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  • lncRNAs
  • Some argue that these observations suggest non-functionality of the majority of lncRNAs, while others argue that they may be indicative of rapid species-specific adaptive selection. (wikipedia.org)
  • miRNAs
  • This somewhat arbitrary limit distinguishes long ncRNAs from small non-coding RNAs such as microRNAs (miRNAs), short interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs. (wikipedia.org)
  • protein
  • A recent study found only one-fifth of transcription across the human genome is associated with protein-coding genes, indicating at least four times more long non-coding than coding RNA sequences. (wikipedia.org)
  • Long
  • It has been suggested through multiple studies that testis, and neural tissues express the greatest amount of long non-coding RNAs of any tissue type. (wikipedia.org)
  • molecules
  • As part of this effort to control mosquitoes, my lab is trying to understand how the mosquito larva is able to make its digestive system so extremely alkaline, and to use this information to identify mosquito-specific molecules that could be used in new generations of mosquitocides to selectively kill mosquito larvae. (ufl.edu)
  • These sensors include various nucleotidyl transferases producing second messenger small ribonucleic nucleic acid molecules as well as membrane-bound receptors ultimately leading to phosphorylation of transcription factors driving cytokine and interferon expression. (keystonesymposia.org)
  • Substantial progress has been made in identification of the structures of these sensors, their nucleic acid ligands and second messenger molecules, as well as the underlying molecular pathways leading to transcriptional activation. (keystonesymposia.org)
  • In mouse brain cDNA libraries generated from small RNA molecules we have identified a total of 201 different expressed RNA sequences potentially encoding novel small non‐messenger RNA species (snmRNAs). (embopress.org)
  • motifs
  • Based on sequence and structural motifs, 113 of these RNAs can be assigned to the C/D box or H/ACA box subclass of small nucleolar RNAs (snoRNAs), known as guide RNAs for rRNA. (embopress.org)
  • cells
  • Most enterocyte-specific gene products are first expressed as the migrating cells approach the crypt-villus junction, approximately concurrently with the cessation of cell division (for reviews, see Refs. (physiology.org)
  • Among the layers of the retina, specific labeling was found in the soma of some cells in the innermost lamina of the inner nuclear layer. (springer.com)
  • Dussaillant M, Sarrieau A, Gozes I, Berod A, Rostène W (1992) Distribution of cells expressing vasoactive intestinal peptide/ peptide histidine isoleucine-amide precursor messenger RNA in the rat brain. (springer.com)
  • In this review, the systems are talked about by us root the selecting Flavopiridol HCl to EVs of different classes of substances, as well as the part of extracellular RNAs and the connected protein in changing gene phrase in the receiver cells. (biobeds.info)
  • In general conditions, the idea that the EV content material can be particular can be generally approved right now, implying a specialised function for them, and the possible lifestyle of cells- and cell-specific systems managing their creation (discover below). (biobeds.info)
  • Einstein researcher Robert Singer, Ph.D., discusses a breakthrough in microscopy that is allowing scientists to track messenger RNA in living cells in real time. (labroots.com)
  • libraries
  • We introduce a k -mer-based computational protocol, DE-kupl, for capturing local RNA variation in a set of RNA-seq libraries, independently of a reference genome or transcriptome. (biomedcentral.com)
  • regulation
  • Recent advances, such as findings of extensive modifications of regulatory RNAs, indicate that our understanding of the role of RNAs in gene regulation is far from complete. (biomedcentral.com)
  • IMPs are capable of sequence specific RNA recognition and regulation, as originally shown by the interaction of IMP1 with a 54-nucleotide cis-acting element in the 3ʹ untranslated region (UTR) of the β-actin mRNA, the "zipcode. (yu.edu)
  • interaction
  • RBP-RNA interaction can begin during transcription and be sustained until the RNA is degraded or occur transiently to mediate or regulate specific processes, e.g. splicing, transport, localization, translation and decay [ 2 ]. (biochemsoctrans.org)
  • FXR1P muscle-specific isoforms bind p21 mRNA via direct interaction with a conserved G-quadruplex located in its 3′ untranslated region. (prolekare.cz)
  • temporal
  • We have used this approach to compare the spatial and temporal distribution patterns of the RNA and protein products of the segmentation gene hunchback (hb) during the early stages of embryogenesis. (nih.gov)
  • intestinal
  • Denis P, Dussaillant M, Nordmann JP, Elena PP, Saraux H, Rostène W (1991) Autoradiographic characterization and localization of vasoactive intestinal peptide binding sites in albino rat and rabbit eyes. (springer.com)
  • complexes
  • Although our knowledge of the components of the mRNP complexes is growing, the list we give here is by no means comprehensive and merely a general impression of the multitude of interactions necessary for the localization process. (biologists.org)
  • transcript
  • We propose that Egl and BicD are core components of a selective dynein motor complex that drives transcript localization in a variety of tissues. (ucl.ac.uk)
  • 3' RNA sequencing provides an alternative to whole transcript analysis. (biomedcentral.com)
  • expression
  • The macrophage transcriptome reacts to infections with the induction of a pathogen-unspecific expression program as well as the induction of pathogen-specific expression signatures, both of which contribute to the immunologic activation of the infected cell. (stanford.edu)
  • modifications
  • Among these, for the first time, we identified four C/D box snoRNAs and four H/ACA box snoRNAs predicted to direct modifications within U2, U4 or U6 small nuclear RNAs (snRNAs). (embopress.org)
  • approaches
  • Despite the many approaches to study differential splicing from RNA-seq, many challenges remain unsolved, including computing capacity and sequencing depth requirements. (biomedcentral.com)
  • genetic
  • We show that in laboratory-derived mutants of Mycobacterium tuberculosis, rifampin resistance is universally associated with a competitive fitness cost and that this cost is determined by the specific resistance mutation and strain genetic background. (stanford.edu)
  • processes
  • Despite progress in the understanding of the function of SMN in these processes, very little is known about the cause of the mainly motoneuron-specific pathology in SMA. (rupress.org)