Mesenchymal stem cell transplantation precursors bone marrow transplantation. Medical search. Frequent questions

Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (wikipedia.org)
While the terms mesenchymal stem cell (MSC) and marrow stromal cell have been used interchangeably for many years, neither term is sufficiently descriptive: Mesenchyme is embryonic connective tissue that is derived from the mesoderm and that differentiates into hematopoietic and connective tissue, whereas MSCs do not differentiate into hematopoietic cells. (wikipedia.org)
Mesenchymal stem cells (MSCs), a term first coined by Arnold I. Caplan in 1991, are characterized morphologically by a small cell body with a few cell processes that are long and thin. (wikipedia.org)
Bone marrow was the original source of MSCs, and is still the most frequently utilized source. (wikipedia.org)
However, MSCs are found in much higher concentration in the Wharton's jelly compared to cord blood, which is a rich source of hematopoietic stem cells. (wikipedia.org)
These cells have several advantages over bone-marrow-derived MSCs. (wikipedia.org)
Adipose-tissue-derived MSCs (AdMSCs), in addition to being easier and safer to isolate than bone-marrow-derived MSCs, can be obtained in larger quantities. (wikipedia.org)
MSCs have been seen to even differentiate into neuron-like cells, but doubt remains about whether the MSC-derived neurons are functional. (wikipedia.org)
BALB/c → C57BL/6 allografts were reconstituted with iPSC-derived MSCs (2 million/transplant/at d0), and allografts were examined for regulatory T cells (Tregs), oxygenation, microvascular blood flow, airway epithelium, and collagen deposition during rejection. (biomedcentral.com)
We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
The present study had aimed to evaluate the effect of a feeder layer of irradiated MSCs in the in vitro expansion of NK cells. (springer.com)
MSCs were obtained from the bone marrow (BM) cells remaining in the bag and filter used in the transplantation of hematopoietic stem cells. (springer.com)
NK expansion and activation were stimulated by culture with artificial antigen-presenting cells (aAPCs) and IL-2, in the presence or absence of BM-MSCs. (springer.com)
New treatment strategies have pursued the idea of using mesenchymal stromal cells (MSCs) in combination with osteoinductive materials to guide differentiation of MSCs into bone cells ensuring complete bone regeneration. (nature.com)
After bone fractures mesenchymal stromal cells (MSCs) take on a key role in the in vivo bone repair process 1 . (nature.com)
MSCs have the ability to differentiate into adipocytes and chondrocytes forming fat tissue and cartilage as well as into bone cells - called osteocytes. (nature.com)
The use of donor derived MSCs for triggering the bone regeneration in vivo is a promising tool for assisting the healing process. (nature.com)
Nevertheless, MSCs can lose their differentiation potential after expansion in vitro and transplantation into the site of injury 7 . (nature.com)
In order to cope with this task, in vitro systems are required which allow studies regarding cell-material interactions to unfold the impact of material surface properties on MSCs. (nature.com)
Interaction of MSCs with bone morphogenic proteins (BMPs) in an alginate scaffold mimicking the extracellular matrix (ECM) in vivo enhances their differentiation into bone cells 9 . (nature.com)
Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) were derived from syngenic mouse bone marrow. (vinastemcelllab.com)
6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)
The ability to restore cells and tissue function without the need of immunosuppressive drugs and without the concern for tissue compatibility makes Mesenchymal Stem Cells (MSCs, usual acronym) a strong promise for the future. (bvsalud.org)
In addition to their stem/progenitor properties, mesenchymal stromal cells (MSCs) possess broad immunoregulatory properties that are being investigated for potential clinical application in treating immune-based disorders. (pdffox.com)
Introduction Mesenchymal stromal cells (MSCs) are adult, fibroblast-like multipotent cells characterized by the ability to differentiate into tissues of mesodermal origin, such as adipocytes, chondroblasts, and osteoblasts (Friedenstein et al. (pdffox.com)
1999). First identified and isolated from the bone marrow (BM), MSCs can now be expanded from a variety of other tissues including adipose tissue (AT), umbilical cord blood (UCB), skin, tendon, muscle, and dental pulp (Im et al. (pdffox.com)
In response to this challenge, the International Society for Cellular Therapy formulated minimal criteria for defining MSCs in order to create a broader consensus for more uniform characterization of these cells (Dominici et al. (pdffox.com)
2007). In addition to their stem/progenitor properties, MSCs have also been shown to possess broad immunoregulatory abilities and are capable of influencing both adaptive and innate immune responses. (pdffox.com)
This ability of MSCs to adopt a different phenotype in response to sensing an inflammatory environment is not captured in assays that are commonly used to characterize these cells, but it is crucial for understanding their therapeutic potential in immune-mediated disorders. (pdffox.com)
Insulin-producing cells (IPCs) differentiated from mesenchymal stem cells (MSCs) hold great promise in the treatment of DM. (biomedcentral.com)
Laminin 411 markedly induced the expression of the genes Foxa2 and Sox17 , markers for pancreatic precursor cells, efficiently induced IPC differentiation from MSCs, and up-regulated insulin expression at both mRNA and protein levels. (biomedcentral.com)
Mesenchymal stem cells (MSCs) have gained interest because of its potential application in regeneration medicine and cytotherapy. (biomedcentral.com)
Objectives: Evaluation of the therapeutic effects of intrapulmonary transplantation of BM-MSCs to improvement of clinical signs in experimental model of ARDS created by lipopolysaccharide(LPS)E.Coli strains-O55:B5 in sheep is the aim of this study. (ac.ir)
Of sheep in the treatment group after anesthesia with ketamine and xylazine collected bone marrow samples and in the clean room BM-MSCs isolated, amplified and were identified with the evaluation of surface markers. (ac.ir)
After confirming inflammation, the sheep were anesthetized and on sternal position 50×106 cells of BM-MSCs third passage were transferred in treatment group as autograft by the catheter lavage in the bifurcation of the trachea and PBS in control group. (ac.ir)
Results: The data showed transplantation of BM-MSCs caused significant improvement in clinical signs including heart rate, respiratory rate, body temperature, respiratory sounds, cough, mucosal status, nasal secretions, appetite and physical condition compared with control group. (ac.ir)
Conclusions: This study showed that transplantation of BM-MSCs can cause improves and the reduction in the severity of the clinical signs of ARDS, significantly. (ac.ir)

Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation (19:11). (medicaldaily.com)
Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
Therapeutic regeneration of molecularly engineered and transplanted autologous stem cells in neurological and cardiovascular diseases due to inability of self-regeneration or repair of endogenous stem cells at sites of inflammation or disease at various stages of progress for regeneration of the damaged tissue depending upon the sites and nature of degeneration. (hoajonline.com)
Autologous hematopoietic stem cell transplantation and reconstitution: Different species and including primates and humans for studies are being used for development, localization, and therapeutic strategies. (hoajonline.com)
Human adult stem cells (hASCs) have become an attractive source for autologous cell transplantation, tissue engineering, developmental biology, and the generation of human-based alternative in vitro models. (ac.be)
Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
To determine the safety and efficacy of intramyocardial autologous blood stem cell injection for cardiomyopathy. (tci-thaijo.org)
Artificial reproduction of Descemet membrane with respect to topography and similar stiffness offers a potential innovative way to bioengineer a functional CEC monolayer from autologous stem cells. (lww.com)
A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. (cellsurgicalnetwork.com)
1, 2 Recently, Prolotherapists have begun to utilize the potential of autologous adipose (fat)-derived stem/stromal cells (AD-SC) within non-manipulated fat graft scaffolding, combined with high-density PRP concentrates (HD-PRP) to provide a potent biological therapeutic combination. (journalofprolotherapy.com)
6 Cosmetic-plastic surgeons have studied autologous fat grafting for structural augmentation via transplantation of lipoaspirants for many years. (journalofprolotherapy.com)
A few exceptions emerged when successful functional correction was exhibited in children with severe combined immunodeficiency (ADA-SCID and X-SCID) or chronic granulomatous disease following infusion of retrovirally transduced autologous CD34+ cells [12C14]. (eyesoftheelephants.com)
The use of olfactory progenitors as a cell-based therapy for Parkinson's disease (PD) would allow harvest without invasive surgery, provide an autologous cell population, eliminate need for immunosuppression and avoid the ethical concerns associated with embryonic tissues. (scirp.org)

As many as 1 in 100 cells collected during amniocentesis are pluripotent mesenchymal stem cells. (wikipedia.org)
Bone marrow stem cells, including the pluripotent hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs), are being considered as potential targets for cell and gene therapy-based approaches against a variety of different diseases. (hindawi.com)
The novel Cymerus™ manufacturing facilitates production of a virtually limitless supply of consistent human induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells, which could play a key role in selective immunosuppression and graft repair during rejection. (biomedcentral.com)
The pluripotent stem cells (eg. (hoajonline.com)
Retention of cellular phenotype is the hallmark of differentiation of pluripotent stem cells. (hoajonline.com)
6 Induced pluripotent stem cells from human extra-embryonic amnion cells: role of dna methylation in mainting stemness. (vinastemcelllab.com)
12 Induced pluripotent stem cell production and characterization: an overview of somatic cell reprogramming. (vinastemcelllab.com)
14 Pluripotent cell-derived glial precursor cells for the delivery of therapeutic proteins to the central nervous system. (vinastemcelllab.com)
At first, the mesenchymal stem cell was thought to be the primary component of this undifferentiated cell type, however it is now evident that within the adipose extracellular matrix are also adipocytic precursors (known as progenitor cells) adherent to adipocytes, and in close approximation to a variety of additional undifferentiated multipotent and pluripotent cells, including pericytes and endothelial cells, all thought to play important roles in mesenchymal-stromal derived tissue regeneration. (journalofprolotherapy.com)
At the same time, the first three trials using cells derived from pluripotent cells have begun. (biomedcentral.com)
Embryonic stem cells are present only in the early stages of development and are able to generate any cell type (Pluripotent Stem Cells). (bvsalud.org)
They are pluripotent, meaning they can give rise to any type of cell in the body (image 4). (the-dna-universe.com)
Myc, Oct3/4, Sox2 and Klf4) that encode transcription factors (Yamanaka factors) for the conversion of somatic cells into pluripotent stem cells. (the-dna-universe.com)
Figure 5: Depiction of the process to generate induced pluripotent stem cells. (the-dna-universe.com)

Embryonic stem cells which are characteristic of totipotency differentiate into generations of the multiple organs. (hoajonline.com)
The totipotentstem cells differentiate further into pluripotency thatpopulate the organs with different sub-divisional components of the various individual organs. (hoajonline.com)
mesenchymal stem cells - placenta) differentiate into multipotency as precursors to formation of the cellular components. (hoajonline.com)
Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells. (lww.com)
Intradermal adipocyte progenitor cells are activated toward the end of the telogen phase to proliferate and differentiate into mature adipocytes. (jcadonline.com)
In addition cIAP1 Ligand-Linker Conjugates 14 to HSC, bone marrow contains mesenchymal stem/progenitor cells (MSC), which can differentiate into mature cells of multiple mesenchymal tissues cIAP1 Ligand-Linker Conjugates 14 including fat, bone, and cartilage. (eyesoftheelephants.com)
These stem cells in turn are able to proliferate and re-differentiate to give rise to any other cell type. (the-dna-universe.com)
Adult stem cells are more specialised than embryonic stem cells and can be found in different organs throughout the body, where they divide and further differentiate to replenish lost cells. (the-dna-universe.com)
Unlike embryonic stem cells, they are multipotent, meaning they can only differentiate into specific cell types. (the-dna-universe.com)
For instance, neural stem cells can only differentiate into glial and neuronal cells. (the-dna-universe.com)
Mesenchymal stem cells (mesenchymal stromal cells) are another type of adult stem cells that have been featured prominently in clinical trials recently due to their ability to differentiate into a variety of cell types. (the-dna-universe.com)
They can be induced to differentiate into neuronal precursors and mature neurons, a promising development in the treatment of central nervous system disease. (the-dna-universe.com)
As needed, the stem cells differentiate to become a particular kind of cell-a white blood cell, red blood cell, or platelet. (medscape.com)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)

Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
Stromal cells are connective tissue cells that form the supportive structure in which the functional cells of the tissue reside. (wikipedia.org)
The term encompasses multipotent cells derived from other non-marrow tissues, such as placenta, umbilical cord blood, adipose tissue, adult muscle, corneal stroma, or the dental pulp of deciduous (baby) teeth. (wikipedia.org)
Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
However, obtaining primary neuronal cells from adult tissue is difficult and faces major ethical issues in clinical practice. (hindawi.com)
To better understand whether the intrinsic properties of these cells contribute to the overall differentiation potential of hASCs, we compared the global gene expression profiles of 4 mesoderm-derived stem cell populations: human adipose tissue-derived stromal cells, human bone marrow-derived stromal cells (hBMSCs), human (fore)skin-derived precursor cells (hSKPs), and human Wharton's jelly-derived mesenchymal stem cells (hWJs). (ac.be)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
10 The potential of stem cells and tissue engineered scaffolds for repair of the central nervous system. (vinastemcelllab.com)
24 Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types. (vinastemcelllab.com)
Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy. (cellsurgicalnetwork.com)
Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
Critical to the hypothesis is the experimental fact that human endometrial-derived stem cells (hEnSCs) as multipotent accessible source of cells are known as useful cell candidates in the field of nerve tissue engineering. (scirp.org)
These novel differentiated cells in fibrin gel might open new opportunities for the management of cell survival and neurotrophic potential in tissue engineering approaches for nerve repair. (scirp.org)
One explanation for deficient repair is when undifferentiated adult stem repair cells are inadequate in number or cannot be stimulated within the damaged tissue site. (journalofprolotherapy.com)
With improved understanding of tissue healing and regeneration, stem cell Prolotherapy is gaining significant clinical importance and potential. (journalofprolotherapy.com)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
As a result of being capable of differentiating into a variety of cell types, it can be presumed that stem cell therapy has an advantage when compared to other tissue repair methods. (bvsalud.org)
The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)
For stem cells to be used in tissue engineering a scaffold is essential to provide the necessary support for the transport of nutrients, oxygen and the elimination of metabolic waste 30 , promoting a conducive environment for cell growth and differentiation. (bvsalud.org)
The high regeneration potential has aroused a great interest in the scientific community 3 , due to its many clinical applications in cell therapy or tissue engineering. (bvsalud.org)
Cell therapy is a therapy where cellular material is injected systemically or directly into the injured tissue, to promote local repair or to restore systemic health. (bvsalud.org)
There have been numerous studies utilizing mesenchymal stem cells to enhance tissue repair and decrease inflammatory damage in both in vitro lab studies and in vivo clinical models. (medicalpressopenaccess.com)
Cells grown in vitro from neoplastic tissue. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
Trophic factors modulate the local immune system, enhance angiogenesis, prevent cell apoptosis, and stimulate the survival, proliferation, and differentiation of resident tissue stem cells. (the-dna-universe.com)
In this way, it will provide a scaffold for stem cells and will both 1) allow for cell differentiation into organized, contractile tissue over time, and 2) nourish cellular environments via its retained native vascular conduits - together enabling the bioengineering of functional, human-sized whole heart in vitro. (savingtinyhearts.org)
Bone marrow is the soft, spongy, gelatinous tissue found in the hollow spaces in the interior of bones. (medscape.com)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
Bone marrow can be 1 of 2 types, red or yellow, depending on whether it consists of mainly hematopoietic (and therefore, red-colored) tissue or fatty (and therefore a yellow-colored) tissue. (medscape.com)
however, significant vacuolization is present in the heart's connective tissue cells of the heart valves. (medscape.com)

The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
The best hope for regeneration of these permanently damaged cells is optic stem cell therapy combined with continued drug treatments or other exogenous biomaterial implants depending upon the relevant ophthalmological condition. (hoajonline.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
Schwann cells (SCs) have important roles in development, myelination and regeneration in the peripheral nervous system. (scirp.org)
This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)
Recellularized nerve allografts with differentiated mesenchymal stem cells promote peripheral nerve regeneration. (stgmu.ru)

They are sometimes referred to as bone marrow stromal stem cells. (wikipedia.org)
The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)

It is known that BMC contains mesenchymal stem cells as well as a number of other cell types including but not limited to: hematopoietic stem cells, endothelial progenitor cells, and platelets. (medicalpressopenaccess.com)
The bone marrow stroma contains mesenchymal stem cells. (medscape.com)

3. Maintenance of neural stem cells in the brain: role of notch signaling. (vinastemcelllab.com)
20 Malignant gliomas: treatment using genetically-modified neural stem cells. (vinastemcelllab.com)
More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)

hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)
Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
Recognition of the vast number of undifferentiated cells associated with the stromal vascular fraction has resulted in extensive research demonstrating the heterogeneity of such cells, and their ability to participate in production of all mesodermal-derived tissues. (journalofprolotherapy.com)
Stem cells from dental tissues have a real potential in Advanced Therapies. (bvsalud.org)
Until now, several progenitor cells derived from dental tissues have been isolated and characterized ( table I ). (bvsalud.org)
Stem cells derived from dental tissues are isolated from specialized tissues and have a strong ability to give rise to other cell lines, but with a different potential of bone marrow stem cells 16 . (bvsalud.org)
Stem cells are classified into two main: embryonic stem cells, which are found in the embryos and adult stem cells, found in adult tissues. (bvsalud.org)
Adult stem cells are found in differentiated tissues and are able to generate specialized cells in some types of tissues (Multipotent Stem Cells). (bvsalud.org)
In clinical practice, these involve the life-long immunosuppression of the organ transplantation patients, the creation of the supporting environment for engineered tissues in the mended organ, the unsolved issues of cell survival and differentiation of the cell-based therapy, and the selection and development of vectors for gene therapy. (biomedcentral.com)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
This involved stem cells being infused into his heart to restore the function of the damaged tissues. (the-dna-universe.com)
When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)

Indeed, the potent pathotropic migratory properties of BMSCs and ability to circumvent both the complications associated with immune rejection of allogenic cells and many of the moral reasons associated with embryonic stem cell use suggest that BMSCs are most promising stem cells as a potential target for the clinical use of genetically engineered stem cells [ 14 , 15 ]. (hindawi.com)
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. (ca.gov)
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. (ca.gov)
Cellular differentiation begins with the fertilized egg which serves as the identifying characteristic of an embryonic stem cell. (jcpa.org)
In 2009, in a major reversal of U.S. policy, President Obama signed an executive order pledging to "vigorously support" embryonic stem cell research. (jcpa.org)
Image 4: Depiction of embryonic stem cell differentiation. (the-dna-universe.com)

Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)
For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
1 Neural stem/progenitor cell proliferation and differentiation: role of sonic hedgehog and wingless/int-1 proteins. (vinastemcelllab.com)
We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)
Using these systems, we seek to identify reparative and progenitor cell lung populations, and the genetic programs that control their fate. (bu.edu)
Anderson, L. and Caldwell, M.A. (2007) Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease. (scirp.org)
Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)

Here we investigate the ability of resident skeletal stem-cell (SSC) populations to regenerate cartilage in relation to age, a possible contributor to the development of osteoarthritis5,6,7. (howhelp.org)
These data indicate that following MF, a resident stem-cell population can be induced to generate cartilage for treatment of localized chondral disease in OA. (howhelp.org)
The most severely affected system is the skeletal system, in which trabeculation of bone and cartilage structures are abnormal. (medscape.com)

As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
Studies have increasingly focused on the potential therapeutic effects of stem cell transplantation for neurological diseases [ 10 ]. (hindawi.com)
Despite initial therapeutic outcomes, conventional stem cells face key limitations. (biomedcentral.com)
Recently, mesenchymal stromal cell (MSC)-derived small extracellular vesicles (EVs) have emerged as a potential new therapeutic agent for stroke treatment. (explorationpub.com)
Cancer stem cellsand their susceptibility over their expected to be "downstream or progeny" cancer cells represent a target for therapeutic interventions to prevent latency and consequently relapse or metastasis of the malignant disease. (hoajonline.com)
The potential therapeutic use of stem cells has been broadly researched in recent years. (bvsalud.org)
The stem cells from exfoliated deciduous teeth (SHEDs) have a great potential for therapeutic use because of its differentiation capability and its easy access, since the collection is performed at the physiological exfoliation stage of the deciduous teeth. (bvsalud.org)
This astonishing regenerative ability of stem cells and their potential therapeutic applications have intrigued scientists for years, and we are now starting to see the results of the scientists' hard work in the form of successful treatments for illnesses that were previously difficult to treat. (the-dna-universe.com)
Background: ARDS is a lung disorder that causes death in human and livestock and new therapeutic approaches such as stem cell therapy are essential because of lack of specific drug therapies for it. (ac.ir)

Inhibition of hematopoiesis results in reduced populations of blood forming cells. (hoajonline.com)
Among the 3 germ cell layers, the mesoderm is the origin of today's most widely used and characterized hASC populations. (ac.be)
A variety of isolated nonhematopoietic mesoderm-derived stem cell populations exist, and all of them show important differences in terms of function, efficacy, and differentiation potential both in vivo and in vitro. (ac.be)
The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
This state-of-affairs is a direct result of a variety of technical issues such as a deficiency of informative markers that can be used to precisely characterize putative stem cell populations in the lung. (bu.edu)
An important extension of this work is to understand how the phenotype of smooth muscle cell populations becomes altered in disease. (bu.edu)

These bone marrow stem cells do not contribute to the formation of blood cells, and so do not express the hematopoietic stem cell marker CD34. (wikipedia.org)
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. (ca.gov)

Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Our data provide evidence that adult stem cells in bone marrow can be efficiently transduced vector administration without preconditioning. (eyesoftheelephants.com)

Then, the effects of BMSC-derived MVs and THBS2-deficient BMSC-derived MVs on the GC cell line MGC-803 were assessed by in vitro proliferation, migration, and invasion assays. (bvsalud.org)
We discovered that myocilin increased cell proliferation and survival. (nih.gov)
NK cell proliferation, phenotypic expression and cytotoxic activity were evaluated. (springer.com)
13 Proliferation of bone marrow-derived human mesenchymal stem cells: role of enamel matrix proteins. (vinastemcelllab.com)

Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)

More importantly, L-Fucose treatment significantly promoted the proportion of ENPCs differentiated into neurons and glial cells both in vitro and in vivo, accompanied by inhibiting SMAD2 phosphorylation. (bvsalud.org)

Shaping of natural killer cell antitumor activity by ex vivo cultivation. (springer.com)
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. (ca.gov)
2 Despite having high metabolic activity, human CECs (hCECs) do not proliferate in vivo because these cells arrest in the G1 phase of the cell cycle. (lww.com)
Enhancing trophic support of mesenchymal stem cells by ex vivo treatment with trophic factors. (cellsurgicalnetwork.com)
The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)

BACKGROUND: Our previous study found that bone marrow-derived mesenchymal stem cells (BMSCs) promote Helicobacter pylori (H pylori)-associated gastric cancer (GC) progression by secreting thrombospondin-2 (THBS2). (bvsalud.org)
The use of human telomerase reverse transcriptase-immortalized bone marrow mesenchymal stromal cells (hTERT-BMSCs) as vehicles to deliver antinociceptive galanin (GAL) molecules into pain-processing centers represents a novel cell therapy strategy for pain management. (hindawi.com)
Here, an hTERT-BMSCs/Tet-on/GAL cell line was constructed using a single Tet-on-inducible lentivirus system, and subsequent experiments demonstrated that the secretion of rat GAL from hTERT-BMSCs/Tet-on/GAL was switched on and off under the control of an inducer in a dose-dependent manner. (hindawi.com)
The construction of this cell line is the first promising step in the regulation of GAL secretion from hTERT-immortalized BMSCs, and the potential application of this system may provide a stem cell-based research platform for pain. (hindawi.com)
In contrast, BMSCs are capable of differentiating into mesenchymal lineages such as osteoblasts, chondrocytes, adipocytes, and even neurons and astrocytes [ 12 ]. (hindawi.com)
Demyelinating conditions are difficult to treat and stem cell therapy using bone marrow mesenchymal stem cells (BMSCs) is a promising novel strategy. (biomedcentral.com)
A bolus of BMSCs (5 × 10 7 cells/kg) was injected via tail vein. (biomedcentral.com)

In this assay hematopoietic cells are cultured in MyeloCult™ medium with supportive human or mouse stromal cell layers and tested for their ability to generate myeloid clonogenic progenitors for several weeks as assayed by replating the cells in a colony-forming unit (CFU) assay using MethoCult™ medium. (stemcell.com)
Establish stromal cell layers and culture hematopoietic progenitors in "Dexter-type" long-term bone marrow cultures. (stemcell.com)
We will use a perfusion bioreactor to simulate physiological conditions in the ECM, onto which we will seed uncommitted progenitors, cardiac precursors, and/or bone marrow-derived mesenchymal stem cells. (savingtinyhearts.org)

The cells, which are long and thin, are widely dispersed, and the adjacent extracellular matrix is populated by a few reticular fibrils, but is devoid of the other types of collagen fibrils. (wikipedia.org)
When administered post-stroke, mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) induce neuroprotection, promote brain remodeling and plasticity, and enhance neurological recovery in rodents and non-human primates via mechanisms that involve immunomodulation and anti-inflammation. (explorationpub.com)
For this purpose, we developed a fibrous scaffold resembling the bone/bone marrow extracellular matrix (ECM) based on protein without addition of synthetic polymers. (nature.com)

Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
Stem cell-based immunotherapy has been recognized as a crucial immunoregulatory regimen in various preclinical and clinical studies. (biomedcentral.com)
Osteopetrosis is a clinical syndrome characterized by the failure of osteoclasts to resorb bone. (medscape.com)
Large or complex bone fractures often need clinical treatments for sufficient bone repair. (nature.com)
Large bone defects can often not sufficiently be repaired by the body itself and require new clinical therapies 1 . (nature.com)
His background includes research (physiology, cell biology, neurophysiology), clinical practice (nutrition, diabetes & regenerative medicine), and was formerly Medical Director for Johnson & Johnson. (barefacedtruth.com)
Stem cells in human neurodegenerative disorders-time for clinical translation? (cellsurgicalnetwork.com)
The Stem Cells Portal provides coverage of the latest research, clinical applications, policies, and developments in the stem cell and regenerative medicine fields. (stemcellsportal.com)
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)
There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)

These stem cells are capable of differentiating into chondrocytes, cardiomyocytes, melanocytes, and hepatocyte‐like cells in vitro. (wikipedia.org)
Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)

16 Microencapsulation procedures for the immunoisolation of wharton's jelly mesenchymal stem cells: a review. (vinastemcelllab.com)

Does Transplantation Induce Aging In Patients? (medicaldaily.com)
Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
Although human HSCs as vehicles to treat metachromatic leukodystrophy (MLD) has been used to treat patients with early onset MLD in a phase I/II trial, the HSCs give rise to all different blood cell lineages, such as the myeloid and lymphoid cell lineages [ 11 ]. (hindawi.com)
Lung transplantation is a life-saving surgical replacement of diseased lungs in patients with end-stage respiratory malfunctions. (biomedcentral.com)
Lung transplantation is a life-saving surgical procedure for patients with end-stage lung diseases. (biomedcentral.com)
The prognosis of some patients with infantile osteopetrosis can markedly change after bone marrow transplantation (BMT). (medscape.com)
Between May 2005 and February 2010, 126 consecutive patients underwent intramyocardial cell injection. (tci-thaijo.org)
In aging western societies, patients with bone injuries are admitted more and more frequently to clinics. (nature.com)
25 Severe combined immunodefieciency patients: immune recovery after stem cell transplantation. (vinastemcelllab.com)
A two-year follow-up study of co-transplantation with neural stem/precursor cells and mesenchymal stromal cells in ischemic stroke patients. (cellsurgicalnetwork.com)
Since endometrial stromal cells are easy to isolate, and expand rapidly from patients without leading to major ethical and technical problems. (scirp.org)
A paucity of platelets, red blood cells (RBCs), granulocytes, monocytes, and reticulocytes is found in patients with aplastic anemia. (medscape.com)
Because the extent of previous transfusion has been shown to significantly affect the outcomes of patients undergoing hematopoietic cell transplantation (HCT) for aplastic anemia, the rapidity with which these data are obtained is crucial. (medscape.com)
Early enzymologic studies showed that cultured fibroblasts from patients with I-cell disease were deficient in numerous lysosomal enzymes. (medscape.com)

These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
NK cells were obtained from peripheral blood (PB) of healthy volunteers. (springer.com)
Ruengsakulrach P, Visudharom K, Chaothawee L, Belkin M. Safety and Efficacy of Intramyocardial Implantation of Peripheral Blood Stem Cell for Cardiomyopathy. (tci-thaijo.org)
Following intravenous administration of a first-generation LV into adult mice, we found that bone marrow exhibited the highest levels of transgene among nine organs examined, with more than 10% green fluorescent protein-positive (GFP+) cells detected in peripheral blood leukocytes (PBL) in these mice [9]. (eyesoftheelephants.com)

The tumor will rapidly recur if the therapy eliminates cancer cells but spares a significant population of the cancer stem cells. (hoajonline.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
Understanding of molecular mechanisms in natural killer cell therapy. (springer.com)
2014). Human NK cells: From surface receptors to the therapy of leukemias and solid tumors. (springer.com)
Trang chủ Công trình KHCN Sách/Chương sách Improving the Efficacy of Diabetes Mellitus Treatment by Combining Cell Replacement Therapy. (vinastemcelllab.com)
Stem cell therapy has the potential to overcome these limitations and may offer the best outcomes for treating diabetes mellitus. (vinastemcelllab.com)
Based on the pathophysiology of diabetes mellitus, stem cell therapy targets two mechanisms, namely cell replacement and immune correction. (vinastemcelllab.com)
The aim of this series of studies was to evaluate the efficiency of diabetic treatment by combining cell replacement therapy with immune correction therapy. (vinastemcelllab.com)
These findings provide hope for a new strategy that can improve the outcomes of stem cell-based therapy for diabetes in humans. (vinastemcelllab.com)
18 Adipose-derived stem cells: therapy through paracrine actions. (vinastemcelllab.com)
Corneal transplantation is currently the only therapy for severe corneal disorders. (lww.com)
Bone marrow stem cells from adults have been viewed as the ideal target for gene- and cell-based therapy of genetic diseases, selected malignant diseases, and AIDS. (eyesoftheelephants.com)
There is mounting evidence to support the use of biologic and cell- based therapy for chronic discogenic low back pain. (medicalpressopenaccess.com)
Due to his refusal of surgical treatment, his physician suggested stem cell therapy. (the-dna-universe.com)
Let's first rewind a little bit to the origins of stem cell research and stem cell therapy. (the-dna-universe.com)
After the success of his first bone marrow transplant therapy, Georges Marthé once again astonished the scientific community by curing a case of leukaemia using bone marrow transplantation in 1963 (figure 3). (the-dna-universe.com)

The standard test to confirm multipotency is differentiation of the cells into osteoblasts, adipocytes and chondrocytes as well as myocytes. (wikipedia.org)
[ 5 ] Osteoblasts synthesize bone matrix, which is composed predominantly of type I collagen and is found at the bone-forming surface. (medscape.com)
Osteoblasts arise from multipotent mesenchymal stem cells. (medscape.com)
Osteoblasts are responsible for synthesizing bone matrix and thereby creating an environment that supports the growth, maturation, and function of osteoclasts. (medscape.com)
Osteoblasts dissipate calcium and phosphate ions into the subjacent collagenous bone for the formation of hydroxyapatite (Ca 5 (PO 4 ) 3 (OH)) for bone stiffening 5 , 6 . (nature.com)
It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
Here we show that bone marrow endosteal SSCs are defined by fibroblast growth factor receptor 3 ( Fgfr3 ) and osteoblast-chondrocyte transitional (OCT) identities with some characteristics of bone osteoblasts and chondrocytes. (nature.com)
Therefore, Fgfr3 + endosteal SSCs are abundant in young bone marrow and provide a robust source of osteoblasts, contributing to both normal and aberrant osteogenesis. (nature.com)
Of note, we define OCT identities as a state with some characteristics of both osteoblasts and chondrocytes, instead of cell-type plasticity between osteoblasts and chondrocytes. (nature.com)

The decrease in the number of neurons and glial cells in the ENS of diabetic mice were reversed by L-Fucose treatment. (bvsalud.org)

26,27 Dermal adipocytes are organized in small clusters under the reticular dermis and interact with the hair follicular cells regulating the hair cycle. (jcadonline.com)

Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. (lww.com)
1 If the number of corneal endothelial cells (CECs) falls below a certain threshold because of traumatic injury, disease, or normal aging processes, functionality of the CE is decreased, and the cornea swells and becomes milky, leading to eventual vision loss. (lww.com)

this limitation has been overcome via ectopic expression of human telomerase reverse transcriptase (hTERT), the catalytic component of telomerase, to produce large quantities of these cells as an attractive source for cellular transplantation [ 16 - 18 ]. (hindawi.com)
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. (ca.gov)
Myelin Restoration: Progress and Prospects for Human Cell Replacement Therapies. (ca.gov)
17 Human hair follical stem cells: markers, selection and perspective clinic application. (vinastemcelllab.com)
Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macacafascicularis. (cellsurgicalnetwork.com)
These results show that for the first time, human endometrial stem cells can be differentiated into Schwann cells in 2D and 3D culture. (scirp.org)
Stem cell research is, in part, a quest to understand cellular differentiation, the process by which a human being develops from one fertilized cell into a multicellular organism composed of over 200 different cell types - for example muscle, nerve, blood cell, or kidney. (jcpa.org)
Similarly, when the fertilized egg divides from two cells into four cells, each of these four cells has the potential to individually form a human fetus. (jcpa.org)
Contrary to popular belief, stem cells are present in the human body throughout life and are found in many adult organs. (jcpa.org)

Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)

In marked contrast to the cancer stem cells, the tumor cells without "stemness" have either no capacity or a markedly diminished capacity, to form new tumors. (hoajonline.com)
Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. (cellsurgicalnetwork.com)

4 Maintenance of hematopoiesis: role of early b cell factor 2 matthias kieslinger. (vinastemcelllab.com)
gene transfer, hematopoietic stem cells, lentiviral vectors, mesenchymal stem/progenitor cells, bone marrow transplantation, hematopoiesis Introduction HIV-based lentiviral vectors (LV) were proven to be capable of transducing a broad spectrum of nondividing cells in multiple mammalian species cIAP1 Ligand-Linker Conjugates 14 [1]. (eyesoftheelephants.com)

hSKPs predominantly expressed genes involved in neurogenesis, skin, and bone development, whereas hWJs and, to some extent, hBMSCs showed an increased expression of genes involved in cardiovascular and liver development. (ac.be)

Immunotolerance is a major immunological phase, which facilitates reparative microenvironment during transplantation, and plays a vital role to suppress alloimmune responses. (biomedcentral.com)

Stem cells are present in amniotic fluid. (wikipedia.org)

This reduced differentiation of CD34+ hematopoietic progenitor stem cells could occur due to both infectious and non-communicable diseases and also due to their drug induced treatments. (hoajonline.com)
While there is a great deal published on the potential medical applications of stem cell research to treat or cure diseases such as diabetes, Alzheimer's disease, Parkinson's disease, cancer, and heart disease, much less has been published on the future impact of stem cell research in reproductive medicine. (jcpa.org)
As in many of the lysosomal storage diseases, the functional deficiency of lysosomal enzymes results in abnormal cell architecture. (medscape.com)

26 Transplanted mesenchymal stem cells aid the injured brain through trophic support mechanisms.Index. (vinastemcelllab.com)

To understand the etiology of osteopetrosis, it is very essential to understand the bone-remodeling cycle and the cell biology of osteoclasts. (medscape.com)
In 1999, Baron clearly and concisely reviewed the cell biology of the bone remodeling. (medscape.com)
International Journal of Biochemistry & Cell Biology, 40 , 2335-2340. (springer.com)
Natural killer cell biology: An update and future directions. (springer.com)
Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. (ca.gov)
Dr. John is the CEO and chief scientist at Cellese, with a passion for stem cell biology as it relates to skin and wound healing. (barefacedtruth.com)
Our interest in stem cell biology grew out of our work in diabetes. (barefacedtruth.com)
He is an-NIH funded Principal Investigator and Director of the Stem Cell Biology Program at the Boston University Pulmonary Center. (bu.edu)
Knowledge about the identity, localization, and biology of lung stem/progenitor cells has lagged behind what is known for other organ systems. (bu.edu)
Advancements in the field have also been limited by impediments imposed by the unique biology of the lung, including its marked cellular complexity and slow cell turnover. (bu.edu)
4 4Department of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. (ac.ir)

Acute myeloid leukemia-derived exosomes deliver miR-24-3p to hinder the T-cell immune response through DENN/MADD targeting in the NF-κB signaling pathways. (ac.be)
This will be coupled with next generation sequencing based approaches to understanding the consequences of perturbing immune cell function. (lu.se)
While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
A report suggests that there is accumulation of inclusion bodies in B-cells of individuals with I-cell disease, which may imply impairment of the immune system. (medscape.com)

The cells do not have the capacity to reconstitute an entire organ. (wikipedia.org)
Existing immunosuppressive drugs for organ transplantation may achieve sufficient immunosuppression to prevent organ rejection or limit autoreactivity, but they are typically not successful in achieving long-term survival of the graft or preventing progression of fibrosis and chronic rejection [ 3 ]. (biomedcentral.com)
Bone marrow supersedes the liver as the major hematopoietic organ at 32-36 weeks' gestation. (medscape.com)

Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. (ca.gov)
The results showed that transplantation of both IPCs and HSCs elicited greater improvements in body weight, blood glucose level and survival time than did transplantation of HSCs or IPCs alone. (vinastemcelllab.com)
Blood glucose, insulin levels, and survival of rats were monitored periodically following intravenous injection of the tested cells. (biomedcentral.com)

however, a variety of other cell types are found as well, collectively labeled as stromal vascular fraction (SVF). (jcadonline.com)
One particular interest involves understanding the origin, expansion mechanisms, and differentiation pathways controlling bronchial and pulmonary artery vascular smooth muscle cells during embryogenesis and disease. (bu.edu)
Our data indicate that this signaling system controls key aspects of a mature vascular smooth muscle cell phenotype, including a capacity to respond to vasoactive agonists in post-natal life. (bu.edu)
For these studies, we developed a series of unique mice that enable the high fidelity and independent isolation of bronchial or vascular smooth muscle cells for analysis. (bu.edu)
Both types of bone marrow are highly vascular, being enriched with numerous blood vessels and capillaries. (medscape.com)

Isolation, expansion, and characterization of natural killer cells and their precursors as a tool to study cancer immunosurveillance. (springer.com)

Mesoderm-derived stem cells: the link between the transcriptome and their differentiation potential. (ac.be)
As such, our data suggest that the intrinsic gene expression of the undifferentiated stem cells has an important impact on their overall differentiation potential as well as their application in stem cell-based research. (ac.be)

He is also the recipient of a Congressionally Directed Medical Research Program Award (CDMRP) that is focused on developing novel cell based treatments for acute lung injury. (bu.edu)

Stem cell transplantation for ischemic stroke. (cellsurgicalnetwork.com)

Using a variety of novel genetic mouse models along with embryonic lung cultures, the contribution of mesothelial cells to normal lung development is being investigated. (bu.edu)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

Anatomy30

Organisms14

Diseases43

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment75

Psychiatry and Psychology2

Phenomena and Processes42

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science3

Named Groups4

Health Care13

MSCs45

Autologous13

Pluripotent14

Differentiate14

Tissue32

Regeneration8

Stromal stem cells2

Contains mesenchymal stem2

Neural stem3

Tissues13

Embryonic stem6

Progenitor cell12

Cartilage3

Therapeutic9

Populations7

Hematopoietic stem2

Adult stem2

Proliferation4

Placenta1

Vitro and in vivo1

Vivo5

BMSCs7

PROGENITORS3

Extracellular3

Clinical15

Cardiomyocytes2

Wharton's1

Patients15

Peripheral blood4

Therapy16

Osteoblasts9

Glial1

Adipocytes1

Endothelial cells2

Human9

Cardiac1

Markedly2

Hematopoiesis2

Expressed genes1

Microenvironment1

Amniotic fluid1

Diseases3

Trophic support1

Biology11

Immune4

Organ3

Survival3

Vascular5

Characterization1

Differentiation potential2

Acute1

Ischemic stroke1

Mesothelial cells2