• The metanephrogenic blastema or metanephric blastema (or metanephric mesenchyme, or metanephric mesoderm) is one of the two embryological structures that give rise to the kidney, the other being the ureteric bud. (wikipedia.org)
  • The system of tissue induction between the ureteric bud and the metanephric blastema is a reciprocal control system. (wikipedia.org)
  • GDNF, glial cell-derived neurotrophic factor, is produced by the metanephric blastema and is essential in binding to the Ret receptor on the ureteric bud, which bifurcates and coalesces as a result to form the renal pelvis, major and minor calyces and collecting ducts. (wikipedia.org)
  • The posterior location of the ureteric bud results from a combination of repression of GDNF expression in the more anterior regions by the actions of Slit-2/Robo-2 in the mesenchyme and Sprouty , which reduces the sensitivity of the anterior mesonephric duct to the action of GDNF. (clinicalgate.com)
  • Bone morphogenetic protein ( BMP ) signaling in the surrounding mesoderm is also inhibitory to outgrowth of the ureteric bud, but within the metanephrogenic blastema its action is counteracted by the BMP-inhibitory actions of gremlin , which is produced within the blastema itself. (clinicalgate.com)
  • The formation of GDNF in the metanephric mesenchyme is regulated by WT-1 . (clinicalgate.com)
  • These early forms of the kidney are later supplanted by the definitive metanephric kidneys, but as they regress, certain components are retained to be reused by other components of the urogenital system. (clinicalgate.com)