Amyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesProtein PrecursorsCell MembraneMembranesIntracellular MembranesMembrane LipidsAspartic Acid EndopeptidasesAmyloid beta-PeptidesAlzheimer DiseaseMembrane PotentialsMembranes, ArtificialPresenilin-1Molecular Sequence DataAmino Acid SequenceProtein Processing, Post-TranslationalEndopeptidasesErythrocyte MembraneMembrane FluidityCell LineProtein TransportMembrane Transport ProteinsMutationBase SequencePeptide FragmentsCell Membrane PermeabilityProtein Structure, TertiaryEnzyme PrecursorsBasement MembraneProtein BindingMice, TransgenicCells, CulturedNeuronsBrainMembrane GlycoproteinsPlaque, AmyloidProtein Sorting SignalsPresenilin-2Membrane ProteinsMitochondriaRecombinant Fusion ProteinsCloning, MolecularModels, BiologicalMicroscopy, ElectronEscherichia coliElectrophoresis, Polyacrylamide GelProtease NexinsRecombinant ProteinsNerve Tissue ProteinsAmyloidMolecular WeightMitochondrial MembranesPresenilinsCarrier ProteinsTransfectionLipid BilayersPeptidesBlotting, WesternChloroplastsEndoplasmic ReticulumBinding SitesKineticsSequence Homology, Amino AcidCricetinaeGolgi ApparatusRNA, MessengerCHO CellsImmunohistochemistryCell FractionationSignal TransductionPeasTime FactorsBacterial ProteinsLiposomesProtein ConformationSubcellular FractionsHydrogen-Ion ConcentrationMice, Inbred C57BLCalciumSynaptic MembranesMitochondrial Membrane Transport ProteinsMicroscopy, FluorescenceDetergentsCytoplasmEndocytosisDisease Models, AnimalRNA PrecursorsProtein BiosynthesisCytosolCOS CellsModels, MolecularMicroscopy, ConfocalReceptors, Cell SurfaceCell DifferentiationRabbitsSolubilityEndosomesDNA, ComplementaryAmyloidogenic ProteinsTemperature