Mesenchymal stem cells cell hypoxia. Medical search. Frequent questions

Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
In the 1980's, Arnold Caplan and his colleagues published an isolation method of fibroblast-like stromal cells from bone marrow and first identified them as mesenchymal stem cells (MSCs) because of their multilineage differentiation potential ( Caplan, 1991 ). (frontiersin.org)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Derubeis, A.R. and Cancedda, R. (2004) Bone marrow stromal cells (BMSCs) in bone engineering: Limitations and recent advances. (scirp.org)
Mesenchymal stem/stromal cells (MSCs)‐based therapy brings the reassuring capability to regenerative medicine through their self‐renewal and multilineage potency. (biomedcentral.com)
For most studies, the adult stem cell in question is actually a mesenchymal stem cell or mesenchymal stromal cell. (vin.com)
Mesenchymal stem cells or mesenchymal stromal cells (MSC) are plastic adherent and assume a fibroblast-like morphology during culture. (vin.com)
Enomoto M. The future of bone marrow stromal cell transplantation for the treatment of spinal cord injury[J]. Neural Regen Res, 2015, 10: 383-384. (magtechjournal.com)
The metastatic process involves sequential steps, including invasion through the surrounding extracellular matrix (ECM) and stromal cell layers, intravasation into the lumina of blood vessels, and survival in the circulation. (medscape.com)
Direct invasion by carcinoma cells of the stromal compartment involves active proteolysis effected principally by matrix metalloproteinases (MMPs), while degrading the BM and other ECM that lie in the path of invading tumor cells, MMP-expressing cells also liberate growth factors that are sequestered there, thereby fostering cancer cell proliferation. (medscape.com)

In recent years, one of the main research strategies used to induce angiogenesis in vivo has been via stem cell therapy, especially therapy using mesenchymal stem cells (MSCs). (minervamedica.it)
Therefore, this study aimed to investigate the effects of hypoxia-preconditioned MSCs from human adipose tissue-derived MSCs (AT-MSCs) and from human umbilical cord-derived MSCs (UC-MSCs). (minervamedica.it)
We evaluated the role of hypoxia on the angiogenic potency of these MSCs. (minervamedica.it)
METHODS: Both AT-MSCs and UC-MSCs were obtained from an established cell bank and expanded in vitro . (minervamedica.it)
The concentrations of growth factors (such as HGF, bFGF, and VEGF) in the cell culture supernatants collected from culture media of the hypoxia-preconditioned AT-MSCs and UC-MSCs (as well as those from AT-MSCs and UC-MSCs cultured in normoxia) were measured by ELISA. (minervamedica.it)
RESULTS: The data showed that preconditioning with hypoxia promoted the secretion of bFGF, VEGF, and HGF by both AT-MSCs and UC-MSCs. (minervamedica.it)
For AT-MSCs, there was a significant increase in VEGF and bFGF production when preconditioned with hypoxia, compared to normoxia, while HGF production was only slightly increased. (minervamedica.it)
However, when preconditioned with hypoxia (5% O 2 ), the angiogenic potency of both AT-MSCs and UC-MSCs was similar. (minervamedica.it)
This study investigated whether hypoxic OM-MSCs could inhibit microglial cell death upon I/R insult in vitro . (aging-us.com)
Results showed that OGD/R induced apoptosis and pyroptosis in microglial cells while hypoxia in OM-MSCs significantly attenuated these effects. (aging-us.com)
Moreover, the effects of OM-MSCs were mediated by Hypoxia-inducible factor 1-alpha (HIF-1α). (aging-us.com)
In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
We proposed that hypoxic preconditioning could increase survival of bone marrow mesenchymal stem cells (MSCs) via upregulation of Pim-1 and aimed to determine the microRNAs that modulate the expression of Pim-1. (biomedcentral.com)
MSCs were subjected to hypoxia exposure. (biomedcentral.com)
In addition, gain and loss-of-function studies with miR-206 mimics and inhibitors showed that inhibition of miR-206 in hypoxic MSCs promoted the migration ability of the cells, prevented cell apoptosis, and protected membrane potential of mitochondria, while the benefits were all blocked by Pim-1 inhibitor. (biomedcentral.com)
We demonstrated that hypoxia preconditioning enhanced the expression of Pim-1 kinase in MSCs in a time-dependent manner, as detected by quantitative PCR (qPCR) and western blot. (biomedcentral.com)
Mesenchymal stem cells (MSCs) possess great therapeutic potential. (hindawi.com)
In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)
The differentiation of mesenchymal stem cells (MSCs) into multiple cell lineages can be exploited as an attractive strategy for cell-based therapy and regenerative medicine [ 1 ]. (hindawi.com)
However, MSCs need to be expanded in vitro in order to obtain sufficient cells for clinical trials since they are extremely rare in various tissues. (hindawi.com)
Unlike embryonic stem cells, adult stem cells (MSCs) have a limited lifespan and stop proliferating during in vitro culture due to replicative senescence [ 8 ]. (hindawi.com)
Although mesenchymal stem cells (MSCs) have been shown as a novel approach in tissue regeneration, the therapeutic potential of MSCs mediated by the interaction between MSC-derived paracrine mediators and Mφs remains elusive. (frontiersin.org)
Mesenchymal stem cells (MSCs) have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation, differentiation, and immune regulation. (techscience.com)
Indeed, MSCs ex vivo pre-conditioning by hypoxia, inflammatory stimulus, or other factors/conditions may stimulate their survival, proliferation, migration, exosome secretion, and pro-angiogenic and anti-inflammatory characteristics in vivo. (biomedcentral.com)
Although there is no particular quantitative assay to provide MSCs identification in mixed cells population [ 8 ], the International Society for Cellular Therapy (ISCT) has provided minimum principles to determine MSCs. (biomedcentral.com)
However, natural MSCs in vivo survival and their biological effects on tissue recovery decrease with long-term cultivation called aging and also injected cells demonstrate poor targeted migration [ 21 ]. (biomedcentral.com)
Mesenchymal stem cells (MSCs) derived from adipose are widely used as a source of stem cells. (unair.ac.id)
It is hoped that the survival, engraftment, and function of implanted MSCs by preconditioning the cells will be improved. (unair.ac.id)
Objective To explore the effect of miR-34c-5p knockdown on improving the survival rate of bone marrow derived mesenchymal stem cells (BM-MSCs). (magtechjournal.com)
Methods The BM-MSCs were divided into normoxia group, hypoxia group, normoxia inhibitor NC group, hypoxia inhibitor NC group, normoxia microRNA(miR) inhibitor group and hypoxia miR inhibitor group. (magtechjournal.com)
Conclusions miR-34c-5p knockdown may antagonize hypoxia induced cell apoptosis of BM-MSCs in rat. (magtechjournal.com)
This kind of plasticity has been suggested to be a fundamental feature of mesenchymal stem cells (MSCs) as well. (biomedcentral.com)
Mesenchymal stem cells (MSCs) are multi-potent cells that persist in adult life in some tissue types, such as bone-marrow stroma, fat, skeletal muscle, and synovium without loosing their capacity to proliferate and differentiate [ 9 , 10 ]. (biomedcentral.com)

Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
Mesenchymal stem cells secrete factors that inhibit apoptosis in H9c2 cardiac myoblasts. (anl.gov)
MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome. (nih.gov)
These protective effects may be associated with the inhibition of apoptosis and inflammation, as reflected by less TUNEL-positive cells and lower levels of serum proinflammatory cytokines (Interleukin-1β, Interleukin-6, tumor necrosis factor-α) and cardiac troponin I in the N-CM group compared with the vehicle group. (researchsquare.com)
Conclusion: For the protection of stem cells against apoptosis, different pathways, namely Phosphoinositide 3-Kinase (PI3K/AKT), Hypoxia-Inducible Factor (HIF1), Mitogen-Activated Protein Kinases (MAPK) and Hippo, are discussed. (benthamscience.com)
Animal miRNA are involved in neuronal cell fate, cell proliferation and differentiation, metabolism, aging, apoptosis and organ morphogenesis, suggest that miRNAs are particularly critical in the development, health, and aging of animals ( Ameres & Zamore, 2013 ). (peerj.com)
CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. (exbio.cz)
Cell apoptosis was detected by flow cytometry and TUNEL. (magtechjournal.com)
Cancer is a complex disease in which many basic processes, such as cell division, apoptosis, and cell migration are dysregulated. (medscape.com)

Starting with cell source, choice of donor and recipient, as well as isolation methods, we will then discuss existing expansion protocols (two-/three-dimensional cultivation, basal medium, medium supplements, static/dynamic conditions, and hypoxic/normoxic conditions) and influence of these strategies on the cell functionality after implantation. (frontiersin.org)
9 ] reported that hypoxic preconditioning increases survival of cardiac progenitor cells via upregulation of Pim-1, discovering a method for nongenetic modification of Pim-1 in stem cells. (biomedcentral.com)
Both progenitor cell populations responded to hypoxic stimuli by stabilizing the hypoxia inducible factor (HIF)-1alpha protein. (ox.ac.uk)
Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
One such attempt is to propagate these stem cells in a hypoxic environment, which mimics the natural tissue oxygen environment. (unair.ac.id)
Zhu Y, Sun Y, Xie L, Jin K, Sheibani N, Greenberg DA: Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells. (exbio.cz)

Mesenchymal stem cells protect from hypoxia-induced alveolar epithelial-mesenchymal transition. (stembook.org)
The role of miR-34c-5p/Notch in epithelial-mesenchymal transition (EMT) in endometriosis[J]. Cell Signal, 2020, 72:109666. (magtechjournal.com)

Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
The cells were phenotypically categorized according to the expression of CD29, CD90, CD34 and CD45, and submitted to adipogenic and chondrogenic differentiation for 21 days and osteogenic differentiation for 7, 14 and 21 days. (scielo.br)
On days 7, 14 and 21 of osteogenic differentiation, the cultures were submitted to evaluations of MTT conversion in formazan, of alkaline phosphatase activity (AP), of collagen and mineralized matrix synthesis, evaluation of the number of cells per field and there was quantification of the gene transcripts for osterix, bone sialoprotein (BSP), osteonectin (ON) and osteocalcin (OC). (scielo.br)

Overexpression of Pim-1 in stem/progenitor cells stimulated cell cycling and enhanced cardiac regeneration in vivo. (biomedcentral.com)
Umbilical cord blood (UCB) and bone marrow (BM)-derived stem and progenitor cells possess two characteristics required for successful tissue regeneration: extensive proliferative capacity and the ability to differentiate into multiple cell lineages. (ox.ac.uk)
These results, therefore, provide a global view of the signaling and regulatory network that controls oxygen sensing in human adult stem/progenitor cells derived from hematopoietic tissues. (ox.ac.uk)
Erythropoietin is a glycoprotein hormone that stimulates red blood cell (RBC) production in bone marrow via binding to the cell-surface receptor on hematopoietic progenitor cells, and it has been widely used for treating anemia [ 13 ]. (hindawi.com)
Small-molecule inhibitor cocktail promotes the proliferation of pre-existing liver progenitor cells. (kyoto-u.ac.jp)

They also can inspire angiogenesis by direct differentiation, cell-to-cell interaction, or paracrine effects. (biomedcentral.com)
CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. (exbio.cz)
Mesenchymal stem cell-derived exosomes improve the microenvironment of infarcted myocardium contributing to angiogenesis and anti-inflammation[J]. Cell Physiol Biochem, 2015, 37:2415-2424. (magtechjournal.com)
Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis[J]. J Thorac Cardiovasc Surg, 2008, 135: 799-808. (magtechjournal.com)
Although tumor-associated angiogenesis has traditionally been defined as the sprouting of new vessels from preexisting vessels, it is becoming clear that the blood vessels that support tumor growth can also originate from cells recruited from the bone marrow or can even differentiate from tumor stem cells (vascular mimicry). (medscape.com)
The critical initial stimulus for angiogenesis is hypoxia in the growing tumor. (medscape.com)

Also, following transplantation and migration to target tissue, they encounter a harsh milieu accompanied by death signals because of the lack of proper tensegrity structure between the cells and matrix. (biomedcentral.com)
Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats. (kyoto-u.ac.jp)
A comparative study of mesenchymal stem cell transplantation and NTG-101 molecular therapy to treat degenerative disc disease. (kyoto-u.ac.jp)

2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)
The basic defect in HO is the inappropriate differentiation of fibroblasts into bone-forming cells. (medscape.com)

The aim of this study was to compare the osteogenic potential of mesenchymal stem cells obtained from bone marrow (BM-MSC) with those extracted from adipose tissue (AT-MSC) of adult dogs. (scielo.br)

Intravenous administration of mesenchymal stem cells ( MSC ) following myocardial infarction prevents contractile dysfunction. (anl.gov)
Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. (kyoto-u.ac.jp)

Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
Huang, G.T., Gronthos, S. and Shi, S. (2009) Mesenchymal stem cells derived from dental tissues vs. those from other sources: Their biology and role in regenerative medicine. (scirp.org)
Ramalingam, M. Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine. (benthamscience.com)
The role of hypoxia in bone marrow-derived mesenchymal stem cells: considerations for regenerative medicine approaches[J]. Tissue Eng Part B Rev, 2010, 16: 159-168. (magtechjournal.com)

Here we report application of human umbilical cord mesenchymal stem cell (HUCMSC)-derived therapy for pulmonary arterial hypertension (PAH). (nature.com)
Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)

Hypoxia is a known regulator of stem cell fate, the effects of which can be mimicked using hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors such as dimethyloxalylglycine (DMOG). (amrita.edu)

The properties of HUCMSCs were validated by untargeted label-free quantitation of the cell and CM proteome, suggesting increased activity of regeneration, autophagy and anti-inflammation pathways and mitochondrial function. (nature.com)
NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
1:van Tilborg E, Achterberg EJM, van Kammen CM, van der Toorn A, Groenendaal F, Dijkhuizen RM, Heijnen CJ, Vanderschuren LJMJ, Benders MNJL, Nijboer CH. Combined fetal inflammation and postnatal hypoxia causes myelin deficits and autism-like behavior in a rat model of diffuse white matter injury. (umcutrecht.nl)
1. Peritoneal involvement: Cancer cells can spread to the peritoneum, leading to inflammation and the production of fluid. (researchgate.net)
The efficiency of transplanted stem cells reduces due to conditions like hypoxia, inflammation, nutrient deprivation, immunogenicity, extracellular matrix loss on delivery and mechanical stress. (benthamscience.com)

A unique type of MSC termed olfactory mucosa mesenchymal stem cell (OM-MSC) confers neuroprotection by promoting the secretion of paracrine factors, and neuroprotection. (aging-us.com)

Recent years have brought increased interest in the potential for adult stem cells to help in the treatment of many diseases through both their regenerative properties as well as their apparent ability to alter the environment in injured and diseased tissues. (vin.com)
Adult stem cells can be obtained from many differentiated tissues including but not limited to bone marrow, bone, fat, and muscle. (vin.com)
The generation and maintenance of replenishing tissues relies on an appropriately regulated balance between self-renewal and differentiation within a relatively small population of adult stem cells. (biomedcentral.com)

Taken together, these findings reveal that hypoxia-preconditioned OM-MSC inhibits pyroptotic and apoptotic death of microglial cell in response to cerebral ischemia/reperfusion insult by activating HIF-1α in vitro . (aging-us.com)
In most cases, clinically relevant cell numbers for MSC-based therapies can be only obtained by in vitro expansion of isolated cells. (frontiersin.org)
Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
For i n vitro examinations, 1 × 10 5 rat bone marrow cells in 2 ml culture medium were then cultured with the addition of dexamethasone and laminin. (scirp.org)
It is concluded that laminin is useful for bone formation, as in an in vitro culture study using bone marrow cells, in hydroxyapatite scaffolds in vivo . (scirp.org)
Yoshikawa, M. , Kakigi, H. , Yabuuchi, T. and Hayashi, H. (2014) Effects of laminin on hard tissue formation by bone marrow cells in vivo and in vitro . (scirp.org)
HADSCs were induced to confirm that they can express the characteristics of endothelial cells (ECs) in vitro. (molvis.org)
Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)
Mesenchymal stem cells clearly modulate immune responses, as demonstrated by both in vitro and in vivo studies. (vin.com)
In vitro cultivated stem cell populations are in general heterogeneous with respect to their expression of differentiation markers. (biomedcentral.com)
Individual cell-based models are well-suited to provide quantitative predictions on essential features of the spatio-temporal organisation of MSC in vitro . (biomedcentral.com)
They may contribute to a better understanding of MSC organisation in vitro , including features of clonal expansion, environmental adaptation and stem cell ageing. (biomedcentral.com)
Under appropriate culture conditions, they can multiply and transform into specialized cell types in vitro . (biomedcentral.com)

In this study, the transcriptional profiles and proliferation and differentiation potential of UCB CD133(+) cells and BM mesenchymal cells (BMMC) exposed to normoxia and hypoxia were analyzed and compared. (ox.ac.uk)

Stem cells differentiate into different types of cells, such as neural, hematopoietic, adipose, etc. and are used for the treatment of various conditions like myocardial infarction, spinal cord injury, Parkinson's disease and diabetes. (benthamscience.com)
After that, Kaplan firstly proposes the term "mesenchymal stem cells," which are cells isolated from fully developed bone marrow (BM) that can usually differentiate into several types of mesenchymal origin cells [ 4 ]. (biomedcentral.com)
A stem cell is a generic term referring to any unspecialized cell that is capable of long-term self-renewal through cell division but that can be induced to differentiate into a specialized, functional cell. (vin.com)
Mesenchymal stem cells are multipotent but not pluripotent, which means they can differentiate into some, or "multiple," but not all tissue types. (vin.com)
Most importantly stem cells possess the ability to differentiate into cell types of multiple lineages including adipocytes, chrondrocytes, and osteocytes. (vin.com)
4,6,7 It has been proposed that some of these MSC may actually differentiate into functional renal tubular epithelial cells, though this theory remains controversial. (vin.com)

25-hydroxyvitamin D3 inhibits oxidative stress and ferroptosis in retinal microvascular endothelial cells induced by high glucose through down-regulation of miR-93. (nih.gov)
Aifantis, I. Regulation of stem cell function by protein ubiquitylation. (benthamscience.com)
Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. (thermofisher.com)
Hypoxia leads to the up-regulation of hypoxia-induced transcription factors (HIF)-a and HIF-2a, which are the master regulators of proangiogenic signals, mainly the vascular endothelial cell growth factors (VEGFs). (medscape.com)

The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)
The administration of bone marrow-derived mesenchymal stem cells (BMSCs) is emerging as a promising approach for I/R injury-induced myocardial infarction due to its multiple differentiation potential(7, 8). (researchsquare.com)

After induction, hADSCs expressed von Willebrand Factor (vWF), the cell marker of ECs. (molvis.org)
Another P4H family, the HIF-P4Hs, hydroxylates specific prolines in the alpha subunit of the hypoxia-inducible transcription factor (HIF), a master regulator of hypoxia-inducible genes, and controls its stability in an oxygen-dependent manner. (indexindex.com)
However, the organisation of stem cell populations is strongly influenced by environmental factors such as specific cell-cell interactions, growth factor and oxygen supply, as well as the geometry and mechanical properties of the local environment [ 3 , 4 ]. (biomedcentral.com)
HO may be due to an interaction between local factors (eg, the pool of available calcium in adjacent skeleton, soft-tissue edema, vascular stasis tissue hypoxia, mesenchymal cells with osteoblastic activity) and an unknown systemic factor or factors. (medscape.com)

2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)

From the in vivo examination, laminin coating of the scaffolds induced hard tissue in the pores with the cells. (scirp.org)

Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)

By releasing DMOG from mesenchymal stem cell (MSC) laden alginate hydrogels, it is possible to stabilize HIF-1α and enhance its nuclear localization. (amrita.edu)
Results: To increase the viability of stem cells, techniques like scaffolds of stem cells with hydrogel or alginate, pre-conditioning, different routes of administration and encapsulation, are implemented. (benthamscience.com)
Alginate hydrogel is an ideal medium for encapsulating cells and facilitating the production of cartilage tissue due to its desirable properties. (authorea.com)
In this project, alginate and chitosan, which are structurally similar to glycosaminoglycans, were assembled layer by layer on alginate microcapsules containing mesenchymal stem cells. (authorea.com)

MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)

The differentiation potential of UCB CD133(+) clonogenic myeloid cells was unaltered by short exposures to hypoxia. (ox.ac.uk)
In contrast, the chondrogenic differentiation potential of BMMCs was enhanced by hypoxia, whereas adipogenesis and osteogenesis were unaltered. (ox.ac.uk)

Controlling the phenotype of transplanted stem cells is integral to ensuring their therapeutic efficacy. (amrita.edu)

Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)

Research has been directed at developing treatments that modulate inflammatory responses and protect against cell death caused by cerebral I/R. Key among such treatments include mesenchymal stem cell (MSC) therapy. (aging-us.com)
3: Hersenstichting Nederland -Fellowship Stroke (2014): "Mesenchymal stem cell therapy to repair white matter injury in the preterm neonatal brain: boosting oligodendrocyte differentiation and myelination. (umcutrecht.nl)
Shende, P. Role of liposome-based stem cells for multimodal cancer therapy. (benthamscience.com)
Stem cell therapy has been the subject of many studies for its potential to cure many disorders. (biomedcentral.com)
Stem cell-based therapy is one of the most promising strategies in promoting tissue regeneration. (unair.ac.id)
Hypoxia preconditioning represents a comprehensive increase in regenerative gene expression in stem cell therapy. (unair.ac.id)
There are significant advantages in stem cell therapy with hypoxia preconditioning. (unair.ac.id)
Stem cell therapy in particular is an innovative new field of scientific investigation and clinical application that holds promise for a variety of diseases in veterinary medicine as well as human medicine. (vin.com)
In addition, it is also important to keep the immune modulatory properties of MSC in mind when interpreting the results of many stem cell therapy studies. (vin.com)

Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)

This 90 kDa disulfide-linked homodimer is expressed by vascular endothelial cells. (thermofisher.com)
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. (thermofisher.com)

Zhang, Y. Integrin β1 increases stem cell survival and cardiac function after myocardial infarction. (benthamscience.com)

Additionally cell surface marker characterization via flow cytometry differentiates them from hematopoetic cells, though no truly unique MSC molecule has been identified. (vin.com)
Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)

It is also used to induce hypoxia-like environment in mesenchymal stem cells. (wikipedia.org)

citation needed] Deferoxamine may modulate expression and release of inflammatory mediators by specific cell types. (wikipedia.org)

Background: Stem cells are of two types: embryonic and adult stem cells and they act as a repair system by replenishing body tissue. (benthamscience.com)
Melton, D.A. "Stemness": Transcriptional profiling of embryonic and adult stem cells. (benthamscience.com)
In particular, adult stem cells called mesenchymal stem cells can migrate to affected areas and may be able to support the growth of other stem cells as well as moderate the response of the immune system. (vin.com)
Stem cells are generally divided into two groups, embryonic stem cells and adult stem cells. (vin.com)
Obtaining adult stem cells also does not raise ethical concerns. (vin.com)

These steps are supported by functions of the cancer cells themselves or of the tumor microenvironment. (medscape.com)
thus, a successful metastatic colony depends on the ability of cancer cells to appropriate distinct microenvironments at each step in the metastatic cascade: the primary tumor, systemic circulation, and the final metastatic destination. (medscape.com)

Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. (kyoto-u.ac.jp)

Cortical bone-derived stem cells (CBSCs) are reportedly essential for osteogenic lineages, bone maintenance and repair. (biomedcentral.com)

[ 4 ] EMT programs are orchestrated by a set of pleiotropically acting transcription factors, including Slug, Snail, Twist, ZEB1, and ZEB2, which organize entrance into a mesenchymal state by suppressing expression of epithelial markers (E-cadherin) and inducing expression of other markers associated with the mesenchymal state. (medscape.com)

A comparative analysis of single-cell RNA sequencing data collected from three HUCMSCs and two human umbilical vein endothelial cell (HUVEC) controls identified eight common cell clusters, all of which indicated regenerative potential specific for HUCMSCs. (nature.com)

Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxia. (ox.ac.uk)
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex. (stembook.org)
We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)

Within the normal BM and in pathological conditions, areas of hypoxia may have a role in maintaining stem cell fate or determining the fine equilibrium between their proliferation and differentiation. (ox.ac.uk)
In cell encapsulation, a suitable environment is provided for cell growth, proliferation and differentiation. (authorea.com)

Background: While the diagnosis of papillary thyroid carcinomas (PTCs) with tall cell features (PTCtcf) is often made for carcinomas with histological features intermediate between classic and tall cell subtypes of PTC (tcPTC), its comparative signature to that of either tcPTC or classic PTC is less clear. (bvsalud.org)

He has taught anatomy, physiology, and cell biology at Trinity Christian College for 34 years, and he still teaches there in addition to his work at Argonne. (anl.gov)
The International Journal of Biochemistry & Cell Biology, 36, 568-584. (scirp.org)
Development: For advances in developmental biology and stem cells. (lu.se)

Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)

Anatomy43

Organisms9

Diseases5

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes39

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MSCs34

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