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  • hindlimb
  • To survey functional abnormalities of the JP-1 knockout muscle, we examined the contraction profiles of a hindlimb muscle bundle (musculus vastus lateralis) from the mutant neonates. (nih.gov)
  • These results provide evidence that the increased glucose uptake observed with AMPK activation by AICA-riboside in perfused rat hindlimb muscles is due to an increase in the translocation of GLUT4 to surface membranes. (diabetesjournals.org)
  • Electrically induced 30-s hindlimb muscle contraction in decerebrate rats with hypertension evoked larger renal sympathoexcitatory and pressor responses [+1,173 ± 212 arbitrary units (AU) and +35 ± 5 mmHg, n = compared with sham normotensive rats (+419 ± 103 AU and +13 ± 2 mmHg, n = 11). (physiology.org)
  • glucose transport
  • The electrical stimulation of isolated soleus muscle in vitro increased the rate of glucose transport, but this required 20 min to reach maximum. (edu.au)
  • In an attempt to further clarify a role for PKc in the mechanism of glucose transport activation isolated soleus muscle was depleted ("downregulated") of PKc activity by prolonged TPA treatment. (edu.au)
  • The response to both insulin and contraction in terms of glucose transport was assessed. (edu.au)
  • Thus, it is concluded that treatment of isolated soleus muscle with TPA gives rise to a marked loss of contraction-induced glucose transport. (edu.au)
  • surface membrane
  • The basic unit of activity in the two main fiber types is the "twitch," in which a single action potential (AP) on the fiber's surface membrane elicits a brief contractile response. (rupress.org)
  • junctional
  • In triads of differentiated skeletal muscle, RYR tetramers cluster in orderly arrays of two rows, extending along junctional SR segments of variable lengths (from 0.2 up to 1-2 µm) that face the T tubules. (rupress.org)
  • Freeze-dried rotary shadowed junctional SR membrane from guinea pig. (rupress.org)
  • vertebrate
  • This is true for the three-dimensional (3D) reconstruction studies described in this chapter, which include the cilium, the kinetochore, sites of vertebrate calcification, the dendrite, the Golgi apparatus, patch-clamped membranes, and puff ball spores. (springer.com)
  • The results strongly support the hypothesis that nifedipine-sensitive intramembrane charge movement is the signal tansduction mechanism of vertebrate skeletal muscle E-C coupling. (nii.ac.jp)
  • voluntary
  • 6. The voluntary loaded running exercise is more effective for muscle enlargement than treadmill running training and/or voluntary running training with no load in rat skeletal muscle. (nii.ac.jp)
  • Voluntary muscle contraction is used to move the body and can be finely controlled, such as movements of the finger or gross movements that of the biceps and triceps. (wikibooks.org)
  • Skeletal muscle or "voluntary muscle" is anchored by tendons to the bone and is used to effect skeletal movement such as locomotion. (wikibooks.org)
  • This research identified high biological variation between individual mdx mice in the severity of the dystrophic pathology, and supported a relationship between extent of muscle damage in adult mdx mice and their individual enthusiasm for voluntary wheel running. (deepdyve.com)
  • stimuli
  • The mutant muscle developed less contractile force (evoked by low-frequency electrical stimuli) and showed abnormal sensitivities to extracellular Ca2+. (nih.gov)
  • Electrical stimuli at low frequencies developed less contractile forces in the mutant muscle compared with wild-type muscle. (nih.gov)
  • Coupling
  • A salient property of VSMs, equally valid for EC coupling, channels and voltage-sensitive phosphatases (VSPs), is their tendency to enter a functionally disabled state upon sustained increase of the membrane potential to zero and beyond. (rupress.org)
  • Our results indicate that JP-1 contributes to the construction of triad junctions and that it is essential for the efficiency of signal conversion during E-C coupling in skeletal muscle. (nih.gov)
  • Twitch tension developed in the mutant muscle was reduced to about half the value of that in control muscle, although there is no significant difference in the maximum force between the genotypes (Table I). Thus, the force-frequency curve of the mutant muscle was shifted downward, indicating that the loss of JP-1 reduced the efficiency of E-C coupling. (nih.gov)
  • Among the three RyR subtypes, RyR-1 mediates skeletal muscle E-C coupling, whereas RyR-2 and RyR-3 cannot substitute for RyR-1. (semanticscholar.org)
  • nerve
  • In humans with hypertension, the elevation in muscle sympathetic nerve activity seen during postexercise ischemia, a maneuver that selectively excites chemically sensitive muscle afferents, was higher than that in normotensive subjects ( 10 ). (physiology.org)
  • These rodent and human studies suggest that the skeletal muscle contraction-mediated reflex sympathetic nerve response is exaggerated in hypertension, thereby contributing to the excess sympathoexcitation and blood pressure elevation seen during exercise in this pathological condition. (physiology.org)
  • autonomic
  • 2) sympathomimetic (adrenergic stimulating) drugs which directly or indirectly stimulate the dilator pupillae muscle which is innervated by the sympathetic division of the autonomic nervous system. (thefreedictionary.com)
  • Diacylglycerol
  • Electrical-induced contraction of the gastrocnemius' - plantaris-soleus muscle group resulted in a time-dependent translocation of PKc and a 2-fold increase in the concentration of both diacylglycerol and phosphatidic acid. (edu.au)
  • Thus, it is concluded that electrical-induced muscle contraction increased the production of diacylglycerol and the translocation of PKc. (edu.au)
  • basal
  • Muscles treated with TPA showed an increased basal rate of 3-0-methylglucose uptake, responded partially to insulin, but did not respond to contraction. (edu.au)
  • Perfusion medium containing AICA-riboside was found to significantly increase AMPK activity, glucose uptake, and GLUT4 translocation in skeletal muscle above basal levels. (diabetesjournals.org)
  • Insulin-perfused muscles showed significant increases in glucose uptake and GLUT4 translocation, but AMPK activation was not significantly changed from basal levels. (diabetesjournals.org)
  • junction
  • The DHPRs then activate the SR Ca 2+ release channels, whose large cytoplasmic domain spans the gap between the T-tubular and SR membranes at the triadic junction ( Franzini-Armstrong and Nunzi, 1983 ). (rupress.org)
  • nervous system
  • Muscle spindles are distributed throughout the muscles, and provide sensory feedback information to the central nervous system. (wikibooks.org)
  • ACh exists only momentarily after its formation, being hydrolysed by the enzyme acetylcholinesterase which is present in the neurons of cholinergic nerves throughout their entire lengths and at neuromuscular junctions: this process is essential for proper muscle function as otherwise the accumulation of ACh would result in continuous stimulation of the muscles, glands and central nervous system. (thefreedictionary.com)