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  • gastrulation
  • Serotonin levels peak immediately prior to gastrulation, a cell movement process that places them in locations where they will eventually develop into different tissue types, and serotonin is localized to cells that will initiate these movements. (gwu.edu)
  • From these studies we have hypothesized that serotonin initiates gastrulation cell movements by first binding to Type 7 and/or 2 serotonin receptors. (gwu.edu)
  • Inversion of the chordate body axis: The behaviour and function of bottle cells during gastrulation of Xenopus laevis. (currentscore.info)
  • Gastrulation and later stages of histo- and organogenesis depend on changes in developmental stage, such as epithelial-mesenchymal transition (EMT), whereby adherent cells disintegrate their intercellular contacts, organize their motility apparatus, and move to new locations in the developing body. (springer.com)
  • transition
  • Bone morphogenetic protein 7-SMAD is then required for transition to a distinct compartment in which cells become inducible by WNT9b/β-catenin, allowing them to progress toward epithelialization. (pnas.org)
  • This transition is associated with the invagination and condensation of mesenchyme. (bmj.com)
  • EMT generates transitory mesenchymal cells, which can differentiate into myofibroblasts or pericytes (in the case of endothelial-mesenchymal transition (EndMT)), or feed the progenitor pools of cell lineages (e.g., blood, muscle, bone, adipose, and neuronal). (springer.com)
  • Skeletal
  • We currently focus on characterization of a newly identified and isolated population of skeletal stem cells with long-term self-renewal and differentiating and regenerative abilities, contributing directly to tissue repair by replacing the damaged skeleton. (rochester.edu)
  • BMP4
  • Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. (uniprot.org)
  • BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). (uniprot.org)
  • pathways
  • KEGG analysis of differentially expressed genes between stages revealed down-regulation of pathways associated with ECM, cell division, metabolism and development at onset of notochord segmentation. (biomedcentral.com)
  • induction
  • In the presence of mesenchyme, Ngn3 induction was delayed, and few β-cells developed. (diabetesjournals.org)
  • This effect of the mesenchyme on Ngn3 induction was mediated by cell-cell contacts and required a functional Notch pathway. (diabetesjournals.org)
  • Significantly, CITED1 + cells are refractory to WNT/β-catenin induction. (pnas.org)
  • We propose a model in which the primitive CITED1 + compartment is refractory to induction by WNT9b/β-catenin, ensuring maintenance of undifferentiated progenitor cells for future nephrogenesis. (pnas.org)
  • survival
  • Detection of cancer cells at early stages could potentially increase survival rates in cancer patients. (aacrjournals.org)
  • In addition, we are interested in survival and development of neural stem cells regulated by the SUMO pathway. (rochester.edu)
  • We have demonstrated the requirement of SUMO-specific protease 2 in survival and development of tissue-specific stem cells and niches. (rochester.edu)
  • progenitor
  • Embryonic nephron progenitor cells are segregated in molecularly distinct compartments of unknown function. (pnas.org)
  • Formation of a sufficient number of nephrons during kidney development relies on a continuous supply of nephron progenitor cells. (pnas.org)
  • As the collecting system branches, progenitor cell aggregates at collecting duct tips known as cap mesenchymes are induced to form nephrons. (pnas.org)
  • genes
  • Recent publications have shown the presence of promoter hypermethylation of various genes in clinical specimens containing exfoliated tumor cells (such as malignant effusions, sputum, serum, etc. (aacrjournals.org)
  • We also found overall suppressed expression of these genes and their corresponding proteins in a panel of human LUAD cell lines. (frontiersin.org)
  • capacities
  • In that sense, cancer cells undergoing EMT have some of the capacities that one would expect from the so-called "tumor-initiating cells. (springer.com)
  • neural stem
  • For instance, in the brain of mice deficient in specific members of the basic helix-loop-helix Hairy and Enhancer-of-Split family (Hes), virtually the entire pool of neural stem cells differentiates simultaneously and prematurely into neurons, without generating the later-born cell types ( 1 ). (diabetesjournals.org)
  • Transient
  • These results suggest that transient expression of Lv-snail may be important for the differentiation of a subset of axially patterned nonskeletogenic mesenchyme cells and suggest conserved functions for snail family members in deuterostome development. (nih.gov)
  • Pluripotent Stem
  • The significance of these compartments is unclear, and understanding their functions is important for our basic knowledge of kidney development and for ongoing efforts to differentiate kidney tissue from pluripotent stem cells. (pnas.org)
  • gastrula stage
  • At the late gastrula stage, a contiguous cluster of cells on the left side of the tip of the archenteron is Lv-snail-positive. (nih.gov)
  • expression
  • When using a pattern-matching algorithm, we showed that TBX's overexpression mimic molecular signatures from azacitidine treated NCI-H1299 cells which in turn are inversely correlated to expression profiles of both human and murine lung tumors relative to matched normal lung. (frontiersin.org)
  • We have identified populations of patterned, nonskeletogenic mesenchyme in the sea urchin Lytechinus variegatus by their expression of a sea urchin member of the snail family (Lv-snail). (nih.gov)
  • phenotype
  • The NHEKs exhibiting the EMT phenotype acquired extended replicative potential and an increased telomere length compared with the control cells. (telomerescience.com)
  • However, the full range of MSC-mediated immune-modulation remains incompletely understood, as emerging reports also reveal that MSCs can adopt an immunogenic phenotype, stimulate immune cells, and yield seemingly contradictory results in experimental animal models of inflammatory disease. (wjgnet.com)
  • Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. (rochester.edu)