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Transcription FactorsMSX1 Transcription FactorTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceHomeodomain ProteinsTranscriptional ActivationBinding SitesTrans-ActivatorsBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerProtein BindingNuclear ProteinsTranscription Factor AP-1Gene Expression Regulation, DevelopmentalRepressor ProteinsCell LineForkhead Transcription FactorsSignal TransductionAmino Acid SequenceDNABasic-Leucine Zipper Transcription FactorsMutationTranscription Factor AP-2Cell DifferentiationCell NucleusTransfectionKruppel-Like Transcription FactorsTranscription Factors, TFIIGenes, ReporterChromatin ImmunoprecipitationYY1 Transcription FactorHeLa CellsCells, CulturedSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDPaired Box Transcription FactorsNFATC Transcription FactorsActivating Transcription Factor 3Reverse Transcriptase Polymerase Chain ReactionSp3 Transcription FactorTranscription Initiation SiteNF-kappa BZinc FingersElectrophoretic Mobility Shift AssayEnhancer Elements, GeneticActivating Transcription Factor 2Transcription Factor TFIIBRegulatory Sequences, Nucleic AcidGene Expression ProfilingE2F1 Transcription FactorRNA Polymerase IICloning, MolecularGene ExpressionRecombinant Fusion ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsPlasmidsMEF2 Transcription FactorsGATA3 Transcription FactorGATA1 Transcription FactorGATA2 Transcription FactorGene Expression Regulation, FungalTCF Transcription FactorsGATA Transcription FactorsMicrophthalmia-Associated Transcription FactorProtein Structure, TertiaryLuciferasesSTAT1 Transcription FactorActivating Transcription FactorsCell Line, TumorTranscription Factor RelAE2F Transcription FactorsPhosphorylationHelix-Loop-Helix MotifsChromatinOligonucleotide Array Sequence AnalysisModels, BiologicalSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsMice, KnockoutGene Expression Regulation, PlantSequence Homology, Amino AcidGATA6 Transcription FactorIn Situ HybridizationActivating Transcription Factor 4Transcription Factor 7-Like 1 ProteinActivating Transcription Factor 1Cyclic AMP Response Element-Binding ProteinProto-Oncogene ProteinsDown-RegulationMice, TransgenicTranscription Factor TFIIIABlotting, WesternTATA BoxNFI Transcription Factors
Epithelial mesenchymaEncodes a transcriptionMigrateCytokinesRegulateFibroblast GrowthRegulationKnockoutNeuralCellsGenesActivatorFateProteinsLymphoidSignaling pathwayExpressionAnalysisMouseCriticalShownDerived mesenchymal stemStemTranscriptionalMsx2StromalOsteogenicDifferentiationHumanFormPeriodProteinsCommonGrowth factorDevelopmentObtainSites
Epithelial mesenchyma2
  • Msx2 downregulates E-cadherins and upregulates N-cadherin and vimentin which indicates its role in inducing epithelial mesenchymal transition (EMT). (wikipedia.org)
  • Once NC induction is accomplished NC cells undergo the epithelial-mesenchymal transition (EMT) and eventually migrate along predetermined trajectories. (biomedcentral.com)
Encodes a transcription2
  • Msx2 is a homeobox gene localized on human chromosome 5 that encodes a transcription repressor and activator (MSX-2) responsible for craniofacial and limb-bud development. (wikipedia.org)
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)
Migrate1
  • Shortly after their dorsal specification, neural crest cells undergo an epithelial-to-mesenchymal transition, migrate, and finally, upon arrival at their destination, they give rise to a variety of cell types. (biomedcentral.com)
Cytokines1
  • Taken jointly, our information indicated that the actual regulation of Msx1 through BMP4/pSmad1/5 signaling is mediated through importin7 within mouse button dental care mesenchymal tissue.Cytokines communicate carefully with each other and also enjoy a crucial role in the continuing development of sepsis. (microtubule-signal.com)
Regulate3
  • Nonetheless, the precise co-factors which help pSmad1/5 going into the particular nucleus to regulate Msx1 in dental mesenchymal cells remain unknown. (microtubule-signal.com)
  • Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. (biomedcentral.com)
  • Differentiated somatic cells can be reprogrammed into a pluripotent-like state through four defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc (OSKM) [ 1 , 2 ]. (biomedcentral.com)
Fibroblast Growth2
  • Families of molecules such as those of Wnt, Hh (hedgehog), FGFs (Fibroblast Growth Factor) and BMPs (Bone Morphogenetic Protein, of TGFßs - Transforming Growth Factor family) have been identified, in different proportions and sites, with tissue-specific and stage-specific functions 1-2 . (bvsalud.org)
  • Morphorgens such as Wnt, fibroblast growth factor (FGF), retinoic acid (RA) and bone morphogenetic protein (BMP) secreted from the paraxial mesoderm and epidermis regulates the expression of a group of transcription factors ( Pax3, Zic1, Msx1 ) whereby defines the boarder of neural crest. (biomedcentral.com)
Regulation1
  • There has been one previous report showing that overexpression of Sirt6 in aged human dermal fibroblasts could improve iPS generation via regulation of miR-766 transcription [ 19 ]. (biomedcentral.com)
Knockout2
  • Germline knockout mice have been created for this gene (Msx2 +/-) in order to examine functional loss. (wikipedia.org)
  • Particularly, by performing transcriptome analysis, we observed that several pluripotent transcriptional factors increase in knockout cell line, which explains the underlying loss of pluripotency in Sirt6-null iPS-like cell line. (biomedcentral.com)
Neural1
  • Secreted from neighboring tissues, signaling molecules of the Wnt, Fgf, and Bmp families cooperate to activate a distinct combination of transcription factors at the neural plate border. (biomedcentral.com)
Cells6
  • It is well documented that expression of cell-cell adhesion molecules such as E-cadherins will promote structural integrity and an epithelial arrangement of cells, while expression of N-cadherin and vimentin promote mesenchymal arrangement and cell migration. (wikipedia.org)
  • [ 2 ] It is 2-5 cells thick and covers a layer of undifferentiated, proliferating mesenchymal cells 5-15 cells thick. (medscape.com)
  • During the fifth week, differentiating mesenchymal cells condense in a proximal-to-distal fashion to form blastemas, which eventually develop into cartilaginous models of, ultimately, the bones of the upper extremity. (medscape.com)
  • Mesenchymal cells derived from the dermomyotome condense within connective tissue (mesenchymal) scaffolds to form 2 common muscle masses. (medscape.com)
  • Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. (123dok.net)
  • Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
Genes3
  • Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
  • Recent advances in understanding the molecular events underlying hypohidrotic ectodermal dysplasia (HED) caused by mutations of the genes encoding proteins of the tumor necrosis factor α (TNFα)-related signaling pathway have been presented. (springer.com)
  • HED embraces a genetically heterogeneous group of diseases and is due to mutations of several genes that encode components of the tumor necrosis factor α (TNFα)-related signaling pathway (Cluzeau et al. (springer.com)
Activator1
  • We herein report the involvement of janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling in palatal fusion and that folic acid rescues the fusing defect by reactivating JAK2/STAT3. (bvsalud.org)
Fate1
  • When we reviewed pretransplantation factorHD, individual aspects including HCT-CI as well as Ps3 had been from the progression of candidemia, which implies which significantly not well patients together with transplantation-associated complications will build candidemia.Msx1 is vital for your upkeep of the actual odontogenic fate regarding dentistry mesenchymal cellular material, which is regulated simply by BMP/Smad1/5 signaling in a Smad4-independent way. (microtubule-signal.com)
Proteins1
  • The AER and PZ work as a functional unit responsible for the outgrowth of the limb along the proximodistal axis, and the marginal blood vessel may convey messenger proteins that integrate this process. (medscape.com)
Lymphoid1
  • The downstream signal transduction toward Eda-A1 involves the canonical Wnt/β-catenin pathway (Clevers 2006 ) and requires lymphoid enhancer-binding factor-1 (Lef-1) for activation of the Ed1 ( Ta ) expression (Durmowicz et al. (springer.com)
Signaling pathway1
Expression1
  • Next, knockdown involving IPO7 canceled your upregulation associated with Msx1 caused by simply BMP4, whilst overexpression associated with Smad1 could recovery the particular Msx1 expression. (microtubule-signal.com)
Analysis1
  • Finally, ChIP along with Re-ChIP analysis revealed IPO7 helped the particular employment of pSmad1/5 for the Msx1 promoter. (microtubule-signal.com)
Mouse4
  • We aimed to test the Arl15 gene as a functional candidate for metabolic traits in the mouse. (bvsalud.org)
  • This study aspires to investigate regardless of whether IPO7 takes part within the atomic translocation of pSmad1/5 triggered through BMP4 to manage find more Msx1 phrase in computer mouse dental mesenchymal cellular material. (microtubule-signal.com)
  • In the current review, we all discovered that IPO7 has been firmly indicated inside the mouse button tooth mesenchymal cellular material in postnatal first day (PN1) both in vitro as well as in vivo. (microtubule-signal.com)
  • Mouse embryonic fibroblasts isolated from transgenic Oct4-GFP reporter mice with or without Sirt6 were used for reprogramming by Yamanaka factors. (biomedcentral.com)
Critical1
  • Importin7 (IPO7) is amongst the critical members of importin β-superfamily, generally responsible for nucleocytoplasmic driving regarding RNAs and meats, which include transcription aspects. (microtubule-signal.com)
Shown1
  • Msh homeobox 2 has been shown to interact with DLX5, DLX2 and MSX1. (wikipedia.org)
Derived mesenchymal stem1
  • 27. AML‑derived mesenchymal stem cells upregulate CTGF expression through the BMP pathway and induce K562‑ADM fusiform transformation and chemoresistance. (nih.gov)
Stem5
  • from the Zhang laboratory differentiated human pluripotent stem cells (ESCs and iPSCs) initially to neuroepithelia, and then to midbrain neural progenitors and functional dopaminergic neurons. (medscape.com)
  • The Zhang laboratory has also established a protocol for the differentiation of astroglia from human pluripotent stem cells by removing mitogens and adding the growth factor CNTF. (medscape.com)
  • Our analysis showed that Sox4, Sox5, Sox9, Sox11, and Sox12 are mainly expressed in mesenchymal stem/stromal cells (MSCs) representing osteogenic cells at different stages of differentiation. (bvsalud.org)
  • Recently, a bone forming peptide-1 (BFP-1) that derived from bone morphogenetic protein-7 (BMP-7) has confirmed its excellent performance in promoting the osteogenic induction of human stem cells mainly human mesenchymal stem cells. (researchsquare.com)
  • Stem cells of human mesenchymal stem cells (hMSCs) and human pluripotent stem cells (hPSCs) are commonly applied to induce osteoblast-like cells in vitro . (researchsquare.com)
Transcriptional2
  • 25. LIM homeobox transcription factor Lhx2 inhibits skeletal muscle differentiation in part via transcriptional activation of Msx1 and Msx2. (nih.gov)
  • The localization of transcriptional activity in specialized transcription bodies is a hallmark of gene expression in eukaryotic cells.1-3 How proteins of the transcriptional machinery come together to form such bodies, however, is unclear. (bvsalud.org)
Msx22
  • Msx2 is a homeobox gene localized on human chromosome 5 that encodes a transcription repressor and activator (MSX-2) responsible for craniofacial and limb-bud development. (wikipedia.org)
  • Germline knockout mice have been created for this gene (Msx2 +/-) in order to examine functional loss. (wikipedia.org)
Stromal1
  • [ 24 ] The three techniques used a growth factor (noggin), a culturing process (with the stromal [e.g., connective tissue] cell line PA6), and another culturing process (with a laminin substrate and neural induction media). (medscape.com)
Osteogenic2
  • Our work has a great value in improving the in vitro osteogenic differentiation efficiency of hPSCs by adding functional osteogenesis compounds at specific stages and promoting the fundamental and clinical applications of osteoblast like cells. (researchsquare.com)
  • Notably, during the in vivo embryonic development, mesoderm and ectoderm cells differentiate toward mesenchymal cells, which further differentiate into osteogenic precursor cells and osteoblasts 10 , 11 . (researchsquare.com)
Differentiation2
Human2
  • 26. A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix.1. (nih.gov)
  • from the Brüstle laboratory developed a stable protocol for differentiating neurons and glia from multiple human pluripotent (ESC and iPSC) lines in a process that included withdrawing growth factors. (medscape.com)
Form1
  • Here, we take advantage of two large, isolated, and long-lived transcription bodies that reproducibly form during early zebrafish embryogenesis to characterize the dynamics of transcription body formation. (bvsalud.org)
Period1
  • The common muscle masses also continue to separate into individual muscles during this period, and the joints cavitate and become functional. (medscape.com)
Proteins2
  • The AER and PZ work as a functional unit responsible for the outgrowth of the limb along the proximodistal axis, and the marginal blood vessel may convey messenger proteins that integrate this process. (medscape.com)
  • The modification of proteins by s mall u biquitin-related mo difier (SUMO) molecules, SUMOylation, is a key post-translational modification involved in a variety of biological processes, such as chromosome organization, DNA replication and repair, transcription, nuclear transport, and cell signaling transduction. (mdpi.com)
Common2
  • Syndactyly is a condition well documented in current literature due to it being the most common congenital hand defect, with a large aesthetic and functional significance. (openorthopaedicsjournal.com)
  • Common in some species, including birds and kangaroos, it has a large aesthetic and functional significance for humans born with the condition. (openorthopaedicsjournal.com)
Growth factor2
  • Families of molecules such as those of Wnt, Hh (hedgehog), FGFs (Fibroblast Growth Factor) and BMPs (Bone Morphogenetic Protein, of TGFßs - Transforming Growth Factor family) have been identified, in different proportions and sites, with tissue-specific and stage-specific functions 1-2 . (bvsalud.org)
  • There is no doubt that each growth factor should be supplemented at a specific stage to treat corresponding cell types. (researchsquare.com)
Development1
  • This suggests that the same transcription factors and signaling pathways could activate cell-type-specific responses in multiple components of the musculoskeletal complex that may help coordinate the development of this intricate system. (elifesciences.org)
Obtain2
  • [ 18 ] A chemical culturing process was used to obtain neuroepithelia, and the application of growth factors was used to obtain neural progenitors and dopaminergic neurons. (medscape.com)
  • Then, to obtain dopaminergic neurons, growth factors (SHH and FGF8, then GDNF and BDNF) were introduced to the NSCs, again in a xeno-free culturing process. (medscape.com)
Sites1
  • Leukemia inhibitory factor (LIF) injections were given intraperitoneally and implantation sites visualized. (nih.gov)