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  • biosynthesis
  • Despite the vast amount of research that has been performed on investigating the biosynthesis and potential metabolic engineering of cannabinoids, no current technique has been capable of achieving the same yield quantities as the native cannabis plant species. (news-medical.net)
  • As all known naturally occurring carbapenems are derived from a common intermediate, our engineered strain provides a platform for biosynthesis of tailored carbapenem derivatives in a genetically tractable and fast-growing species. (nih.gov)
  • In practice, however, efforts to modify the biosynthesis of a variety of plant primary and secondary metabolites have been confounded by the very metabolic flexibility that researchers are trying to exploit. (plantcell.org)
  • coli
  • Rational strain development of E. coli achieved by metabolic engineering strategies has provided new processes for efficiently biotechnological production of various high-value chemical building blocks. (mendeley.com)
  • Compared to previous reviews, this review focuses on recent advances in metabolic engineering of the industrial model bacteria E. coli that lead to efficient recombinant biocatalysts for the production of high-value organic acids like succinic acid, lactic acid, 3-hydroxypropanoic acid and glucaric acid as well as alcohols like 1,3-propanediol, xylitol, mannitol, and glycerol with the discussion of the future research in this area. (mendeley.com)
  • One of the signature projects of the Keasling Lab is the engineering of E. coli and S. cerevisiae for production of the antimalarial drug artemisinin. (lbl.gov)
  • To produce these important molecules, the Keasling Lab has engineered fatty acid metabolism in E. coli and S. cerevisiae . (lbl.gov)
  • The engineered E. coli BWapld (pWYC09) produced 5.00 g/L P3HB from 16.50 g/L glucose in 24 h batch fermentation, and P3HB production yield from glucose was 0.30 g/g, which reached up to 63% of maximal theoretical yield. (hindawi.com)
  • However, on a limited scale, E. coli strains have been isolated for recombinant helical bundle membrane protein production using both selection- and engineering-based approaches. (bioportfolio.com)
  • Yong-Su Jin, a departmental colleague and professor in the U of I's Institute for Genomic Biology, believed he could synthesize this oligosaccharide found in breast milk using a strain of E. coli engineered for that purpose. (medicalxpress.com)
  • A new postdoctoral researcher in Jin's laboratory had done some of the legwork for such a project in Korea, and they used their combined experience and expertise to engineer an HMO that can be produced very cheaply and quickly: 1 gram of 2FL per liter of E. coli broth. (medicalxpress.com)
  • Bacteria
  • The considerable commercial importance has stimulated a plethora of research projects studying the genomics, molecular biology and metabolic engineering of these bacteria and prompted the need for this concise book which provides a timely overview of the field. (caister.com)
  • molecules
  • We are particularly interested in developing new methods and molecules to treat metabolic diseases, which have become increasingly prevalent in the U.S., paralleling the rise in obesity. (tufts.edu)
  • Flux Analysis
  • Perfused organ models coupled with Metabolic Flux Analysis have been used to quantitatively characterize these systemic responses, as well as the effects of interventions aimed at diminishing these responses, in both the liver and the skeletal muscle. (drexel.edu)
  • genetically
  • To speed up identification of the most efficient producers, researchers at Harvard's Wyss Institute for Biologically Inspired Engineering describe new approaches to this process and demonstrate how genetically encoded fluorescent biosensors can enable the generation and testing of billions of individual variants of a metabolic pathway in record time. (nanowerk.com)
  • Now, by having developed both types of genetically encoded biosensors we can close the loop of a fully multiplexed engineering cycle. (nanowerk.com)
  • Although these studies may uncover novel information about a pathway and its regulation that will inform subsequent attempts to manipulate it, such difficulties must be overcome if a genetically engineered crop is to become commercially viable. (plantcell.org)
  • protein
  • A similar approach can be taken in the fields of Protein and Metabolic Engineering. (drexel.edu)
  • Protein Engineering provides a powerful set of tools to design, construct and evaluate new proteins with novel functions and properties. (drexel.edu)
  • In this talk, a recent research project using Protein Engineering to improve the biological production of Vitamin C will be discussed. (drexel.edu)
  • Finally, the talk will conclude with an example of a future research project that combines the fields of Protein and Metabolic Engineering, in an attempt to advance a new therapy for the treatment of Parkinson's disease. (drexel.edu)
  • Researchers
  • Because the engineered mutant cannot use the lactose for its own growth, it instead uses lactose to make great quantities of 2FL, the HMO that many researchers want to study," he said. (medicalxpress.com)
  • diversity
  • The Lactobacillus genus comprises more than 200 formally-recognised species characterized by a phylogenetic and metabolic diversity that exceeds that of a typical bacterial family. (caister.com)
  • approaches
  • By combining these orthogonal approaches, an improved understanding of the metabolic consequences of a diseased state can be elucidated. (drexel.edu)