• Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (wikipedia.org)
  • While the terms mesenchymal stem cell (MSC) and marrow stromal cell have been used interchangeably for many years, neither term is sufficiently descriptive: Mesenchyme is embryonic connective tissue that is derived from the mesoderm and that differentiates into hematopoietic and connective tissue, whereas MSCs do not differentiate into hematopoietic cells. (wikipedia.org)
  • Mesenchymal stem cells (MSCs), a term first coined by Arnold I. Caplan in 1991, are characterized morphologically by a small cell body with a few cell processes that are long and thin. (wikipedia.org)
  • Mesenchymal stromal cells (MSCs) are widely spread in adult organisms. (weizmann.ac.il)
  • We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated experimental autoimmune uveoretinitis (EAU) in rats. (nature.com)
  • Aims In vitro expansion changes replication and differentiation capacity of mesenchymal stem cells (MSCs), increasing challenges and risks, while limiting the sufficient number of MSCs required for cytotherapy. (mendeley.com)
  • Less quantity of transplanted mesenchymal stem cells (MSCs) influences the therapeutic effects on radiation-induced lung injury (RILI). (hindawi.com)
  • It has been observed that mesenchymal stem cells (MSCs) could home and engraft within the injured tissues and differentiate into vascular cells and alveolar cells to regenerate the damage in the irradiated mouse lung [ 10 ]. (hindawi.com)
  • Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
  • Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
  • Interest in human mesenchymal stem cells (MSCs) as an immune therapy has been on the rise for the past two decades with cutting edge research yielding promising results, but there are currently no MSC therapies approved by the food and drug administration (FDA). (biorxiv.org)
  • Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
  • Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
  • Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating in specific directions. (wjgnet.com)
  • Mesenchymal Stem Cells (MSCs) are a heterogeneous subset of stromal stem cells that originate from the mesoderm layer of the fetus. (tocris.com)
  • In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
  • Mesenchymal stromal cells (MSCs) are cells of non-haematopoietic origin, with the capacity to differentiate into multiple lineages of the mesenchyme, that is, chondrocytes, osteoblasts and adipocytes. (bmj.com)
  • 3 4 Since then, it has become evident that MSCs reside in many tissues, including mesenchymal tissues (bone, adipose tissue, connective tissue), umbilical cord and several organs including the liver, spleen and lung. (bmj.com)
  • Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
  • Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of self-renewal and exhibit multilineage differentiation properties. (techscience.com)
  • The Mesenchymal and Tissue Stem Cell Committee, which belongs to the International Society for Cellular Therapy, stated that plastic-adherent properties are the minimum criteria for determining MSCs. (techscience.com)
  • Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
  • Mesenchymal stem cells (MSCs - sometimes referred to as mesenchymal stromal cells or bone marrow stromal cells) are adult stem cells that can produce many different types of cells, including muscle, cartilage and nerve cells. (msif.org)
  • Mesenchymal stem cells (MSCs) exhibit a promising therapeutic potential in the field of cell-based tissue engineering and regenerative medicine due to their immunomodulatory properties and differentiation capacity. (uni-muenchen.de)
  • We aimed to produce highly homogeneous induced pluripotent stem cell-derived mesenchymal stem cells (iP-MSCs) in an autologous manner from initially isolated human mucosa mesenchymal stem cells (mMSCs) of the upper respiratory tract. (uni-muenchen.de)
  • This study demonstrates the use of a microfluidic platform for long-term cultivation (3 weeks) of human mesenchymal stem-like cells (MSCs), a cell population of high interest for tissue engineering. (rsc.org)
  • 2 (2007) observed that cell adhesion and proliferation, as well as the osteogenic differentiation of mouse mesenchymal stem cells (MSCs) to Ti discs were significantly similar to those on the plastic surface of the culture, indicating Ti as an excellent material for repairing hard tissue in the field of bone tissue engineering. (bvsalud.org)
  • Mesenchymal stromal cells (MSCs) constitute the cell type more frequently used in many regenerative medicine approaches due to their exclusive immunomodulatory properties, and they have been reported to mediate profound immunomodulatory effects in vivo. (bvsalud.org)
  • The stromal cell system has been proposed to consist of marrow mesenchymal stem cells that are capable of self-renewal and differentiation into various connective tissue lineages. (nih.gov)
  • Figure 1 Illustration demonstrating a hypothetical summary of the potential effect of aryl-hydrocarbon receptor activation on multipotent mesenchymal stromal cell function. (wjgnet.com)
  • MSC: Multipotent mesenchymal stromal cell. (wjgnet.com)
  • The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
  • Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease? (bmj.com)
  • Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocytes. (mdpi.com)
  • Exofucosylation of Adipose Mesenchymal Stromal Cells Alters Their Secretome Profile. (bvsalud.org)
  • Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
  • Osteogenic differentiation of electrostimulated human mesenchymal stem" by ANIL SERA ÇAKMAK, SONER ÇAKMAK et al. (tubitak.gov.tr)
  • The aim of this study was to investigate the osteogenic differentiation potential of human mesenchymal stem cells (hMSCs) cultivated on silk-fibroin films in response to different parameters, i.e. (tubitak.gov.tr)
  • Zhou JQ, Wan HY, Wang ZX, Jiang N. Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells. (wjgnet.com)
  • We identified the microRNAs (miRNAs) miR-221 and miR-222 (miR-221/222) as basal-like subtype-specific miRNAs and showed that expression of miR-221/222 decreased expression of epithelial-specific genes and increased expression of mesenchymal-specific genes, and increased cell migration and invasion in a manner characteristic of the epithelial-to-mesenchymal transition (EMT). (nih.gov)
  • Here we show that the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal transition (EMT), an important step in the progression of primary tumors toward metastasis. (jci.org)
  • Overexpression of Brachyury in human carcinoma cells induced changes characteristic of EMT, including upregulation of mesenchymal markers, downregulation of epithelial markers, and an increase in cell migration and invasion. (jci.org)
  • Epithelial-mesenchymal transformation is now recognised as an important feature of tissue remodelling. (ersjournals.com)
  • Reports from several laboratories suggest that a phenomenon termed epithelial-mesenchymal transformation, in which epithelial cells transform into fibroblasts capable of producing connective tissue matrix, is an important feature of tissue remodelling 10 , 11 . (ersjournals.com)
  • In the present study, the hypothesis that adenoviral infection followed by persistent expression of its E1A gene is capable of producing epithelial-mesenchymal transformation was examined by investigating guinea pig PLECs that express adenoviral E1A. (ersjournals.com)
  • Sarcomatoid conversion of clear cell renal cell carcinoma in relation to epithelial-to-mesenchymal transition. (lu.se)
  • In the present study we investigate whether the sarcomatoid conversion of clear cell renal cell carcinoma could be interpreted as linked to the process of epithelial-mesenchymal transition. (lu.se)
  • Furthermore the sarcomatoid elements demonstrate an enhanced expression of epithelial-mesenchymal transition related mesenchymal markers as compared with the clear cell renal cell carcinoma counterparts. (lu.se)
  • We further selected a representative case, clinically demonstrating direct overgrowth of the sarcomatoid component into the liver and colon, for extended immunohistochemical characterization, resulting in a further set of positive and negative epithelial-mesenchymal transition markers as well as pronounced transforming growth factor β positivity, indicating that sarcomatoid clear cell renal cell carcinoma may be associated to epithelial-mesenchymal transition. (lu.se)
  • Corresponding changes in RNA levels for key epithelial-mesenchymal transition markers were also seen. (lu.se)
  • We therefore suggest that sarcomatoid clear cell renal cell carcinoma morphologically and immunohistochemically may represent a completed epithelial-mesenchymal transition and that transforming growth factor β1 could be an important driving force during the sarcomatoid transdifferentiation of clear cell renal cell carcinoma. (lu.se)
  • Role of epithelial-mesenchymal transition (EMT) and fibroblast function in cerium oxide nanoparticle s-induced lung fibrosis. (cdc.gov)
  • The objective of the present study was to investigate the modification of fibroblast function and the role of epithelial-mesenchymal transition (EMT) in CeO2-induced fibrosis. (cdc.gov)
  • These distinctive morphological features of mesenchymal stem cells can be visualized label-free using live cell imaging. (wikipedia.org)
  • As many as 1 in 100 cells collected during amniocentesis are pluripotent mesenchymal stem cells. (wikipedia.org)
  • Preclinical and early clinical safety studies are paving the way for further applications of mesenchymal stem cells in the field of transplantation with respect to hematopoietic support, immunoregulation, and graft facilitation. (nih.gov)
  • Mesenchymal stem cells of differe. (mendeley.com)
  • Nolta, J. (2006) Genetic Engineering of Mesenchymal Stem Cells. (scirp.org)
  • The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)
  • Human Mesenchymal Stem Cells Report by Material, Application, and Geography Global Forecast to 2023 is a professional and comprehensive research report on the worlds major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, United Kingdom, Japan, South Korea and China). (aarkstore.com)
  • In this report, the global Human Mesenchymal Stem Cells market is valued at USD XX million in 2023 and is projected to reach USD XX million by the end of 2027, growing at a CAGR of XX% during the period 2023 to 2027. (aarkstore.com)
  • mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • Conversely, inhibition of Brachyury resulted in downregulation of mesenchymal markers and loss of cell migration and invasion and diminished the ability of human tumor cells to form lung metastases in a xenograft model. (jci.org)
  • Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
  • How to Harvest Bone Marrow Derived Mesenchymal Stem Cells for Expansion and Injection. (ivis.org)
  • The use of mesenchymal stem cells or progenitor cells has been advocated for treatment of many musculoskeletal diseases in the equine. (ivis.org)
  • The mesenchymal stem cells market is anticipated to grow at a CAGR of 7.0% from 2018 to 2026. (medgadget.com)
  • Mesenchymal stem cells are adult stem cells, which are traditionally found in the bone marrow. (medgadget.com)
  • The global mesenchymal stem cells market growth is primarily driven by the increasing demand for these stem cells as an effective treatment alternative for knee replacement in the recent past. (medgadget.com)
  • However, some of the political point of views, and higher cost of treatment by using mesenchymal stem cells might restraint the growth during the forecast period. (medgadget.com)
  • Increasing demand for better healthcare facilities, rising geriatric population across the globe, and continuous research and development activities in this area by the key players is expected to have a positive impact on the growth of Mesenchymal Stem Cells market. (medgadget.com)
  • Mesenchymal stem cells are the stem cells of the connective tissue and thus the essential stem cells for the restoration of destroyed tissues and organs. (donau-uni.ac.at)
  • In addition to their regenerative ability, mesenchymal stem cells can also take on immunoregulatory abilities, although the exact mechanisms are unknown. (donau-uni.ac.at)
  • In this research project, molecular mechanisms as well as physical properties of mesenchymal stem cells will be investigated and correlated to their immunoregulatory abilities. (donau-uni.ac.at)
  • Is the Subject Area "Mesenchymal stem cells" applicable to this article? (plos.org)
  • Tocris offers the following scientific literature for Mesenchymal Stem Cells to showcase our products. (tocris.com)
  • Bioincompatible dialysis fluid causes mesothelial cells to undergo uncontrolled mesothelial-to-mesenchymal transition triggered by Transforming growth factor-β1, which leads morphological and functional disruption of membrane. (ukessays.com)
  • Viscotaxis'- Directed Migration of Mesenchymal Stem Cells in Response to Loss Modulus Gradient. (ncbs.res.in)
  • We cultured human mesenchymal stem cells (hMSCs) on a collagen-coated polyacrylamide gel with constant storage modulus (G) but with a gradient in the loss modulus (G). We found hMSCs to migrate from high to low loss modulus. (ncbs.res.in)
  • The MESEMS (mesenchymal stem cells for MS) trial, which was partly funded by MSIF, took place in centres in North America, Europe and Australia. (msif.org)
  • Increasing β-hexosaminidase A activity using genetically modified mesenchymal stem cells. (stembook.org)
  • The Immortalized Rat Metanephric Mesenchymal Precursor Cells (KMM) is suitable for KSHV infection related studies, such as the growth deregulation mechanisms, as it is able to cause tumor formation. (topsan.org)
  • We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
  • Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)
  • Trajectory analysis of single cell RNA-seq datasets of E12.5 and adult mesenchymal cells suggest that adult smooth muscle cells and fibroblasts derive from distinct embryonic intermediates and that adult fibroblast subsets develop in a linear trajectory from CD81 + fibroblasts. (lu.se)
  • Aim: To evaluate the adhesion of mouse bone marrow mesenchymal cells (MBMMC) on different titanium surfaces. (bvsalud.org)
  • mesenchymal stem cells, bone marrow, titanium. (bvsalud.org)
  • SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
  • Transforming growth factor β1 exposure of in vitro cultured primary clear cell renal cell carcinoma cells resulted in cells adopting a mesenchymal morphology similar to sarcomatoid clear cell renal cell carcinoma. (lu.se)
  • Given this, the ALINE MANICA2 cryopreservation of adipose tissue-derived mesenchymal stem cells (ADMSCs) could be a JULIANA CRISTINA SCHMIDT2 way to collect them in one surgical procedure and after performing fractional fat grafting. (bvsalud.org)
  • Cryopreservation of mesenchymal stem cells: Alternative to fat grafting in breast reconstruction análise das CTDAs, após 1 e 3 meses de congelamento, indicou que as amostras tratadas com L-prolina + trealose apresentaram viabilidade semelhante àquelas preservadas com DMSO e SFB ( p =0,444). (bvsalud.org)
  • Neoplasms and other masses originating from vascular or mesenchymal tissues also may be found. (medscape.com)
  • Tumors originating from lymphatic, vascular, or mesenchymal tissues can also be found in this compartment. (medscape.com)
  • lowest mesenchymal stem cell therapy cost? (checkbiotech.org)
  • Mesenchymal stem cell therapy cost Varies on protocol, provider and location but national average is $5500. (checkbiotech.org)
  • The international MESEMS trial, which recently reported its final results, showed that mesenchymal stem cell therapy was safe and well tolerated by people with MS, but was not effective at reducing inflammation in people with active forms of MS. (msif.org)
  • The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1 + precursors. (lu.se)
  • These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
  • In the present study, we conducted overexpressing CXCR4 human umbilical cord mesenchymal stem cell (HUMSC) therapy for RILI. (hindawi.com)
  • Chondrosarcoma , Mesenchymal C04.557.450.565.325. (nih.gov)
  • This literature review is about mechanism of mesothelial -mesenchymal transition (MMT), myofibroblasts and its origin hypothesis, clock genes and their cross relation with organ fibrosis. (ukessays.com)
  • A particular stem cell type in the adult human-being is the 'Mesenchymal stem cell' (MSC). (europa.eu)
  • Lymphomas, primary or ectopic endocrine tumors, and a wide variety of mesenchymal tumors can occur in the mediastinum. (medscape.com)
  • Mesenchymal stem cell (MSC)-based therapy for the treatment of autoimmune diseases has demonstrated a particular promise after its successful applications in both animal models and patients. (nature.com)
  • Strategies for regeneration of the bone using porcine adult adipose-derived mesenchymal stem cells. (oregonstate.edu)
  • Adipose-derived mesenchymal stem cells (ASCs) are considered to be a useful tool for regenerative medicine, owing to their capabilities in differentiation, self-renewal, and immunomodulation. (uni-frankfurt.de)
  • Here we describe the conjugation of polymer prodrugs to tumor homing mesenchymal stem cells as a novel approach to chemotherapeutic drug delivery. (umass.edu)
  • Epithelial-mesenchymal transition (EMT) is a critical process in cancer cell metastasis , during which epithelial cells acquire mesenchymal characteristics, including enhanced cell motility and migration. (abcam.com)
  • These changes in epithelial and mesenchymal cell marker expression lead to a reduction in adhesion between the transitioning cell and adjacent epithelial cells and an increase in the secretion of enzymes that degrade the extracellular matrix. (abcam.com)
  • As epithelial cells become mesenchymal cells, cytoskeletal changes occur that promote cell motility. (abcam.com)
  • The present study explores the mechanism of resistance to pulmonary fibrosis by observing the possible effects of serum containing drugs prepared from Gua Lou Xie Bai decoction (GLXB-D) on transforming growth factor beta 1 (TGF-β1) induced Epithelial-mesenchymal transition (EMT) of A549 human alveolar epithelial cells. (degruyter.com)
  • The transition of epithelial cells into a mesenchymal state (epithelial-to-mesenchymal transition or EMT) is a highly dynamic process implicated in various biological processes. (nih.gov)
  • Yao H, Zou Y, Yang K, Yin L, Liu Y, Li R. TGFβ1 induces bone formation from BMP9-activated Bone Mesenchymal Stem Cells, with possible involvement of non-canonical pathways. (medsci.org)
  • Integrated control of proliferation and differentiation of mesenchymal stem cells. (nih.gov)
  • RESEARCH OBJECTIVES Background Mesenchymal stem cells are pluripotent progenitor cells located in bone marrow that can differentiate into a variety of non-hematopoietic tissues including bone, cartilage, tendon, fat, muscle, and early progenitors of neural cells. (nih.gov)
  • Tissue-resident mesenchymal stem/progenitor cells in skeletal muscle: collaborators or saboteurs? (nih.gov)
  • There has been a surge of interest in developing cell-based therapies, focused particularly on the use of mesenchymal stem/progenitor cells with or without scaffolds. (unboundmedicine.com)
  • Mesenchymal stem/progenitor cells are promising graft cells for tissue regeneration, but the most suitable source of cells for cartilage repair remains controversial. (unboundmedicine.com)
  • The tissue origin of mesenchymal stem/progenitor cells notably influences the biological properties and therapeutic potential. (unboundmedicine.com)
  • The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understood. (jci.org)
  • Epithelial-to-mesenchymal transition (EMT) is an essential step in mediating distant metastasis in human cancers. (bmj.com)
  • Then they will spend a significant amount of time to discuss this epithelial mesenchymal transition and cellular plasticity metastasis. (hstalks.com)
  • CircCSNK1G3 up-regulates miR-181b to promote growth and metastasis via TIMP3-mediated epithelial to mesenchymal transitions in renal cell carcinoma. (physiciansweekly.com)
  • Furthermore, the decreased TIMP3 leads to the enhanced epithelial to mesenchymal transition (EMT) process, thus promoting the cancer metastasis. (physiciansweekly.com)
  • The molecular mechanisms of EMT were primarily studied in epithelial cell lines, leading to the discovery of transduction pathways involved in the loss of epithelial cell polarity and the acquisition of a variety of mesenchymal phenotypic traits. (nih.gov)
  • Lymphomas, primary or ectopic endocrine tumors, and a wide variety of mesenchymal tumors can occur in the mediastinum. (medscape.com)
  • o Basic research studies to develop future mesenchymal stem cell therapies to correct genetic diseases or for repair or regeneration of tissue or organ damage. (nih.gov)
  • Therefore, in this article, we summarize the current status of mesenchymal stem cell therapies in infertility pathophysiology and discuss potential areas of further research in regenerative medicine. (hindawi.com)
  • [ 15 ] Finally, their ability to differentiate into several mesenchymal lineages has also been used as an identity marker. (medscape.com)
  • Introduction: Human mesenchymal stem cells (hMSC) are easily obtainable from bone mar-row and possess the ability to differentiate into osteoblasts. (uni-muenchen.de)
  • Background: Mesenchymal stem cells have properties that make them amenable to therapeutic use. (harvard.edu)
  • Human mesenchymal stem cells hold great promise as therapeutic agents because of their differentiation ability (thus their potential to replace damaged tissue) and for their immunomodulatory properties. (biopharminternational.com)
  • These molecular and biological insights inform a potential therapeutic strategy for targeting aggressive mesenchymal features of PDAC. (nih.gov)
  • Human umbilical cord blood-derived mesenchymal stem cells (hUCBMSCs) are being scrutinized as a potential therapeutic tool to prevent various neurodegenerative diseases including AD. (nih.gov)
  • o Identification and characterization of mechanisms by which mesenchymal stem cells increase stem cell engraftment. (nih.gov)
  • Because of their biological characteristics, mesenchymal stem cells can regulate immunologic mechanisms and repair the uterus, ovaries, and oviductal tissue. (hindawi.com)
  • We compared and contrasted the phenotype of tissue cultures in which mesenchymal stem cells are rich and rare. (harvard.edu)
  • Our data indicate that aging and anti-diabetic TZD therapy may affect mesenchymal stem cell phenotype through modulation of PPARgamma2 activity. (nih.gov)
  • However, emerging evidence suggests that epithelial-mesenchymal transitions (EMTs) represent one important source of these cells. (jci.org)
  • Next we discuss the impact of mesenchymal stem cells on vascularization and immunomodulation of islet transplantation. (wjgnet.com)
  • When maintained under optimal growth conditions, ATCC Normal Human Umbilical Cord-Derived Mesenchymal Stem Cells have been shown to be multipotent, capable of differentiating down the adipogenic, osteogenic, and chondrogenic lineages. (atcc.org)
  • o Refinement of cellular culture systems and elucidation of the molecular events that permit ex vivo expansion of mesenchymal stem cells. (nih.gov)
  • These heterogeneous cellular pools with mesenchymal lineage potentially play important roles in tissue homeostasis, with reciprocal collaborations between these cells and satellite cells appearing critical for effective regeneration. (nih.gov)
  • Increased protein turnover renders mesenchymal sub-populations highly susceptible to pharmacological and genetic perturbation of the cellular proteostatic machinery and the IRE1-α-MKK4 arm of the endoplasmic-reticulum-stress-response pathway. (nih.gov)
  • Scientists at the National Eye Institute (NEI) have developed a method to treat glaucoma using exosomes derived from bone marrow-derived mesenchymal stem cells (BMSC). (nih.gov)
  • Preclinical studies suggest mesenchymal stem cells may enhance the ability of the bone marrow microenviornment to support hematopoiesis after stem cell transplantation. (nih.gov)
  • Although more success has been achieved in preclinical trials on the use of mesenchymal stem cells in animal models than in human clinical trials, particularly in septic shock and Chagas disease, more progress has been made in both disorders after the recent use of specific sources and certain doses of mesenchymal stem cells. (intechopen.com)
  • Vodyanik MA, Yu J, Zhang X et al (2010) A mesoderm-derived precursor for mesenchymal stem and endothelial cells. (springer.com)
  • Subsequently, the progenitor stem-like cells were directly differentiated into endothelial, mesenchymal stem, and osteogenic cells that constitute the periodontal ligament. (dentistrytoday.com)
  • The progenitor stem-like cells were differentiated into endothelial, mesenchymal stem, and osteogenic cells, which constitute the periodontal ligament, using a direct reprogramming method that induces the differentiation of progenitor stem cells into the target cells. (dentistrytoday.com)
  • The progenitor stem-like cells were differentiated into endothelial, mesenchymal stem, and osteogenic cells. (dentistrytoday.com)
  • Dr. Quinones-Hinojosa's research team has found that when human mesenchymal stem cells (hMSCs) are packed with the bone morphogenetic protein 4 (BMP4) protein - either through the lab's novel nanoparticle formulation or via viral reengineering - brain tumor initiating cells (BTICs) are rendered extremely sensitive to chemotherapy and radiation, with significant shrinkage in tumor volume. (mayo.edu)
  • To better our understanding of the role of specific pro-resolving mediators (SPMs) in inflamed human bone marrow-derived mesenchymal stem cells (hBMMSCs), we studied the effects of Resolvin E1 (RvE1) and Maresin 1 (MaR1) in lipopoly-saccharide (LPS) stimulated hBMMSCs. (mdpi.com)
  • As many as 1 in 100 cells collected during amniocentesis are pluripotent mesenchymal stem cells. (wikipedia.org)
  • Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. (nih.gov)
  • Specifically, combination regimens that impair the unfolded protein responses block the emergence of aggressive mesenchymal subpopulations in mouse and patient-derived PDAC models. (nih.gov)
  • o Novel markers for mesenchymal stem cell identification to enhance isolation and purification and to facilitate ex vivo stem cell expansion systems. (nih.gov)
  • EMT is characterized by a loss of epithelial cell markers, such as cytokeratins and E-cadherin, followed by an upregulation in the expression of mesenchymal cell markers, such as N-cadherin, vimentin , and fibronectin. (abcam.com)
  • Our aim was to identify markers differentially expressed between mesenchymal stem cell and non-stem cell mesenchymal cell cultures. (harvard.edu)
  • Importantly, it was also observed that common mesenchymal stem cell markers, and fibroblast-associated markers, do not discriminate between mesenchymal stem cell and non-stem cell mesenchymal cell cultures. (harvard.edu)
  • Examination and comparison of the phenotypes of mesenchymal stem cell and non-stem cell mesenchymal cell cultures revealed three differentially expressed markers - CD24, CD108 and CD40. (harvard.edu)
  • Conclusion: We indicate the importance of establishing differential marker expression between mesenchymal stem cells and non-stem cell mesenchymal cells in order to determine stem cell specific markers. (harvard.edu)
  • Bone marrow mesenchymal stem cells (BMSC) have been the choice, thus far, for stem cell therapy for bone regeneration. (oregonstate.edu)
  • Figliuzzi M, Bonandrini B, Silvani S, Remuzzi A. Mesenchymal stem cells help pancreatic islet transplantation to control type 1 diabetes. (wjgnet.com)
  • The National Heart, Lung and Blood Institute and National Institute on Aging invite applications on basic research on mesenchymal stem cell biology that will provide the basis for clinical application to hematopoietic and non-hematopoietic stem cell transplantation. (nih.gov)
  • The scope of this RFA also includes applications that address the undefined lineage relationship of hematopoietic and mesenchymal stem cells. (nih.gov)
  • Mesenchymal stem cells also provide support and maintenance for the other major stem cell population in the bone marrow, the hematopoietic stem cells (2). (biopharminternational.com)
  • Human mesenchymal stem cells have historically been isolated based on the ability of these cells to form adherent cell layers in culture and the concomitant lack of adherence of other cells in the bone marrow stroma, such as hematopoietic stem cells, adipocytes, and macrophages (1). (biopharminternational.com)
  • The Brain Tumor Stem Cell Research Lab is preparing to translate its provisionally patented research on using mesenchymal stem cells to treat cancer into clinical trials at Mayo Clinic. (mayo.edu)
  • Chemotherapeutic Drugs Endow Gastric Cancer Mesenchymal Stem Cells with Stronger Tumor-Promoting Ability. (bvsalud.org)
  • o Identification and characterization of functional, molecular regulators of mesenchymal stem cell self-renewal and commitment. (nih.gov)
  • The authors describe the growth characteristics of human mesenchymal stem cells cultured in a stirred-tank bioreactor. (biopharminternational.com)
  • These distinctive morphological features of mesenchymal stem cells can be visualized label-free using live cell imaging. (wikipedia.org)
  • However, the scope of the RFA is not limited to the areas defined above and research applications addressing other important areas of mesenchymal cell biology are encouraged. (nih.gov)
  • Examples of research areas of interest: o Basic mesenchymal stem cell biology. (nih.gov)
  • By initially assessing mesenchymal stem cell differentiation, we established that bone marrow and breast adipose cultures are rich in mesenchymal stem cells while, in our hands, foreskin fibroblast and olfactory tissue cultures contain rare mesenchymal stem cells. (harvard.edu)
  • In particular, olfactory tissue cells represent non-stem cell mesenchymal cells. (harvard.edu)
  • The study, " Direct Reprogramming of Epithelial Cell Rests of Malassez into Mesenchymal-Like Cells by Epigenetic Agents ," was published by Scientific Reports . (dentistrytoday.com)
  • Tuning microenvironment modulus and biochemical composition promotes human mesenchymal stem cell tenogenic differentiation. (ca.gov)
  • Our results showed that the oMCs were composed of five ovarian differentiated MC (odMC) populations and one ovarian mesenchymal progenitor (oMP) cell population. (sens.org)
  • Mesenchymal stem cell (MSC) therapy has potential applications in treating atherosclerosis and coronary heart disease (CAD). (spandidos-publications.com)
  • Vimentin is an intermediate filament protein that is ubiquitously expressed in normal mesenchymal cells. (degruyter.com)
  • o Studies defining the lineage relationship between mesenchymal stem cells and other stem cells. (nih.gov)
  • The loss of E-cadherin is typically associated with a gain of expression of the mesenchymal marker, N-cadherin, in many cancer types. (abcam.com)
  • To date, there are no conclusive marker (s) for the exclusive isolation of mesenchymal stem cells. (harvard.edu)
  • Ovarian mesenchymal cells (oMCs) constitute a distinct microenvironment that supports folliculogenesis under physiological conditions. (sens.org)
  • Transcriptomic and functional analyses of Kras-independent escapers reveal the presence of Smarcb1-Myc-network-driven mesenchymal reprogramming and independence from MAPK signalling. (nih.gov)
  • Aim: To evaluate the adhesion of mouse bone marrow mesenchymal cells (MBMMC) on different titanium surfaces. (bvsalud.org)
  • However, the acceptance of mesenchymal stem cells in clinical practice requires standardized techniques for their specific isolation. (harvard.edu)