Mesenchymal stroma. Medical search. Frequent questions

LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). (aacrjournals.org)
Here, we demonstrated that mesenchymal progenitor- or stromal fibroblast-specific deletion of Lkb1 results in fully penetrant polyposis in mice. (jci.org)
Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
The bone marrow niche includes cells belonging to the stroma, which includes mesenchymal stromal cells , adipocytes (fat cells), nerve cells, connective tissue cells, and cells involved in bone formation and remodeling. (medicalnewstoday.com)
Mesenchymal stromal cells can divide and differentiate into a number of cell types, including bone, cartilage, and adipocytes. (medicalnewstoday.com)
The present study found that aged mice showed a decrease in the population of mesenchymal stromal cells and osteoprogenitor cells that are involved in bone formation in the endosteum. (medicalnewstoday.com)
In contrast, there was an increase in the number of mesenchymal stromal cells in the central marrow of aged mice. (medicalnewstoday.com)
Although this stromal desmoplastic reaction has long been recognized as a hallmark histological feature the contribution of the mesenchymal compartment and desmoplastic stroma to tumour formation and progression has only recently been recognized. (sciencepop.org)
One type of stem cell is involved in producing blood cells and the other is involved in producing stromal cells, which are responsible for the supporting stroma. (medscape.com)
We have identified and isolated mesenchymal stromal cells and studied some of their functions. (lu.se)

In the 1970s, mesenchymal stem cells (MSCs) were discovered by A.J. Friedenstein. (wikipedia.org)
Mesenchymal stem cell research has yielded the most promising results for craniofacial regeneration, as MSCs can be found in many types of postnatal tissues, including orofacial tissues. (wikipedia.org)
How does osmotic modulation of the extracellular matrix affect the osteogenic differentiation of mesenchymal stroma cells (MSCs)? (charite.de)
On a cellular level, osmotic pressure influences cell fate decisions of mesenchymal stroma cells (MSCs). (charite.de)
Less quantity of transplanted mesenchymal stem cells (MSCs) influences the therapeutic effects on radiation-induced lung injury (RILI). (hindawi.com)
It has been observed that mesenchymal stem cells (MSCs) could home and engraft within the injured tissues and differentiate into vascular cells and alveolar cells to regenerate the damage in the irradiated mouse lung [ 10 ]. (hindawi.com)
To conclude tumour cell-derived EVs can donate to the era of tumour stroma through fibroblastic differentiation of MSCs and will also selectively modulate the mobile discharge of soluble elements such as for example IL-6 by MSCs that may subsequently alter tumour cell proliferation. (sciencepop.org)
Keywords: biliary tract tumor stem TCS PIM-1 1 cells exosomes gene appearance RNA genes paracrine signalling Bone tissue marrow-derived mesenchymal stem cells (MSCs) certainly are a potential way to obtain tissue replacement for TCS PIM-1 1 their regenerative capability and multipotent capacity. (sciencepop.org)
Inside the tumour microenvironment MSCs can differentiate into myofibroblasts cancer-associated fibroblasts fibrocytes or pericytes and thus represent a potential way to obtain tumour stroma and desmoplasia (4-6). (sciencepop.org)
A contribution of interactions between MSCs within tumour stroma and malignancy cells to tumour progression and metastases has been recognized (7-9). (sciencepop.org)

Microscopic examination revealed fibroblastic stroma with spindled mesenchymal cells and multinucleated osteoclast-like giant cells ( Figure 2 ). (pathologyoutlines.com)

Such stem cells include bone marrow mesenchymal stem cells (BMMSC), adipose-derived mesenchymal stem cells (AMCs), muscle satellite cells (MuSCs), periodontal ligament stem cells (PDLSCs), and stem cells from human exfoliated deciduous (SHED teeth). (wikipedia.org)
Adipose-derived mesenchymal stem cells differentiate into heterogeneous cancer-associated fibroblasts in a stroma-rich xenograft model. (go.jp)

Salama, M. E., W. S. Ibrahim, and D. A. Khairy, ' comparison of CD10 expression in stroma of epithelial and mesenchymal tumors of the breast ', global advanced research journal of medicine and medical sciences , vol. 4, issue 1, pp. 051-056, Submitted. (cu.edu.eg)
Both non-neoplastic meningothelial cells and meningiomas possess mixed features of epithelial and mesenchymal cells. (medscape.com)

After co-culture with tumour-associated pancreatic stellate cells (TPSCs), pancreatic cancer cells displayed up to 8-fold reduction in levels of epithelial-mesenchymal transition (EMT) markers E-cadherin and ZO-1, while β-catenin and vimentin levels were increased. (lu.se)
Collectively, the metabolic interplay between tumor cells and adipocytes induces adipocyte mesenchymal transition and contributes to reconfigure the stroma into a more tumor-friendly microenvironment. (usda.gov)
Upon the progression of carcinoma, changes in cell plasticity by the epithelial to mesenchymal transition (EMT) are of particular significance for local cell invasion, immune cell interactions, entry into vessels and chemoresistance. (meduniwien.ac.at)
We are also investigating the role of Gli2 in the canonical and non canonical Wnt signalling as well as the role of Gli2 in epithelial mesenchymal transition (EMT). (qmul.ac.uk)
Expression of PAX2/PAX8 in S-SCT may reflect an overactive epithelial-to-mesenchymal transition as has been shown in experimental models of acute and chronic seminiferous tubular injury and might be related to the process generating the stroma in these tumors. (nih.gov)
Microglia cells have been implicated to play an important role in the tumor microenvironment, and we found spatial co-localization of microglia and epithelial-to-mesenchymal transition (EMT) signatures in our patient cohort. (kth.se)
Current interest in this process, which is described as an epithelial-mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. (rupress.org)
The EMT International Association was formed in 2002 to provide an international body for those interested in EMT and the reverse process, mesenchymal-epithelial transition, and, most importantly, to bring together those working on EMT in development, cancer, fibrosis, and pathology. (rupress.org)
Bioincompatible dialysis fluid causes mesothelial cells to undergo uncontrolled mesothelial-to-mesenchymal transition triggered by Transforming growth factor-Î²1, which leads morphological and functional disruption of membrane. (ukessays.com)
This literature review is about mechanism of mesothelial -mesenchymal transition (MMT), myofibroblasts and its origin hypothesis, clock genes and their cross relation with organ fibrosis. (ukessays.com)

Osteosarcoma is an aggressive malignancy of mesenchymal origin, characterized by irregular immature bone formation, osteoid matrix production and malignant spindle cell stroma. (bvsalud.org)
DSRCT is composed of small cells with round hyperchromatic nuclei and a dense fibrous or spindle cell stroma. (medscape.com)

The process of regeneration is initiated by an inflammatory response to injury, followed by angiogenesis, leading to mesenchymal stem cell (MSC) differentiation. (wikipedia.org)
Finally, a new class was defined called carcinoma with pleomorphic, sarcomatoid, or sarcomatous elements, which brings together a number of proliferations characterized by a spectrum of epithelial to mesenchymal differentiation. (ersjournals.com)

Histologically, central giant cell granulomas are characterized by spindle cells within fibrous stroma, with numerous multinucleated giant cells in a patchy distribution, usually near areas of hemorrhage. (pathologyoutlines.com)
These tumours are characterized by tumour cells closely intertwined with a dense fibrous stroma (16-19). (sciencepop.org)

Firstly, we could confirm that transforming growth factor β1 (TGFβ1) secreted from breast tumor cells is a paracrine mediator of tumor-stroma interaction leading to the activation of autophagy in the stroma component fibroblasts. (nature.com)
Retrieval of individual tumor cells from the microfluidic system and their subsequent genomic analysis was possible, allowing us to determine the nature of the factor mediating tumor-stroma interactions. (nature.com)
However, to the best of our knowledge, single-cell-based techniques have been rarely used for studying the interactions of tumor cells with tissues surrounding them, i.e., the stroma. (nature.com)
In this study, MDA-MB-231 (MDA) triple-negative breast carcinoma cells were used as a tumor cell model and mouse fibroblasts expressing an autophagy marker protein called GFP-LC3, were used as a stroma model. (nature.com)
Compared with follicular epithelial cells, there are a few morphological studies on the stroma of human thyroid gland. (nih.gov)
Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
Ovarian mesenchymal cells (oMCs) constitute a distinct microenvironment that supports folliculogenesis under physiological conditions. (sens.org)
Supplementation of exogenous non-ovarian mesenchymal-related cells has been reported to be an efficient approach to improve ovarian functions. (sens.org)
These cells could differentiate into various odMCs via an oMP-derived route to construct the ovarian stroma structures. (sens.org)
We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)
The tissue was composed of cells containing elongated nucleus, with discrete pleomorphism and rare stroma. (vin.com)
To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)
However, limited information is currently available regarding the effects of Cimicifugae Rhizoma on dental tissue, including mesenchymal stem cells derived from gingiva. (spandidos-publications.com)
In particular the TCS PIM-1 1 source of tumour stroma and the nature of the connections between tumour cells and stroma are unidentified. (sciencepop.org)
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
Cell culture media notably influence properties of human mesenchymal stroma/stem-like cells from different tissues. (bvsalud.org)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
The bone marrow stroma contains mesenchymal stem cells. (medscape.com)
The stroma is not directly involved in the primary function of hematopoiesis, but it provides the microenvironment and colony-stimulating factors needed to facilitate hematopoiesis by the parenchymal cells. (medscape.com)
The applicant is responsible for a brain tumor tissue biobank which provides the basis for the studies on human GBM tumor cells and stroma. (lu.se)
SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)

A crucial role for cancer-associated fibroblasts and activated macrophages in these cancers is emerging (17 18 20 Despite this recent interest the cellular origins and mechanistic contribution of tumour stroma to tumour growth TCS PIM-1 1 remain poorly comprehended. (sciencepop.org)

Furthermore, we found homogenous and recurrent iCNV profiles in the high-grade tumors of relapse patients and identified expression of gene SPP1 in the tumor stroma as a potential prognostic mRNA marker in pediatric brain tumor relapse patients. (kth.se)

In the present study, we conducted overexpressing CXCR4 human umbilical cord mesenchymal stem cell (HUMSC) therapy for RILI. (hindawi.com)

One major research line is to clarify changes in the glioblastoma (GBM) stroma between primary surgery and tumor recurrence. (lu.se)

Our results showed that the oMCs were composed of five ovarian differentiated MC (odMC) populations and one ovarian mesenchymal progenitor (oMP) cell population. (sens.org)

In the histopathologic exam, it was observed the presence of exuberant production of mesenchymal tissue, showing multiples cellular bundles randomly. (vin.com)

In early experiments, physical separation of mesenchymal and epithelial stroma from embryonic murine thymus resulted in defective thymus development when epithelium was cultured in vitro in the absence of mesenchyme ( 7 ). (frontiersin.org)
In Basal Cell Carcinoma we are investigating the role of paracrine Hedgehog (HH) signalling between the stroma and epithelium and the role of oncogene induced senescence (OIS). (qmul.ac.uk)

Therefore, our microfluidic platform might be used as a promising tool for quantitative investigation of tumor-stroma interactions, especially for and high-throughput screening of paracrine factors that are secreted from heterogeneous tumor cell populations. (nature.com)
In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)

Mucinous cystic neoplasms are known to harbor ovarian-like mesenchymal stroma (OLS) expressing progesterone and estrogen receptors. (elsevierpure.com)

H-scores of cytochrome P450 17α-hydroxylase/c17-20 lyase (P450c17) and 5α-reductase-1 (5αRED-1) in the stroma were significantly higher in OLS of hepatic and pancreatic MCN than in the stroma of ovarian MCN and normal ovary. (elsevierpure.com)

Hence our aims had been to examine the consequences of tumour cell-MSC connections regarding EVs and their contribution to tumour stroma development and tumour development. (sciencepop.org)

Pancreatic cancer is associated with a highly abundant stroma and low-grade inflammation. (lu.se)

It represents a highly ordered stroma, with potential structural and functional similarities to the stroma of bone marrow (Yamazaki and Allen, 1990). (nih.gov)

In this study, we designed a biochip system that allows the time-course measurement of cancer cell-stroma interactions at a single-cell level. (nature.com)

The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. (rupress.org)

Mesenchymal loss of Lkb1 is sufficient to drive fully penetrant PJS polyposis in mice. (jci.org)

Müllerian adenosarcoma (MA) is a rare mixed and low malignant tumor of female genital system, and is a biphasic differential tumor that is composed of admixed benign epithelial and sarcomatoid mesenchymal components. (scirp.org)

Anatomy1

Diseases1

Stromal12

MSCs10

Spindled mesenchymal cells1

Adipose-derived mesenchymal stem2

Epithelial and mesenchymal2

Transition10

Spindle cell stroma2

Differentiation2

Fibrous stroma2

Cells22

Fibroblasts1

Tumors1

Stem cell1

Glioblastoma1

Progenitor1

Tissue1

Epithelium2

Populations2

Neoplasms1

Ovarian1

Tumour1

Pancreatic1

Functional1

Interactions1

Structural1

Mice1

Rare1