Mesenchymal differentiate differentiation of cells. Medical search. Frequent questions

Melatonin (MLT) has been reported to act as an antioxidant during cell proliferation and differentiation, but its antioxidant effect and mechanism of action during osteogenesis of MSCs in the inflammatory microenvironment, especially in the presence of TNF- α , remain unknown and need further study. (hindawi.com)
Mesenchymal stem cells (MSCs) are promising for the regeneration of tendon and ligament tissues. (ca.gov)
In order for MSCs to differentiate to tendon tissue, they require appropriate environmental cues. (ca.gov)
The ability of MSCs to differentiate into chondrocytes has also made them the foremost option in cartilage repair studies. (aiche.org)
Since capsules wall acts as a diffusion barrier for nutrients and growth factors, employing the microcapsules in a perfusion chip will facilitate the cell access to nutrients and growth factors required for MSCs differentiation. (aiche.org)
In this research, the simultaneous effect of microencapsulation and perfusion on the differentiation of MSCs to chondrocytes has been investigated. (aiche.org)
It has been shown that mesenchymal stem cells (MSCs) obtained from umbilical cords, dental pulp and adipose tissue, which are all biological discards, are able to differentiate into muscle, fat, bone and cartilage cell lineages. (biomedcentral.com)
The aim of this study was to isolate, expand, characterize and assess the differentiation potential of MSCs from human fallopian tubes (hFTs). (biomedcentral.com)
Human tube MSCs can be easily isolated, expanded in vitro , present a mesenchymal profile and are able to differentiate into muscle, fat, cartilage and bone in vitro . (biomedcentral.com)
Mesenchymal stem/stromal cells (MSCs) are found in almost all postnatal organs. (lu.se)
Under appropriate environmental cues, multipotency enables MSCs to serve as progenitors for several lineage-specific, differentiated cell types. (lu.se)
In vitro expansion and differentiation of MSCs give the opportunity to obtain hardly available somatic cells, such as neurons. (lu.se)
Therefore, we hypothesized that multipotent mesenchymal stem cells (MSCs) from MC3RhDM/hDM mice are predisposed towards adipocyte differentiation and away from osteoblast differentiation. (nih.gov)
Bone-derived MSCs were differentiated into either adipocytes or osteoblasts, and the accumulation of triglycerides for adipocytes and calcium for osteoblasts were measured by Oil Red O and Alizarin Red S staining. (nih.gov)
MC3RhDM/hDM MSCs had ~40% increased capacity to differentiate into triglyceride-storing adipocytes than MC3RhWT/hWT MSCs, and mRNAs of adipocyte markers were correspondingly increased. (nih.gov)
In contrast, MC3RhDM/hDM MSCs have ~50% less capacity to differentiate into osteoblasts than MC3RhWT/hWT MSCs, and mRNA of osteoblast markers were correspondingly reduced. (nih.gov)
Intramyocardial transplantation of mesenchymal stem cells (MSCs) has emerged as a leading contender in the pursuit of clinical intervention and therapy. (springer.com)
MSCs are capable of secreting a large array of soluble factors, which have had demonstrated effects on pathogenic cardiac remolding, fibrosis, immune activation, and cardiac stem cell proliferation within the damaged heart. (springer.com)
MSCs are also capable of differentiation into cardiomyocytes, endothelial cells, and vascular smooth muscle cells, although the relative contribution of trilineage differentiation and paracrine effectors on cardiac repair remains the subject of active investigation. (springer.com)
Multipotent mesenchymal stem cells (MSCs) maintain the ability to differentiate into adipogenic, chondrogenic, or osteogenic cell lineages. (nih.gov)
The objective of the current study was to evaluate the potential of the prototypic AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to disrupt osteogenic differentiation of human bone-derived MSCs (hBMSCs) in vitro. (nih.gov)
The first is to engraft mesenchymal stem cells (MSCs) onto a graft or a biosynthetic matrix to provide a viable osteoinductive scaffold material for segmental defect repair. (ispub.com)
Mesenchymal adult stem cells ( MSCs ) are stromal cells with anti-inflammatory , immunomodulatory , self-renewal , cell-division , signaling , and multilineage differentiation properties. (plexusnc.com)
The word ' mesenchymal ' indicates the embryonic origins of MSCs, specifically those that are derived from the mesoderm germ layer. (plexusnc.com)
The differentiation of MSCs may be affected by growth factors, hormones, source of the MSCs, presence of other cells in the microenvironment (laboratory conditions), etc. (plexusnc.com)
MSCs have the potential to differentiate into different types of specialized cells. (plexusnc.com)
MSCs promote tissue regeneration by secreting cytokines and growth factors that can bring new cells/tissues to the site of injury or damage. (plexusnc.com)
Scientific abstract of thesis submitted by Jemima Lois Whyte for the degree of Doctor of Philosophy entitled 'Density dependent differentiation of mesenchymal stem cells to endothelial cells' September 2010.The differentiation of mesenchymal stem cells (MSCs) to endothelium is a critical but poorly understood feature of tissue vascularisation and considerable scepticism still remains surrounding this important differentiation event. (manchester.ac.uk)
During vasculogenesis, communication between MSCs and differentiated ECs or vascular smooth muscle cells, or between MSCs themselves is likely to influence MSC differentiation. (manchester.ac.uk)
Thus, this study not only provides evidence that MSC density is an essential microenvironmental factor stimulating the in vitro differentiation of MSCs to ECs but also demonstrates that MSCs can be differentiated to a functional EC. (manchester.ac.uk)
Taken together, defining how these crucial MSC differentiation events are regulated in vitro, provides an insight into how MSCs differentiate to ECs during postnatal neovascularisation and an opportunity for the therapeutic manipulation of MSCs in vivo, enabling targeted modulation of neovascularisation in ischaemia, wound healing and tumourigenesis. (manchester.ac.uk)
Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)
Bone marrow: Bone marrow is a rich source of two important adult stem cell lineages: Hematopoietic Stem Cells (HSCs) and Mesenchymal Stem Cells (MSCs). (ijbiotech.com)
Mesenchymal Stem Cells (MSCs): There are different sources of MSCs and their isolation is relatively easy. (ijbiotech.com)
So far several cell types have been differentiated from MSCs. (ijbiotech.com)

One could go in and compare certain lineage factors between in vivo and in vitro, as well as look at what factors influence the stem cells down specific pathways. (wikipedia.org)
This study confirmed that melatonin can inhibit the generation of ROS during osteogenic differentiation of BMSCs and reverse the inhibition of osteogenic differentiation of BMSCs in vitro, suggesting that melatonin can antagonize TNF- α -induced ROS generation and promote the great effect of osteogenic differentiation of BMSCs. (hindawi.com)
In vitro experiments demonstrate that this is a cell-autonomous function of beta-catenin in an osteoblast precursor. (nih.gov)
Furthermore, detailed in vivo and in vitro loss- and gain-of-function analyses reveal that beta-catenin activity is necessary and sufficient to repress the differentiation of mesenchymal cells into Runx2- and Sox9-positive skeletal precursors. (nih.gov)
Creating an in-vitro microenvironment for cells which can mimic the in-vivo conditions will facilitate the differentiation process. (aiche.org)
In addition, cell fate and function in-vitro are greatly affected by the composition of the extracellular matrix in which for cartilage is made of different type of glycosaminoglycans (GAGs). (aiche.org)
This funding opportunity will define the factors and mechanisms controlling the differentiation of embryonic or adult stem or progenitor cells, either in vitro or in vivo. (nih.gov)
The long range goal of this program is the development of methods to direct the differentiation or development of stem cells along specific cell lineages to yield replacement cells for clinical use, whether the replacement cells are formed in vitro for delivery or formed in vivo in the tissue or organ environment. (nih.gov)
The burgeoning preclinical and clinical experience with human adult adipose-derived cells appears to be promising but interpretation of the current literature with in vitro studies, translational research and FDA-registered investigations emphasizes the need for standardized methods to advance basic science knowledge and beneficial safe clinical outcomes. (scirp.org)
Furthermore hASC-derived myofibroblasts as well as conditioned medium from these cells promote the in vitro invasion of MDAMB231 breast cancer cells. (uni-muenchen.de)
Overall, the data of the present study suggest that human adipose tissue derived stem cells can differentiate into carcinoma-associated myofibroblast under the influence of TGFβ1 secreted from breast cancer cells in vitro. (uni-muenchen.de)
Using an in vitro 3D-model to simulate tumor architecture at an early stage, we showed that MSC specifically supported spheroid formation in CRC cells with a dysfunctional E-cadherin system. (uib.no)
Lineages of hFTs were expanded, had their karyotype analyzed, were characterized by flow cytometry and underwent in vitro adipogenic, chondrogenic, osteogenic, and myogenic differentiation. (biomedcentral.com)
Due to their embryonic ontology, stem cells residing in the stroma of the dental pulp chamber are an exciting source for in vitro neural cell differentiation. (lu.se)
We postulate that because DPSCs are stem cells with very close ontology to neurogenic lineages, they may serve as excellent targets for neuronal differentiation in vitro and even for direct reprogramming. (lu.se)
In the present study, three protocols for in vitro myogenic differentiation of bfMSC based on the use of DNA methyltransferase inhibitor 5-Aza-2-deoxycytidine (5-Aza), myoblast-secreted factor Galectin-1 (Gal-1), and myoblast culture medium SkGM-2 BulletKit were used. (unesp.br)
Furthermore, in vitro and in vivo inhibition of G9a could increase the differentiation and proliferation of pacemaker-like cells by decreasing the levels of H3K9me2 in the promoter region of HCN4 gene. (spandidos-publications.com)
The third strategy uses targeted delivery of therapeutic genes (using viral and non-viral vectors) that either transduce host cells in vivo or stably transduce cells in vitro for subsequent implantation in vivo. (ispub.com)
The in vitro osteogenic differentiation of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) have been one of the hot topics in bone tissue engineering. (researchsquare.com)
Our work has a great value in improving the in vitro osteogenic differentiation efficiency of hPSCs by adding functional osteogenesis compounds at specific stages and promoting the fundamental and clinical applications of osteoblast like cells. (researchsquare.com)
Stem cells of human mesenchymal stem cells (hMSCs) and human pluripotent stem cells (hPSCs) are commonly applied to induce osteoblast-like cells in vitro . (researchsquare.com)
Characterization of these cells were carried out by using in vitro two- and three-dimensional cultures and in vivo reconstitution of mice after orthotopic or intravenous injection, in conjunction with quantitative reverse transcription polymerase chain reaction, Western blotting, immunohisto(cyto)chemistry/immunofluorescence, and RNA seq analysis. (nih.gov)
We examined the effects of human umbilical cord-derived mesenchymal stem cells (HUMSCs) in Wharton's jelly on ovariectomy (OVX)-induced osteoporosis by using in vitro and in vivo experiments. (nycu.edu.tw)
Chromium effects on chondrocytic differentiation in vitro. (cdc.gov)
The study is to investigate BMSCs ability to differentiate cardiomyocytes, especially discussed cell generations and 5-Aaz concentration influence on BMSCs capability of proliferation and differentiation into cardiomyocytes during constructing the engineered myocardium-like tissue in vitro . (scirp.org)
Rat BMSCs could be differentiated into cardiomyocytes-like cells, which have a good biocompatibility with acellular bovine pericardium, and myocardium-like tissue could be engineered with BMSCs and acellular bovine pericardium in vitro . (scirp.org)
In conclusion, BMSCs could be induced and differentiated into cardiomyocytes-like cells in vitro . (scirp.org)
In conclusion, these findings provided insights into the regulatory role of the EMT on in vitro hepatic maturation, suggesting that inhibition of the EMT may drive transformation of hepatoblast cells into mature and polarized HLCs. (korea.ac.kr)

ROS can downregulate the osteogenic differentiation markers and cause osteogenic damage to the osteoblast cell line MC3T3-E1 [ 7 ]. (hindawi.com)
Although numerous transcription factors involved in chondrocyte and osteoblast differentiation have been identified, little is known about the signals controlling lineage decisions of the two cell types. (nih.gov)
Here, we show by conditionally deleting beta-catenin in limb and head mesenchyme that beta-catenin is required for osteoblast lineage differentiation. (nih.gov)
Osteoblast precursors lacking beta-catenin are blocked in differentiation and develop into chondrocytes instead. (nih.gov)
Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. (nih.gov)
It is now clear that hormones and growth factors produced by cells of other tissues are able to modulate bone modeling and remodeling by altering osteoblast, osteoclast, and osteocyte functions. (frontiersin.org)
In certain circumstances, other cell types (e.g., smooth muscle cells, cancer cells) also undergo osteoblast-like differentiation to develop pathological calcification. (frontiersin.org)
Moreover, disseminated cancer cells also modulate the functions of bone resident osteoblast and osteoclast cells to deteriorate bone health. (frontiersin.org)
Atypical osteoblast-like differentiation and disease. (frontiersin.org)
In past work, the team found that a protein called Cbfβ is involved in osteoblast differentiation. (nih.gov)
They deleted the Cbfβ gene at three different stages of osteoblast development: in mesenchymal stem cells, an intermediate stage, and early osteoblasts. (nih.gov)
These results suggest that a drop in Cbfβ could contribute to the age-related shift from osteoblast to fat cell production. (nih.gov)
A series of lab experiments confirmed that, without Cbfβ, cells at any stage of osteoblast differentiation could switch to form fat cells. (nih.gov)
16. [The crosstalk between canonical and noncanonical Wnt signaling pathway in osteoblast differentiation of periodontal ligament stem cells in inflammatory microenvironments]. (nih.gov)
Evidence for Aryl hydrocarbon Receptor-Mediated Inhibition of Osteoblast Differentiation in Human Mesenchymal Stem Cells. (nih.gov)
To study how Allogro® can induce osteoblast differentiation in mesenchymal stem cells, the expression levels of bone related genes and mesenchymal stem cells marker were analyzed, using real time Reverse Transcription-Polymerase Chain Reaction. (ispub.com)
Osteoblast differentiation is definitely controlled by multiple signaling systems. (ap26113.com)
Through the endochondral bone tissue formation, Ihh, made by hypertrophic chondrocytes, induces osteoblast differentiation of mesenchymal progenitor cells in the perichondrium of endochondral bone fragments [7]. (ap26113.com)
Wnt signaling is vital for osteoblast differentiation in both membranous and endochondral bone tissue development [8-11]. (ap26113.com)
B-catenin-independent, non-canonical Wnt signaling pathways also regulate features and differentiation of cells from the osteoblast-lineage [13]. (ap26113.com)
Runx2 is vital for osteoblast differentiation [22, 23]. (ap26113.com)
Osterix (Osx, Sp7) that serves at a rate genetically downstream of Runx2 may be the various other transcription aspect essential for osteoblast differentiation [24]. (ap26113.com)
It is well known that hPSCs must be differentiated towards osteoprogenitor cells or osteoblast-like cells before transplantation to avoid the tumorigenicity. (researchsquare.com)
In this regard, many kinds of growth factors have been applied to establish robust and efficient induction methods for the derivation of osteoblast like cells from hPSCs 8 , 9 . (researchsquare.com)

Osteoblasts and chondrocytes are involved in building up the vertebrate skeleton and are thought to differentiate from a common mesenchymal precursor, the osteo-chondroprogenitor. (nih.gov)
Mesenchymal stem cells have the ability to differentiate into one of the three cell types: osteoblasts, chondrocytes, or adipocytes. (frontiersin.org)
Osteoblasts, the cells that build bone, are derived from mesenchymal stem cells in the bone marrow. (nih.gov)
The bone marrow of older adults has fewer bone-building osteoblasts and more fat cells than that of younger people. (nih.gov)
A research team led by Drs. Yi-Ping Li and Wei Chen at the University of Alabama at Birmingham has been studying the signals that determine whether marrow mesenchymal stem cells develop, or "differentiate," into osteoblasts or fat cells. (nih.gov)
Our data detail the underlying pathways that cause progenitor cells and early osteoblasts to create fat cells instead of bone-producing cells," Li says. (nih.gov)
Osteoblasts are derived from bone marrow mesenchymal stem cells (BMMSCs) and play important role in bone remodeling. (ijstemcell.com)
While our previous studies have investigated the cell subtypes and heterogeneity in osteoblasts and BMMSCs separately, cell-to-cell communications between osteoblasts and BMMSCs in vivo in humans have not been characterized. (ijstemcell.com)
The aim of this study was to investigate the cellular communication between human primary osteoblasts and bone marrow mesenchymal stem cells. (ijstemcell.com)
To investigate the cell-to-cell communications between osteoblasts and BMMSCs and identify new cell subtypes, we performed a systematic integration analysis with our single-cell RNA sequencing (scRNA-seq) transcriptomes data from BMMSCs and osteoblasts. (ijstemcell.com)
Biological functional annotations of the transcriptomes suggested that the novel preosteoblasts subtype may inhibit osteoblasts differentiation, maintain cells to a less differentiated status and recruit osteoclasts. (ijstemcell.com)
WIF1 and SFRP4 , which were highly expressed in mature osteoblasts were reported to inhibit osteogenic differentiation. (ijstemcell.com)
We speculated that WIF1 and sFRP4 expressed in mature osteoblasts inhibited the binding of FZD1 to Wnt ligand in BMMSCs, thereby further inhibiting osteogenic differentiation of BMMSCs. (ijstemcell.com)
At the single cell level, this study provided insights into the cell-to-cell communications between BMMSCs and osteoblasts and mature osteoblasts may mediate negative feedback regulation of osteogenesis process. (ijstemcell.com)
Osteoblasts are differentiated from regional mesenchymal progenitor cells. (ap26113.com)
Osteoblasts make mineralized bone tissue matrix whose main component is definitely type I collagen, after that die or additional differentiate into bone-lining cells or osteocytes that are inlayed in the bone tissue matrix. (ap26113.com)
Notch signaling [14], mediated by Notch receptors (Notch 1-4) as well as the ligands, Jagged 1 and 2, and Delta-like 1, 3, and 4, suppresses differentiation of mesenchymal cells into pre-osteoblastic cells, whereas it promotes differentiation of preosteoblasts into osteoblasts. (ap26113.com)
these development elements, in turn, control the function and differentiation of osteoblasts. (ap26113.com)
However, how to obtain enough functional seed cells of osteoblasts is still needed to be solved. (researchsquare.com)
Notably, during the in vivo embryonic development, mesoderm and ectoderm cells differentiate toward mesenchymal cells, which further differentiate into osteogenic precursor cells and osteoblasts 10 , 11 . (researchsquare.com)
For example, it is reported that enamel matrix derivatives (EMD) added at the early stage promote the differentiation of hPSCs into osteoblasts, but it inhibited cell maturation and mineralization at the late stage 12 . (researchsquare.com)
Plenty of transplanted HUMSCs remained viable and differentiated into osteoblasts. (nycu.edu.tw)
Compared with HUMSCs cultured alone, HUMSCs cocultured with osteoblasts showed that the percentage of cells differentiating into osteoblasts significantly increased. (nycu.edu.tw)

Under normal physiological conditions, ROS remain at low levels with no obvious cytotoxicity and they can play an important role in cell signaling and homeostasis, promoting cell proliferation and differentiation [ 2 ]. (hindawi.com)
Several studies have suggested ROS can affect the proliferation and differentiation of BMSCs. (hindawi.com)
4. Brain-derived neurotrophic factor stimulates proliferation and differentiation of neural stem cells, possibly by triggering the Wnt/β-catenin signaling pathway. (nih.gov)
While providing short-term pain relief, standard approaches should also be used with caution in patients with tendinopathy because NSAIDS may impair the proliferation and differentiation of tenocytes, negatively affecting tendon healing, and corticosteroids can lead to tenocyte death and tendon rupture. (umms.org)
Previous studies have reported that histone H3 at lysine 9 (H3K9) methylation is widely involved in the proliferation and differentiation of cardiomyocytes, but the specific role of H3K9 dimethylation (H3K9me2) in the formation of pacemaker cells remains unclear. (spandidos-publications.com)

Recent advances in adipogenesis had provided insights into understanding of the complex cues for influencing the cytoarchitecture, epigenomic remodeling, signaling pathways and transcription regulators on gene actions for both white and brown adipogenic progression from mesenchymal stem cells to matured committed adipocytes. (scirp.org)
Skeletal muscle contains a second type of stem cell, called fibro/adipogenic progenitors (FAPs). (nature.com)
After induction, the hydrogel coating contributed to osteogenic differentiation, adipogenic differentiation and differentiation into neural-like cells of SHED. (biomedcentral.com)
Visceral ASCs have a higher potential to differentiate into adipogenic and osteogenic cells when compared to subcutaneous ASCs. (uni-frankfurt.de)

These progenitor cells which constitute a reservoir found within the connective tissue of most organs are involved in the maintenance and repair of tissues throughout the postnatal life of an individual. (biomedcentral.com)
Researchers at the Health Sciences University of Hokkaido used stimulation with epigenetic agents to transform epithelial cell rests of Malassez derived from periodontal ligament into progenitor stem-like cells. (dentistrytoday.com)
Subsequently, the progenitor stem-like cells were directly differentiated into endothelial, mesenchymal stem, and osteogenic cells that constitute the periodontal ligament. (dentistrytoday.com)
In the current study, the researchers generated the progenitor stem-like cells from ERM cells in the periodontal ligament using epigenetic modifications without gene transfer. (dentistrytoday.com)
The progenitor stem-like cells were differentiated into endothelial, mesenchymal stem, and osteogenic cells, which constitute the periodontal ligament, using a direct reprogramming method that induces the differentiation of progenitor stem cells into the target cells. (dentistrytoday.com)
The isolated ERM cells were induced to differentiate into progenitor stem-like cells, which were similar to stem cells, following stimulation with the epigenetic agents, 5-Azacytidine and Valporic acid, for one week. (dentistrytoday.com)
The progenitor stem-like cells expressed the protein stem cell markers NANOG and OCT3/4, which were also observed in the iPS cells. (dentistrytoday.com)
The progenitor stem-like cells were differentiated into endothelial, mesenchymal stem, and osteogenic cells. (dentistrytoday.com)
Stem cells or progenitor cells are defined by a capacity for self-renewal and the ability to generate different types of cells (multipotentiality) that are involved in the formation of mature tissues. (intechopen.com)
The first step in your hPSC-to-neural workflow is neural induction of hPSCs to generate central nervous system neural progenitor cells (NPCs). (stemcell.com)
If hPSC-derived NCCs are your progenitor cell type of interest, you can obtain a highly pure population from hPSCs using the STEMdiff™ Neural Crest Differentiation Kit . (stemcell.com)
Furthermore, the euchromatic histone lysine methyltransferase 2 (G9a) inhibitor BIX01294 can increase the number of cardiac progenitor cells without impairing their differentiation ability, which suggests that the drug may have the effect of producing a large number of cardiac progenitor cells for cardiac repair ( 10 ). (spandidos-publications.com)
Stromal cell-derived factor 1-alpha (SDF) is a potent bone marrow chemokine capable of recruiting circulating progenitor populations to injured tissue. (stanford.edu)
During skeletal development, mesenchymal progenitor cells go through a multistage differentiation course of action where they proliferate and be bone tissue- and cartilage-forming cells. (ap26113.com)
Studies of thyroid stem/progenitor cells have been hampered due to the small organ size and lack of tissue, which limits the yield of these cells. (nih.gov)
A continuous source that allows the study and characterization of thyroid stem/progenitor cells is desired to push the field forward. (nih.gov)
A cell line was established from Hoechst-resistant side population cells derived from mouse thyroid that were previously shown to contain stem/progenitor-like cells. (nih.gov)
During liver development, nonpolarized hepatic progenitor cells differentiate into mature hepatocytes with distinct polarity. (korea.ac.kr)

Accumulation of reactive oxygen species (ROS), which can be induced by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF- α ), can significantly inhibit the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). (hindawi.com)
In the skeletal system, bone marrow mesenchymal stem cells (BMSCs) play an important role in bone formation. (hindawi.com)
Bone marrow mesenchymal stem cells (bMSCs) are a promising cell source for variety of tissue engineering applications due to their pluripotency and differentiation capacities. (aiche.org)
Embryonic stem cells, skeletal myoblasts, bone marrow-derived stem cells and mesenchymal stem cells are current candidates for cell therapy in end-stage cardiovascular diseases. (medscape.com)
Given the success of the previous collection, Bone Cell Differentiation in Health and Disease, and the new advances in the field, we are pleased to announce the launch of Volume II. (frontiersin.org)
Similarly, obese adipocytes, high-cholesterol and diabetic situations disturb bone cell functions and bone health. (frontiersin.org)
Bone is comprised of a mineral and protein scaffold filled with bone cells. (nih.gov)
Cbfβ deficiency at all three stages of differentiation reduced bone density in the mice and dramatically increased their bone marrow fat content. (nih.gov)
Further testing confirmed that there were more fat cells in the bone marrow of the Cbfβ-deficient mice than the control mice. (nih.gov)
Based on current evidence, clinical use of dental stem cells may be closest to fruition for root canal therapy or repair of bone defects caused by gum disease. (nih.gov)
The present study evaluated the functional role of H3K9me2 in the differentiation of bone marrow mesenchymal stem cells (BMSCs) into pacemaker-like cells. (spandidos-publications.com)
Tbx18-mediated phenotypic transformation of bone marrow mesenchymal stem cells (BMSCs) into pacemaker-like cells has been reported at both the mRNA and protein levels ( 3 - 5 ). (spandidos-publications.com)
Cranial neural crest (CNC) cells give rise to bone, cartilage, tendons, and ligaments of the vertebrate craniofacial musculoskeletal complex, as well as regulate mesoderm-derived craniofacial muscle development through cell-cell interactions. (elifesciences.org)
To investigate the osteogenic differentiation of PB-hMSCs, the quantitative expression of the mRNA of specific genes, like transcriptional factors (RUNX2), bone related genes (SPP1, COL1A1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cells marker (CD105) were examined by means of real time Reverse Transcription-Polymerase Chain Reaction (real time RT-PCR). (ispub.com)
Bone marrow from DsRed-transgenic donors was transplanted into recipients to lineage-trace circulating cells after myocardial infarction (MI). (stanford.edu)
Bone tissue resorption is normally mediated by osteoclasts that are differentiated from precursor cells from the monocyte/macrophage lineage. (ap26113.com)
Initial characterization of the human fetal bone marrow and adult adipose tissues revealed that a subpopulation of CD146+ perivascular cells was capable of supporting the self-renewal of transplantable human cord blood HSCs ex vivo. (escholarship.org)
Recently, a bone forming peptide-1 (BFP-1) that derived from bone morphogenetic protein-7 (BMP-7) has confirmed its excellent performance in promoting the osteogenic induction of human stem cells mainly human mesenchymal stem cells. (researchsquare.com)
The mesoderm alone gives rise to different types of connective cells/tissues like cartilage, muscle, bone, and fat. (plexusnc.com)
Wakitami, S., Saito, T. and Caplan, A.I. (1995) Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. (scirp.org)
These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis as well as the development of new teeth. (bvsalud.org)
Bone marrow, embryo and cord blood are the major stem cell sources which are believed to act systemically for regeneration of tissues and organs in an organism. (ijbiotech.com)

Because of their anatomical location, hOMSCs are easy to isolate, have multilineage differentiation capacity and express embryonic stem cells markers such as-Sox2, Oct3/4 and Nanog. (nih.gov)
1,2 Regarding the origin, they can be classified as embryonic stem cells (ESCs) and adult stem cells (ASCs). (bvsalud.org)
In this study, we found that phthalazinone pyrazole (PP), a selective inhibitor of Aurora-A kinase (Aurora-A), suppressed the EMT during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells. (korea.ac.kr)
Embryonic stem cells (ES): ES cells are pluripotent stem cells derived from the inner cell mass of a blastocyst. (ijbiotech.com)

The cell biology of adipocytes has led to a number of promising concepts in the last century, especially in the areas of obesity and associated diseases, lipid homeostasis and endocrine functions. (scirp.org)
Mesenchymal stem cells differentiated into adipocytes from double-mutant mice appear to retain fatty acids as triglycerides more readily than the cells from wild type MC3R mice. (nih.gov)

Thus, canonical Wnt/beta-catenin signaling is essential for skeletal lineage differentiation, preventing transdifferentiation of osteoblastic cells into chondrocytes. (nih.gov)
Upon differentiation, its appearance becomes limited to chondrocytes. (ap26113.com)
Myocyte enhancer aspect 2 (MEF2) family members transcription elements promote hypertrophic differentiation of chondrocytes. (ap26113.com)
The micromass culture technique of Solursh was used to determine whether hexavalent chromium (7440473) (Cr(IV)) can affect mesenchymal cells to differentiate into chondrocytes. (cdc.gov)

Growth promotion of colorectal cancer by mesenchymal stromal cells - when and how? (uib.no)
Given their ubiquitous presence as perivascular cells as well as their resistance to genotoxic damage multipotent mesenchymal stromal cells (MSC) may represent a pivotal part of the stroma in primary as well as metastasizing CRC. (uib.no)
Prockop, D.J. (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. (scirp.org)

The Stem Cell Lineage Database (SCLD) is a database of resources used to identify cell lineages. (wikipedia.org)
The Stem Cell Lineage Database (SCLD) was created by the University of Connecticut in order to have a more user friendly approach to retrieve and share data. (wikipedia.org)
The Stem Cell Lineage Database could help compare stem cell information around the world and eliminate taking a global gene expression profiling approach, which although sufficient, is not as effective as it could be. (wikipedia.org)
Toward realizing this potential, microenvironment conditions are needed for promoting robust lineage-specific differentiation into tenocytes/ligament fibroblasts. (ca.gov)
Lineage tracing demonstrates that neither multipotent vascular stem cells nor proliferative or synthetic smooth muscle cells arise from the de-differentiation of mature smooth muscle cells. (ca.gov)
On the other hand, we perform lineage tracing with smooth muscle myosin heavy chain as a marker and find that multipotent vascular stem cells and proliferative or synthetic smooth muscle cells do not arise from the de-differentiation of mature smooth muscle cells. (ca.gov)
Using the mouse soft palate as a model, we performed an unbiased single-cell RNA-seq analysis to investigate the heterogeneity and lineage commitment of CNC derivatives during craniofacial muscle development. (elifesciences.org)
Hematopoietic stem cells (HSCs) are characterized by their ability to self-renew and contribute to multi-lineage differentiation, critical functions that ensure homeostatic production of all blood cells throughout life. (escholarship.org)
Vector integration site-based lineage tracing technology was utilized to gain insights into the stages through which hPSC differentiate into mesodermal derivatives of the HSC niche. (escholarship.org)
High throughput sequencing revealed the presence of mesodermal progenitors with trilineage (hematopoietic, endothelial and mesenchymal) potential during hPSC differentiation and uncovered the lineage bifurcation of hematopoietic and mesenchyme early on in separated bipotent populations. (escholarship.org)
These findings elucidated lineage commitment events during early human embryogenesis and informed strategies to optimize the therapeutic development of cell lineages from hPSC. (escholarship.org)
Moreover, the expression of marker genes relating to germ layers and epithelial-mesenchymal transition (EMT) was investigated at day 7, aiming to study the impact of BFP1 peptide on the lineage differentiation and osteogenic induction process of hESCs and hiPSCs. (researchsquare.com)
In this study, the possibility that cell density can influence MSC differentiation along the EC lineage was examined. (manchester.ac.uk)
Cell-cell contact-induced Notch signalling was a key initiating step regulating commitment towards an EC lineage, whilst VEGF-A stimulation was required to consolidate the EC fate. (manchester.ac.uk)
Stem cells from different sources with different potential (plasticity) may be used to obtain ideal cell lineage with a defined function. (ijbiotech.com)

One of the major factors that separates SCLD from other stem cell databases is that it allows users to edit information pertaining to cell types, markers, and lineages. (wikipedia.org)
The purpose of the database is to provide an openly available, quick reference for information pertaining to stem cell lineages. (wikipedia.org)
Currently, the database only includes human and mouse stem cell lineages, but the database hopes to expand into more species. (wikipedia.org)
This approach can be combined with other stimuli (for example, mechanical stimulation) toward a better mechanistic understanding of differentiation down these challenging lineages. (ca.gov)
These cells can be differentiated into various cell lineages and considering their rapid proliferation, multipotency and immunomodulatory properties they are widely used for treatment of various diseases. (ijbiotech.com)

We found that RESV induces mesenchymal to epithelial transition (MET) and inhibits transforming growth factor-β2(TGF-β2)-induced EMT of RPE cells by deacetylating SMAD4. (nature.com)
This study demonstrates that trifluridine induces single-strand DNA damage in ESCC cells, as evidenced by phosphorylated replication protein 32. (bvsalud.org)
Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). (nih.gov)

Cell-biology-related research on preadipocyte (adiposal-mesenchymal cell) differentiation laid the foundation for discoveries of adipose-derived cells (both in stromal vascular fraction, or SVF, and adipose-derived stromal/stem cells, or ASCs), which had become an increasing interest to both stem cell biologists and clinicians because of their potential for angiogenesis and suppression of inflammation for tissue engineering and treatments. (scirp.org)
The four regenerative medicine approaches currently used at University of Maryland Orthopedics include dextrose prolotherapy, platelet-rich plasma, amniotic tissue allografts and adipose-derived mesenchymal stem cells, which are explained briefly below. (umms.org)
Adipose-derived mesenchymal stem cells (ASCs) are considered to be a useful tool for regenerative medicine, owing to their capabilities in differentiation, self-renewal, and immunomodulation. (uni-frankfurt.de)

1. [Differentiation of induced pluripotent stem cells into neural stem cells induced by brain-derived neurotrophic factor via Wnt/β-catenin and extracellular signal-regulated kinase/mitogen-activated protein kinases signal pathway]. (nih.gov)
2. Both Wnt/β-catenin and ERK5 signaling pathways are involved in BDNF-induced differentiation of pluripotent stem cells into neural stem cells. (nih.gov)
Human pluripotent stem cells (hPSCs), including human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are self-renewing cells with the potential to develop into cells of all three germ layers. (stemcell.com)
Whether you're starting from primary cells, tissue samples, or pluripotent stem cells, explore our complete portfolio of products to support your neural culture workflow. (stemcell.com)
My goal was to reconstruct an optimal hematopoietic niche from mesodermal differentiation of human pluripotent stem cells (hPSC) to facilitate the maintenance of functional HSCs. (escholarship.org)
However, the differentiation process of hPSCs is much more complex than adult stem cells, and the unknown effect of material addition at different stages hamper the establish of step-wise induction systems for these human pluripotent stem cells (hPSCs). (researchsquare.com)

Three key components are necessary for this database to be effective: cell type-specific gene expression profiles, anatomical and developmental relationships between cells and tissues and signals important for development and differentiation of stem cells to mature cell types. (wikipedia.org)
More reliable markers for dental stem cells will help scientists trace the process of stem cell development and differentiation as it naturally occurs in the body during normal growth or after tissue injury or damage. (nih.gov)
Uncovering the mechanisms that control development and differentiation of the digestive tract before birth and in neonatal life could generate new insights for regenerative therapies to treat digestive cancers and other diseases, as well as provide new insights into disease pathogenesis. (nih.gov)

The latter exhibit better abilities in both long-term self-renewal and specialized differentiation, becoming an outstanding cell source in the field of regenerative medicine 3 , 4 . (researchsquare.com)
Stem cells (SCs) are undifferentiated cells with self-renewal ability and capacity to differentiate into specialized cell types. (bvsalud.org)
The HSCs with self-renewal capacity can differentiate into different types of blood cells, including those involved in the human immune system. (ijbiotech.com)

Here, we utilized a mathematical design of experiments to examine the effects that different combinations of environmental stimuli have on MSC differentiation into tendon and ligament tissues. (ca.gov)
Stem cells seem to have unlimited potential for repairing injured tissues derived from cardiovascular diseases. (medscape.com)
In many tissues, wound healing and regeneration depends on stem cells to replace the lost or damaged cells. (nature.com)
The search for sources to obtain multipotent stem cells from discarded tissues or through non-invasive procedures is of great interest. (biomedcentral.com)
Despite the successful isolation and characterization of stem cells from various tissues, relatively few animal studies have been done to investigate the efficacy of stem cell transplantation. (intechopen.com)
These readily accessible cells raised early hopes that they might revolutionize repair of teeth and oral tissues, and possibly lead to new therapies for diabetes, heart disease, and neural conditions. (nih.gov)
Liposarcoma is a rare cancer of connective tissues that resemble fat cells under a microscope. (sarcomahelp.org)
They are adult stem cells that can divide and develop into many specialized cell types in specific organs and/or tissues, and are considered to be ideal for organ transplantation procedures. (plexusnc.com)
Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
These reservoir cells play a major role in development and growth of the tissues and organs. (ijbiotech.com)
In addition to embryonic and adult stem cells, there are other sources such as skin, which is a good source of adult stem cells involved in local repair and regeneration of epidermal and dermal tissues (1). (ijbiotech.com)
The diversity of the stem cells present in different tissues implies that the body reserves all the cell types with stemness properties to guarantee important physiological processes and regeneration of organs. (ijbiotech.com)
Adult stem cells: The pluripotency of adult stem cells isolated from different tissues was approved by showing their differentiation potential into cell types from different germ layers. (ijbiotech.com)

5. [Role and mechanism of nonreceptor tyrosine kinase Tec in endotoxin/lipopolysaccharide-induced interleukin-8 production in human alveolar epithelial cells A549]. (nih.gov)
[8] Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest. (knowpia.com)

We have used SHEM (supplemented hormonal epithelial medium) media and cultured hOMSCs over human amniotic membrane and determined the cell's capacity to differentiate to an epithelial-like phenotype and to express corneal specific epithelial markers-CK3, CK12, CK19, Pan-cadherin and E-cadherin. (nih.gov)
It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile to the proliferative/synthetic phenotype, has an important role during vascular remodelling and diseases. (ca.gov)

It is a rare malignant mesenchymal tumor. (thieme-connect.com)
Synovial sarcoma is a rare malignant mesenchymal tumor. (thieme-connect.com)
However, recently the importance of the stromal compartment surrounding cancer cells in facilitating tumor growth, invasion and metastasis has been widely recognized. (uni-muenchen.de)
hASCs are locally adjacent to epithelial breast cancer cells and might represent early response cells within the tumor stroma. (uni-muenchen.de)
The differentiation of hASCs towards these tumor-promoting cells can be abolished by targeting the TGFβ1 signaling pathway. (uni-muenchen.de)
In addition, the impact of the stroma and particularly of MSC or MSC-derived CAF on the CRC growth may depend on the variable mutational background of the tumor cells. (uib.no)
Expression of collagen in MSC increased upon stimulation with TGF-β as well as with tumor cell-conditioned media. (uib.no)
Taken together our data demonstrate that MSC specifically support the growth of α-catenin deficient CRC cells during an early phase of tumor growth through CRC cell expressed β1-integrin. (uib.no)
Decreased expression of ITGB1 correlates with acquiring multidrug resistance of tumor cells in the presence of anti-tumor drug. (thermofisher.com)
Well-differentiated liposarcoma is the most common subtype and usually starts as a low grade tumor. (sarcomahelp.org)
Low grade tumor cells look much like normal fat cells under the microscope and tend to grow and change slowly. (sarcomahelp.org)
Pleomorphic liposarcoma is the rarest subtype and is a high grade tumor with cells that look very different from normal cells. (sarcomahelp.org)
Dedifferentiated liposarcoma occurs when a low grade tumor changes , and the newer cells in the tumor are high grade. (sarcomahelp.org)
Tumor microenvironment (TME) Oncology research solutions TABLE OF CONTENTS Molecular drivers of cancer pathogenesis Cancer progression is associated with the interplay between tumor cells and the surrounding environment, which requires signal transduction pathways to relay messages throughout the cell.1,2 Cell signaling pathways regulate everything from cell growth to proliferation to survival. (technologynetworks.com)
Many of the genes commonly mutated encode Purpose and scope INTRODUCTION components or targets of the PI3K/AKT and Ras/ERK pathways, causing dysregulation of cellular signaling.1 This dysregulation drives cancer progression by influencing the behavior of tumor cells through cell proliferation, survival, migration, differentiation, metabolism, polarity, angiogenesis, and the tumor microenvironment. (technologynetworks.com)
The tumor is characterized by the presence of bizarre round, spindle, and polygonal cells. (nih.gov)
Hereditary Wilms' Tumor Familial embryonal neoplasm derived from nephrogenic blastemal cells. (nih.gov)

6. Neural differentiation of brain-derived neurotrophic factor-expressing human umbilical cord blood-derived mesenchymal stem cells in culture via TrkB-mediated ERK and β-catenin phosphorylation and following transplantation into the developing brain. (nih.gov)

With these cells, scientists will be able to better understand how these cells are differentiated by the process of turning on and off genes. (wikipedia.org)
In order to identify and enrich stem cells, NIDCR-supported researchers are looking for proteins or genes specifically expressed by dental stem cells that can serve as identifiers, or markers, to distinguish them from other cells. (nih.gov)
Melanomas have been linked to mutations in two genes involved in cell cycle regulation, CDKN2A (protein p16) and CDK4 . (nih.gov)
In line with these observations, visceral ASCs demonstrate a more active sonic hedgehog pathway that is linked to a high expression of cilia/differentiation related genes. (uni-frankfurt.de)

Accordingly, it may be possible to counteract the inhibition of osteogenic differentiation of BMSCs by reducing ROS generation. (hindawi.com)
Moreover inhibition of the TGFβ1 signaling pathway in hASCs reduces the potential of these cells to enhance the invasion of breast cancer cells. (uni-muenchen.de)
The DNA damage response includes cyclin-dependent kinase 1 (CDK1) (Tyr15) phosphorylation as CDK1 inhibition and a decrease of the proportion of phospho-histone H3 (p-hH3)-positive cells, indicating cell cycle arrest at the G2 phase before mitosis entry. (bvsalud.org)

Beltrami AP, Barlucchi L, Torella D et al (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. (springer.com)
Through this type of research, scientists have been able to identify stem cells within the adult intestine that are capable of forming the cell types needed to continually renew this organ throughout life. (nih.gov)
Regardless of the differences in differentiation capacity of embryonic and adult stem cells, both the cells are rich sources of stem cells with therapeutic application. (ijbiotech.com)
Moreover, manipulation of adult stem cells and reprogramming or reverting embryonic-like state cells can be considered as additional tools for stem cell applications. (ijbiotech.com)
Pluripotency distinguishes ES cells from adult stem cells which are multipotent cells with the capacity to produce limited number of cell types (2). (ijbiotech.com)
Placental stem cells: The placenta has become useful source of stem cells that offer advantages in terms of proliferation and plasticity when compared with adult cells (3). (ijbiotech.com)
Mesenchymal (or adult) stem cells are widely used for tissue engineering purposes because they proliferate rapidly and can become a variety of cell types. (olabisilab.com)

Rat BMSCs pretreated with the euchromatic histone lysine methyltransferase 2 (G9a) inhibitor BIX01294 were transfected with a T-box 18 overexpression plasmid to induce BMSCs to form pacemaker-like cells. (spandidos-publications.com)
Therefore, the present study assessed a potential new method to improve the efficiency of differentiation of BMSCs into pacemaker-like cells. (spandidos-publications.com)

GISTs are a subset of mesenchymal tumors and represent the most common mesenchymal neoplasms of GI tract. (biomedcentral.com)

Our study provided a more systematic and comprehensive understanding of the heterogeneity of osteogenic cells. (ijstemcell.com)

Multipotent vascular stem cells can differentiate into neural cells and mesenchymal stem cell-like cells that subsequently differentiate into smooth muscle cells. (ca.gov)

3 Embrionic stem cells (ESCs) are derived from the inner cell mass of the blastocyst and form all cell types, derived from the three germ layers, and are therefore pluripotent. (bvsalud.org)
ES cells are readily differentiated into primary germ layers, viz. (ijbiotech.com)

Vodyanik MA, Yu J, Zhang X et al (2010) A mesoderm-derived precursor for mesenchymal stem and endothelial cells. (springer.com)
Defining features of endothelial cells (ECs) are their ability to exist as contact-inhibited polarised monolayers that are stabilised by intercellular junctions, and the expression and activity of endothelial markers. (manchester.ac.uk)

By having this information openly available to the public, it gives researchers a place to meet and share information that could possibly enhance the experimental success of stem cell research as well as provide techniques to influence stem cells down specific pathways. (wikipedia.org)
In this review, we summarize the current understanding of the molecular mechanisms by which SUMOylation pathways regulate skeletal cells in physiological and disease contexts. (mdpi.com)
This suggests that the same transcription factors and signaling pathways could activate cell-type-specific responses in multiple components of the musculoskeletal complex that may help coordinate the development of this intricate system. (elifesciences.org)
tyrosine/kinase receptors, fibroblast development element receptors (FGFR1-4 in human beings and mice) that activate multiple intracellular signaling pathways, including MAPK, phosphoinositide 3-kinase (PI3K), and JAK/STAT1 (Janus kinase/transmission transducer and activator of transcription) to modify chondrocyte differentiation Rabbit Polyclonal to ATP5A1 [6]. (ap26113.com)
Finally, downstream nuclear targets of signaling pathways like the transcription factors Myc and NF-κB, chromatin remodelers, and cell cycle effectors are also commonly altered. (technologynetworks.com)

Human oral mucosa stem cells (hOMSCs) arise from the neural crest, they can self-renew, proliferate, and differentiate to several cell lines and could represent a good source for application in tissue engineering. (nih.gov)
We investigated the impact of bevacizumab, antihuman vascular endothelial growth factor (VEGF) antibody, and anticonnective tissue growth factor (anti-CTGF) neutralizing antibody, individually or in combination, on proangiogenic and profibrotic properties of RPE cells. (molvis.org)
Ensuing specialists later determined that this multifunctional organ contained a number of valuable resident cells, other worthy non-indigenous cellular populations and a quantity of distinct structural elements, which possessed the potential to optimize fat graft survival and eventually further tissue engineering applications in regenerative medicine. (scirp.org)
The role of human adipose tissue derived stem cells (hASCs) in this context has not been studied so far. (uni-muenchen.de)
ITGB1 is up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue. (thermofisher.com)
You can also generate organoids containing various differentiated neural cell types arranged in a 3D tissue structure from hPSCs. (stemcell.com)
One area of inquiry addresses a needle-in-the-haystack issue: sorting out the relatively scarce stem cells from the other cell types in dental tissue. (nih.gov)
Nadya Lumelsky, PhD, director of NIDCR's Tissue Engineering and Regenerative Medicine Program, notes that highly enriched dental stem cell populations will also be key to developing potential therapies. (nih.gov)
Separating the irrelevant cells from a population means that a higher fraction are true stem cells, which means the replacement tissue is higher quality and can more reliably repair defects," Lumelsky says. (nih.gov)
It could also help scientists learn how to reliably prompt cells to differentiate into one cell type and not another-in the case of dental stem cells, how to produce the hard tissue called dentin instead of pulp, for instance. (nih.gov)
It also explores how dysregulation can lead to pathogenesis with examples across a broad range of cell and tissue types. (technologynetworks.com)
The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)
In explant method, the dental tissue is placed on a plastic surface and the cells migrate out from the tissue fragment adhering to culture flasks or dishes ( Figure 1 ). (bvsalud.org)
Their origin was at first attributed to Cajal's cells, in mesodermal tissue but it has nowadays been recognized that GISTs arise from multipotential mesenchymal stem cells [ 2 ]. (biomedcentral.com)
These cells have been isolated from human and mouse tissue as well as from cell lines originated from the mammary gland that can give rise to both the luminal and myoepithelial cell types of the gland. (ijbiotech.com)
Neural stem cells: The presence of stem cells in the mature animal brain tissue indicates that during the neurogenesis process generation of new neurons continues into adulthood. (ijbiotech.com)
It is characterized by the presence of invasive and anaplastic trophoblastic tissue composed of intermediate trophoblastic cells, cytotrophoblasts and syncytiotrophoblasts, abundant vascularity, and secretion of human chorionic gonadotropin. (nih.gov)

In contrast, precursor cells are unipotential cells with limited proliferative capacity. (intechopen.com)

Malignant C4258 Pleomorphic Rhabdomyosarcoma An aggressive malignant mesenchymal neoplasm with skeletal muscle differentiation, occurring in adults and rarely in children. (nih.gov)

Sex determining area Y (SRY) container 9 (Sox9) can be an important transcription aspect for chondrocyte differentiation. (ap26113.com)

Differentiation of multipotent vascular stem cells contributes to vascular diseases. (ca.gov)
We identify a new type of stem cell in the blood vessel wall, named multipotent vascular stem cells. (ca.gov)
In response to vascular injuries, multipotent vascular stem cells, instead of smooth muscle cells, become proliferative, and differentiate into smooth muscle cells and chondrogenic cells, thus contributing to vascular remodelling and neointimal hyperplasia. (ca.gov)
These findings support a new hypothesis that the differentiation of multipotent vascular stem cells, rather than the de-differentiation of smooth muscle cells, contributes to vascular remodelling and diseases. (ca.gov)
Multipotent vascular stem cells express markers, including Sox17, Sox10 and S100beta, are cloneable, have telomerase activity, and can differentiate into neural cells and mesenchymal stem cell-like cells that subsequently differentiate into smooth muscle cells. (ca.gov)
Fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) can enhances the vascular differentiation and osteogenic differentiation of SHED. (biomedcentral.com)

Moreover, we summarize the various presently available methods used for neural differentiation of human DPSCs also emphasizing the difficulties in reproducibly high production of such cells. (lu.se)

However, before large-scale clinical trials can take place, a few safety concerns have to be clarified, such as atherogenesis, postangioplasty or stenting restenosis, tumorigenesis, stem cell metastasis, stem cell-mobilized cytokine-related complications and arrhythmogenesis. (medscape.com)
In animal models: atherosclerosis and postangioplasty restenosis, tumorigenesis and stem cell metastasis. (medscape.com)
In our view, these data argue for a specific role of MSC in the early phase of metastasis growth of specific CRC cells. (uib.no)
Regardless of cell type, the tumorigenic changes that drive cancer growth and metastasis are complex. (technologynetworks.com)

In conclusion, protocols evaluated in bfMSC induced progress into myogenic differentiation until certain extent evidenced by changes in MRF gene expression. (unesp.br)

The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. (nih.gov)

The actions of these two cell types as well as their differentiation is modulated by osteocytes. (frontiersin.org)

Recently, CNC cells have been shown to regulate formation of mesoderm-derived craniofacial muscles through cell-cell interactions. (elifesciences.org)
Biocompatible BFP1 peptide could remarkably promote the generation of mesoderm cells and mesenchymal-like cells from hiPSCs through the enhanced epithelial-mesenchymal transition, but the effect was not found in hESCs because of cell line difference. (researchsquare.com)
The mesoderm also forms cells that make up blood vessels, blood cells, as well as the urogenital systems. (plexusnc.com)
For example, neural stem cells derived from ectoderm can differentiate into ectoderm, mesoderm, and endoderm. (ijbiotech.com)

Stem cells derived from dental pulp or periodontal ligament have been used in regenerative dentistry. (dentistrytoday.com)
Although it is relatively easy to collect dental pulp stem cells, the researchers said, it is difficult to obtain adequate numbers of good quality cells. (dentistrytoday.com)
In this study, we review the key properties of dental pulp stem cells (DPSCs), with a particular focus on their neurogenic potential. (lu.se)
Results: there are five main sources of stem cells of dental origin: stem cells from dental pulp of permanent teeth and deciduous teeth, apical papilla, periodontal ligament and dental follicle. (bvsalud.org)

Exposure to 10 nM TCDD resulted in an overall consistent attenuation of alkaline phosphatase (ALP) activity and matrix mineralization at terminal stages of differentiation in primary hBMSCs. (nih.gov)

Anatomy65

Organisms8

Diseases8

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes57

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

MSCs35

Vitro28

Osteoblast24

Osteoblasts23

Proliferation and differentiation5

Adipogenic4

Progenitor18

Bone22

Embryonic stem4

Adipocytes2

Chondrocytes4

Stromal cells3

Lineage15

Lineages5

Induces3

Adipose-derived3

Pluripotent stem6

Development and differentiation3

Self-renewal3

Tissues15

Epithelial cells2

Phenotype2

Tumor17

Umbilical1

Genes4

Inhibition3

Adult7

BMSCs2

Common mesenchymal1

Osteogenic cells1

Stem cells can differentiate1

Germ layers2

Endothelial cells2

Pathways5

Tissue17

Precursor cells1

Malignant mesenchymal1

Chondrocyte differentiation1

Vascular6

Neural differentiation1

Metastasis4

Myogenic differentiation1

Neuronal differentiation1

Osteocytes1

Mesoderm4

Dental pulp4

Stages of differentiation1