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Ergoloid mesylateNucleophilic substitution reactionsMesilateDementiaChlorideEsterDrugsAlcoholPeoplePatientsGroups

Ergoloid mesylate2

• In this climate, hydergine (ergoloid mesylate) was touted as a treatment for AD and for a short time was used extensively. (medscape.com)
• Ergoloid Mesylate may increase cerebral metabolism and blood flow. (pharmacycode.com)

Nucleophilic substitution reactions1

• Mesylate is considered a leaving group in nucleophilic substitution reactions. (wikipedia.org)

Mesilate1

• When modifying the international nonproprietary name of a pharmaceutical substance containing the group or anion, the spelling used is sometimes mesilate (as in imatinib mesilate, the mesylate salt of imatinib). (wikipedia.org)

Dementia2

• Ergoloid Mesylates for Dementia - Medscape - Dec 12, 2003. (medscape.com)
• Further study is needed to determine the risk-benefit profile of ergoloid mesylates in the treatment of dementia. (pharmacycode.com)

Chloride1

• Mesylates are generally prepared by treating an alcohol and methanesulfonyl chloride in the presence of a base, such as triethylamine. (wikipedia.org)

Ester1

• In organosulfur chemistry, a mesylate is any salt or ester of methanesulfonic acid (CH3SO3H). (wikipedia.org)

Drugs1

• WebDoxazosin MESYLATE - Uses, Side Effects, and More Common Brand (S): Cardura Uses Doxazosin is used alone or with other drugs to treat high blood pressure (hypertension). (urlbacklinks.com)

Alcohol2

• WebNotice, though, that unlike the halogenation reactions above, conversion of an alcohol to a tosylate or mesylate proceeds with retention of configuration at the electrophilic carbon. (urlbacklinks.com)
• WebHow to convert an alcohol into a mesylate or tosylate, making it a good leaving group. (urlbacklinks.com)

People2

• This graph shows the total number of publications written about "Mesylates" by people in Harvard Catalyst Profiles by year, and whether "Mesylates" was a major or minor topic of these publication. (harvard.edu)
• Below are the most recent publications written about "Mesylates" by people in Profiles. (harvard.edu)

Patients2

• Do ergoloid mesylates have a use in the management of patients with Alzheimer's disease (AD) or other dementias? (medscape.com)
• A recent controlled study in patients with Alzheimer's disease found that there was no advantage to the use of ergoloid mesylates compared to placebo, suggesting that ergoloid mesylates may lower scores on some cognitive and behavioral rating scales. (pharmacycode.com)

Groups1

• Whereas mesylates are often hydrolytically labile, mesyl groups, when attached to nitrogen, are resistant to hydrolysis. (wikipedia.org)