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  • adjuvant
  • We tested the adjuvant administration of paquinimod and the anti-HMGB1 antibody in our pneumococcal meningitis mouse model assessing clinical (clinical score, open-field-test, temperature) and pathophysiological parameters (intracranial pressure, white blood cell count in CSF, bleeding area) as well as bacterial titers in blood and brain 24 h after administration and 48 h after infection. (biomedcentral.com)
  • lumbar
  • If the provider thinks meningitis is possible, a lumbar puncture ( spinal tap ) will likely be done to remove a sample of spinal fluid for testing. (baptistjax.com)
  • A full examination and septic screen with lumbar puncture should have taken place immediately after the claimant's examination, and would have revealed the early onset of pneumococcal bacteraemia. (boyesturnerclaims.com)
  • blood-brain b
  • The release of inflammatory mediators facilitates pneumococcal crossing of the blood-brain barrier into the brain, where the bacteria multiply freely and trigger activation of circulating antigen-presenting cells and resident microglial cells. (nih.gov)
  • Pneumococcal bacteria penetrates the blood-brain barrier (BBB), but the bacterial factors that enable this process are not known. (jci.org)
  • ceftriaxone
  • Children with pneumococcal meningitis caused by penicillin- or ceftriaxone-nonsusceptible organisms and those infected by susceptible strains had similar clinical presentation and outcome. (aappublications.org)
  • A 60-year-old man presented with pneumococcal meningitis which did not respond to the ceftriaxone therapy, in spite of in-vitro susceptibility ( minimal inhibitory concentration of 0.016 μg/dLit ) of the isolated organism to this antibacterial agent, although ceftriaxone is still the drug of choice for such pneumococcal meningitis. (hindawi.com)