• In 1967, in a classic experiment, Lerner and colleagues transferred anti-GBM disease to monkeys by injecting them with kidney-bound antibodies from patients with anti-GBM nephritis. (medscape.com)
  • The fact that the anti-GBM antibodies are directed against the noncollagenous globular domain (NC1 domain) of the alpha-3 chain of type IV GBM collagen is well known. (medscape.com)
  • Anti-GBM antibodies are directed against an epitope located at the NC1 domain at the C-terminal of the alpha-3 chain of type IV collagen. (medscape.com)
  • Antibodies reacting with the alpha-3 chain of type IV collagen can be detected in the serum and can be eluted from kidneys of patients with anti-GBM nephritis. (medscape.com)
  • Once the anti-GBM antibodies bind to the specific GBM antigen, complement is activated. (medscape.com)
  • Approximately 20-40% of patients positive for anti-GBM antibodies also have antineutrophilic cytoplasmic antibodies (ANCAs). (medscape.com)
  • Coexistence of ANCAs (mostly myeloperoxidase [MPO-ANCAs]) with anti-GBM antibodies is thought to occur when the renal involvement in ANCA vasculitis leads to the exposure of antigens from the basement membrane and the formation of anti-GBM antibodies. (medscape.com)
  • 2. Tomana M, Novak J, Julian BA, Matousovic K, Konecny K, Mestecky J. Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. (southernbiotech.com)
  • Over the years, tremendous gains have been made in our knowledge of the pathogenic mechanisms underlying anti-GBM nephritis, and the fact that the anti-GBM antibodies are directed against the noncollagenous globular domain (NC1 domain) of the alpha-3 chain of type IV GBM collagen is well known. (medscape.com)
  • Prompt identification of antineutrophil cytoplasmic antibodies, vasculitis, and anti-glomerular basement membrane antibodies allows for early initiation of treatment and may improve patient outcomes. (mayocliniclabs.com)
  • 70% of primary cases are associated with anti-PLA2R antibodies. (shiken.ai)
  • [ 4 ] Anti-PLA2R antibodies have been found in patients with viral infections (eg, hepatitis B, hepatitis C, HIV), but those patients may have had coincidental primary membranous nephropathy. (medscape.com)
  • [ 6 ] Detection of anti-PLA2R antibodies in glomeruli but not in liver parenchyma is a common finding in phatients with membranous nephropathy associated with autoimmune liver disease, suggesting that these autoantibodies are not exclusive to idiopathic membranous nephropathy. (medscape.com)
  • [ 8 , 9 ] Hoxha et al reported expression of THSD7A in a gallbladder carcinoma, in a patient who developed membranous nephropathy with anti-THSD7A antibodies, and subsequently found anti-THSD7A antibodies in six other patients with membranous nephropathy and malignant tumors, suggesting that THSD7A production by malignancies is a possible mechanism for membranous nephropathy. (medscape.com)
  • Debiec et al reported that four of nine patients with childhood membranous nephropathy had high levels of circulating anti-bovine serum albumin antibodies and circulating cationic bovine serum albumin. (medscape.com)
  • We are presenting a case of renal failure with anti-GBM and p-ANCA antibodies positive. (dokumen.tips)
  • Patients with dual antibodies are con- sidered to be a vasculitis-variant of anti-GBM antibody nephritis. (dokumen.tips)
  • We recommend that patients suspected with pulmonary-renal syndrome should be checked for anti-GBM and p-ANCA antibodies, should undergo renal biopsy and should should have close long term follow up to watch for recurrence. (dokumen.tips)
  • Crescents are occasionally encountered in biopsies of primary membranous glomerulopathy in absence of ​ ANCA or anti GBM antibodies. (nephro-pathology.com)
  • This finding suggested an abnormality in type IV collagen, against which the anti-GBM antibodies are directed. (abcmedicalnotes.com)
  • Single-nucleotide polymorphism rs4664308 in PLA2R1 gene is associated with the risk of idiopathic membranous nephropathy: a meta-analysis. (cdc.gov)
  • Identical twins with idiopathic membranous nephropathy. (cdc.gov)
  • Effects of CYP3A5 Polymorphisms on Efficacy and Safety of Tacrolimus Therapy in Patients with Idiopathic Membranous Nephropathy. (cdc.gov)
  • Association between PLA2R1 rs4664308 and susceptibility to idiopathic membranous nephropathy: Protocol for a systematic review and meta-analysis of case-control studies. (cdc.gov)
  • M-type phospholipase A2 receptor (PLA2R) has been identified as the major target antigen in idiopathic membranous nephropathy in adults. (medscape.com)
  • Circulating autoantibodies against PLA2R have been found in 70-80% of patients with idiopathic membranous nephropathy. (medscape.com)
  • Patients who are positive for anti-THSD7A autoantibodies represent a distinct subgroup with this disease and make up approximately 2.5 to 5% of adultts with idiopathic membranous nephropathy. (medscape.com)
  • The M-type phospholipase A2 receptor (PLA2R)-associated idiopathic membranous nephropathy (IMN) is a common immune-related disease in adults. (biomedcentral.com)
  • The M-type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (TSHD7A), and neural epidermal growth factor-like 1 protein (NELL-1) are major autoantigens against podocyte antigens in idiopathic membranous nephropathy (IMN) [ 1 ]. (biomedcentral.com)
  • To investigate the efficacy of combined immunosuppressive regimens of cyclosporine (CsA), tacrolimus (TAC), or cyclophosphamide (CTX) combined with steroids in the treatment of idiopathic membranous nephropathy (IMN). (revistanefrologia.com)
  • An early and precise diagnosis of anti-GBM disease is extremely important for preventing death and preserving renal function. (medscape.com)
  • Etiologies for rapid progression with membranous nephropathy include concurrent bilateral renal vein thrombosis, malignant hypertension, and crescentic membranous nephropathy. (biomedcentral.com)
  • A 38-year-old woman with a history of Crohn's disease and a recent diagnosis of biopsy-proven membranous nephropathy with left renal vein thrombosis, presented with severe, non-oliguric acute kidney injury and volume overload. (biomedcentral.com)
  • Investigations at that time revealed left renal vein thrombosis (diagnosed via Doppler ultrasonography) along with nephrotic range proteinuria (urine albumin-to-creatinine ratio [UACR] 7900 mg/g) and hypoalbuminemia (2.3 g/dL) but with preserved kidney function (serum creatinine 0.76 mg/dL, estimated glomerular filtration rate [eGFR] 100 mL/min/1.73m 2 ). (biomedcentral.com)
  • We offer comprehensive renal testing services and concise results to deliver answers your practice needs to increase accuracy and improve outcomes for glomerular diseases. (mayocliniclabs.com)
  • US Renal Data System 2015 Annual Data Report: Epidemiology of Kidney Disease in the United States. (smw.ch)
  • End-Stage Renal Disease and Mortality Outcomes Across Different Glomerulonephropathies in a Large Diverse US Population. (smw.ch)
  • Хронічна хвороба нирок Chronic kidney disease (CKD) is long-standing, progressive deterioration of renal function. (msdmanuals.com)
  • Membranous nephropathy (MN) is one of the most common causes of nephritic syndrome in adults and is the second most common glomerulopathy to progress to end-stage renal disease (ESRD). (biomedcentral.com)
  • Most people with this disease will have kidney damage and some people will develop end-stage renal disease . (medlineplus.gov)
  • Awareness of atypi- cal presentations, the risk of recurrence, and overlap between ANCA vasculitis and anti-GBM nephritis is critical for early diagnosis, appropriate treatment, and improved renal out- come in these patients. (dokumen.tips)
  • In this review we discuss current evidence that complement activation contributes to progression of CKD, how complement could cause renal inflammation and whether complement inhibition would slow progression of renal disease. (wjgnet.com)
  • 2 The deposition of LECT-2 was different from other types of renal amyloid in demonstrating congophilia within all compartments of the kidney including mesangium, glomerular basement membrane, interstitium, arterioles, and arteries. (highwire.org)
  • Inflammation of the renal glomeruli ( KIDNEY GLOMERULUS ) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. (lookformedical.com)
  • Clinical signs include persistent PROTEINURIA , from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE. (lookformedical.com)
  • Glomerular involvement is a common renal complication associated with Hepatitis B infection. (clinicalcasereportsjournal.com)
  • The kidney is surrounding by an outer membrane called the renal capsule. (armandoh.org)
  • The paper further underestimates chronic kidney disease because their endpoint was restricted to the absence of chronic dialysis or need for renal transplantation. (abdominalkey.com)
  • The glomerular filtration rate reduced, while the renal tubular reabsorption has not decreased and even increased. (tcm-nephritis.com)
  • It aims to improve the body's ability to remove antigens, reduce and repair damage to the basement membrane, increase renal blood flow and make glomeruli repair gradually, meantime, the progress of immune complexes and renal fibrosis get inhibited. (tcm-nephritis.com)
  • It must be aware that proteinuria plays a vital role in the development and prognosis of renal disease. (tcm-nephritis.com)
  • The Role of HBx Gene Mutations in PLA R Positive Hepatitis-B-associated Membranous Nephropathy. (cdc.gov)
  • Glomerular diseases include a number of conditions that can damage the kidneys' filtering units, the glomeruli, resulting in protein and red blood cells leaking into the urine. (mayocliniclabs.com)
  • Glomerulopathies can further be classified as primary or secondary, with primary diseases directly affecting the kidneys and secondary diseases caused by another disease or process. (shiken.ai)
  • The glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. (medlineplus.gov)
  • Pain around the kidneys is an uncommon symptom in kidney disease except with kidney stones , and usually has alternative explanations. (edren.org)
  • The second is that the kidneys have a glomerular-tubule imbalance. (tcm-nephritis.com)
  • Some patients with light chain deposition disease will make so many that they overwhelm the kidneys' ability to recycle or get rid of them all, and some of those proteins get stuck in the kidney. (unckidneycenter.org)
  • Association of SNPs in PLA2R1 with idiopathic and secondary membranous nephropathy in two Chinese cohorts. (cdc.gov)
  • Our menu of clinically validated assays assists with diagnosis, monitors disease progression, and guides clinical outcomes. (mayocliniclabs.com)
  • Future investigations into the roles of uromodulin and regulatory mechanisms are likely to yield even more profound implications for kidney disease diagnosis, risk assessment, and management. (bvsalud.org)
  • Identification of large TBM deposits using light microscopy and IgG staining of apical aspects of proximal tubules using immunofluorescence microscopy can point to the correct diagnosis of anti-LRP2 nephropathy and prompt confirmatory studies. (elsevierpure.com)
  • Particularly in older patients with immune complex-mediated TIN who lack clinical, laboratory, radiographic, and/or characteristic histologic features of IgG4-TIN or other autoimmune, infectious, or drug-related injury, a diagnosis of anti-LRP2 nephropathy should be considered. (elsevierpure.com)
  • My clinical expertise is in the diagnosis of non-neoplastic kidney and liver disease (including transplantation). (stanford.edu)
  • We encountered a woman with microscopic hematuria and proteinuria at 33 years of age with a diagnosis of thin basement membrane disease who was approaching end stage kidney disease at 59 years of age. (stanford.edu)
  • Actually, not only kidney problem, but also other chronic disease is easy to get relapse without a correct diagnosis. (tcm-nephritis.com)
  • 10. Detlefsen S, Bräsen JH, Zamboni G, Capelli P, Klöppel G. Deposition of complement C3c, immunoglobulin (Ig)G4 and IgG at the basement membrane of pancreatic ducts and acini in autoimmune pancreatitis. (southernbiotech.com)
  • Absence of glomerular IgG4 deposition in patients with membranous nephropathy may indicate malignancy. (southernbiotech.com)
  • Subepithelial deposition of immune complexes with basement membrane thickening -produces a spiked appearance on silver stain. (shiken.ai)
  • Amyloidosis is a rare group of diseases characterized by abnormal folding of proteins and extracellular deposition of insoluble fibrils. (highwire.org)
  • Patients with light chain deposition disease make far too many light chains, which get deposited in lots of different tissues in the body, including the kidney. (unckidneycenter.org)
  • The pathologist viewing the biopsy can tell it is light chain deposition disease because it has a different appearance from other deposition diseases. (unckidneycenter.org)
  • In other deposition diseases, the chains will appear to form a pattern and are found in one particular section of the kidney. (unckidneycenter.org)
  • In light deposition disease, the chains do not form a pattern and can be found in various sections of the kidney. (unckidneycenter.org)
  • Light chain deposition usually occurs along with another disease affecting the whole body. (unckidneycenter.org)
  • The risk of developing light chain deposition varies significantly depending on the other disease that the patient has. (unckidneycenter.org)
  • Deposition of light chains in the heart muscle is seen in about 80% of patients with this disease, and symptoms related to the heart muscle damage can be more prominent than symptoms from the kidney. (unckidneycenter.org)
  • The outcome of patients with light chain deposition disease remains uncertain. (unckidneycenter.org)
  • The clinical trajectory for patients with primary membranous nephropathy ranges widely from spontaneous remission to a rapid decline in kidney function. (biomedcentral.com)
  • Given the heterogeneous severity in clinical course for patients with primary membranous nephropathy, the decision on whether to start immunosuppressive therapy upon presentation or allow for an initial observation period is often challenging and centers around the perceived risk for accelerated disease [ 7 ]. (biomedcentral.com)
  • HLA class II alleles differing by a single amino acid associate with clinical phenotype and outcome in patients with primary membranous nephropathy. (cdc.gov)
  • The Genetic and Environmental Factors of Primary Membranous Nephropathy: An Overview from China. (cdc.gov)
  • HLA-D and PLA2R1 risk alleles associate with recurrent primary membranous nephropathy in kidney transplant recipients. (cdc.gov)
  • In conclusion, uromodulin holds great promise as an informative biomarker, providing valuable insights into kidney function and disease progression in various clinical scenarios. (bvsalud.org)
  • Genetic factors such as APOL-L1 mutations are associated with an increased risk of FSGS and progression to end-stage kidney disease. (shiken.ai)
  • The goal of treatment is to reduce symptoms and slow the progression of the disease. (medlineplus.gov)
  • Juxtaglomerular cells are modified SMOOTH MUSCLE CELLS found in the walls of afferent glomerular arterioles and sometimes the efferent arterioles. (lookformedical.com)
  • For example, focal segmental glomerulosclerosis can be both primary and an adaptive response to severe obesity, certain drugs (e.g. heroin) or reflux nephropathy. (pulsenotes.com)
  • Along with the combination of TBM deposits, tubulointerstitial nephritis (TIN), and segmental glomerular subepithelial immune deposits seen in both entities, this newly described feature adds to the morphologic overlap with IgG4-related TIN. (elsevierpure.com)
  • Although membranous nephropathy is the pathology most frequently encountered, other glomerular diseases, such as focal and segmental glomerulosclerosis (FSGS), are rare. (clinicalcasereportsjournal.com)
  • Because of the lack of consistently effective treatment for primary focal segmental glomerular sclerosis, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers are commonly used for patients with mild disease to control symptoms. (basicmedicalkey.com)
  • Herein, we present a 57 years old Caucasian female with anti-GBM nephritis who presented with vasculitis symptoms and additionally had positive p- ANCA titers. (dokumen.tips)
  • Anti-glomerular basement membrane (GBM) disease is a rapidly progressive glomerulopathy that can occur in conjunction with membranous nephropathy on rare occasions. (ajkdblog.org)
  • From the pathology standpoint, it is important to determine whether the membranous glomerulopathy may be due to a secondary cause such as an autoimmune disease, neoplasia, infection, or drugs. (abdominalkey.com)
  • In a Mayo clinic cohort of patients with C3 glomerulopathy, three basic triggers were identified: monoclonal Ig (especially in DDD), infections, and autoimmune disease. (glomcon.org)
  • Its cationic nature allows binding to the anionic glomerular capillary wall with resultant immune complex formation, a parallel to experimental models. (medscape.com)
  • The capillary wall, which serves as a filtration barrier, consists of three well-defined layers: fenestrated endothelium, glomerular basement membrane (GBM), and epithelial cell layer. (basicmedicalkey.com)
  • EM: mesangial/capillary wall (subendothelial) deposits, cellular interposition and new basement membrane formation leading to double contours. (glomcon.org)
  • The clinical and immunological features of patients with combined anti-glomerular basement membrane disease and membranous nephropathy. (southernbiotech.com)
  • Prediction of membranous nephropathy recurrence after transplantation by monitoring of anti-PLA2R1 (M-type phospholipase A2 receptor) autoantibodies: a case series of 15 patients. (southernbiotech.com)
  • 4. Xu P, Cui Z, Chen M, Hellmark T, Zhao M. Comparison of characteristics of natural autoantibodies against myeloperoxidase and anti-myeloperoxidase autoantibodies from patients with microscopic polyangiitis. (southernbiotech.com)
  • The disease is rare, accounting for only 5% of human glomerulonephritides and approximately 10-20% of patients with rapidly progressive crescentic glomerulonephritides. (medscape.com)
  • Primary glomerular nephropathy among hospitalized patients in a national database in China. (cdc.gov)
  • Clinical observation on the effect of Wuzhi soft capsule on FK506 concentration in membranous nephropathy patients. (cdc.gov)
  • Neutral endopeptidase, a podocyte antigen that can digest biologically active peptides, was identified as the target antigen in a subset of patients with antenatal membranous nephropathy. (medscape.com)
  • Recently, investigators described a small series of older patients (aged 66-80 years) with acute kidney injury and a kidney biopsy demonstrating tubular basement membrane (TBM) immune deposits of polytypic immunoglobulin G (IgG) and C3, acute tubular injury, and tubulointerstitial inflammation. (elsevierpure.com)
  • While eventual development of SLE in these patients remains a possibility, few of these patients do not develop the distinct clinical features of SLE and these cases have been referred to as " non lupus full house nephropathy" (FHN) by some authors. (nephro-pathology.com)
  • The potential for FGN fibrils to regress spontaneously is important in the management of FGN patients considering that currently available immunosuppressive agents have limited efficacy, and is an encouraging finding for future studies aiming to find a cure for the disease. (nephro-pathology.com)
  • In general, all patients with hypercholesterolemia secondary to nephrotic syndrome should be treated with lipid-lowering agents because they are at increased risk for cardiovascular disease. (armandoh.org)
  • Steroids and immunosuppressive agents are reserved for patients with severe disease. (basicmedicalkey.com)
  • Many patients choose large-scale hospital and famous experts when they treat kidney disease. (tcm-nephritis.com)
  • Most of patients with chronic nephritis have recurrent edema and different types of nephropathy edema. (tcm-nephritis.com)
  • Almost 90% of patients with kidney disease will have protein leakage in the early stage. (tcm-nephritis.com)
  • Patients with this disease typically are over the age of 50 and have an average age of 67. (unckidneycenter.org)
  • Classically associated with a pauci immune RPGN, ANCA disease has traditionally been not associated with complement activation. (nephronpower.com)
  • Glomerulonephropathies are diseases which cause inflammation in the glomeruli. (shiken.ai)
  • Diabetes mellitus is an important secondary cause of glomerular injury, and a thorough discussion of the pathophysiology and management of this condition can be found in Chapter 57 . (basicmedicalkey.com)
  • By immunofluorescence, we investigated collagen IV chain composition of the glomerular basement membrane (GBM). (stanford.edu)
  • ALECT2 may be confused with amyloidosis associated with light and heavy chain monoclonal gammopathy if the immunofluorescence is positive with anti-light chain and anti-AA sera. (highwire.org)
  • The optimal treatment for lupus nephritis depends on the underlying lesion and disease activity, as well as the severity and duration of the clinical presentation. (basicmedicalkey.com)
  • [ 5 ] Immunosuppression with high-dose steroids and oral cyclophosphamide, together with plasmapheresis, is used in the treatment of severe forms of this disease. (medscape.com)
  • Based on univariate and multivariable Cox regression analysis, more severe glomerular lesions, including glomerular mesangiolysis, glomerular basement membrane double contours and glomerular mesangial proliferation, were identified as risk factors predicting worse prognosis. (referencecitationanalysis.com)
  • Immunosuppressive drug therapy and any disease (eg, HIV infection) resulting in suppression of the normal inflammatory and immune mechanisms can cause or enhance severe periodontal diseases. (medscape.com)
  • It is more likely to be connected to kidney disease in people who are young, or have severe high blood pressure. (edren.org)
  • Nephritic syndrome occurs due to inflammation and damage to endothelial cells of glomerular capillaries and can be triggered by several disease processes. (shiken.ai)
  • Vascular endothelial growth factor A (VEGFA) is the key mediator of angiogenesis, which leads to numerous kidney diseases. (biomedcentral.com)
  • Hence, the most likely statement that makes sense is a common process that leads to endothelial damage leads to both microalbuminuria and cardiac disease. (nephronpower.com)
  • These can be divided into nephrotic and nephritic syndrome, and this article will cover the causes and management of a patient with suspected glomerular disease. (shiken.ai)
  • Nephrotic syndrome and nephritic syndrome are terms describing a group of symptoms caused by different diseases. (shiken.ai)
  • Some of the glomerular cells, such as the epithelial cells, have phagocytic function that can remove macromolecules trapped within the filtration barrier. (basicmedicalkey.com)
  • Nephrologists 2023 international conference is to ameliorate the knowledge, awareness, and education on Nephrology and Urology, leading to the discovery of Nephrology & Urology Therapies which aid to alleviate the human disease as it is the most significant emerging technology in the discriminations of Medical, Biotechnology, Pharmaceuticals, Hospitals and Academia. (insightconferences.com)
  • In Nephrology Dept of HHHTCM, nephropathy edema gets treated in the principle of combining TCM syndrome differentiation and disease differentiation. (tcm-nephritis.com)
  • Secondary causes include systemic diseases such as systemic lupus erythematosus and IgG4-related disease, solid tumor malignancies, chronic infections, and drugs. (biomedcentral.com)
  • Mannose-Binding Lectin2 Gene Polymorphism and IgG4 in Membranous Nephropathy. (cdc.gov)
  • Passive transfer of anti MPO in mice induced ANCA associated necrotizing crescentic GN with activation of alternate complement system. (nephronpower.com)
  • In a different study , the elevated plasma and urinary C5a levels indicated complement activation in human ANCA disease. (nephronpower.com)
  • The role of complement in ANCA disease is not completely novel. (nephronpower.com)
  • Herein, we describe the clinical course of a young patient who initially developed a typical presentation of membranous nephropathy with consistent kidney biopsy findings. (biomedcentral.com)
  • Extensive clinical, laboratory, and pathologic evaluation accurately identifies the underlying etiology of different types of glomerular disease. (mayocliniclabs.com)
  • Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE. (lookformedical.com)
  • Given the wide heterogeneity in prognosis, timing of immunosuppressive therapy is often challenging and centers around an individual patient's perceived risk for rapidly progressive disease. (biomedcentral.com)
  • We discuss the value of repeat kidney biopsy in identifying the etiology of the accelerated decline and explore the pros and cons of early immunosuppressive therapy in membranous nephropathy. (biomedcentral.com)
  • Since 1950's corticosteroids (CS) have remained the cornerstone of immunosuppressive therapy for immune-mediated kidney diseases. (omnidoctor.ru)
  • Human IgG subclass responses in relation to serum bactericidal and opsonic activities after immunization with three doses of the Norwegian serogroup B meningococcal outer membrane vesicle vaccine. (southernbiotech.com)
  • Over the years, studies have revealed compelling associations between urinary and serum concentrations of uromodulin and various parameters, encompassing kidney function, graft survival, cardiovascular disease, glucose metabolism, and overall mortality. (bvsalud.org)
  • This serum uromodulin level is closely associated with kidney function and histological severity, suggesting its potential as a biomarker capable of reflecting disease severity across a spectrum of kidney disorders. (bvsalud.org)
  • In this report, we describe a case of biopsy-proven membranous nephropathy where an initial observation period was undertaken during which the patient developed an accelerated decline in kidney function. (biomedcentral.com)
  • With kidney function being restored, kidney disease edema will be treated from the root and external symptoms. (tcm-nephritis.com)
  • It is caused by increased basement membrane permeability, causing increased urinary loss of protein (including albumin). (shiken.ai)
  • Primary or secondary to HIV, drugs (e.g. pamidronate), urinary reflux, sickle cell disease. (shiken.ai)
  • These cells also synthesize and respond to various cytokines and thus play a key role in immune-mediated glomerular diseases. (basicmedicalkey.com)
  • This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. (lookformedical.com)
  • Women are overrepresented in the early chronic kidney disease (CKD) population. (ajkdblog.org)
  • In this multicenter, prospective, longitudinal cohort study of 3,939 adults with chronic kidney disease (CKD), the rates of cardiovascular events and death were high. (ajkdblog.org)
  • Chronic kidney disease (CKD) is common and the cause of significant morbidity and mortality. (wjgnet.com)
  • Complement activation occurs in progressive chronic kidney disease and may contribute to the chronic inflammation that is characteristically found in the kidney. (wjgnet.com)