• We find that tissue architecture enhances the correction of merotelic microtubule - kinetochore attachments, and this is especially important for maintaining chromosome stability in the polyploid liver . (bvsalud.org)
  • A stretched merotelic kinetochore (green) segregates toward the pole with which it has the strongest attachment (right). (rupress.org)
  • 5. Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms. (nih.gov)
  • Merotelic chromosome attachments present the cell with a particularly threatening scenario. (rupress.org)
  • The group first determined that only 8 out of 54 merotelic attachments were corrected during metaphase. (rupress.org)
  • With the sister kinetochore departed for its pole, the merotelic kinetochore experienced the same force at both of its attachments. (rupress.org)
  • Due to their undesirable position close to and often behind the spindle pole, these chromosomes may be particularly prone to the formation of erroneous kinetochore-microtubule interactions, such as merotelic attachments. (irb.hr)