bone marrow suppression and cardiotoxicity, suggesting that metabolic reprogramming of the liver by tumour-derived EVPs may limit chemotherapy tolerance in patients with cancer. (nature.com)
OBJECTIVE: With hepatic steatosis (HS) being an established risk factor for CVD in the general population, it may also be a predictor of CVD in patients with schizophrenia. (aau.dk)

Increasing values of PFI were associated with declining hepatic functional reserve. (duke.edu)

Anatomy20

Organisms10

Diseases60

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Psychiatry and Psychology1

Phenomena and Processes36

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Named Groups1

Health Care4

Encephalopathy5

Metabolism16

Inflammation7

Dysfunction7

Steatosis in patients1

Syndrome12

NAFLD7

Cirrhosis2

Regulation of hepatic1

Glycogen7

Impairment3

Lipid metabolic1

Hepatocytes3

Biliary1

Obesity2

Pathways4

Stellate1

Cytochrome1

Uremic1

Accumulation2

Diseases4

Fibrosis2

Obese1

Induces2

Uptake2

Cardiovascular1

Disease5

Portal vein3

Glucose production1

Gene2

Inhibition1

Mice2

Oxidation1

Severe1

Quercetin2

Renal1

Vivo2

Homeostasis2

Liver function1

Disorders1

SFAs1

Results2

Fructose1

Significantly1

Genetic1

Patients2

Functional1