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Mesenchymal Stem Cell TransplantationMesenchymal Stromal CellsCell DifferentiationStem CellsCells, CulturedOsteogenesisBone Marrow CellsCell ProliferationChondrogenesisCell LineageAdipogenesisAdult Stem CellsHematopoietic Stem CellsStem Cell TransplantationTissue EngineeringMultipotent Stem CellsCell Culture TechniquesOsteoblastsSignal TransductionGene Expression RegulationTissue ScaffoldsPluripotent Stem CellsCoculture TechniquesNeoplastic Stem CellsCell LineFlow CytometryGene Expression Regulation, DevelopmentalPlant StemsReverse Transcriptase Polymerase Chain ReactionTranscription FactorsMice, Inbred C57BLRegenerationNeural Stem CellsUmbilical CordAdipocytesAlkaline PhosphataseRNA, MessengerCell SeparationEmbryonic Stem CellsStem Cell NicheFetal Stem CellsBone Morphogenetic Protein 2ImmunohistochemistryCell ShapePhenotypeCell DivisionChondrocytesCell SurvivalInduced Pluripotent Stem CellsGene ExpressionCell- and Tissue-Based TherapyRegenerative MedicineCore Binding Factor Alpha 1 SubunitSex DifferentiationMesodermCulture Media, ConditionedGene Expression ProfilingCell MovementBone RegenerationTretinoinTime FactorsBiological MarkersAntigens, DifferentiationHomeodomain ProteinsMice, TransgenicMolecular Sequence DataHematopoietic Stem Cell TransplantationBase SequenceBlotting, WesternCell TrackingNeuronsMice, KnockoutDNA-Binding ProteinsAdipose TissueBone Morphogenetic ProteinsApoptosisOsteocytesParacrine CommunicationImmunomodulationFetal BloodImmunophenotypingMuscle DevelopmentBiocompatible MaterialsStromal CellsEmbryo, MammalianModels, BiologicalUp-RegulationCalcification, PhysiologicOsteocalcinCell AdhesionTransfectionMice, SCIDCartilageAntigens, CDDisease Models, AnimalCell TransdifferentiationDown-RegulationOctamer Transcription Factor-3Real-Time Polymerase Chain ReactionSOX9 Transcription Factor
MSCsChondrogenic differentiationProgenitor cellsOsteogenic differentiation of humanBone marrow and adipose tissueVitroOsteoblastsMultipotentChondrogenesisAdipose-derived mesenchymalLineagesProliferation and osteogenic differentiationTransplantationEngineering and Regenerative MedicineBMSCsObtained from bone marrowAutologousMulti-lineage differentiationDerived stem cellsAdipocyteAdultAdipocytesTerms of differentiationNeuronal differentiationConnective tissueDental tissuesChondrocytesInduceHuman adiposeDifferentiateMaturationRegenerative therapiesPluripotentPrecursorNormal hematopoietic functionSelf-renewalConnect Tissue ResPeroxisome proliferProliferativeTherapiesLineageCapacitiesStromal stem cells
MSCs56
  • Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
  • However, the results indicate that bone marrow -derived MSCs are superior to those from subcutaneous adipose tissue in terms of differentiation into pancreatic islet -like clusters. (bvsalud.org)
  • All MSCs clusters were cultured with an osteogenic and adipogenic differentiation medium. (uniba.it)
  • Homogeneous pools of Mesenchymal Stem Cells (MSCs) were confirmed by Flow-Cytometry Analysis (FACS) and Spectrophotometric Assay. (uniba.it)
  • The ALP, AR stain confirmed the osteogenic differentiation capacity of MSCs towards osteoblast-like-cells. (uniba.it)
  • Mesenchymal stem cells (MSCs) support chondrogenic differentiation and are an attractive cell source for cartilage tissue engineering. (nature.com)
  • Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
  • Mesenchymal stem cells (MSCs) are multipotent cells with regenerative and immunomodulatory properties. (frontiersin.org)
  • Mesenchymal stem cells (MSCs) are multi-potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. (harvard.edu)
  • MSCs isolated from MSCKO mice showed reduced differentiation towards osteoblasts and chondrocytes in vitro, but no difference in proliferation or apoptosis. (harvard.edu)
  • It is known that significant percentages of visceral adipocytes are derived from mesenchymal stem cells and high glucose enhances adipogenic differentiation of mouse bone marrow-derived MSCs (BM-MSCs). (hindawi.com)
  • However, the effect of high glucose on adipogenic differentiation of human bone marrow and gestational tissue-derived MSCs is still poorly characterized. (hindawi.com)
  • This study aims to investigate the effects of high glucose on proliferation as well as adipogenic and osteogenic differentiation of human MSCs derived from bone marrow and several gestational tissues including chorion, placenta, and umbilical cord. (hindawi.com)
  • We found that high glucose reduced proliferation but enhanced adipogenic differentiation of all MSCs examined. (hindawi.com)
  • Although high glucose transiently downregulated the expression levels of some osteogenic genes examined, its effect on the osteogenic differentiation levels of the MSCs is not clearly demonstrated. (hindawi.com)
  • The knowledge gained from this study will increase our understanding about the effect of high glucose on adipogenic differentiation of MSCs and might lead to an improvement in the diabetic treatment in the future. (hindawi.com)
  • It is known that adipocytes are derived, at least in part, from multipotent mesenchymal stem cells (MSCs). (hindawi.com)
  • In contrast to adipogenic differentiation, high glucose suppressed osteogenic differentiation and downregulated the expression levels of osteogenic gene runt-related transcription factor 2 ( RUNX2 ), collagen type I ( COL1A1 ), osteonectin ( ON ), and osteocalcin ( OCN ) of mouse BM-MSCs and MG63 cells [ 7 , 9 ]. (hindawi.com)
  • Although the effects of high glucose on the proliferation and differentiation of rat and mouse BM-MSCs have been previously reported, the effects of high glucose on biological properties of human MSCs derived from gestational tissues which, due to their ease of isolation by noninvasive procedure, are considered more suitable sources of MSCs for clinical applications have yet to be determined. (hindawi.com)
  • The efficacy and safety profile of mesenchymal stem cells (MSCs) augmentation in chondral procedures are controversial. (springer.com)
  • We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
  • Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
  • Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating in specific directions. (wjgnet.com)
  • It is usually considered that the differentiation process of MSCs depends on specialized external stimulating factors, including cell signaling pathways, cytokines, and other physical stimuli. (wjgnet.com)
  • Recent findings have revealed other underrated roles in the differentiation process of MSCs, such as material morphology and exosomes. (wjgnet.com)
  • The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
  • Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition of miR-103-3p showed the opposite results in NOR-MSCs. (techscience.com)
  • Thus, the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs, significantly impacting MDS-MSCs differentiation. (techscience.com)
  • The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation, thereby providing possible target for the treatment of MDS pathogenesis. (techscience.com)
  • The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
  • Mesenchymal Stem Cells (MSCs) are a heterogeneous subset of stromal stem cells that originate from the mesoderm layer of the fetus. (tocris.com)
  • This study demonstrates the use of a microfluidic platform for long-term cultivation (3 weeks) of human mesenchymal stem-like cells (MSCs), a cell population of high interest for tissue engineering. (rsc.org)
  • Successful and reproducible adipogenic and osteogenic differentiation of MSCs in the device was demonstrated, verifying that an adequate long-term microfluidic cultivation environment was obtained. (rsc.org)
  • Human dental pulp-derived mesenchymal stem cells (hDP-MSCs), which include human dental pulp stem cells (hDPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs), are promising cell sources for regenerative therapies. (biomedcentral.com)
  • This systematic review aims to provide a panel of miRNAs that regulate the differentiation of hDP-MSCs including hDPSCs and SHEDs. (biomedcentral.com)
  • Experimental studies assessing the promotive/suppressive effect of miRNAs on the differentiation of hDP-MSCs and studies evaluating changes to the expression of miRNAs during the differentiation of hDP-MSCs were included. (biomedcentral.com)
  • Thirteen miRNAs promoted and 17 suppressed odontogenic/osteogenic differentiation of hDP-MSCs. (biomedcentral.com)
  • hsa-miR-140-5p, hsa-miR-218 and hsa-miR-143 were more frequently reported suppressing the odontogenic/osteogenic differentiation of hDP-MSCs. (biomedcentral.com)
  • KEGG pathway analysis revealed MAPK, PI3K-Akt and FoxO as key signaling pathways involved in the odontogenic/osteogenic differentiation of hDP-MSCs. (biomedcentral.com)
  • The findings of this systematic review support the potential application of the specific miRNAs to regulate the directed differentiation of hDP-MSCs in the field of regenerative therapies. (biomedcentral.com)
  • Mesenchymal stem cells (MSCs) are stromal cells that have two key features, self-renewal and the ability to differentiate along different lineages [ 1 ]. (biomedcentral.com)
  • Gronthos and co-workers were the first to report the isolation and characterization of MSCs from the pulp tissue of third molar teeth [ 5 ]. (biomedcentral.com)
  • hDP-MSCs includes human dental pulp stem cells (hDPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs) which are isolated from the pulp tissue of permanent and deciduous teeth, respectively. (biomedcentral.com)
  • The differentiation, proliferation, prognosis, and safety of MSCs for in vivo therapy remain controversial. (molvis.org)
  • Insulin-producing cells (IPCs) differentiated from mesenchymal stem cells (MSCs) hold great promise in the treatment of DM. (biomedcentral.com)
  • however, little is known about a role of laminin 411 in the regulation of IPC differentiation from human MSCs. (biomedcentral.com)
  • UC-MSCs were then cultured in the IPC induction and differentiation medium in the presence of laminin 411. (biomedcentral.com)
  • Laminin 411 markedly induced the expression of the genes Foxa2 and Sox17 , markers for pancreatic precursor cells, efficiently induced IPC differentiation from MSCs, and up-regulated insulin expression at both mRNA and protein levels. (biomedcentral.com)
  • Our results demonstrate that laminin 411 acts as a potent differentiation inducer of IPCs from UC-MSCs via the Pdx1 and Ngn3 signaling pathways. (biomedcentral.com)
  • Mesenchymal stem cells (MSCs) have gained interest because of its potential application in regeneration medicine and cytotherapy. (biomedcentral.com)
  • Mesenchymal stem cells (MSCs) exhibit a promising therapeutic potential in the field of cell-based tissue engineering and regenerative medicine due to their immunomodulatory properties and differentiation capacity. (uni-muenchen.de)
  • We aimed to produce highly homogeneous induced pluripotent stem cell-derived mesenchymal stem cells (iP-MSCs) in an autologous manner from initially isolated human mucosa mesenchymal stem cells (mMSCs) of the upper respiratory tract. (uni-muenchen.de)
  • Therefore, mMSCs were reprogrammed into induced pluripotent stem cells (iPSCs) by non-integrative chromosomal technologies and differentiated into corresponding iP-MSCs. (uni-muenchen.de)
  • We demonstrated that mMSCs and iP-MSCs show similar cell characteristics in terms of morphology, clonogenic potential, differentiation, and surface phenotype. (uni-muenchen.de)
  • Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)
  • MSCs can be isolated from different locations, such as bone marrow, umbilical cord, placenta, adipose and dental tissues. (bvsalud.org)
Chondrogenic differentiation4
  • The cells were phenotypically categorized according to the expression of CD29, CD90, CD34 and CD45, and submitted to adipogenic and chondrogenic differentiation for 21 days and osteogenic differentiation for 7, 14 and 21 days. (scielo.br)
  • Here we document the effects of specified PEMF parameters over mesenchymal stem cells (MSC) chondrogenic differentiation. (nature.com)
  • Zhou JQ, Wan HY, Wang ZX, Jiang N. Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells. (wjgnet.com)
  • Anatomical region-specific enhancement of 3-dimensional chondrogenic differentiation of human mesenchymal stem cells by soluble meniscus extracellular matrix. (chop.edu)
Progenitor cells3
  • They have a higher odontogenic differentiation capacity compared to other cell groups due to their content of specific progenitor cells. (scielo.br)
  • The goal of this protocol is to test the ability of progenitor cells derived from human perivascular adipose tissue to differentiate into multiple cell lineages. (jove.com)
  • Dynamic Compressive Loading Improves Cartilage Repair in an in vitro Model of Microfracture: Comparison of Two Mechanical Loading Regimens on Simulated Microfracture Based on Fibrin Gel Scaffolds Encapsulating Connective Tissue Progenitor Cells. (chop.edu)
Osteogenic differentiation of human1
Bone marrow and adipose tissue1
Vitro15
  • Differentiation of mesenchymal stem cells derived from human bone marrow and subcutaneous adipose tissue into pancreatic islet-like clusters in vitro. (bvsalud.org)
  • CONCLUSIONS: These in vitro findings of both hAS-SCs and hAV-SCs suggested an important role of these stem cells for future clinical use in bone regeneration. (uniba.it)
  • A common objective is to recreate as closely as possible the in vivo environmental conditions in vitro so that the rate and quality of chondrogenic development is enhanced and the functionality of the repaired tissue improved. (nature.com)
  • These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
  • Second, altering the MSC state by inducing differentiation into multiple lineages did not affect the exosomal properties or endocytosis but triggered the expression of lineage-specific genes and proteins in vitro and in vivo respectively. (frontiersin.org)
  • The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. (scielo.br)
  • In this regard, tissue engineers have sought to leverage native mechanotransduction pathways to enhance in vitro stem cell. (biomedcentral.com)
  • Tissue engineering has developed many paradigms and techniques on how to best integrate cells and extracellular matrix to create in vitro structures that replicate native tissue. (biomedcentral.com)
  • Recent data from in vitro models demonstrating the essential role of stromal support in hematopoiesis shaped the view that cell-cell interactions in the marrow microenvironment are critical for normal hematopoietic function and differentiation. (nih.gov)
  • Dr. Yang has extensive expertise in developing novel biomaterials and stem cell-based therapeutics for musculoskeletal tissue engineering, or engineering 3D in vitro cancer models for drug screening and mechanistic discovery. (stanford.edu)
  • Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)
  • 2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)
  • In vitro repair of meniscus radial tear using hydrogels seeded with adipose stem cells and TGF-β3. (chop.edu)
  • Firstly, the expression of HSP90α in osteoclast differentiation was detected by western blotting in vitro, then the effect of HSP90α inhibition on the formation and differentiation of osteoclasts was examined. (spandidos-publications.com)
  • Low-level laser therapy has been investigated as a possible stimulus for enhancement of proliferation and differentiation of various cell types, but few reports relate undifferentiated mouse pulp cells (OD-21) response to irradiation in in vitro models. (bvsalud.org)
Osteoblasts2
  • Furthermore, mechanical stretch may induce the differentiation of BMSCs into mature osteoblasts and enhance the deposition of the bone matrix [ 18 - 20 ]. (hindawi.com)
  • Stem cells differentiate into bone-forming osteoblasts, and mechanical stimulation is involved in this p. (biomedcentral.com)
Multipotent4
Chondrogenesis1
  • Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)
Adipose-derived mesenchymal1
Lineages4
  • Differentiation was compared to mesenchymal stem cells derived from human bone marrow, which is known to differentiate into adipocyte, osteocyte, and chondrocyte lineages. (jove.com)
  • The stromal cell system has been proposed to consist of marrow mesenchymal stem cells that are capable of self-renewal and differentiation into various connective tissue lineages. (nih.gov)
  • Recent efforts demonstrated that the multiple mesenchymal lineages can be clonally derived from a single mesenchymal stem cell, supporting the proposed paradigm. (nih.gov)
  • hsa-miR-221 and hsa-miR-124 promoted and hsa-miR-140-5p inhibited neuronal differentiation, hsa-miR-26a-5p promoted and hsa-miR-424 suppressed angiogenic differentiation, and hsa-miR-135 and hsa-miR-143 inhibited differentiation within myogenic lineages. (biomedcentral.com)
Proliferation and osteogenic differentiation6
  • OBJECTIVE: To evaluate the different behavior of two different human adult adipocytes derived stem cells (hASCs) during proliferation and osteogenic differentiation. (uniba.it)
  • This study was therefore aimed at establishing the dose-response effect of EPO stimulation on rat BMSCs and investigating the effects of mechanical stretch combined with EPO on the proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
  • The proliferation and osteogenic differentiation of rat BMSCs were examined and compared using EPO with different concentrations. (hindawi.com)
  • Mechanical stretch combined with 20 IU/ml EPO promoted proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
  • EPO was able to promote the proliferation and osteogenic differentiation of BMSCs, and these effects were enhanced when combined with mechanical stretch. (hindawi.com)
  • This study was therefore aimed at addressing three key issues: First, is there a dose-dependent effect of EPO on the proliferation and osteogenic differentiation of BMSCs? (hindawi.com)
Transplantation6
  • Autologous chondrocytes implantation and osteochondral autograft transplantation are limited by scarce cartilage production, low proliferative capacity of chondrocytes, chondrocyte de-differentiation and complications due to donor site morbidity 5 . (nature.com)
  • We are interested in investigating the potential neuroprotective benefits of stem cell transplantation, which has produced encouraging results in different models of CNS degeneration. (nih.gov)
  • Preclinical and early clinical safety studies are paving the way for further applications of mesenchymal stem cells in the field of transplantation with respect to hematopoietic support, immunoregulation, and graft facilitation. (nih.gov)
  • His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
  • Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)
  • Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
Engineering and Regenerative Medicine2
BMSCs4
  • The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)
  • The osteogenic differentiation of BMSCs was detected by alkaline phosphatase (ALP) staining, and the mRNA expression levels of ALP, OCN, COL, and Runx2 were detected by qPCR. (hindawi.com)
  • Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
  • Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
Obtained from bone marrow1
Autologous3
  • Autologous in vivo adipose tissue engineering in hyaluronan-based gels - a pilot study. (wikipedia.org)
  • Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
  • Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
Multi-lineage differentiation1
  • We developed techniques to isolate mouse OMSCs derived from mandibles and verified their MSC characteristics by single colony formation, multi-lineage differentiation, and in vivo tissue regeneration. (ca.gov)
Derived stem cells1
Adipocyte2
  • An increase in adipogenic differentiation levels was accompanied by an upregulation of the expression levels of several adipogenic genes including peroxisome proliferator-activated receptor gamma ( PPAR γ ), adipocyte protein 2 ( AP2 ), adipose tissue-specific secretory factor ( ADSF ), sterol regulatory element-binding protein 1C ( SREBP1C ), lipoprotein lipase ( LPL ), adiponectin ( ADIPOQ ), and glucose transporter type 4 ( GLUT4 ) [ 8 , 9 , 11 ]. (hindawi.com)
  • Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
Adult7
  • Although stem cells are present in various adult tissues and body fluids , bone marrow has been the most popular source of stem cells for treatment of a wide range of diseases . (bvsalud.org)
  • PATIENTS AND METHODS: Human adult adipocytes stem cells (hAT-SCs) from visceral (hAV-SCs) and subcutaneous (hAS-SCs) sites were obtained after surgery procedures of seven patients. (uniba.it)
  • His research centres on soft tissue and cardiovascular tissue engineering and adult stem cells in regenerative medicine and is well known in European Commission funded projects. (wikipedia.org)
  • Olfactomedin 1 (Olfm1) and the closely related genes Olfactomedin 2 (Olfm2) and Olfactomedin 3 (Olfm3) show overlapping expression patterns demonstrating preferential expression in the developing and adult neuronal tissues. (nih.gov)
  • Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
  • Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
  • 1,2 Regarding the origin, they can be classified as embryonic stem cells (ESCs) and adult stem cells (ASCs). (bvsalud.org)
Adipocytes1
  • Adipocytes in the accumulated fat tissues, especially around waist area and visceral organs, release several cytokines which reduce the sensitivity of several cell types to insulin leading to insulin resistant and type 2 diabetes [ 4 , 5 ]. (hindawi.com)
Terms of differentiation1
  • Therefore, it is not surprising to find that human OMSCs are distinct from BMMSCs in terms of differentiation traits and immunoregulation. (ca.gov)
Neuronal differentiation1
  • Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamol. (cdc.gov)
Connective tissue1
Dental tissues2
  • Although different stem cells, morphogens and scaffolds can be combined to simulate natural odontogenic regeneration, it is crucial to determine which options most closely replicate the characteristics of human dental tissues. (scielo.br)
  • In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)
Chondrocytes1
  • Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
Induce1
Human adipose1
  • We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
Differentiate3
  • The results reveal that mesenchymal stem cells (MSC) derived from bone marrow and subcutaneous adipose tissue can differentiate into pancreatic islet -like clusters, as evidenced by their islet-like morphology, positive dithizone staining and expression of genes such as Nestin , PDX1, Isl 1, Ngn 3, Pax 4 and Insulin . (bvsalud.org)
  • Stem cells (SCs) are undifferentiated cells with self-renewal ability and capacity to differentiate into specialized cell types. (bvsalud.org)
  • Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
Maturation1
  • The TGFβ-1 protein triggers chemical signals that regulate various cell activities, including the growth and division (proliferation) of cells, the maturation of cells to carry out specific functions (differentiation), cell movement (motility), and controlled cell death (apoptosis ). (medlineplus.gov)
Regenerative therapies1
  • Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
Pluripotent2
  • Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids. (tocris.com)
  • 3 Embrionic stem cells (ESCs) are derived from the inner cell mass of the blastocyst and form all cell types, derived from the three germ layers, and are therefore pluripotent. (bvsalud.org)
Precursor2
  • Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
  • We derive HPAd from human subcutaneous and heart adipose tissue and cryopreserve these fibroblast-like precursor cells at the end of primary culture. (cellapplications.com)
Normal hematopoietic function1
  • It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
Self-renewal1
  • This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. (tocris.com)
Connect Tissue Res1
Peroxisome prolifer1
  • The main pathogenesis of OP is excessive proliferation and differentiation of osteoclasts, in which the peroxisome proliferator‑activated receptor γ (PPARγ) pathway has a pivotal role. (spandidos-publications.com)
Proliferative2
  • The major advantage of these stem cells over their counterparts is their amazing proliferative and differentiation potency . (bvsalud.org)
  • Specific properties, such as proliferative and differentiation potential, are slightly different among DSCs. (bvsalud.org)
Therapies3
  • Our lab's mission is to develop therapies for regenerating human tissues lost due to diseases or aging, and to build tissue engineered 3D models for understanding disease progression and informing drug discovery. (stanford.edu)
  • Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? (lu.se)
  • Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)
Lineage2
  • The pancreatic lineage differentiation was further corroborated by positive results in the glucose challenge assay. (bvsalud.org)
  • Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)
Capacities1
Stromal stem cells1