• Differentiating acquired zinc deficiency disorders from acrodermatitis enteropathica is difficult because they have similar clinical presentations. (medscape.com)
  • Metabolic disorders include toxic epidermal necrolysis , acrodermatitis enteropathica, acanthosis nigricans, and migratory epidermal necrolysis. (medscape.com)
  • Tabanlioglu D, Ersoy-Evans S, Karaduman A. Acrodermatitis enteropathica-like eruption in metabolic disorders: acrodermatitis dysmetabolica is proposed as a better term. (medscape.com)
  • In certain metabolic disorders ( ADA and PNP deficiency) enzyme substitution therapy can be applied. (lu.se)
  • Acrodermatitis enteropathica is an autosomal recessive disorder occurring as a result of mutations in the SLC39A4 ( solute carrier family 39 member A4) gene located on band 8q24.3. (medscape.com)
  • Acrodermatitis enteropathica is an autosomal recessive metabolic disorder affecting the uptake of zinc through the inner lining of the bowel, the mucous membrane. (wikipedia.org)
  • Acrodermatitis enteropathica, in terms of genetics, indicates that a mutation of the SLC39A4 gene on chromosome 8 q24.3 is responsible for the disorder. (wikipedia.org)
  • Acrodermatitis enteropathica is an autosomal recessive disorder postulated to occur as a result of mutations in the SLC39A4 gene located on band 8q24.3. (medscape.com)
  • This progressive skin disorder is due to the effect of chronic infection with the spirochete borrelia afzelii , which is the predominant cause of acrodermatitis chronica atrophicans. (wikidoc.org)
  • Mutations in ZIP4 result in zinc deficiency and a disorder known as acrodermatitis enteropathica that is characterized by alopecia ( hair loss), diarrhea, and skin lesions [6]. (healthquestionsmatters.com)
  • 100.kk - ?underlying cause for pruritus Metabolic disorder Arthropod bites Folliculitis Atopy py Prurigo nodularis Histology: - Prominent hyperkeratosis, focal parakeratosis - Marked irregular acanthosis - Tends to be folliculocentric - Pseudoepitheliomatous hyperplasia Case 8 Seborrheic dermatitis Clinical: Erythematous, scaling papules and plaques, sometimes with a greasy g y yyellow appearance. (doczz.net)
  • Acrodermatitis enteropathica-like eruption in an infant with nonketotic hyperglycinemia. (medscape.com)
  • Genetic counseling is recommended for family members of parents with the congenital form of acrodermatitis enteropathica. (medscape.com)
  • Acrodermatitis enteropathica is a rare inherited form of zinc deficiency that was initially described by Brandt in 1936 and subsequently identified a as a definite disease by Danbolt and Closs in 1942. (medscape.com)
  • Acrodermatitis enteropathica is a rare inherited form of zinc deficiency, characterized by periorificial and acral dermatitis, alopecia, and diarrhea. (medscape.com)
  • Age, male sex, and pre-existing chronic metabolic diseases including diabetes, cardiovascular disease, and obesity are associated with greater severity of infection ( 20 ). (frontiersin.org)
  • The diagnosis of an individual with acrodermatitis enteropathica includes each of the following: Plasma zinc level (lab) Light microscopy (skin biopsy) Electron microscopy (histology) Microscope Electron Microscope Acrodermatitis enteropathica without treatment is fatal, and affected individuals may die within a few years. (wikipedia.org)
  • brain SPECT may provide useful information on cerebral flow and metabolic distribution corresponding to the neurologic deficits of neuronopathic Gaucher's disease . (lookfordiagnosis.com)
  • [ 21 ] Infants can also develop acrodermatitis enteropathica if their mothers have a mutation of the SLC30A2 gene located on band 1p36.11, which results in inadequate secretion of zinc into their breast milk. (medscape.com)
  • [ 2 ] This is due to the obesity epidemic and the significant improvement that we see not only in weight reduction but also in the metabolic consequences, such as diabetes, hyperlipidemia, and cardiovascular risks, and even cancer risk. (medscape.com)
  • Individuals with acrodermatitis enteropathica may present with the following: Blistering of skin Dry skin Emotional lability Glossitis Pustule Alopecia (loss of hair from the scalp, eyebrows, and eyelashes) may occur. (wikipedia.org)
  • Examples include Acrodermatitis enteropathica and some kinds of alopecia (4). (tswassist.com)
  • Zinc is a trace element needed by the body to regulate some metabolic processes such as immune responses, wound healing, and blood clotting. (tswassist.com)
  • Zinc is involved in the metabolic processes of the thyroid and adrenal glands, ovaries and testes. (dkart.in)
  • Wang K, Pugh EW, Griffen S, Doheny KF, Mostafa WZ, al-Aboosi MM. Homozygosity mapping places the acrodermatitis enteropathica gene on chromosomal region 8q24.3. (medscape.com)
  • Perafan-Riveros C, Franca LF, Alves AC, Sanches JA Jr. Acrodermatitis enteropathica: case report and review of the literature. (medscape.com)
  • Based on numerous studies, majority of skin biopsies from acrodermatitis chronica atrophicans patients demonstrated borrelia afzelii . (wikidoc.org)
  • 1997). "Detection of Borrelia afzelii, Borrelia burgdorferi sensu stricto, Borrelia garinii and group VS116 by PCR in skin biopsies of patients with erythema migrans and acrodermatitis chronica atrophicans" . (wikidoc.org)
  • Niiyama S, Koelker S, Degen I, Hoffmann GF, Happle R, Hoffmann R. Acrodermatitis acidemica secondary to malnutrition in glutaric aciduria type I. Eur J Dermatol . (medscape.com)
  • Zinc is considered as a "type 2 nutrient," which means it is required for general, non-specific metabolic functions. (vivreaveclafibrosekystique.com)
  • Wang K, Zhou B, Kuo YM, Zemansky J, Gitschier J. A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. (medscape.com)
  • Acrodermatitis enteropathica is an inherited condition in which your body is unable to resorb zinc from your digestive tract. (cura4u.com)
  • The gut flora (microbiota) plays an important role in human health through their metabolic function in breaking down ingested food to provide nutrients to cells and organs of the body. (healthquestionsmatters.com)
  • Acrodermatitis enteropathica is an autosomal recessive disorder occurring as a result of mutations in the SLC39A4 ( solute carrier family 39 member A4) gene located on band 8q24.3. (medscape.com)
  • Acrodermatitis enteropathica is an autosomal recessive metabolic disorder affecting the uptake of zinc through the inner lining of the bowel, the mucous membrane. (wikipedia.org)
  • Acrodermatitis enteropathica (AE) is a rare autosomal recessive metabolic disorder. (qxmd.com)
  • Acrodermatitis continua of Hallopeau (ACH) is a rare type of pustular psoriasis affecting the digits. (karger.com)
  • Piquero-Casals J, Fonseca de Mello AP, Dal Coleto C, Fonseca Takahashi MD, Simonsen Nico MM: Using oral tetracycline and topical betamethasone valerate to treat acrodermatitis continua of Hallopeau. (karger.com)
  • Emtestam L, Weden U: Successful treatment for acrodermatitis continua of Hallopeau using topical calcipotriol. (karger.com)
  • Tsuji T, Nishimura M: Topically administered fluorouracil in acrodermatitis continua of Hallopeau. (karger.com)
  • Kokelj F, Plozzer C, Trevisan G: Uselessness of topical calcipotriol as monotherapy for acrodermatitis continua of Hallopeau. (karger.com)
  • Bauer W, Calkins E, Reznick L: Clinical and metabolic effects of prednisone, prednisolone and cortisone in a patient with acrodermatitis continua (Hallopeau). (karger.com)
  • Kuijpers AL, van Dooren-Greebe RJ, van de Kerkhof PC: Acrodermatitis continua of Hallopeau: Response to combined treatment with acitretin and calcipotriol ointment. (karger.com)
  • Behrens S, von Kobyletzki G, Hoffmann K, Altmeyer P, Kerscher M: PUVA-Bad-Photochemotherapie bei Acrodermatitis continua suppurativa Hallopeau. (karger.com)
  • Chowdhury MM, Motley RJ: Treatment of acrodermatitis continua of Hallopeau with oral propylthiouracil and methotrexate. (karger.com)
  • Korstanje MJ, Bessems PJ, Hulsmans RF, van de Staak WJ: Pustular psoriasis and acrodermatitis continua (Hallopeau) need high doses of systemic ciclosporin A. Dermatologica 1989;179:90-91. (karger.com)
  • Acrodermatitis continua of Hallopeau is considered a form of pustular psoriasis that affects the hands and feet. (medscape.com)
  • The palmoplantar pustulosis variant is localized to palms and soles, whereas acrodermatitis continua of Hallopeau is localized to the nail apparatus. (bvsalud.org)
  • Two types of localized pustular psoriasis include psoriasis pustulosa palmoplantaris (PPP) and acrodermatitis continua of Hallopeau, both forms are localized to the hands and feet. (mdwiki.org)
  • Cutaneous lesions resembling acrodermatitis enteropathica were present in two infants with methylmalonic acidemia and in one infant with propionic acidemia. (nih.gov)
  • Wilsmann-Theis D, Hagemann T, Dederer H, Wenzel J, Bieber T, Novak N: Successful treatment of acrodermatitis continua suppurativa with topical tacrolimus 0.1% ointment. (karger.com)
  • Acrodermatitis enteropathica (AE) is a disorder of zinc metabolism that can either be inherited or acquired. (nih.gov)
  • Consistent meal timing, aligned with the body's internal clock, is linked to several health benefits, including lower risks of obesity, poor sleep quality, and life-threatening diseases like metabolic conditions, cancer, and Alzheimer's disease. (hcn.health)
  • People with acrodermatitis enteropathica (a genetic disorder affecting zinc absorption), experience skin irritation, hair loss, diarrhea, and high rates of infection. (selfhacked.com)
  • Patients with severe pustular or erythrodermic psoriasis may require hospital admission for metabolic stabilization and pain management. (medscape.com)
  • Individuals with acrodermatitis enteropathica may present with the following: Blistering of skin Dry skin Emotional lability Glossitis Pustule Alopecia (loss of hair from the scalp, eyebrows, and eyelashes) may occur. (wikipedia.org)
  • Kuliyev E, Zhang C, Sui D, Hu J. Zinc transporter mutations linked to acrodermatitis enteropathica disrupt function and cause mistrafficking. (medscape.com)
  • Lyme disease causes metabolic/endocrine dysfunctions that lead to weight loss or commonly chronic weight gain. (tripod.com)
  • Acrodermatitis enteropathica is a rare inherited form of zinc deficiency that was initially described by Brandt in 1936 and subsequently identified a as a definite disease by Danbolt and Closs in 1942. (medscape.com)
  • [ 21 ] Infants can also develop acrodermatitis enteropathica if their mothers have a mutation of the SLC30A2 gene located on band 1p36.11, which results in inadequate secretion of zinc into their breast milk. (medscape.com)
  • Wang K, Pugh EW, Griffen S, Doheny KF, Mostafa WZ, al-Aboosi MM. Homozygosity mapping places the acrodermatitis enteropathica gene on chromosomal region 8q24.3. (medscape.com)
  • Various metabolic abnormalities and nutritional deficiencies also have been implicated in the pathogenesis of NME. (medscape.com)
  • Acrodermatitis in breast-fed premature infants: evidence for a defect of mammary zinc secretion. (medscape.com)
  • The diagnosis of an individual with acrodermatitis enteropathica includes each of the following: Plasma zinc level (lab) Light microscopy (skin biopsy) Electron microscopy (histology) Microscope Electron Microscope Acrodermatitis enteropathica without treatment is fatal, and affected individuals may die within a few years. (wikipedia.org)
  • Clinical diagnosis of acrodermatitis enteropathica was considered and confirmed by low zinc levels (repeated plasma zinc levels were below 0.6 mcg/ml). (qxmd.com)
  • Early diagnosis of acrodermatitis enteropathica is essential for preventing complications. (qxmd.com)
  • Acrodermatitis enteropathica typically appears in the first few weeks after birth if the child is fed bovine milk or shortly after cessation of breastfeeding. (medscape.com)
  • We conclude that dietary deficiencies associated with the treatment of organic aciduria should be added to the causes of acrodermatitis enteropathica-like cutaneous lesions. (nih.gov)
  • Glycogen storage disease type V is a metabolic disorder , more specifically a glycogen storage disease , caused by a deficiency of myophosphorylase. (chemeurope.com)
  • Perafan-Riveros C, Franca LF, Alves AC, Sanches JA Jr. Acrodermatitis enteropathica: case report and review of the literature. (medscape.com)