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  • rRNA
  • Based on sequence and structural motifs, 113 of these RNAs can be assigned to the C/D box or H/ACA box subclass of small nucleolar RNAs (snoRNAs), known as guide RNAs for rRNA. (embopress.org)
  • Abstract
  • RNA methylation and diseases: experimental results, databases, Web servers and computational models Chen, Xing;Sun, Ya-Zhou;Liu, Hui;Zhang, Lin;Li, Jian-Qiang;Meng, Jia 2017-11-18 00:00:00 Abstract Ribonucleic acid (RNA) methylation is a type of posttranscriptional modifications occurring in all kingdoms of life. (deepdyve.com)
  • nascent
  • Here, we describe a method of fluctuation analysis of fluorescently labeled RNA to measure dynamics of nascent RNA-including initiation, elongation, and termination-at an active yeast locus. (yu.edu)
  • microRNAs
  • The identification of the expression and function of cardiovascular noncoding ribonucleic acids (RNAs), such as microRNAs (miRNAs) (or "miR," which refers to the mature form of miRNA), has opened a new avenue of genome-regulatory paradigms. (onlinejacc.org)
  • The conference opened with a series of talks describing novel techniques that show great promise as agents to deliver small interfering RNAs (siRNAs) and microRNAs (miRNAs) to target cells. (libpubmedia.co.uk)
  • RBPs
  • In many cases, specific sequence elements, `zipcodes', in the untranslated region (UTR) form a secondary structure that serves as a docking site for the RBPs and thus promotes the localization process. (biologists.org)
  • In fact RBPs are involved in every step of the RNA lifecycle, e.g., transport of mRNA to the site of translation, storage and mRNA degradation ( Figure 1 ) [ 1 ]. (mdpi.com)
  • Once in the cytoplasm, each mRNA has a specific turn-over rate ( 4 ) that can be modulated by association with selective RBPs. (mdpi.com)
  • complexes
  • Although our knowledge of the components of the mRNP complexes is growing, the list we give here is by no means comprehensive and merely a general impression of the multitude of interactions necessary for the localization process. (biologists.org)
  • modifications
  • Among these, for the first time, we identified four C/D box snoRNAs and four H/ACA box snoRNAs predicted to direct modifications within U2, U4 or U6 small nuclear RNAs (snRNAs). (embopress.org)
  • Transgenic mice carrying site-specific genome modifications (knockout, knock-in) are of vital importance for dissecting complex biological systems as well as for modeling human diseases and testing therapeutic strategies. (jove.com)
  • 100 chemically distinct RNA modifications involve the addition of methyl groups [5, (deepdyve.com)
  • organisms
  • Gene finding is complicated in organisms that exhibit insertional RNA editing. (pubmedcentralcanada.ca)
  • These site-specific alterations occur in a wide variety of organisms, extending from viruses and single cell protists to man and, depending on the mRNA and organism, can involve changes ranging from a single nucleotide to more than 50% of the residues in a mature transcript ( 1 - 4 ). (pubmedcentralcanada.ca)
  • cells
  • mRNA localization mechanisms also allow local translation in the extremities (dendrites and axons) of cells from the neuronal system ( Job and Eberwine, 2001 ). (biologists.org)
  • In general conditions, the idea that the EV content material can be particular can be generally approved right now, implying a specialised function for them, and the possible lifestyle of cells- and cell-specific systems managing their creation (discover below). (biobeds.info)
  • Einstein researcher Robert Singer, Ph.D., discusses a breakthrough in microscopy that is allowing scientists to track messenger RNA in living cells in real time. (labroots.com)
  • reveals
  • Real-time measurement of fluorescent RNA reveals transcription kinetics. (yu.edu)
  • libraries
  • We introduce a k -mer-based computational protocol, DE-kupl, for capturing local RNA variation in a set of RNA-seq libraries, independently of a reference genome or transcriptome. (biomedcentral.com)
  • small
  • If the potential of small RNAs as therapeutic agents is to be realised, the development of powerful, efficient delivery methods are crucial. (libpubmedia.co.uk)
  • differential
  • Despite the many approaches to study differential splicing from RNA-seq, many challenges remain unsolved, including computing capacity and sequencing depth requirements. (biomedcentral.com)
  • We further introduced seven publicly available RNA methylation-related databases, and some important publicly available RNA-methylation-related Web servers and software for RNA methylation site identification, differential analysis and so on. (deepdyve.com)
  • computational
  • Meanwhile, various computational models have been developed to analyze and mining increasing RNA methylation data. (deepdyve.com)
  • We also analyzed the limitations of these models and discussed the future directions of developing computational models for RNA methylation research. (deepdyve.com)
  • RNA methylation, biological function, disease, database, Web server and software, computational model RNA methylation Methylation is a form of alkylation in chemistry, which adds a methyl group on a substrate or substitutes the original atom or group. (deepdyve.com)