• A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). (mdpi.com)
  • EBM tools include, but are not limited to, randomized controlled trials, systematic reviews (of a series of trials) and meta-analyses. (dmoztools.net)
  • Recently, the rs7677751 single nucleotide polymorphism (SNP) at the platelet-derived growth factor receptor alpha (PDGFRA) locus was found to be associated with corneal astigmatism in people of Asian ancestry.Gene-based pathway analysis identified a significant association between the Gene Ontology 'segmentation' (GO:0035282) pathway, corrected p=0.009.Better-powered studies are required to validate the novel putative findings of our study. (nih.gov)
  • Tang C, Yu S, Jiang H, Li W, Xu X, Cheng X, Peng K, Chen E, Cui Y, Liu T. A Meta-Analysis: Methylenetetrahydrofolate Reductase C677T Polymorphism in Gastric Cancer Patients Treated with 5-Fu Based Chemotherapy Predicts Serious Hematologic Toxicity but Not Prognosis. (jcancer.org)
  • Here, we empirically examined the appropriateness of converting continuous outcomes (expressed as mean+/-SD) into dichotomous outcomes (expressed as response rates) in four completed meta-analyses of depression and anxiety, assuming normal distribution of the continuous outcome measures. (biomedsearch.com)
  • When individual trials report the means+/-SDs of their outcome measures but fail to report response rates, it may therefore be possible to impute the response rates based on the means+/-SDs, and then submit the meta-analysis to worst case/best case analyses. (biomedsearch.com)
  • The analysis showed an increase in benefit of statins with longer duration of treatment with the OR varying from 0.90 for a treatment duration of 6 months (a 10% reduction in risk) to 0.45 for a treatment duration of 14 years (a 55% reduction in risk). (bio-medicine.org)
  • Because many metrics of test performance are of interest, the meta-analysis of medical tests is more complex than the meta-analysis of interventions or associations. (ahrq.gov)
  • 26 - 30 However, such meta-analyses do not overcome the limitations and biases of individual trials because they generate a single best estimate through the pooling of treatment effect estimates. (aappublications.org)
  • Not referring to important related research is also against the principles of evidence-based medicine, because meta-analysts agree that all available evidence should be systematically searched and reviewed in an unbiased manner [ 12 ]. (biomedcentral.com)
  • This meta-analysis provides evidence that MTHFR rs1801133 and F5 rs6025 are associated with an increased risk of PE, especially in Caucasians. (pubmedcentralcanada.ca)
  • Our objective was to examine the relationship between stimulant treatment of ADHD and cigarette smoking by using meta-analysis, and to identify study and sample characteristics that moderate this relationship. (aappublications.org)
  • Initially, each cohort was analyzed separately, before being combined for meta- and subsequent genome-wide pathway analysis. (nih.gov)
  • This meta-analysis enabled us to obtain a precise estimation of the association between gene polymorphisms on chromosome 1 ( MTHFR , AGT , F5 , IL-10 , LEPR ) and the susceptibility to pre-eclampsia (PE) in order to reach a uniform conclusion. (pubmedcentralcanada.ca)
  • These plots display the most significant result in the meta-analysis genome-wide association study (GWAS). (nih.gov)
  • Association of Apathy With Risk of Incident Dementia: A Systematic Review and Meta-analysis. (scoop.it)
  • A total of 16 646 PE patients and 28 901 normal-pregnancy patients were included in this meta-analysis. (pubmedcentralcanada.ca)
  • Meta-regression showed that younger people were more likely to benefit, with an OR of 0.50 for patients in their 40s and an OR of 0.90 for patients in their 70s. (bio-medicine.org)
  • The fundamental assumption underlying meta-analysis, that both the independent and dependent variables are fairly homogeneous, seems not to have been met at all and it just gets worse from there (I am happy to elaborate if anyone is interested, although it will probably put you rapidly to sleep). (taperssection.com)
  • Attitude-behaviour relations: A theoretical analysis and review of empirical research. (scirp.org)