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Multipotent Stem CellsCell DifferentiationStem CellsMesenchymal Stromal CellsMesenchymal Stem Cell TransplantationAdult Stem CellsStem Cell TransplantationCell LineageHematopoietic Stem CellsCells, CulturedBone Marrow CellsEmbryonic Stem CellsPluripotent Stem CellsCell ProliferationOsteogenesisChondrogenesisStem Cell NicheCell Culture TechniquesNeural Stem CellsNeural CrestHematopoietic Stem Cell TransplantationInduced Pluripotent Stem CellsFlow CytometryNeoplastic Stem CellsRegenerationCell SeparationStem Cell FactorFetal Stem CellsTissue EngineeringPlant StemsImmunohistochemistryRegenerative MedicineNeuronsNeurogliaMice, Inbred C57BLAdipogenesisStem Cell ResearchCell- and Tissue-Based TherapyCoculture TechniquesHematopoiesisSignal TransductionNestinOctamer Transcription Factor-3Colony-Forming Units AssayAntigens, CD34Tissue ScaffoldsReverse Transcriptase Polymerase Chain ReactionMice, SCIDCell SurvivalCell ShapeBiological MarkersMice, TransgenicUmbilical CordCell MovementHair FollicleSOXB1 Transcription FactorsPhenotypeGene Expression Regulation, DevelopmentalStromal CellsGene Expression RegulationGene Expression ProfilingCell LineFetal BloodEmbryo, MammalianSpermatogoniaOsteoblastsHematopoietic Stem Cell MobilizationGreen Fluorescent ProteinsCell TransplantationCell DivisionAntigens, CDMesodermCulture Media, ConditionedTransplantation, HomologousModels, BiologicalTotipotent Stem CellsImmunophenotypingCell DedifferentiationProto-Oncogene Proteins c-kitHomeodomain ProteinsClone CellsTranscription FactorsGerm CellsTransplantation, HeterologousBone MarrowCellular MicroenvironmentGene ExpressionTime FactorsAdipocytesCell CountMice, Inbred NODImmunomodulationTransplantation, AutologousCell TrackingBone Marrow TransplantationIntermediate Filament ProteinsSpheroids, CellularAlkaline PhosphataseAdipose TissueBone Regeneration
MSCsProgenitor cellsUmbilical cordProliferationTissuesTissueRegenerativeTherapeuticDifferentiation potentialIsolationAutologous mesenchymalStromal stem cellsEndothelial CellsTransplantationAdipocytesEmbryonic stem2022OsteoblastsPluripotentSelf-renewalFetalMarrowPrecursor cellsRegenerationMononuclearVitroOsteoarthritisAdult stemPhenotypeTherapyBiologyPlacentaFibroblastsFactorsHumanHeterogeneityIsolateExtracellular vesiclesExosomesAmniotic fluidDiseasesTypes of stem cellsAntigen-preseExperimentalMigrationLund Stem Cell Center
MSCs41
  • OBJECTIVE: This study was undertaken to isolate and characterize multipotent mesenchymal stem cells from term human placenta (placenta-derived mesenchymal stem cells, PD-MSCs). (uzh.ch)
  • Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (wikipedia.org)
  • While the terms mesenchymal stem cell (MSC) and marrow stromal cell have been used interchangeably for many years, neither term is sufficiently descriptive: Mesenchyme is embryonic connective tissue that is derived from the mesoderm and that differentiates into hematopoietic and connective tissue, whereas MSCs do not differentiate into hematopoietic cells. (wikipedia.org)
  • Mesenchymal stem cells (MSCs), a term first coined by Arnold I. Caplan in 1991, are characterized morphologically by a small cell body with a few cell processes that are long and thin. (wikipedia.org)
  • However, MSCs are found in much higher concentration in the Wharton's jelly compared to cord blood, which is a rich source of hematopoietic stem cells. (wikipedia.org)
  • These cells have several advantages over bone-marrow-derived MSCs. (wikipedia.org)
  • MSCs have been seen to even differentiate into neuron-like cells, but doubt remains about whether the MSC-derived neurons are functional. (wikipedia.org)
  • While multipotent mesenchymal stromal cells have been recently isolated from adult lung (L-MSCs), there is very limited data on their biological properties and therapeutic potential in vivo. (nih.gov)
  • Over the last decades, mesenchymal stem cells (MSCs) have attracted extensive attention in the field of bone regeneration [ 4 - 7 ]. (hindawi.com)
  • MSCs are a population of nonhematopoietic adult stem cells that have the property of self-renewal and can differentiate into multiple lineages [ 8 - 10 ]. (hindawi.com)
  • Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
  • Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
  • Mesenchymal stem cells (MSCs) are multipotent cells with regenerative and immunomodulatory properties. (frontiersin.org)
  • Overall, the results presented in this study show a common mechanism of endocytosis for MSC EVs across different cell types and the feasibility to generate functionally enhanced EVs by modifications to parental MSCs. (frontiersin.org)
  • Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating in specific directions. (wjgnet.com)
  • It is usually considered that the differentiation process of MSCs depends on specialized external stimulating factors, including cell signaling pathways, cytokines, and other physical stimuli. (wjgnet.com)
  • Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
  • MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. (techscience.com)
  • Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of self-renewal and exhibit multilineage differentiation properties. (techscience.com)
  • The Mesenchymal and Tissue Stem Cell Committee, which belongs to the International Society for Cellular Therapy, stated that plastic-adherent properties are the minimum criteria for determining MSCs. (techscience.com)
  • The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)
  • Mesenchymal stem cells (MSCs) have been widely tested for treating a variety of refectory medical indications such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease due to their multiple differentiation potentials and immunomodulation capability [1-5]. (researchsquare.com)
  • Over the past few years, MSCs researches have achieved some inspiring results and some of which moved up to clinic period from preclinical phases, resulting in the marketing approval of a few cell-based therapy products (CTPs) by different national regulatory authorities [18]. (researchsquare.com)
  • We established a Good Manufacturing Practice (GMP) grade cell facility to produce clinic-grade human umbilical cord derived MSCs (HUCMSCs) for treating premature ovarian failure (POF) and recurrent uterine adhesion [18, 20]. (researchsquare.com)
  • Multipotent stem cells of both tissues - hematopoietic stem cells (HSCs) for blood and mesenchymal stem/stromal (MSCs) for bone - are the basis for their regenerative capacity. (europa.eu)
  • Mesenchymal stem cells (MSCs) are multi-potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. (harvard.edu)
  • Moreover, while β-catenin itself (T41A mutant resistant to cytosolic turnover) accumulated in the nuclei of wild-type MSCs, it was unable to do so in MSCKO cells. (harvard.edu)
  • In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
  • Mesenchymal stromal cells (MSCs) are cells of non-haematopoietic origin, with the capacity to differentiate into multiple lineages of the mesenchyme, that is, chondrocytes, osteoblasts and adipocytes. (bmj.com)
  • 1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
  • 2 MSCs were first described in the bone marrow where they constitute a small fraction of cells (0.001%-0.01%) that closely interact with haematopoietic cells to support haematopoiesis and skeletal homeostasis. (bmj.com)
  • 3 4 Since then, it has become evident that MSCs reside in many tissues, including mesenchymal tissues (bone, adipose tissue, connective tissue), umbilical cord and several organs including the liver, spleen and lung. (bmj.com)
  • Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)
  • MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
  • The present study had aimed to evaluate the effect of a feeder layer of irradiated MSCs in the in vitro expansion of NK cells. (springer.com)
  • MSCs were obtained from the bone marrow (BM) cells remaining in the bag and filter used in the transplantation of hematopoietic stem cells. (springer.com)
  • NK expansion and activation were stimulated by culture with artificial antigen-presenting cells (aAPCs) and IL-2, in the presence or absence of BM-MSCs. (springer.com)
  • Mesenchymal stem cells (MSCs) are "adult" or tissue-resident stem cells. (rvc.ac.uk)
  • Mesenchymal stem cells (MSCs) have the ability to modulate the immune system and are multipotent, which allow these adult stem cells to be valuable therapeutic candidates. (irvinesci.com)
  • 6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)
  • The clinic uses MSCs or Mesenchymal Stem Cells from neonatal sources like Placenta that includes a heterogeneous population of multipotent progenitor cells that are inclusive of biological properties making them perfect for cell therapy. (placidway.com)
Progenitor cells11
  • However, it can be challenging to differentiate when they are connected with wounded tissue, opposed to when they instruct tissue-specific progenitor cells responsible for the redevelopment of damaged tissue. (techscience.com)
  • The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
  • Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
  • Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
  • Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
  • Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
  • Intradermal adipocyte progenitor cells are activated toward the end of the telogen phase to proliferate and differentiate into mature adipocytes. (jcadonline.com)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • This process relies on the formation of a blastema, a pool of progenitor cells that is formed in response to amputation. (lu.se)
Umbilical cord9
Proliferation10
  • Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
  • Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
  • Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
  • The morphology of the cells was viewed under an inverted microscope and the analysis of cell proliferation was performed using a Cell Counting kit‑8 (CCK‑8) assay on days 1, 3, 5 and 7. (spandidos-publications.com)
  • NK cell proliferation, phenotypic expression and cytotoxic activity were evaluated. (springer.com)
  • Angiogenesis is important for the proliferation and survival of multiple myeloma (MM) cells. (koreamed.org)
  • Among their other immunological properties, MSC inhibit lymphocyte proliferation and cytokine production, suppress dendritic cell function and alter DC cytokine production, and decrease IFN-g production by NK cells. (vin.com)
  • We monitored these cells during their expansion ex vivo with respect to proliferation kinetics, surface marker profile and differentiation potential. (biomedcentral.com)
  • Materials and method: The pulp tissue, obtained from wisdom teeth, was placed in a 6-well plate containing proper culture medium, and stored at 37 °C and 5% CO2 for cell proliferation and plastic adherence. (bvsalud.org)
  • Conclusion: Our results suggest that the explant method - or cell proliferation method - is suitable for the isolation and culture of stem cells from dental pulp of permanent teeth. (bvsalud.org)
Tissues10
  • Cell-based therapy using systemic infusion of GMSC in experimental colitis significantly ameliorated both clinical and histopathological severity of the colonic inflammation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and suppressed the overall disease activity in mice. (ca.gov)
  • Human mesenchymal stem cells (HMSCs) are multipotent somatic stem cells that can be isolated from a variety of tissues such as the bone marrow, adipose tissue, and dental pulp. (frontiersin.org)
  • Within the limits of this study, Cimicifugae Rhizoma influenced the viability of stem cells derived from the gingiva, and its direct application onto oral tissues may have adverse effects at high concentrations. (spandidos-publications.com)
  • Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)
  • Recent years have brought increased interest in the potential for adult stem cells to help in the treatment of many diseases through both their regenerative properties as well as their apparent ability to alter the environment in injured and diseased tissues. (vin.com)
  • Adult stem cells can be obtained from many differentiated tissues including but not limited to bone marrow, bone, fat, and muscle. (vin.com)
  • It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)
  • Over the last years, dentistry has been exploring the potential application of stem cells from different origins in the regeneration of oral tissues that were lost or damaged by disease or trauma 1 . (bvsalud.org)
  • When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
Tissue25
  • Stromal cells are connective tissue cells that form the supportive structure in which the functional cells of the tissue reside. (wikipedia.org)
  • By examining the process of stem cells turning into cells in bones, heart muscle, nerves, and other organs and tissue, researchers can better understand how diseases and conditions develop. (globenewswire.com)
  • Stem cells have the potential to be grown to become new tissue for use in transplant and regenerative medicine. (globenewswire.com)
  • New areas of study include the effectiveness of using human stem cells that have been programmed into tissue-specific cells to test new drugs. (globenewswire.com)
  • Cell and tissue banking applications will account for the leading share of the market by 2020. (globenewswire.com)
  • Among these, adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cell isolated from adipose tissue, which has the advantages of abundant storage in vivo , easy acquisition, and expansion [ 13 - 15 ]. (hindawi.com)
  • Recently, a number of studies have confirmed that ADSCs possess the ability to differentiate into adipocytes, osteoblasts, and chondrocytes [ 16 - 18 ], suggesting that a broader source of stem cells is available for application in tissue engineering. (hindawi.com)
  • Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
  • We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)
  • Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)
  • Enhanced expression of IL-6, IGF-1, TGF-β, and VEGF has also been observed in LC treated BMSCc+ groups, suggested the cardiac differentiation of BMSCc+, and can be utilized in tissue engineering for cardiac cell therapy. (techscience.com)
  • Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
  • Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • However, limited information is currently available regarding the effects of Cimicifugae Rhizoma on dental tissue, including mesenchymal stem cells derived from gingiva. (spandidos-publications.com)
  • PURPOSE: Fluorodeoxyglucose (FDG) uptake of bone marrow (BM) and adipose tissue is known to reflect systemic inflammatory response to cancer cell. (koreamed.org)
  • Harvest cells by massaging the cord tissue. (irvinesci.com)
  • Mesenchymal stem cells are multipotent but not pluripotent, which means they can differentiate into some, or "multiple," but not all tissue types. (vin.com)
  • The results of this study are expected not only to increase the tissue-selective anti-inflammatory effects of mesenchymal stem cells, but also to lead to tissue regenerative medicine in the future. (nii.ac.jp)
  • Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
  • Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
  • One great advantage of MSC is that these cells may be directly obtained from individual patients, thereby eliminating the complications associated with immune rejection of allogenic tissue and infectious diseases. (biomedcentral.com)
  • The isolated cells may be considered stem cells, based on the current criteria for their characterization, such as plastic adherence, expression of certain markers, and the absence of others, as well as multi-differentiation potential, which showed to be promising for the application in tissue regeneration. (bvsalud.org)
  • Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
  • There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
  • A fraction of ADIPOSE TISSUE prepared to enrich in STEM CELLS with the capacity for multi-lineage differentiation. (bvsalud.org)
Regenerative8
  • A comparative analysis of single-cell RNA sequencing data collected from three HUCMSCs and two human umbilical vein endothelial cell (HUVEC) controls identified eight common cell clusters, all of which indicated regenerative potential specific for HUCMSCs. (nature.com)
  • The demand for stem cell manufacturing has also been rising as stem cells are being used to generate healthy cells and replace diseased cells or in the development of regenerative medicine. (globenewswire.com)
  • Researchers continue to advance knowledge on stem cells and their applications in transplant and regenerative medicine. (globenewswire.com)
  • The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
  • Therefore, research on exosomes produced by MSC has been intensified for use in cell-free regenerative medicine. (frontiersin.org)
  • Although MSC EVs show great promise for regenerative medicine applications, insights into their uptake mechanisms by different target cells and the ability to control MSC EV properties for defined function in vivo have remained elusive knowledge gaps. (frontiersin.org)
  • Kim and Park, 2017 ) and make HMSCs attractive cells for regenerative therapies. (frontiersin.org)
  • Whilst we still don't completely understand the underlying mechanisms, current research suggests that the beneficial effects of stem cell therapy are more likely to be derived from their immunomodulatory properties, rather than being truly regenerative, however some degree of regeneration has been shown in some research. (rvc.ac.uk)
Therapeutic8
  • Progressing a cell-based therapeutic from pre-clinical stage production through later clinical stages and into commercial production requires scale-up, which is one of the chief drivers for the stem cell manufacturing market growth. (globenewswire.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
  • Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
  • BACKGROUND AND OBJECTIVES: Most studies in cardiac regeneration have explored bone marrow mesenchymal stem cells (BM-MSC) with variable therapeutic effects. (koreamed.org)
  • In cell therapy, in vivo kinetic control of the therapeutic cells, such as accumulation of the cells at the target site of therapy and enhancement of their interaction with the target cells, may lead to improved therapeutic efficacy. (nii.ac.jp)
  • With a variety of assays we could show that MSC represent a cell population which can be expanded for therapeutic applications. (biomedcentral.com)
  • In recent years mesenchymal stem cells (MSC) have generated a great deal of interest as a potential source for cell-based therapeutic strategies. (biomedcentral.com)
Differentiation potential3
  • However, mutating K49R or K345R in β-catenin to mimic deacetylation restored nuclear localization and differentiation potential in MSCKO cells. (harvard.edu)
  • Mesenchymal stem cells have anti-inflammatory, immunomodulatory, and multipotent differentiation potential, but disappear from the body relatively quickly after intravenous administration. (nii.ac.jp)
  • In addition, cells were assessed for multi-differentiation potential. (bvsalud.org)
Isolation3
  • Embryonic stem cells isolation primarily requires the consent of donors and can include the killing of fertilized eggs. (techscience.com)
  • Isolation, expansion, and characterization of natural killer cells and their precursors as a tool to study cancer immunosurveillance. (springer.com)
  • fication and isolation via fluorescence-activated cell sort- ing (FACS). (lu.se)
Autologous mesenchymal2
  • Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
  • At the RVC Stem Cell Centre, we prepare autologous mesenchymal stem cells in our Veterinary Medicines Directorate-licenced laboratory and under the same quality control as for horse stem cells. (rvc.ac.uk)
Stromal stem cells1
Endothelial Cells4
  • They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)
  • 2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
  • Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. (lww.com)
  • 1 If the number of corneal endothelial cells (CECs) falls below a certain threshold because of traumatic injury, disease, or normal aging processes, functionality of the CE is decreased, and the cornea swells and becomes milky, leading to eventual vision loss. (lww.com)
Transplantation3
Adipocytes4
Embryonic stem1
20221
Osteoblasts4
Pluripotent2
  • While they are described as multipotent, it is possible that they are pluripotent. (wikipedia.org)
  • As many as 1 in 100 cells collected during amniocentesis are pluripotent mesenchymal stem cells. (wikipedia.org)
Self-renewal3
  • Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
  • A stem cell is a generic term referring to any unspecialized cell that is capable of long-term self-renewal through cell division but that can be induced to differentiate into a specialized, functional cell. (vin.com)
  • Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)
Fetal1
  • Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
Marrow20
  • These bone marrow stem cells do not contribute to the formation of blood cells, and so do not express the hematopoietic stem cell marker CD34. (wikipedia.org)
  • The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
  • These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
  • The term "transitional" emphasizes the unique feature of these cells that are particularly abundant in the young bone marrow. (nature.com)
  • MSC mediated bone formation involves in both donor and recipient cells, but only recipient cells contribute to marrow element formation. (ca.gov)
  • The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
  • Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
  • Previously my team and I developed a simplified bone marrow analog that bases on macroporous, cell-laden biomaterials with tunable physical, biochemical and biological properties. (europa.eu)
  • These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
  • We studied young and aged male inbred Lewis rats that were used as donors of bone marrow mononuclear cells (BM-MNCs), divided in four experimental groups: controls, sham operated, 48 h post-myocardial infarction (MI), and 28 days post-MI. (bvsalud.org)
  • Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)
  • However, the yellow marrow can revert to red if there is increased demand for red blood cells, such as in instances of blood loss. (medscape.com)
  • Normally, only mature cells are released from the marrow into the bloodstream. (medscape.com)
  • These stem cells divide to eventually give rise to red blood cells, platelets, and most white blood cells in the red marrow. (medscape.com)
  • Bone marrow thus contains blood cells at varying stages of development. (medscape.com)
  • Illustration of the pelvis to show the site of bone marrow and blood cells derived from bone marrow. (medscape.com)
  • Similarly, the bone marrow produces and releases more white blood cells in response to infections, and it produces and releases more platelets in response to bleeding. (medscape.com)
  • As age progresses, more of the red bone marrow turns into yellow bone marrow and the production of new blood cells becomes more difficult. (medscape.com)
  • The bone marrow stroma contains mesenchymal stem cells. (medscape.com)
  • The blood vessels constitute a barrier, inhibiting immature blood cells from leaving the bone marrow. (medscape.com)
Precursor cells1
  • Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
Regeneration2
  • The properties of HUCMSCs were validated by untargeted label-free quantitation of the cell and CM proteome, suggesting increased activity of regeneration, autophagy and anti-inflammation pathways and mitochondrial function. (nature.com)
  • This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
Mononuclear2
  • Isolate mononuclear cells (MNCs) by density gradient centrifugation at 400xg for 30 minutes at room temperature using Ficoll-Paque™ Premium according to the manufacturer's instructions. (irvinesci.com)
  • A study found that the 3 leading cell type therapies used to treat COVID-19 were mesenchymal stem cells or multipotent stromal cells, natural killer cells, and mononuclear cells. (drugtopics.com)
Vitro5
  • These cells could be differentiated toward mesodermal lineage in vitro up to passage 20. (uzh.ch)
  • These stem cells are capable of differentiating into chondrocytes, cardiomyocytes, melanocytes, and hepatocyte‐like cells in vitro. (wikipedia.org)
  • 2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)
  • In this review, we discuss the rationale for MSC-based cell therapy in COPD, the main findings from in vitro and in vivo preclinical COPD model studies, clinical trials in patients with COPD and directions for further research. (bmj.com)
  • Mesenchymal stem cells clearly modulate immune responses, as demonstrated by both in vitro and in vivo studies. (vin.com)
Osteoarthritis3
  • Injecting stem cells into joints can reduce pain and increase limb function in dogs with osteoarthritis and degenerative joint disease. (rvc.ac.uk)
  • Technology insight: adult mesenchymal stem cells for osteoarthritis therapy. (stemcellclinicsofamerica.net)
  • Stem Cell Therapy for Osteoarthritis is quite a popular orthopedic procedure in Los Algodones, Mexic. (placidway.com)
Adult stem2
Phenotype2
  • Flow cytometry and immunocytochemistry confirmed the mesenchymal stem cell phenotype. (uzh.ch)
  • Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). (cancerindex.org)
Therapy17
  • Technological advancements in cell therapy and an increased emphasis on the development of personalized medicines are further contributing to market growth. (globenewswire.com)
  • However, the standardization of the manufacturing process of MSC-based cell therapy medicinal products in compliance with the requirements of the local authorities is obligatory and will allow us to obtain the necessary permits for product administration according to its intended use. (mdpi.com)
  • Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease? (bmj.com)
  • Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
  • Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
  • Understanding of molecular mechanisms in natural killer cell therapy. (springer.com)
  • 2014). Human NK cells: From surface receptors to the therapy of leukemias and solid tumors. (springer.com)
  • What are stem cells and how does stem cell therapy work? (rvc.ac.uk)
  • What is the difference between stem cell therapy and platelet rich plasma (PRP)? (rvc.ac.uk)
  • PRP is very quick and simple to prepare and therefore cheaper than stem cell therapy, however due to a lack of large studies published it is hard to say how effective PRP is, and it can vary in quality depending on how it is prepared. (rvc.ac.uk)
  • Are there any negative side effects or risks associated with canine stem cell therapy? (rvc.ac.uk)
  • Stem cell therapy in particular is an innovative new field of scientific investigation and clinical application that holds promise for a variety of diseases in veterinary medicine as well as human medicine. (vin.com)
  • In addition, it is also important to keep the immune modulatory properties of MSC in mind when interpreting the results of many stem cell therapy studies. (vin.com)
  • Mora MV, Ibán MAR, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. (wjgnet.com)
  • For more information on Stem Cell Therapy for Anti Aging Solutions at PRMEIDICA in Cabo San Lucas, Mexico, click the button below! (placidway.com)
  • Learn more information about stem cell therapy you can in the appropriate section of our portal. (stemcellrussia.com)
Biology4
  • To understand the etiology of osteopetrosis, it is very essential to understand the bone-remodeling cycle and the cell biology of osteoclasts. (medscape.com)
  • In 1999, Baron clearly and concisely reviewed the cell biology of the bone remodeling. (medscape.com)
  • International Journal of Biochemistry & Cell Biology, 40 , 2335-2340. (springer.com)
  • Natural killer cell biology: An update and future directions. (springer.com)
Placenta6
  • CONCLUSION: Term placenta constitutes a rich, very reliable source of maternal mesenchymal stem cells that remain differentiable, even at high passage numbers. (uzh.ch)
  • Placenta also exerts excellent effects on immune responses as it interacts with both adaptive and innate immune cells. (placidway.com)
  • Thus, by using Placenta Stem Cell Treatments, PRMEDICA successfully treats several diseases and achieve a high level of success. (placidway.com)
  • Which Diseases can be Treated with Placenta Stem Cells? (placidway.com)
  • What are the Benefits of Placenta Stem Cells? (placidway.com)
  • What is the Cost of Placenta Stem Cell Treatment at PRMEDICA, Cabo San Lucas, Mexico? (placidway.com)
Fibroblasts1
Factors5
  • Major factors driving market revenue growth include increasing use of stem cells to treat various diseases, rising stem cell-based research activities, and growing funding from private and public organizations for stem cell-based research. (globenewswire.com)
  • Factors, such as the unavailability of FDA-approved stem cell treatment products, risks related to unproven stem cell treatments, and lack of government regulations in underdeveloped countries, are expected to restrain market growth. (globenewswire.com)
  • Zhou JQ, Wan HY, Wang ZX, Jiang N. Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells. (wjgnet.com)
  • The stroma is not directly involved in the primary function of hematopoiesis, but it provides the microenvironment and colony-stimulating factors needed to facilitate hematopoiesis by the parenchymal cells. (medscape.com)
  • Our objective is to identify the cells and factors that are essential in the engineering process. (lu.se)
Human10
  • This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
  • The present study was performed to evaluate the extracts of Cimicifugae Rhizoma on the morphology and viability of human stem cells derived from gingiva. (spandidos-publications.com)
  • The aim of the present study was to evaluate the effects of extracts of Cimicifugae Rhizoma on the morphology and viability of human stem cells derived from gingiva. (spandidos-publications.com)
  • Gimble, J.M., Bunnell, B.A. and Guilak, F. (2012) Human Adipose-Derived Cells: An Update on the Transition to Clinical Translation. (scirp.org)
  • Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells. (lww.com)
  • 2 Despite having high metabolic activity, human CECs (hCECs) do not proliferate in vivo because these cells arrest in the G1 phase of the cell cycle. (lww.com)
  • Effects of a tetramethoxyhydroxyflavone p7f on the expression of inflammatory mediators in LPS-treated human synovial fibroblast and macrophage cells. (stemcellclinicsofamerica.net)
  • In this study we asked if human MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if cultivation conditions exert any influence on their stem cell maintenance. (biomedcentral.com)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
Heterogeneity1
  • Hart, D.A. (2014) Why Mesenchymal Stem Cell/Progenitor Cell Heterogeneity in Specific Environments? (scirp.org)
Isolate1
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
Extracellular vesicles2
  • The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from evaginations of the plasma membrane. (frontiersin.org)
  • The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)
Exosomes1
  • By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
Amniotic fluid1
Diseases4
  • The stem cell manufacturing market has been driven by growing need to understand how diseases occur. (globenewswire.com)
  • GMSC can function as an immunomodulatory and anti-inflammatory component of the immune system in vivo and is a promising cell source for cell-based treatment in experimental inflammatory diseases. (ca.gov)
  • Multipotent mesenchymal stromal cells in articular diseases. (stemcellclinicsofamerica.net)
  • These protocols rely on the quality of stem cells used to treat different types of diseases at PRMEDICA in Cabo San Lucas, Mexico. (placidway.com)
Types of stem cells1
  • Before using investigational drugs in people, researchers use some types of stem cells to test the drugs for safety and quality. (globenewswire.com)
Antigen-prese1
  • For example, MSC are poor antigen presenting cells and do not express MHC class II or co-stimulatory molecules and only low levels of MHC class I molecules. (vin.com)
Experimental1
  • Percentage of CD34+/CD45+(low) cells was similar among different experimental groups in young rats, but was significantly higher in aged animals (p (bvsalud.org)
Migration1
  • This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (cancerindex.org)
Lund Stem Cell Center1
  • This is a tool to help students find the right project for their Bachelor's and Master's thesis at Lund Stem Cell Center. (lu.se)