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MembranesMembrane LipidsCell MembraneIntracellular MembranesMembrane PotentialsMembranes, ArtificialErythrocyte MembraneMembrane FluidityCell Membrane PermeabilityBasement MembraneMembrane Transport ProteinsMembrane GlycoproteinsLipid BilayersMitochondrial MembranesMicroscopy, ElectronProtein TransportSynaptic MembranesCell LineLiposomesProtein BindingCalciumModels, BiologicalCell FractionationProtein Structure, TertiaryCarrier ProteinsExtraembryonic MembranesHydrogen-Ion ConcentrationDetergentsEscherichia coliElectrophoresis, Polyacrylamide GelEndoplasmic ReticulumPhosphatidylcholinesCells, CulturedGolgi ApparatusMutationBacterial ProteinsMicroscopy, FluorescenceFreeze FracturingMolecular Sequence DataMolecular WeightRecombinant Fusion ProteinsCell Membrane StructuresPotassiumMicrovilliTemperatureSubcellular FractionsMitochondriaAmino Acid SequenceBiological Transport, ActiveEndocytosisMicroscopy, ConfocalCytoplasmErythrocytesModels, MolecularBinding SitesRabbitsMembrane Potential, MitochondrialPurple MembraneIon ChannelsTime FactorsSodiumProtein ConformationSolubilityCattleBase SequenceFluorescent Antibody TechniqueFluorescent DyesAdenosine TriphosphateElectric ConductivityNictitating MembraneBruch MembranePermeabilitySignal TransductionProtein Structure, SecondaryOctoxynolMicroscopy, ImmunoelectronCytosolExocytosisCricetinaeCholesterolPeptidesRecombinant ProteinsSequence Homology, Amino AcidDiffusionEndosomesBlotting, WesternPhosphatidylethanolaminesVacuolesCloning, MolecularEscherichia coli ProteinsPhosphatidylserinesTransfectionPorinsKineticsGreen Fluorescent ProteinsMicrosomesUnilamellar LiposomesElectrophysiologySpectrometry, FluorescenceImmunoblotting
Plasma membraneSmall vesiclesInteractorsInteractionsPlantOrganellesActivityFunction
Plasma membrane8
  • WDFY2 knockout causes a strong redistribution of VAMP3 into small vesicles near the plasma membrane. (nature.com)
  • After internalization, MT1-MMP is sorted in endosomal compartments, and a fraction is recycled back to the plasma membrane. (nature.com)
  • Here, we have studied the function of WDFY2, a cytosolic protein that has been described to reside on endocytic vesicles close to the plasma membrane 6 . (nature.com)
  • Whereas APPL1- positive vesicles localize close to the plasma membrane, we observed that WDFY2 localized to a pool of vesicles that was further from the plasma membrane and negative for APPL1. (nature.com)
  • Here we show that depletion of diacylglycerol kinase α (DGKα), a kinase devoid of a clathrin-dependent adaptor protein complex 2 binding site, caused a delay in MHC I recycling to the plasma membrane without affecting the rate of MHC I internalization. (nebraska.edu)
  • For instance, condensates of the TPLATE, a plant-specific complicated modulating endocytosis, can doubtless type on the plasma membrane [ 14 ]. (keiseronlineuniversity.com)
  • We have now additionally proven that condensates of processing our bodies type on membranes in Arabidopsis and might attain polarity (i.e., localizing asymmetrically on the plasma membrane) [ 13 ]. (keiseronlineuniversity.com)
  • Nevertheless, the practical significance of condensates on the plasma membrane is unclear. (keiseronlineuniversity.com)
Small vesicles1
Interactors1
  • I published the first report of plant ER reticulon protein interactors by Co-IP and FRET-FLIM. (brookes.ac.uk)
Interactions2
  • I am committed to interdisciplinary research, and an example of the successes gained from this approach is the project with Prof A Nabok (Engineering Sheffield Hallam University) using total internal reflection ellipsometry to quantify protein-membrane interactions on native plant membranes and human cell lines. (brookes.ac.uk)
  • Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)
Plant2
  • Current proof means that like their animal counterparts, plant condensates can interface with membranes. (keiseronlineuniversity.com)
  • I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
Organelles2
  • Intracellular localization of organelles may depend in part on specific cytoplasmic linker proteins (CLIPs) that link membranous organelles to microtubules. (nih.gov)
  • All cellular membranous organelles have a dynamic nature, changing shape and distribution to some degree and communicating structurally and functionally through membrane trafficking. (molcells.org)
Activity2
  • Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. (nih.gov)
  • The mitochondrial DRPs mediate fission and fusion, presumably through similar membrane remodeling activity. (molcells.org)
Function1
  • Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)