• Bicoid and Hunchback are the maternal effect genes that are most important for patterning of anterior parts (head and thorax) of the Drosophila embryo. (wikipedia.org)
  • Nanos and Caudal are maternal effect genes that are important in the formation of more posterior abdominal segments of the Drosophila embryo. (wikipedia.org)
  • In the Drosophila embryo, apical constriction in a strip of epithelial cells along the ventral midline results in the folding of the tissue and the internalization of ventral cells, forming a ventral furrow (VF). (nature.com)
  • hence,the cardiac progenitors are generated in bilateral, segmentally repeated areas of the dorsal mesoderm of the early embryo. (biologists.com)
  • By using published DNA binding specificity data for five transcription factors active in the early Drosophila embryo, genomic regions containing unusually high concentrations of predicted binding sites were identified for these factors. (sdbonline.org)
  • The transcription factors Bicoid (Bcd), Caudal (Cad), Hunchback (Hb), Krüppel (Kr), and Knirps (Kni) act at very early stages of Drosophila development to define the anterior-posterior axis of the embryo. (sdbonline.org)
  • In the placodes of the forming tubes of the salivary glands in the Drosophila embryo, we previously identified spatially defined cell behaviors of cell wedging, tilting, and cell intercalation that are key to the initial stages of tube formation. (elifesciences.org)
  • We demonstrate that the salivary gland turns and migrates along the visceral mesoderm to become properly oriented with respect to the overall embryo. (johnshopkins.edu)
  • Xwnt-5A mRNAs are stored in the egg, and later are expressed throughout the embryo in both ectoderm and mesoderm, but with a pronounced enrichment in the head and tail. (embl-heidelberg.de)
  • Maternal genes involved in dorsoventral (D/V) patterning of the Drosophila embryo interact to establish a stable nuclear concentration gradient of the Dorsal protein which acts as the morphogen along this axis. (silverchair.com)
  • Genetic analysis of early development in the Drosophila embryo has revealed that embryonic pattern formation depends on both maternal and zygotic genes. (silverchair.com)
  • Using theory and experiment, we have shown that during cellularisation in the Drosophila embryo, cells undergo skew and apical-to-basal neighbour rearrangements to adapt for geometric constraints. (mechanochemistry.org)
  • We have taken advantage of genetically induced smaller embryos in Drosophila to bring new insights into when and where organ scaling occurs in the embryo. (mechanochemistry.org)
  • Prelights article on our paper about scaling in the early Drosophila embryo. (mechanochemistry.org)
  • Both Rho1 signaling pathways contribute to actomyosin contractility, which in turn results in elongation of this ectodermal tissue in the Drosophila embryo ( schematic visualization ). (biologists.com)
  • Based on their previous work and that of others, this process is driven by cell intercalation that depends on medio-apical Myosin II pulsing activity and the planar polarized vertical junctional Myosin II pool, resulting in a shrinkage of vertical junctions, cell shape changes and in subsequent Drosophila embryo elongation. (biologists.com)
  • Her Embryo study combines topics in areas such as Drosophilidae and Drosophila. (research.com)
  • For more details on cleavage and gastrulation stages see [1] or go to Drosophila embryo live cell imaging. (cherrybiotech.com)
  • To tackle this, we propose to use the Drosophila embryo that provides the most advanced genetic tools and study the process of mesoderm internalization. (unice.fr)
  • The results demonstrate both independent and overlapping functions of two FGF8 homologues in mesoderm morphogenesis and differentiation. (biologists.com)
  • By correlating dynamic patterns of transcription factor expression with rigorous, quantitative analyses of cell behaviors across the salivary gland primordium in Drosophila , their results suggest Hkb and Fkh transcription factor patterning induces switches in cell behaviors at fixed positions to promote continued morphogenesis of the tubular structure. (elifesciences.org)
  • In many well-studied cases of tissue morphogenesis, such as mesoderm invagination or germband extension in the fly, many morphogenetic effectors are induced evenly across the tissue primordium. (elifesciences.org)
  • The TWIST1 protein is highly conserved from Drosophila to humans, where it plays a key role during embryonic morphogenesis, mesoderm patterning and development. (biomedcentral.com)
  • Drosophila embryogenesis, the process by which Drosophila (fruit fly) embryos form, is a favorite model system for genetics and developmental biology. (wikipedia.org)
  • Embryogenesis in Drosophila is unique among model organisms in that cleavage occurs in a multinucleate syncytium (strictly a coenocyte). (wikipedia.org)
  • the Thomas Lecuit lab, Marseille, France) aims to identify upstream regulators of Rho1 activity in germband extension during Drosophila embryogenesis. (biologists.com)
  • Mesoderm development candidate gene 2 (MESDC2), also known as Boca in drosophila, is a 22 kDa protein that is required for formation of the primitive streak and mesoderm during embryogenesis. (bio-techne.com)
  • The Dorsocross genes are induced within the segmental areas of the dorsal mesoderm that receive intersecting Dpp and Wg inputs. (biologists.com)
  • Our loss- and gain-of-function studies, as well as the observed genetic interactions among Dorsocross, tinman and pannier , suggest that co-expression of these three genes in the cardiac mesoderm, which also involves cross-regulation, plays a major role in the specification of cardiac progenitors. (biologists.com)
  • Studies in several vertebrate models and Drosophila have uncovered a surprising degree of evolutionary conservation of regulatory mechanisms and genes that control early cardiogenesis. (biologists.com)
  • In all these organisms, cardiac induction in the lateral mesoderm involves the concerted action of signals mediated by Bmp, Wnt and Fgf family members, which act upon cardiogenic genes encoding NK homeodomain, Gata and T-box transcription factors (reviewed by Zaffran and Frasch, 2002 ). (biologists.com)
  • To generalize and quantify these promising results, a broader collection of 19 well-defined CRMs from 9 Drosophila genes known to be required for proper embryonic development was compiled. (sdbonline.org)
  • We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman, but does not require a differentiated visceral mesoderm. (johnshopkins.edu)
  • twist is one of the first zygotic genes necessary for mesoderm formation. (silverchair.com)
  • In vertebrates this subfamily contains four proteins: TIF1α/TRIM24, TIF1β/TRIM28, TIF1γ/TRIM33, and TIF1δ/TRIM66, while only one protein, Bonus (Bon), is present in Drosophila , making it an attractive model to understand the conserved functions of TIF1 proteins. (elifesciences.org)
  • Proteins that originate from insect species belonging to the genus DROSOPHILA. (lookformedical.com)
  • Thisbe (Ths) and Pyramus (Pyr), two closely related Drosophila homologues of the vertebrate fibroblast growth factor (FGF) 8/17/18 subfamily,are ligands for the FGF receptor Heartless (Htl). (biologists.com)
  • In the Drosophila thorax, opposing gradients of Dachsous and Four-jointed expression, which are constituents of the Fat/Dachsous/Four-jointed planar cell polarity pathway, result in the polarized localization of the myosin Dachs 9 . (nature.com)
  • Adherens junctions (AJs) are thought to be key landmarks for establishing epithelial cell polarity, but the origin of epithelial polarity in Drosophila remains unclear. (rupress.org)
  • Thus, we examined epithelial polarity establishment during early Drosophila development. (rupress.org)
  • Wnts are a recently described family of secreted glycoproteins related to the Drosophila segment polarity gene, wingless, and to the proto-oncogene, int-1. (embl-heidelberg.de)
  • In Drosophila, transduction of the Hedgehog signal is intimately associated with the activity of protein kinase A and the product of the segment polarity gene patched. (syr.edu)
  • In embryos lacking the zygotic contribution of betaPS, loss of betanu resulted in enhanced separation between the midgut and the surrounding visceral mesoderm. (nih.gov)
  • AmphiMnx RNA is detected in two irregular punctate stripes along the developing neural tube, comparable to the distribution of 'dorsal compartment' motor neurons, and also in dorsal endoderm and posterior mesoderm. (ox.ac.uk)
  • By manipulating both expression patterns and binding sites for transcription factors, we show that a complex combination of regulatory activities converge on a single enhancer of eve to generate precisely targeted gene expression within the cardiac mesoderm. (ntnu.edu.tw)
  • Conversely, eliminating eve in the mesoderm expands lbe expression into the normal eve-expressing territory, suggesting that mutual repression between eve and lbe is essential for delineating the spatial patterns of gene expression that specify cell types within the cardiac mesoderm. (ntnu.edu.tw)
  • Heterogeneity in synaptic transmission along a Drosophila larval motor axon. (neurotree.org)
  • Erratum: Heterogeneity in synaptic transmission along a Drosophila larval motor axon Nature Neuroscience . (neurotree.org)
  • Utilizing the Drosophila larval fat body (FB) as a model adipose tissue, we show that a specific actin isoform-Act5C-forms the cortical actin network necessary to expand adipocyte cell size for biomass storage in development. (bvsalud.org)
  • This monograph, written by the most distinguished workers in the field, is the most authoritative and comprehensive synthesis of Drosophila developmental biology available and emphasizes the insights gained by molecular and genetic analysis. (cshlpress.org)
  • The life cycle of drosophila, from egg fertilization to adult life, takes about 10 days at 25°C. Drosophila is a model organism particularly used in developmental biology because it is a holometabolous insect, with major morphological differences occurring between larvae and adult animal (metamorphosis) [1]. (cherrybiotech.com)
  • Many studies using drosophila as a model system have focused on the understanding on how fly structures are formed (developmental biology), how they work (neurobiology), and how organs grow as the animal grows. (cherrybiotech.com)
  • This important study advances our understanding of the functions and regulation of the Drosophila transcriptional regulator Bonus, an ortholog of mammalian TIF1 family members. (elifesciences.org)
  • The building-blocks of anterior-posterior axis patterning in Drosophila are laid out during egg formation (oogenesis), well before the egg is fertilized and deposited. (wikipedia.org)
  • The mesoderm invaginates from the ventral furrow (VF), as does the ectoderm that will give rise to the midgut. (wikipedia.org)
  • The internalized ventral cells give rise to the mesoderm that differentiates into muscle and other internal cell types such as the fat body, macrophages or lymph glands. (nature.com)
  • The proximal half of the Drosophila E-cadherin extracellular region is dispensable for many cadherin-dependent events but required for ventral furrow formation. (brh.co.jp)
  • Xwnt-8 is expressed by mid-blastula stage, in ventral and lateral mesoderm. (embl-heidelberg.de)
  • Both ligands are required for mesoderm development, but their differential expression patterns suggest distinct functions during development. (biologists.com)
  • Drosophila display a holometabolous method of development, meaning that they have three distinct stages of their post-embryonic life cycle, each with a radically different body plan: larva, pupa and finally, adult. (wikipedia.org)
  • The development of Drosophila is particularly well studied, and it is representative of a major class of animals, the insects or insecta. (wikipedia.org)
  • In addition to temporal changes in expression, dynamic expression profiles during Drosophila development also revealed DmFKBP12 localization. (biomedcentral.com)
  • Throughout these changes in distribution, in situ DmFKBP12 mRNA monitoring detected equal distribution of DmFKBP12 mRNA, once again indicating that regulation of DmFKBP12 occurs at the translational level in Drosophila development. (biomedcentral.com)
  • The sternum arises from paired longitudinal concentrations of the somatic mesoderm in the sixth week of development. (medscape.com)
  • We propose that the integration of Pyr and Ths function is required for robustness of Htl-dependent mesoderm spreading and differentiation, but that the functions of Pyr have become more specific, possibly representing an early stage of functional divergence after gene duplication of a common ancestor. (biologists.com)
  • The integration of this new information with previous findings has allowed us to draw a more complete pathway of regulatory events during cardiac induction and differentiation in Drosophila . (biologists.com)
  • Her Zebrafish study integrates concerns from other disciplines, such as Paraxial mesoderm, Chromatophore, Cell type and Neural crest. (research.com)
  • The musculoskeletal system associated with the trunk develops from paraxial and lateral plate (somatic layer) mesoderm. (medscape.com)
  • [ 4 , 5 ] The paraxial mesoderm in the trunk is transiently organized into approximately 40 segmental tissue blocks alongside the neural tube, known as somites, the cells of which segregate into 2 subpopulations. (medscape.com)
  • The ribs are also derived from sclerotomic cells of the paraxial mesoderm. (medscape.com)
  • Here, we focus on the role of directed cell migration in shaping and positioning the Drosophila salivary gland. (johnshopkins.edu)
  • Homeotic mutations in Drosophila can result in dramatic phenotypes that suggest the possibility for rapid morphological evolution, but dissection of the genetic pathway downstream of Ultrabithorax is beginning to reveal how wing morphology may have evolved by more gradual transformations. (lookformedical.com)
  • Introgression of homeotic mutations into wild-type genetic backgrounds results in a wide variety of phenotypes and implies that major effect modifiers of extreme phenotypes are not uncommon in natural populations of Drosophila. (lookformedical.com)
  • The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. (neurotree.org)
  • Here, we study the mechanisms by which positional information conveyed by signaling pathways and a combinatorial code of activating and repressing transcription factors work together to confine the expression of the homeobox gene even-skipped (eve) to a small region of the dorsal mesoderm. (ntnu.edu.tw)
  • Having generated the tools to eliminate integrin function completely, we confirm that Drosophila integrins do not control proliferation as they do in mammals, and have identified alphaPS3 as a heterodimeric partner for betanu. (nih.gov)
  • This preprints identifies two independent Rho1 signaling pathways that regulate actomyosin contractility in two different cell compartments, medio-apically and at cell junction in the Drosophila ectoderm. (biologists.com)
  • In the case of Drosophila heart formation, the cardiac progenitors are specified in precise mesodermal positions, giving rise to multiple cell types in a highly ordered arrangement. (ntnu.edu.tw)
  • We found apical accumulation of both Drosophila E-Cadherin (DE-Cad) and the apical cue Bazooka (Baz) as cells first form. (rupress.org)
  • RhoGEF2 regulates medio-apical Rho1 activity while p114RhoGEF/Wireless controls Rho1 activity at junctions in the Drosophila ectoderm. (biologists.com)
  • and in Drosophila , AJs also assemble through the coalescence of spot junctions into belt junctions ( Tepass and Hartenstein, 1994 ). (rupress.org)
  • To find out where is localized the active Rho1 in the Drosophila ectoderm, the authors elegantly employed a Rho1-GFP biosensor that binds active Rho1-GTP, revealing that active Rho1 localizes medio-apically and in a polarized manner at junctions in ectodermal cells. (biologists.com)
  • Inspired by the work from the Drosophila mesoderm, the authors find that Gα12/13/Cta is required to localize RhoGEF2 and that it does so by releasing RhoGEF2 from microtubule plus ends in order to recruit it medio-apically and at cell junctions. (biologists.com)
  • mesoderm induction early response 1. (nig.ac.jp)
  • Fertilized egg, through the profile as under-membrane cortex distribution concentering onto basement at cellular blastoderm, to the profile as three-gem layer localization in primitive neuronal and digestion architecture of early Drosophila gastrula. (biomedcentral.com)
  • Further study on the differences between mammalian RyR-FKBP12 and Drosophila DmRyR-FKBP12 can be exploited to develop safe pesticides. (biomedcentral.com)
  • We show that localised expression of pyr is required for normal cell protrusions and high levels of MAPK activation in migrating mesoderm cells. (biologists.com)