• Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population. (harvard.edu)
  • CYP1A1 is involved in phase I xenobiotic and drug metabolism (one substrate of it is theophylline). (wikipedia.org)
  • Xenobiotic metabolism is the set of metabolic pathways that chemically modify xenobiotics , which are compounds foreign to an organism's normal biochemistry, such as drugs and poisons. (bionity.com)
  • The reactions in these pathways are of particular interest in medicine as part of drug metabolism and as a factor contributing to multidrug resistance in infectious diseases and cancer chemotherapy . (bionity.com)
  • The actions of some drugs as substrates or inhibitors of enzymes involved in xenobiotic metabolism are a common reason for hazardous drug interactions . (bionity.com)
  • It has numerous functions e.g. manufacture and secretion of bile, maintenance of blood sugar level, regulation of protein and fat metabolism, formation of ketone bodies and plasma proteins, detoxication, Erythropoiesis etc. (harshulayurpharma.com)
  • Termination of drug metabolism. (inhn.org)
  • Furthermore, PON1 participates in metabolism of some drugs which contain lactone and cyclic carbonates. (biochemia-medica.com)
  • Resvero-SE Active is designed to support the immune system, the gastrointestinal system, and metabolic pathways with a concentrated source of resveratrol. (apexenergetics.com)
  • Taking lots of vitamins and supplements without addressing and supporting the main detoxication pathways is often overlooked. (drkaslow.com)
  • A couple of years later Bernard Brodie and his associates revealed that the main pathways used by the organism for metabolizing drugs are: (1) oxidation by microsomal enzymes in the liver, (2) other oxidative reactions, such as dehydrogenation, oxidative deamination, (3) reduction reactions, (4) O-methylation, (5) hydrolysis (of esters and amides) and (6) conjugation (Brodie, Axelrod, Cooper et al. (inhn.org)
  • The transcription factor networks that regulate basal and xenobiotic-modulated expression of the hepatic sulfotransferases affect the dynamics of xenobiotic detoxication, carcinogen bioactivation and metabolic homeostasis. (eurekaselect.com)
  • Everyone is constantly being exposed to environmental, microbial, and metabolic toxins even if they "eat organic" and drink "purified water" and so on. (drkaslow.com)
  • nutrients are converted to their useable forms, what is redundant gets separated for elimination, and toxins - both, those originated externally, and those created during the metabolic process - have to be either neutralized, or safely eliminated. (healthknot.com)
  • These findings boost the design that seizures are the cause of the immune and inflamma- tory disorders observed in patients with drug-resistant epilepsy. (daubnet.com)
  • Liver carcinogenesis is a multistep, long process associated with multiple risk factors, e.g. viral hepatitis, alcohol abuse, metabolic disorders, and obesity [ 2 ]. (aging-us.com)
  • 2 FMOs are involved in the pathogenic process of trimethylaminuria, atherosclerosis, cardiovascular disease, diabetes, and metabolic disorders. (xiahepublishing.com)
  • Hence, we investigated whether other factors considered as potential causes of BEN [a mycotoxin ochratoxin A (OTA), Cd, Pb, Se and As ions and organic compounds (i.e. phthalates) released from lignite deposits in BEN areas] can influence detoxication of AAI, whose concentrations are crucial for BEN development. (nel.edu)
  • Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)
  • It prevents the drugs from being metabolized or oxidized when they first pass through the liver. (curejoy.com)
  • Where drug pharmacokinetics becomes an important factor, this statement has potential implications for sensitization of cyst cells in vivo. (hdacassay.com)
  • The psychomotor stimulant cocaine is inactivated primarily by hydrolysis to benzoylecgonine, the major urinary metabolite of the drug. (inra.fr)
  • The enzymatic activity suggests that it may play an important role in regulating the detoxication of cocaine and in the formation of the active metabolite cocaethylene. (inra.fr)
  • It speeds up the absorption of drugs from the gastrointestinal tract and reduces the time it takes to travel through the tract. (curejoy.com)
  • To overcome these detractions and develop an improved tier 1 screening system that reduces the cost and time required for new compound evaluation, 490 BioTech proposes to develop a panel of multiple continuously bioluminescent human cell lines that will permit the simultaneous monitoring of each line to ascertain both the individual effects of compound treatment as well as the downstream effects of a compound's biotransformed metabolic breakdown products in real-time. (inknowvation.com)
  • en] In vitro repeated dose testing for the assessment of chronic drug-induced effects is a huge challenge in preclinical pharmaceutical drug development. (uni.lu)
  • The drug has anti-inflammatory, antispasmodic and sedative effects. (altmeyers.org)
  • The results show low effects of BBP, cadmium and selenium ions, and/or their combinations on AAI detoxication. (nel.edu)
  • Since our resources are somewhat limited, we need indigenous medicines free from undesirable side effects and using simpler technologies than that being utilized by the multinational drug industry, to serve our needs in the field of human health-care. (harshulayurpharma.com)
  • Adaptocrine is formulated to counter the metabolic effects of temporary stress and support the body when energetically spent. (apexenergetics.com)
  • In this study, we maintained primary human hepatocytes in a serum-free cultivation medium for more than 3 weeks and analyzed physiology, viability and drug metabolizing capacities of the hepatocytes. (uni.lu)
  • Chronic toxicity results in discontinuation of therapy or post-marketing withdrawal of drugs despite in vivo preclinical screening. (uni.lu)
  • In fact, benzoylecgonine can last in the body for a very long time (a few days) and, thus, is responsible for the long-term toxicity of cocaine and a commonly used marker for drug addiction diagnosis in pre-employment drug tests. (inra.fr)
  • Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. (fh-aachen.de)
  • Forget about hazardous, dangerous drugs and enjoy nature's calming influence instead. (nuubuofficial.com)
  • Trimethylaminuria is a currently confirmed rare inherited metabolic disorder associated with abnormal amounts of dietary-derived trimethylamine and is caused by the mutations in FMO3. (xiahepublishing.com)
  • The drug discovery process requires that upwards of 10,000 molecules be screened for each new lead compound developed and relies upon an expensive and time consuming combination of in vitro cell culture-based and in vivo whole animal-based models to identify, validate, and ensure the safety of any resulting potential therapeutic agents. (inknowvation.com)
  • In contrast, OTA might influence this process, by inhibition of AAI detoxication. (nel.edu)
  • So it is assumed that the native activity of PON1 may be lactonase activity and that physiological substrate may be some lactones which are consumed as food ingredients, drug metabolites (statins, spironolactone and glucocorticoid γ-lactones) and derivatives of fatty acid oxidation process such as 5-hydroxy6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HETE) lactone that resides in HDL (13). (biochemia-medica.com)
  • These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. (fh-aachen.de)
  • Cytochrome P450-dependent alpha-hydroxylation, followed by sulfonation, represents a metabolic activation pathway, producing products capable of covalent DNA adduction. (oregonstate.edu)
  • With an average of 10,000 novel molecules that must be screened for each new lead compound developed, and an average of 10 to 15 years of research and development at a cost of up to $1B to manufacture one new drug, pharmaceutical companies must develop new testing regimens that provide more data at a lower cost in order to achieve the economics necessary to remain profitable. (inknowvation.com)
  • Bioavailability is the rate at which a drug is absorbed by the body and successfully reaches the target tissue. (curejoy.com)
  • Pharmacodynamic properties are responsible for the differential effect of a psychotropic drug in different psychiatric diagnoses, whereas pharmacokinetic properties for the differential effect of the same drug within a particular diagnosis. (inhn.org)
  • Additionally, the tumour suppressor p53 has been shown to impact CYP1A1 expression thereby modulating the metabolic activation of several environmental carcinogens such as PAHs. (wikipedia.org)
  • It is involved in the metabolic activation of aromatic hydrocarbons (polycyclic aromatic hydrocarbons, PAH), for example, benzo[a]pyrene (BaP), by transforming it to an epoxide. (wikipedia.org)
  • The risk:benefit depends on the rate of metabolic activation versus detoxication. (oregonstate.edu)
  • Mechanistic knowledge is also useful in forming the basis for therapy and the design of new drugs for treatment of human disease. (cloudaccess.net)
  • Oxidative detoxication of carcinogenic 2-nitroanisole by human, rat and rabbit cytochrome P450. (nel.edu)
  • With current in vitro screening assays now representing a $1.4B market with a predicted 12% annual growth rate, we believe we possess a product capable of significantly impacting the chemical/drug screening market and, here in particular, advancing our understanding of cytotoxic chemical biotransformations as they pertain to public health and consumer safety. (inknowvation.com)
  • This graph shows the total number of publications written about "Metabolic Detoxication, Phase II" by people in Harvard Catalyst Profiles by year, and whether "Metabolic Detoxication, Phase II" was a major or minor topic of these publication. (harvard.edu)
  • While there is no end to the hype of these "magic" cures, lets evaluate the real science of the detoxication claim. (chooseanamazinglife.com)
  • Moody JC, Trait AC, Todrick A. Plasma levels of imipramine and desmethylimipramine during drug therapy. (inhn.org)
  • It is implies that the use of the nanosorbents for the attachment of the probiotical microorganisms are highly perspective for decision the important problems, such as the probiotical preparations delivery to the right address and their attachment to intestines mucosa with the following detoxication of gastro-intestinal tract and the normalization of it's microecology. (fh-aachen.de)
  • Below are the most recent publications written about "Metabolic Detoxication, Phase II" by people in Profiles. (harvard.edu)
  • The respectable one, he says, is the medical treatment of people with life-threatening drug addictions. (chooseanamazinglife.com)
  • The usage of vector modified hematopoietic stem cell therapy by which myelocytotoxic and IS drugs are given to the host to create space in the bone marrow for the homing and development of gene adjusted cells will not be examined. (hdacassay.com)
  • Nutrients or drugs are not effective if they aren't absorbed completely. (curejoy.com)
  • Mortal Institutes of Health discount 100mg kamagra mastercard most effective erectile dysfunction drugs. (wgc2010.sk)
  • Cocaine is one of the most addictive drugs without a U.S. Food and Drug Administration (FDA)-approved medication. (inra.fr)
  • In other cases, however, the added sulfuryl may change a relatively harmless molecule into a powerful carcinogen, or in the case of minoxidil, may convert a neutral molecule into an active drug. (rcsb.org)
  • Metabolic Detoxication, Phase II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Dr. Ward was perceived as a skeptic about alternative medicine because she had written a negative paper on Andrew Ivy, M.D., proponent of the unconventional drug Krebiozen, who had once been president of her medical school. (gerson-research.org)