Mesna, sold under the brand name Mesnex among others, is a medication used in those taking cyclophosphamide or ifosfamide to decrease the risk of bleeding from the bladder. (wikipedia.org)
Mesna is used therapeutically to reduce the incidence of haemorrhagic cystitis and haematuria when a patient receives ifosfamide or cyclophosphamide for cancer chemotherapy. (wikipedia.org)
The IV mesna infusions would be given with IV ifosfamide, while oral mesna would be given with oral cyclophosphamide. (wikipedia.org)
Mesna is a water-soluble compound with antioxidant properties, and is given concomitantly with the chemotherapeutic agents cyclophosphamide and ifosfamide. (wikipedia.org)
Neoadjuvant Interdigitated Chemoradiotherapy Using Mesna, Doxorubicin, and Ifosfamide for Large, High-grade, Soft Tissue Sarcomas of the Extremity: Improved Efficacy and Reduced Toxicity. (rush.edu)
Rapidly converted to mesna disulfide, then back to mesna in the kidneys, where it binds to toxic metabolites of ifosfamide (18-26% excreted as free mesna in urine after IV and PO dosing). (drugguide.com)
Obtain a negative pregnancy test before starting when mesna is given with ifosfamide. (drugguide.com)
Mesna binds to the metabolites of cyclophosphamide and ifosfamide in the kidney and reduces their toxic effects. (caspianpharma.com)
Amifostine and mesna1
The Pediatric Oncology Group study for metastatic Ewing's sarcoma used amifostine and mesna with the alkylating agents. (uaeu.ac.ae)
Infusions2
The oral preparation allows patients to leave the hospital sooner, instead of staying four to five days for all the IV mesna infusions. (wikipedia.org)
WR-1065 and mesna appeared in the cells by the end of the drug infusions, although WR-1065 uptake was more efficient than mesna. (uaeu.ac.ae)
Injection3
These highlights do not include all the information needed to use MESNA INJECTION safely and effectively. (nih.gov)
See full prescribing information for MESNA INJECTION. (nih.gov)
Whether you're looking for Uromitexan Injection (Mesna 200mg), Diane Tablets, Allopathic Medicines etc, you can explore and find the best products from Tradeindia. (tradeindia.com)
Excretion1
Mesna also increases urinary excretion of cysteine. (wikipedia.org)
Intravenous1
The oral doses must be double the intravenous (IV) mesna dose due to bioavailability issues. (wikipedia.org)
Metabolites2
Mesna assists to detoxify these metabolites by reaction of its sulfhydryl group with α,β-unsaturated carbonyl containing compounds such as acrolein. (wikipedia.org)
Mesna concentrates in the bladder where acrolein accumulates after administration of chemotherapy and through a Michael addition, forms a conjugate with acrolein and other urotoxic metabolites. (wikipedia.org)
Cyclophosphamide1
Mesna is used to prevent hemorrhagic cystitis in patients treated with lymphosphamide and cyclophosphamide. (caspianpharma.com)
Drugs1
Injections of oromitexan or mesna are used to treat the harmful effects of some cancer drugs on the bladder. (caspianpharma.com)
Chemotherapy1
Mesna reduces the toxicity of urotoxic compounds that may form after chemotherapy administration. (wikipedia.org)
Dose1
If PO mesna is vomited within 2 hr of administration, repeat dose or use IV mesna. (drugguide.com)
Activities and Accommodation1
Birkebeinerspelet 2018 was performed over three February evenings against the stunning backdrop of Sør-Mesna at Mesna Activities and Accommodation. (ianbrodie.net)
Incubation of a volunteer's blood with mesna, WR-1065, or both revealed that cellular uptake of total reducible drug was ∼10% of plasma level for mesna but ∼60% for WR-1065. (uaeu.ac.ae)
Administration1
Amifostine administration during mesna infusion caused transient increase in mesna levels. (uaeu.ac.ae)
Total1
This graph shows the total number of publications written about "Mesna" by people in this website by year, and whether "Mesna" was a major or minor topic of these publications. (rush.edu)
Year1
My time at Mesna this year is going to be interspersed with a new adventure to an exciting place with a very proud moment taking place whilst I am there. (ianbrodie.net)
TIME1
The concentration-time profiles of mesna in RBC paralleled those in plasma. (uaeu.ac.ae)
Blood1
We also conducted analogous measurements on two patients who received mesna alone and a volunteer's blood following in vitro treatment. (uaeu.ac.ae)
People1
Below are the most recent publications written about "Mesna" by people in Profiles. (rush.edu)