• Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com)
  • CSFV infection is probably a multistep process that involves the proteins in the virus envelope and more than one receptor in the membrane of permissive cells. (bvsalud.org)
  • This review aims to provide an overview of current knowledge on cellular molecules described to be involved in CSFV entry, including complement regulatory protein 46 (CD46), heparan sulphate (HS), Laminin receptor, Integrin ß3, Annexin II, MERKT and ADAM17. (bvsalud.org)
  • SFTSV possesses Gn and Gc glycoproteins, which are responsible for host cell receptor attachment and membrane fusion, respectively, to infect host cells. (bvsalud.org)
  • The team has developed two prostate cancer vaccines, which activate the immune system against two prostate cancer associated proteins - the androgen receptor (AR), and prostatic acid phosphatase (PAP). (pcf.org)
  • The protein includes a diphtheria toxin (DT) without a receptor binding domain and the C1, C2, C3 (3C) domains of Streptococcus protein G, that is DT3C. (cusabio.com)
  • This study aimed to investigate the role of LTα in MOG 35-55 -induced EAE using mice deficient in LTα or its membrane receptor, LTβR. (rusimmun.ru)
  • Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
  • The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. (iiab.me)
  • Monoclonal antibodies (mAbs) are localized to the surface of tumor cells via the specificity and targeting of tumor cell-associated antigens. (cusabio.com)
  • The linker is broken under the action of intracellular low pH or lysosomal proteins, releasing active cytotoxic drugs to damage DNA or prevent tumor cells from dividing, thereby killing tumor cells. (cusabio.com)
  • The mechanism for conformational conversion to the scrapie isoform is speculated to be an elusive ligand -protein, but, so far, no such compound has been identified. (wikidoc.org)
  • Substitution of a valine for a glutamic acid in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (iiab.me)
  • The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
  • In this manner, the reduced detection of self MHC-I molecules by NK cell-inhibitory receptors coupled with an increase in activating signals by recognition of stress-induced surface ligands promote the cytolytic activity of NK cells. (biomedcentral.com)
  • Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membrane antigens. (silverchair.com)
  • Complex immunobiology of lymphotoxin (LTα) is due to multiple modalities of signal transduction, involving a soluble homotrimer and membrane-bound heterotrimers that engage at least three different receptors. (rusimmun.ru)
  • Critically, a H527P mutation captures gB in a prefusion conformation as determined by cryo-EM, a loss of membrane fusion in a virus free assay, and failure of recombinant VZV to spread in cell monolayers. (bvsalud.org)
  • Immunization strategies against this morbillivirus using recombinant adenoviruses expressing PPRV-F or -H proteins can protect PPRV-challenged animals and permit differentiation of infected from vaccinated animals. (biomedcentral.com)
  • produced a recombinant protein through gene recombination technology, which is a tool to evaluate more precisely the efficiency of mAbs' internalization by cells. (cusabio.com)
  • Now, CUSABIO provides recombinant DT3C protein with high purity to fuel ADC development. (cusabio.com)
  • Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)
  • The Mouse Cytokine Array, Panel A utilizes capture antibodies spotted onto a nitrocellulose membrane to allow high-throughput multi-analyte profiling of 40 cytokines, chemokines, and more in a single sample. (rndsystems.com)
  • Mouse splenocytes treated with 100 ng/mL LPS for 20 hours were mixed with a cocktail of biotinylated detection antibodies, and then incubated with the Mouse Cytokine Array. (rndsystems.com)
  • In order to further verify the role of DT3C in the detection of the internalization efficiency of ADC antibodies, in 2015, Miki Yamaguchi et al . (cusabio.com)
  • Whether an antibody can be internalized is mainly determined by the target, and the efficiency of antibody internalization is closely related to the antigen density, antibody affinity, and antibody and antigen-binding epitopes. (cusabio.com)
  • Instead of developing your own assays, explore our kits and services to quickly quantify viral antigens! (acrobiosystems.com)
  • All the viral envelope proteins Erns, E1 and E2 are involved in the entry process to some extent and the experimental approaches conducted until now have helped to unveil their contributions. (bvsalud.org)
  • TRIM7 targets ΦQ-containing proteins for proteasomal degradation in a mechanism reminiscent of the N-end rule and which allows it to potently inhibit viral replication. (mdpi.com)
  • A membrane-based antibody array for the parallel determination of the relative levels of selected mouse cytokines and chemokines. (rndsystems.com)
  • The most commonly used method for measuring immune cell‑mediated killing is the release assay, where effector cell‑mediated disruption of the target cell membrane results in leakage of its cytoplasmic contents into the culture medium. (technologynetworks.com)
  • Membrane fusion mediated by conserved core glycoproteins, the fusogen gB and the heterodimer gH-gL, enables herpesvirus cell entry. (bvsalud.org)
  • In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. (cusabio.com)
  • [15] PrP C attaches to the outer surface of the cell membrane by a glycosylphosphatidylinositol anchor at its C-terminal Ser 231. (wikidoc.org)
  • These results provide evidence that tolerance is not actively acquired to organ-specific antigens in the preimmune B cell repertoire, underscoring the importance of maintaining tolerance to such antigens by other mechanisms. (silverchair.com)
  • Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)
  • Patients will be evaluated for safety, clinical responses, immune system responses against the vaccine antigens (PAP and AR), as well as immune system changes that correlate with clinical responses. (pcf.org)
  • Whether it is for protein electrophoresis or western blot, our pre-stained protein markers help you quickly determine the molecular weight of the target protein or evaluate the transfer efficiency. (acrobiosystems.com)
  • CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease. (ucsf.edu)
  • In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. (iiab.me)
  • Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. (acrobiosystems.com)
  • This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)
  • Many of the proteins made by RNA viruses, including Coxsackievirus, Norovirus and SARS-CoV-2, end in a C-terminal ΦQ motif because they are excised by 3C protease from a precursor polyprotein. (mdpi.com)
  • The human protein structure consists of a globular domain with three α-helices and a two-strand antiparallel β-sheet , an NH 2 -terminal tail, and a short COOH -terminal tail. (wikidoc.org)
  • Therefore, a highly sensitive d-BPE-ECL biosensor for hepatitis C virus envelope protein E2 detection with a linear range from 10-4 to 10 ng/mL and detection limit of 3.3 × 10-5 ng/mL was obtained. (bvsalud.org)
  • codon_start =1 / gene ="psbA" / product ="photosystem II protein D1" / translation ="DLAAIEAPSTNG" / transl_table =11 misc_feature 41. (nig.ac.jp)
  • PRNP ( PR io N P rotein) is the human gene encoding for the major prion protein PrP (for pr ion p rotein), also known as CD230 ( cluster of differentiation 230). (wikidoc.org)
  • How does DT3C mediate the detection of the efficiency of mAbs' internalization by cells? (cusabio.com)
  • Before detailing how DT3C mediates the detection of the efficiency of mAbs' internalization by cells, let's first understand what is ADC internalization. (cusabio.com)
  • Explore our series of high-quality proteins covering comprehensive diagnostic indicators in order to facilitate the in vitro diagnostic research of neurological diseases. (acrobiosystems.com)
  • To study how humoral tolerance is normally maintained to organ-specific membrane antigens, transgenic mice were generated selectively expressing membrane-bound hen egg lysozyme (mHEL) on the thyroid epithelium. (silverchair.com)
  • The role of an intact endothelial barrier in sequestering organ-specific antigens from circulating preimmune B cells is discussed. (silverchair.com)
  • Protein markers are an essential component in biological research and drug development. (acrobiosystems.com)
  • The catalytic domain of DT3C leads to ADP-ribosylation of elongation factor (EF)-2, which subsequently leads to cytotoxicity by inhibiting protein translation machinery. (cusabio.com)
  • PrP messenger RNA contains a pseudoknot structure ( prion pseudoknot ), which is thought to be involved in regulation of PrP protein translation . (wikidoc.org)
  • Feng's team have discovered that some prostate cancers become resistant to PARP-inhibitors by gaining mutations that overwrite the original BRCA2 mutation and restore the activity of the BRCA2 protein. (pcf.org)
  • The table shows the analytes detected and their location on the membrane. (rndsystems.com)
  • We offer a wide array of products pre-conjugated with streptavidin to support your research as well as biotinylated proteins. (acrobiosystems.com)
  • Theranostic Targeting of CUB Domain-Containing Protein 1 (CDCP1) in Multiple Subtypes of Bladder Cancer. (ucsf.edu)