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  • Dose
  • Dose fractionation, vigorous hydration, frequent bladder emptying, and a protector such as mesna can significantly reduce the incidence of hematuria , especially gross hematuria, that is associated with hemorrhagic cystitis . (drugs.com)
  • hydration
  • Most side effects can be minimized by giving fractionated doses, assuring adequate hydration and frequent urination , and using uroprotective agents, such as mesna. (drugs.com)
  • The aim of this study is therefore to determine laboratory and clinical benefit of MESNA, as an adjunct to saline hydration, in patients with known renal impairment receiving contrast media. (clinicaltrials.gov)
  • Patients
  • At daily doses of 1.2 g/m2 for 5 consecutive days without mesna protection, microscopic hematuria is expected in approximately 50% to 100% of patients, and gross hematuria in approximately 8% of patients. (drugs.com)
  • Patients taking mesna should drink at least a quart of liquid a day. (empr.com)
  • study
  • The secondary objective of this study is to evaluate the activity of aldoxorubicin in combination with ifosfamide/mesna in this population, assessed by overall response rate and progression-free survival (PFS). (clinicaltrials.gov)