moreover, they also promote the hematopoietic differentiation of mouse ESCs and favor the development of definitive HSCs from pre-HSCs in the mouse aorta-gonad-mesonephros (AGM) region [ 8 ]. (biomedcentral.com)
These more advanced hematopoietic progenitors isolated from the aorta-gonad-mesonephros (AGM) region at embryonic day 9.5 to 10 can give rise to lymphoid lineages and are LT reconstituting definitive HSCs, but since this time point is after the establishment of the circulatory system in the embryo their source was difficult to determine [ 13 ]. (biomedcentral.com)
Across vertebrate species, definitive HSCs are believed to be generated in the aorta-gonad-mesonephros (AGM) region. (amegroups.org)
Metanephros3
The mesonephros persists and forms the anterior portion of the permanent kidneys in fish and amphibians, but in reptiles, birds, and mammals, it atrophies and for the most part disappears rapidly as the permanent kidney (metanephros) begins to develop during the sixth or seventh week. (wikipedia.org)
This chapter begins with intermediate mesoderm, and discusses the origin of the kidneys in human development, including the pronephros, mesonephros, and metanephros. (taylorfrancis.com)
In females the mesonephros degenerates entirely, though vestigial structures such as Gartner's ducts, the epoophoron, and paroophoron are common. (wikipedia.org)
The mesonephric duct is narrow at its cranial end but enlarges as it courses caudally on the ventral aspect of the mesonephros to terminate in the urogenital sinus. (ehd.org)
A section through the C-6 neural crest, cranial end of the mesonephros and hepatic antrum. (ehd.org)
Embryo3
A pair of excretory ducts of the middle kidneys (MESONEPHROI) of an embryo, also called mesonephric ducts. (harvard.edu)
A-H ) Time lapse analysis of a live chick embryo expressing GFP under the control of Nkx2-5- en analyzed at different time points. (elifesciences.org)
Section of the fold in the mesonephros of a chick embryo of the fourth day. (iiab.me)
Medial3
They arrive at the primitive gonads early in the fifth week of development and, during the sixth week, invade the genital ridges, which lie on the medial aspect of the mesonephros. (medscape.com)
It attaches to the medial side of the mesonephros by the gonadal mesentery where it comes into contact with some of the mesonephric tubules. (ehd.org)
4. The medial position of the subcardinal vein to the mesonephros. (ehd.org)
Anlage1
By Northern analysis the principal transcript expressed in the mesonephros and the anlage of the external genitalia on gestation day 18 appeared to be identical to the mRNA expressed in adult prostate and epididymis. (laprp.com)
By the beginning of the fifth month of human development, only the ducts and a few of the tubules of the mesonephros remain. (wikipedia.org)
Urogenital1
Near the end of the second month, the testis and mesonephros are attached by the urogenital mesentery to the posterior abdominal wall. (medscape.com)
Renal1
mesonephros the intermediate stage of renal development remains at this stage. (edu.au)
Humans2
The Wolffian body is composed of: mesonephros + paramesonephrotic blastema) The mesonephros acts as a structure similar to the kidney that, in humans, functions between the sixth and tenth weeks of embryological life. (wikipedia.org)
In humans, the mesonephros consists of units which are similar in structure and function to nephrons of the adult kidney. (wikipedia.org)
Development2
citation needed] The mesonephros as a whole produces urine from the 6th through the 10th week of development. (wikipedia.org)
F-J ) Cross sections through different stages of embryonic development corresponding to the embryos shown in A-D. The mouse Isl1- en (green, GFP) and control pCAAG-RFP (red). (elifesciences.org)
Primarily1
The Müllerian duct is a tubular structure that primarily forms in mesonephros during embryogenesis in both sexes. (allenpress.com)
Excretory1
The mesonephros (Greek: middle kidney) is one of three excretory organs that develop in vertebrates. (wikipedia.org)
Female1
Differentiated aspect of female and male mouse mesonephroi. (ehu.eus)
Mouse1
Separated channels for the Nkx2-5 -en ( E" ) and Nkx2.5 protein ( E''' ). ( F ). Location of the Isl1 enhancer in chick and mouse genomes. (elifesciences.org)
Structure1
The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. (zfin.org)
Aorta-gonad-mesonephros4
Our laboratory was the first to show that HSCs are born in the aorta-gonad-mesonephros region of the developing mammalian embryo. (ed.ac.uk)
We combine index sorting of single cells from the embryonic aorta-gonad-mesonephros region with endothelial cell co-culture and transplantation to characterize the phenotypic properties and engraftment potential of single hematopoietic precursors. (jove.com)
Immature multipotent hematopoietic progenitors lacking bone-marrow repopulating activity in the aorta-gonad-mesonephros region of murine day 10 fetuses. (kyoto-u.ac.jp)
Intriguingly HSC location changes during development with hematopoiesis shifting from the yolk sac and aorta-gonad-mesonephros region to the placenta fetal liver and bone marrow.1 In adult life HSC remain in dynamic contact with bone marrow niches and can also be found in extramedullary sites such as spleen liver and blood at various levels in response to stress or experimental stimuli. (bio-cavagnou.info)
Embryonic5
However, bulk transplants are still performed when assessing the HSC potential of early embryonic hematopoietic tissues such as the aorta-gonad mesonephros (AGM) due to very low HSC activity content early in development. (upf.edu)
Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) regulates adult RT function and is expressed in the mesenchyme of the embryonic gonad and mesonephros. (nih.gov)
To determine its role in RT development, COUP-TFII was ablated in the embryonic gonad and mesonephros. (nih.gov)
Single-cell RNA sequencing (sc-RNA seq) of BTBR mice traced the origin of immune abnormalities back to the embryonic stages of the yolk sac (YS) and aorta-gonad-mesonephros (AGM) and identified where macrophages (microglia) and peripheral immune cells differentiate. (neurosciencenews.com)
This clone is among a rearrayed set of 15,247 clones from 11 embryo cDNA libraries (including preimplantation stage embryos from unfertilized egg to blastocyst, embryonic part of E7.5 embryos, extraembryonic part of E7.5 embryos, and E12.5 female mesonephros/gonad) and one newborn ovary cDNA library. (nig.ac.jp)
Yolk sac3
The analysis focused on the hematopoietic cells from which immune cells are derived, as well as on the yolk sac (YS) and the aorta-gonad-mesonephros (AGM), which are involved in hematopoiesis during the fetal stage. (neurosciencenews.com)
It is found that both in aorta-gonad-mesonephros (AGM) and yolk sac (YS) progenitors, the dysregulation of HDAC1-mediated epigenetic machinery alters definitive hematopoiesis during embryogenesis and downregulates the expression of the AP-1 complex for microglia development. (neurosciencenews.com)
While the yolk sac is the first tissue in the mammalian conceptus to visibly exhibit hematopoietic cells, the intrabody region-which at different stages of development includes the splanchnopleural mesoderm, para-aortic splanchnopleura (PAS) and the aorta-gonad-mesonephros (AGM) region-clearly contains more potent undifferentiated hematopoietic progenitors and stem cells before the yolk sac. (ox.ac.uk)
Wolffian3
The mesonephros is included in the Wolffian body after Caspar Friedrich Wolff who described it in 1759. (wikipedia.org)
The Wolffian body is composed of: mesonephros + paramesonephrotic blastema) The mesonephros acts as a structure similar to the kidney that, in humans, functions between the sixth and tenth weeks of embryological life. (wikipedia.org)
The second system consists of the mesonephroi (singular = mesonephros) and the mesonephric (Wolffian) ducts. (bmj.com)
Fetal1
Different cell-intrinsic and extrinsic factors direct the specification of early mesodermal progenitor cells towards hematopoietic stem cells (HSC), which arise in the aorta-gonad-mesonephros (AGM) region, mature in the fetal liver and finally home and reside in the bone marrow. (haematologica.org)
Kidneys1
Mesonephroi are the permanent kidneys in adult amphibians and fish. (nih.gov)
Placenta1
This historic 1918 paper by Bremer describes the mesonephros, kidney and placenta in different animals. (edu.au)
Kidney3
The mesonephros (Greek: middle kidney) is one of three excretory organs that develop in vertebrates. (wikipedia.org)
In humans, the mesonephros consists of units which are similar in structure and function to nephrons of the adult kidney. (wikipedia.org)
In the female, when the permanent kidney is rmed, the mesonephros and its duct undergo atrophy to a greater extent than in the ale, and they are only represented in the adult by the vestigial structures present in e broad ligament of the uterus (see pp. 1315 and 1316). (co.ma)
Ovary2
The developing ovary and mesonephros were fluoresently stained with an endothelial and germ cell marker called PECAM (platelet endothelial cell adhesion molecule). (ucsd.edu)
The long projections extending from the right are the endothelial cells migrating into the developing ovary from the adjacent mesonephros. (ucsd.edu)
Ducts1
In females the mesonephros degenerates entirely, though vestigial structures such as Gartner's ducts, the epoophoron, and paroophoron are common. (wikipedia.org)
Transplantation1
Sanjuan-Pla A, Romero-Moya D, Prieto C, Bueno C, Bigas A, Menendez P. Intra-bone marrow transplantation confers superior multilineage engraftment of murine aorta-gonad mesonephros cells over intravenous transplantation. (upf.edu)
Tissues1
Begin by adding Aorta-Gonad-Mesonephros, AGM, tissues dissected from embryos between 9.5 and 11.5 days post coitum to a 15 milliliter conical tube containing 10 milliliters of PBS supplemented with 10%FBS on ice. (jove.com)
Degeneration2
If, then, the mesonephros had functioned as an excretory organ, there must necessarily have been an interruption of this function on its degeneration. (edu.au)
One theory for the development of SNT is that there is incomplete degeneration of a portion of the mesonephros and subsequent development of peritoneal bands [ 3 ]. (hindawi.com)
Hematopoietic1
Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity. (ox.ac.uk)
Anterior1
the latter are formed in mesoderm, known as the metanephric cell mass, which is continuous at its anterior end with the tissue from which the mesonephros is derived. (co.ma)