Mesenchyme cells. Medical search. Frequent questions

Improvement of cell-cell interactions between epithelium and mesenchyme is a potential approach to address this phenotype issue. (ca.gov)

Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. (sigmaaldrich.com)
In most cases, dying cells during development exhibit generalized morphological features typical of apoptosis. (karger.com)
Two morphological types of cell death were found: apoptosis which was characterized by round or semilunar nuclear chromatin condensations, condensation and shrinkage of the cytoplasm and formation of apoptotic bodies, and cell death without the morphological features of apoptosis which was characterized by pyknotic nuclear chromatin condensations, vacuolated cytoplasm and the formation of numerous intercellular spaces. (karger.com)
According to our findings, apoptosis seems to be the most frequently observed type of PCD, but it is not the exclusive type of morphological cell death during the development of axial structures in human embryos. (karger.com)
Here, we use a factorial experimental design coupled with statistical modelling to understand which signalling pathways are involved in the transition between ESCs and EPL cells, and how they underpin changes in morphology, cell number, apoptosis, proliferation and gene expression. (bvsalud.org)

Mesenchyme (/ˈmɛsənkaɪm ˈmiːzən-/) is a type of loosely organized animal embryonic connective tissue of undifferentiated cells that give rise to most tissues, such as skin, blood or bone. (wikipedia.org)
Porifera, Cnidaria, Ctenophora and some triploblasts (the acoelomates), mesenchyme refers to a more-or-less solid but loosely organized tissue consisting of a gel matrix (the mesoglea) with various cellular and fibrous inclusions, located between the epidermis and the gastrodermis (non-triploblast animals usually are considered to lack "connective" tissue). (wikipedia.org)
Mesenchyme cells are incorporated into a wide variety of structures including connective tissue, blood, bone and cartilage as development continues. (xenbase.org)
Fibroblasts are the main connective tissue cells present in the body. (news-medical.net)
In facial morphogenesis, neural crest cells migrate into the facial region, where they form the skeletal and connective tissue and all dental tissues except the enamel. (medscape.com)

These microenvironments are classically defined as distinct cortex and medulla regions that each contain specialized subsets of stromal cells. (frontiersin.org)
Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
The revelation that human amniotic mesenchyme possesses cell populations with both suppressive and stimulatory properties sheds additional light on the immunomodulatory functions of this tissue and may contribute to the clarification of some ongoing controversies associated with mesenchymal stromal cells of other sources, such as the presence of HLA-DR-positive cells and the suppressive versus stimulatory properties of these cells. (unicatt.it)
Adipose mesenchymal stromal cells, haematopoietic stem cells and hepatocytes are among those cell types that are especially responsive. (stanford.edu)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)

Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research Journal of Allergy. (nottingham.ac.uk)
Immunofluorescence staining confirmed human origin, identified differentiated epithelial cell types and verified the presence of supporting mesenchyme. (ca.gov)
Mesoglea, also known as mesohyl, is the translucent, non-living, jelly-like substance found between the two epithelial cell layers (i.e., between the ectoderm and endoderm) in the bodies of cnidarians and sponges. (pearltrees.com)
A combination of environmental, genetic, and other unknown factors probably contribute to alveolar epithelial cell dysfunction or reprogramming, which leads to abnormal fibroproliferation in the lung. (msdmanuals.com)

The interactions between mesenchyme and epithelium help to form nearly every organ in the developing embryo. (wikipedia.org)
The first cells of the embryo to undergo EMT and form mesenchyme are the extra-embryonic cells of the trophectoderm. (wikipedia.org)
The tissue layers formed from the primitive streak invaginate together into the embryo and the induced mesenchymal stem cells will ingress and form the mesoderm. (wikipedia.org)
NCCs ingress into the embryo from the epithelial neuroectodermal layer and migrate throughout the body in order form multiple peripheral nervous system (PNS) cells and melanocytes. (wikipedia.org)
ECSA/DPPA2 is an embryo-cancer antigen that is coexpressed with cancer-testis antigens in non-small cell lung cancer. (nih.gov)
Chu-Wang, I.W., R.W. Oppenheim (1978) Cell death of motoneurons in the chick embryo spinal cord. (karger.com)

This "soup" exists as a combination of the mesenchymal cells plus serous fluid plus the many different tissue proteins. (wikipedia.org)
Epithelial-mesenchymal transition occurs in embryonic cells that require migration through or over tissue, and can be followed with a mesenchymal-epithelial transition to produce secondary epithelial tissues. (wikipedia.org)
Primary mesenchyme is the first embryonic mesenchymal tissue to emerge, and it is produced from EMT in epiblast cells. (wikipedia.org)
IMs are found in the space between the tissue stroma cells and contain, among other components, fibrillar collagens and fibronectin. (nature.com)
We therefore refer to the unfractionated cell population derived from this region as amniotic mesenchymal tissue cells (AMTC). (unicatt.it)
To prioritise pathways we will undertake high-throughput functional genomic screens using CRISPR, perform lung digital spatial transcriptomic profiling and utilise informative cell and tissue models. (nottingham.ac.uk)
This will inform in-depth mechanistic assays at the cell, tissue and organ scales to identify the key mechanisms underpinning regulation of lung function in health and disease. (nottingham.ac.uk)
This property involves activation of the remaining tissue at the site of injury to promote cell division, cell migration and replacement of the missing structures. (unifr.ch)
Portion of embryonic tissue consisting of loosely organized, undifferentiated mesodermal or neural crest derived cells, that have specific properties (they are migratory, have no polarity). (xenbase.org)
Human tissue-engineered colon forms from postnatal progenitor cells: an in vivo murine model. (ca.gov)
This atlas enabled molecular characterization of more than 400 cell types, their distribution across tissues, and tissue-specific variation in gene expression. (stanford.edu)
Using multiple tissues from a single donor enabled identification of the clonal distribution of T cells between tissues, identification of the tissue-specific mutation rate in B cells, and analysis of the cell cycle state and proliferative potential of shared cell types across tissues. (stanford.edu)
Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. (stanford.edu)
We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. (stanford.edu)
Fibrocyte refers to the less active state, when the cell is involved in tissue maintenance and metabolism. (news-medical.net)
Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
However, these experiments conducted at tissue level raise seemingly contradictory models for fate allocation of individual cells. (bvsalud.org)

The interaction with ectoderm and somite-forming morphogenic factors cause some primary mesenchyme to form neural mesenchyme, or paraxial mesoderm, and contribute to somite formation. (wikipedia.org)
Neural mesenchyme soon undergoes a mesenchymal-epithelial transition under the influence of WNT6 produced by ectoderm to form somites. (wikipedia.org)
Addition of 400â µM L-proline to self-renewal medium drives naïve mouse embryonic stem cells (ESCs) to early primitive ectoderm-like (EPL) cells - a transcriptionally distinct primed or partially primed pluripotent state. (bvsalud.org)
EPL cells retain expression of pluripotency genes, upregulate primitive ectoderm markers, undergo a morphological change and have increased cell number. (bvsalud.org)
By simultaneously knocking out Foxi3 in neural plate border cells and following their fates, we show that neural plate border cells lacking Foxi3 contribute to all four lineages of the ectoderm - placodes, epidermis, crest and neural tube. (bvsalud.org)
Here, we carry out single cell RNA sequencing of chick ectoderm from primitive streak to neurulation stage, to explore cell state diversity and heterogeneity. (bvsalud.org)

NC cells differentiate to form a broad array of derivatives, including neurons and glia of the peripheral nervous system, smooth muscle, cartilage, craniofacial mesenchyme, and melanocytes ( Mayor and Theveneau, 2013 ). (jneurosci.org)
Finally, we have focused on the neural crest cells as the source of the craniofacial mesenchyme. (elsevier.com)

The mesenchyme originates from the mesoderm. (wikipedia.org)
The paraxial layer of mesenchyme, which lies adjacent to the notochord, differentiates into the somite ridges, intermediate cell mass, and lateral plate mesoderm. (medscape.com)

The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. (pearltrees.com)
2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. (lww.com)
FGF-10 immunostaining could be related to cell proliferation in epithelium and cell differentiation in epithelium and ectomesenchyme. (bvsalud.org)

Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
Cortical epithelial cells (cTEC) support the earliest thymocyte progenitor populations, guiding them through the cortex, directing them to a T-cell lineage fate and ensuring their functional qualities as self-MHC restricted cells through the process of positive selection ( 2 ). (frontiersin.org)
While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)
We studied the suppressive and stimulatory characteristics of the unfractionated, HLA-DR-positive, and HLA-DR-negative AMTC populations and demonstrated that all three fail to induce an allogeneic T-cell response. (unicatt.it)
We identify two populations of cells with active Wnt signaling: highly proliferative Lgr5 + /Axin2 + cells, as well as secretory Lgr5 − /Axin2 + cells. (nature.com)
Lgr5 is a well-established marker of these basal stem cells in the gastrointestinal tract 1 and lineage tracing experiments have demonstrated that Lgr5 + cells give rise to clonal cell populations establishing entire colonic crypts 2 . (nature.com)
We are currently investigating the regenerative capacity of specific cardiac cell populations and comparing the restorative programs of different fish species. (unifr.ch)
Lun, Richard, and Marioni 2017 ) where it is routinely used to examine the effects of different conditions on the composition of complex cell populations. (bioconductor.org)
We will also use internally standardized qRT-PCR assays to measure circulating tumor cells (CTCs) associated transcripts in whole blood, and use novel ultrasonic wave based microfluidics (acoustophoresis) to enable unbiased, label-free isolation of CTCs and extracellular vesicles (EVs) for subsequent molecular interrogation of the isolated/enriched populations of CTCs and EVs. (lu.se)
As our acoustic separation methods are label-free, we are likely to detect new populations of CTCs and EVs compared to currently available methods, particularly due to mesenchyme-epithelium transitioning of CTCs. (lu.se)

The surface molecules undergo endocytosis and the microtubule cytoskeleton loses shape, enabling mesenchyme to migrate along the extracellular matrix (ECM). (wikipedia.org)
A fibroblast is a type of cell that is responsible for making the extracellular matrix and collagen. (news-medical.net)

Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. (nature.com)

In addition to providing biomechanical support to the islets, ECM components are required for β-cell development, proliferation, survival, and proper insulin secretion. (nature.com)
However, unfractionated AMTC, which could inhibit T-cell allogeneic proliferation responses, induced proliferation of T cells stimulated via the T-cell receptor (TcR), in a cell-cell contact setting. (unicatt.it)
Indeed, even though the HLA-DR-positive AMTC fraction surprisingly failed to induce proliferation of resting allogeneic T cells, they could cause strong proliferation of anti-CD3-primed allogeneic T cells. (unicatt.it)
The thyroid gland forms as a proliferation of endodermal epithelial cells on the median surface of the developing pharyngeal floor. (medscape.com)
Transcription Factor CTCFL Promotes Cell Proliferation, Migration, and Invasion in Gastric Cancer via Activating DPPA2. (nih.gov)
During the third week of embryonic development, proliferation and medial migration of ectodermal cells form the notochord. (medscape.com)

The first emergence of mesenchyme occurs during gastrulation from the epithelial-mesenchymal transition (EMT) process. (wikipedia.org)
This transition occurs through the loss of epithelial cadherin, tight junctions, and adherens junctions on the cell membranes of epithelial cells. (wikipedia.org)
Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. (ox.ac.uk)
In some cases, epithelial cells may also produce fibroblasts, a process which is referred to as epithelial-mesenchymal transition (EMT). (news-medical.net)
and both BMP and TGF-β signaling synergize with Notch to promote the transition of endothelia to mesenchyme and the mesenchymal cell invasiveness. (springer.com)
Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis. (cdc.gov)

Conclusion: Colon can form from human progenitor cells on a scaffold in a mouse host. (ca.gov)
In this study, we developed a model system for improving interactions between human iPS-derived hepatic progenitor cells (iPS-HPCs) and human iPS-derived hepatic stellate cell-like cells (iPS-HSCs). (ca.gov)

Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
While some islet BM components are produced by endothelial cells (ECs), the source of others remains unknown. (nature.com)
Blood vessels in the vertebrate brain are composed of a single layer of endothelial cells that possess distinct functional properties that allow the passage of necessary nutrients yet prevent unwanted entry of specific toxins and pathogens into the brain. (elifesciences.org)
Collectively, endothelial cells and the surrounding perivascular cells form the neurovascular unit. (elifesciences.org)
Barrier properties of brain endothelial cells are induced by extrinsic signals from other cells in the surrounding microenvironment during development ( Stewart and Wiley, 1981 ). (elifesciences.org)

The rudimentary lateral thyroid develops from neural crest cells, while the median thyroid, which forms the bulk of the gland, arises from the primitive pharynx. (medscape.com)
Fibroblasts are originally derived from primitive mesenchyme and therefore display the filament protein vimentin, which acts as a marker of mesodermal origin. (news-medical.net)

Cells derived from the amniotic membrane of human placenta have been receiving particular attention because of their stem cell potentiality and immunomodulatory properties, which make them an attractive candidate source for cell therapy approaches. (unicatt.it)

Mesenchyme is characterized morphologically by a prominent ground substance matrix containing a loose aggregate of reticular fibers and unspecialized mesenchymal stem cells. (wikipedia.org)
Could extracellular vesicles derived from mesenchymal stem cells be a potential therapy for acute pancreatitis-induced cardiac injury? (wjgnet.com)
Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)

LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. (ca.gov)
Next, we generated iPS cell lines overexpressing LIM homeobox 2 (LHX2), which suppresses myofibroblastic changes in HSCs in mice. (ca.gov)

Embryological mesenchymal cells express Protein S100-A4 (S100A4) also known as fibroblast-specific protein, which is indicative of their shared properties with the migratory adult fibroblasts, and c-Fos, an oncogene associated with the down-regulation of epithelial cadherin. (wikipedia.org)
Embryological mesenchyme is particularly transitory and soon differentiates after migration. (wikipedia.org)
The process results in the production of proteins, which influence the cells as they differentiate, move, and contribute to embryological development. (asu.edu)

Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)

Hence, recapitulating the islet ECM in both isolated islets and stem-cell-derived β-cells is of high therapeutic value. (nature.com)
Signals that regulate epithelial regeneration upon stem cell injury are largely unknown. (nature.com)
Expression of Lgr5 is controlled by Wnt signaling, which plays a critical role for stem cell turnover in the gastrointestinal tract 2 . (nature.com)
Rspo proteins are secreted and can stabilize the effects of Wnt ligands by preventing ubiquitination and turnover of the Wnt receptor frizzled 9 , thereby dictating the size of the Lgr5 + stem cell pool by regulating self-renewal of Lgr5 + cells 10 . (nature.com)
We have shown that in the stomach, stem cell homeostasis is regulated by Wnt and Rspo secreted by stromal myofibroblasts 11 . (nature.com)
Some researchers use the term fibroblast for both cellular states but the term "blast" usually refers to a stem cell or a cell's activated state. (news-medical.net)
Stem Cell Res. (sciendo.com)

During mouse embryonic development, a subpopulation of neural crest cell-derived melanocytes migrates and incorporates into a subregion of the cochlear epithelium, forming the intermediate cell layer of the stria vascularis. (jneurosci.org)

Recombinant LASV-Josiah, based on the sequence of an isolate obtained in 1976 from the serum of a 40-year-old man hospitalized at Songo Hospital in Sebgwena, Sierra Leone ( 21 , 22 ), was rescued in BSR-T7/5 cells and passaged twice in Vero-E6 cells (GenBank accession nos. (cdc.gov)

A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinase (Ki = 140 nM for p160 ROCK (ROCK-I). Also inhibits ROCK-II with almost equal potency. (sigmaaldrich.com)
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (K i = 140 nM for p160 ROCK ). (sigmaaldrich.com)
They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. (pearltrees.com)
The phenotype of iPS-HSCs, including gene and protein expression profiles and vitamin A storage, resembled that of hepatic stellate cells. (ca.gov)
Some authors have reported on the use of laboratory tests including sedimentation rate, white blood cell counts, and C-reactive protein levels to help diagnose acute sinusitis. (medscape.com)
To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)

The physical substance of the human organism, composed of living cells and extracellular materials and organized into tissues, organs, and systems. (rincondelvago.com)
Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. (stanford.edu)
We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. (stanford.edu)
Here we performed single-cell RNA sequencing on 20 organs to reveal cell-type-specific responses to young and aged blood in heterochronic parabiosis. (stanford.edu)
Cells Tissues Organs (2001) 169 (4): 347-354. (karger.com)

The abnormal growth of cells like primary or metastatic masses in the head and neck, thyroid and parathyroid lesions, or the traumatic injuries of the head and neck represents malignant neoplasm. (benthamscience.com)

Human induced pluripotent stem cells (iPSCs) offer a potential unlimited source of adult cell types with numerous applications in regenerative medicine. (ca.gov)

My research topics deal with the role of the cranial neural crest cells (CNCc) in bichirs, sturgeons and gars, focusing on the differences in the origin and migration of the CNCc. (elsevier.com)

Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis. (nature.com)
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis. (nature.com)

The vascular BM surrounds the islet capillary network and directly contacts mouse endocrine cells. (nature.com)
Phospholipids and the steroid compound cholesterol are major components of the membrane that surrounds each cell. (rincondelvago.com)

Neural crest cells (NCCs) form from neuroectoderm, instead of the primary mesenchyme, from morphogenic signals of the neural crest. (wikipedia.org)
The neural crest (NC) is comprised of specialized cells that arise from the lateral border of the neural plate and migrate into specific locations during vertebrate embryonic development. (jneurosci.org)
We have found that the hyoid stream of neural crest cells provides supporting mesenchyme for the bichir external gills, and that emigration of the hyoid stream is notably accelerated when compared to the mandibular stream. (elsevier.com)
We contrast Foxi3 with another neural plate border transcription factor, Zic5, the progenitors of which initially contribute broadly to all germ layers until gastrulation and gradually become restricted to the neural crest lineage and dorsal neural tube cells. (bvsalud.org)
Analysis of neural, neural crest and placodal markers reveals that individual NPB cells co-express competing transcriptional programmes suggesting that their ultimate identify is not yet fixed. (bvsalud.org)

However, while many studies demonstrated the importance of the ECM, its interactions with β-cells are still not fully understood. (nature.com)
The interactions with the various BM components differentially affect β-cells, although the underlying mechanism is largely unknown. (nature.com)
In conclusion, this study provides an evidence that LHX2 upregulation in iPS-HSCs promotes hepatocytic maturation of iPS-HPCs, and indicates that genetically modified iPS-HSCs will be of value for research into cell-cell interactions. (ca.gov)

Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
In conclusion, we have uncovered novel roles of the mesenchyme-specific Tgf-β1 ligand in embryonic mouse lung development and generated a mouse model that may prove helpful to identify some of the key pathogenic mechanisms underlying lung hypoplasia in humans. (nih.gov)

Mice homozygous for a null allele exhibit incomplete prenatal lethality, decreased osteoclast cell number, decreased angiogenesis, increased long bone epiphyseal plate size, and short long bones. (jax.org)

Human induced pluripotent stem (iPS) cells can differentiate into hepatocyte lineages, although the phenotype of the differentiated cells is immature compared to adult hepatocytes. (ca.gov)
Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ (2004) Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves. (springer.com)

In the membrane of the signaling cell, there is a ligand (represented by a green oval). (asu.edu)

In early experiments, physical separation of mesenchymal and epithelial stroma from embryonic murine thymus resulted in defective thymus development when epithelium was cultured in vitro in the absence of mesenchyme ( 7 ). (frontiersin.org)
These findings were confirmed in later studies in which removal of mesenchyme from embryonic day 12 murine thymic lobes impaired thymus growth in vitro ( 8 ). (frontiersin.org)

The peri-islet membrane, which encapsulates the islets, separates the endocrine cells from the exocrine pancreas and serves as a barrier from immune cell infiltration to the islets. (nature.com)

Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)

As with TEC, our understanding of NES has been improved through the phenotypic identification of new subpopulations, such studies on thymic mesenchyme and endothelium have provided new and important insight into their complexity and functional importance. (frontiersin.org)
In this study, we isolated cells from the mesenchymal region of amnion and identified two subpopulations discordant for expression of the HLA-DR, CD45, CD14, and CD86 cellular markers. (unicatt.it)
This avoids cluttering the result table with very rare subpopulations that contain only a handful of cells. (bioconductor.org)

Unlike the highly conserved actins and tubulins , more than 40 distinct IF proteins are encoded by a number of genes in mammalian cells. (daviddarling.info)

2019 ) . In this case, we are aiming to identify labels that change in abundance among the compartment of injected cells compared to the background. (bioconductor.org)

These findings may help to generate mature liver cells for drug toxicity studies and ultimately for liver transplantation. (ca.gov)
Considering our findings, we propose a probabilistic model for cell fate choice at the neural plate border. (bvsalud.org)

The mesenchyme develops into the tissues of the lymphatic and circulatory systems, as well as the musculoskeletal system. (wikipedia.org)
Cell type-specific RNA splicing was discovered and analyzed across tissues within an individual. (stanford.edu)

Mesenchymal cells can migrate easily (in contrast to epithelial cells, which lack mobility, are organized into closely adherent sheets, and are polarized in an apical-basal orientation). (wikipedia.org)
During this process, the cells migrate along the crypt wall towards the surface where they are shed into the lumen. (nature.com)

The stria vascularis is a nonsensory structure that is essential for auditory hair cell function by maintaining potassium concentration of the scala media. (jneurosci.org)

Cell biology , the study of structures withing the cell itself (called organelles). (fact-archive.com)
NC cells contribute to several inner ear structures during embryonic development. (jneurosci.org)
We analyzed the morphological features of dying cells in the developing axial structures of 5 human embryos between 5 and 8 weeks of postovulatory age. (karger.com)
Cell death in the axial structures, i.e. spinal cord, notochord and surrounding mesenchyme and somites, was analyzed using light and electron microscopy. (karger.com)
Later, apoptotic death appeared in all the axial structures, with the exception of the notochord, where some dying cells displayed features of secondary necrosis. (karger.com)

These mechanisms underpin progression of stem cells across the in vitro pluripotency continuum and serve as a model for pre-, peri- and post-implantation embryogenesis. (bvsalud.org)

Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
We observed an almost universal loss of gene expression with age that is largely mimicked by parabiosis: aged blood reduces global gene expression, and young blood restores it in select cell types. (stanford.edu)

Click cells to view annotations. (jax.org)

Thus, human endocrine cells are not in direct contact with the vascular BM components but with the invaginated peri-islet membrane. (nature.com)
The Human Lung Cell Atlas: a high-resolution reference map of the human lung in health and disease. (nature.com)
Detection of Human Lung Epithelia Cell Growth Factors Produced by a Lung Carcinoma Cell Line: Use in Culture of Primary Solid Lung Tumors. (epa.gov)
Human Embryonic Palatal Mesenchyme Cell Growth Inhibitaion Assay (Draft) with Cover Letter dated 10/01/87. (epa.gov)
In previous work, human fetal intestinal cells developed epithelium without mesenchyme following implantation in mice. (ca.gov)
Immunofluorescence staining demonstrated human origin and the three differentiated cell types of mature colon epithelium. (ca.gov)
Hepatocytic maturation in iPS-HPCs was significantly increased in direct co-culture with iPS-HSCs overexpressing LHX2, but not in co-culture with a human hepatic stellate cell line (LX-2) overexpressing LHX2. (ca.gov)

β-Cells depend on the islet basement membrane (BM). (nature.com)
Like lipids, proteins are an important constituent of the cell membrane. (rincondelvago.com)

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. (stanford.edu)

Small amounts of carbohydrates also occur in cell membranes, but, in contrast to plants and many invertebrate animals, humans have little structural carbohydrate in their bodies. (rincondelvago.com)

Anatomy88

Organisms22

Diseases10

Chemicals and Drugs80

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes36

Disciplines and Occupations2

Information Science3

Epithelium and Mesenchyme1

Apoptosis5

Connective Tissue5

Stromal cells7

Epithelial cell4

Embryo6

Tissue18

Ectoderm6

Craniofacial2

Mesoderm2

Differentiation4

Populations11

Extracellular matrix2

Idiopathic pulmonar1

Proliferation6

Transition6

Progenitor cells2

Endothelial cells5

Primitive2

Amniotic1

Mesenchymal stem4

Homeobox2

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Cartilage1

Stem cell7

Melanocytes1

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Protein6

Organs5

Abnormal1

Regenerative1

Migration1

Pulmonary2

Surrounds2

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Interactions3

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Angiogenesis1

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Murine2

Separates1

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20191

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