Membrane proteins cell cycle proteins. Medical search. Frequent questions

Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that the candidate reference genes were significantly enriched in cellular metabolic process, protein metabolic process and ribosome in early development and normal adult tissues as well as in cellular localization and endocytosis in the hindgut under sulfide stress. (biomedcentral.com)
Through functional enrichment analysis, the FA pathway genes were positively associated with cell cycle and nucleoplasm and negatively correlated with SRP-dependent co-translational protein targeting to membrane and ribosome. (pulsus.com)
Using bioinformatics analyses, we predicted HNK protein targets from several databases and retrieved the genes differentially expressed in mBCSCs from the GEO database. (hindawi.com)
The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
Western blotting was performed to detect the protein levels of TWIST and EMT-related genes. (hindawi.com)
Viruses have ones to tens of genes packaged in a protein capsule, sometimes with a bit of oily membrane too. (emergingscholars.org)
By comparison, malaria parasites are entire cells with thousands of genes, multiple external proteins, and several distinct life cycle stages with differences in shape and protein expression. (emergingscholars.org)
Therefore, there is need for fundamental distinction between the different types and functions of genes that are involved in anti-cell death in plants. (essaywriter.org)
The main aim of this paper is to review the pathways that lead to cell death in plants with a purpose of identifying the anti-cell death genes. (essaywriter.org)
At the end of the discussion, significant insights will be developed to paint a picture of the emerging trends in plant development with respect to the topical research on anti-cell death genes. (essaywriter.org)
The dominant discovery in these experiments indicates that there is a heterologous expression of certain genes in plants that can regulate cell death. (essaywriter.org)

This will enable synthesis of energy-rich valuable resources such as starch, biofuels, or proteins from simple cellular building blocks-in the future even from carbon dioxide. (singularityhub.com)
If a cell needs to spend that energy, it breaks off one of the molecule's three phosphate groups and the energy bound up in that chemical bond can then power some cellular process. (singularityhub.com)
The non-protein amino acid γ-aminobutyric acid (GABA) has been proposed to be an ancient messenger for cellular communication conserved across biological kingdoms. (nature.com)
The protein has been localized to both the cytoplasm and to cellular membranes. (genetex.com)
Proposed mechanisms for this suppression include blockage of virus binding to the host cell plasma membrane, alteration of essential viral proteins and induction of cellular antiviral responses targeting specific steps in the viral replication cycle. (nutraingredients-usa.com)
The focus on metabolism includes sessions on "Biochemistry of elemental cycling," a theme that centers on microbes and our environment, and "Advances in organismal and cellular metabolism," centering on physiology and disease. (asbmb.org)
These sessions, providing diverse perspectives using different systems, are "Protein machines and disorder," "Organelles, mechanisms and phase properties of cellular quality control," and "Cell signaling - new tools and emerging concepts. (asbmb.org)
Anti-cell death is a technique adopted by multi-cellular organisms as a defensive and developmental mechanism (Franklin-Tong and Gourlay, pg 390). (essaywriter.org)
The cell cycle and cellular differentiation in bacteria. (lu.se)
In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. (lu.se)
This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
Another characteristic architectural feature found in many of these tumors is a pseudoalveolar pattern in which cells are arranged in alveolae with central cellular discohesion (see the fourth image below). (medscape.com)
TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)

In contrast, no significant alteration of apoptosis in the BCa cells with downregulated LAPTM5 was noticed. (spandidos-publications.com)
Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
Loss of mitochondrial membrane potential, upregulation of proapoptotic proteins, activation of MCL-1, PARP-1 and Caspase 9 suggest that MESF treatment leads to activation of mitochondrial pathway of apoptosis. (nature.com)
Sodium butyrate induces mitophagy and apoptosis of bovine skeletal muscle satellite cells through the mammalian target of rapamycin signaling pathway. (usda.gov)
Increasing evidence indicates that EBV miRNAs target the host mRNAs involved in cell proliferation, apoptosis and transformation. (ijbs.com)
In animals, morphological distinctions have since been used to distinguish different types of cell deaths, including apoptosis, necrosis and autophagy. (essaywriter.org)
Primarily, the aim of anti-cell death in animals is to describe the processes of autophagy and apoptosis, while necrosis is the mechanism for defining the uncontrollable or chaotic mode of death. (essaywriter.org)
Majority of the literature and experiments in the field of programmed cell death in plants draw heavily on comparative analysis retrieved from paradigms of animal systems such as apoptosis, necrosis and autophagy. (essaywriter.org)
Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. (caslab.com)
EHD2 overexpression suppressed cell invasion and proliferation, but enhanced cell apoptosis and cell cycle arrest.Conclusions: EHD2 might represent a therapeutic target of colon cancer.IMPACT STATEMENTWhat is already known on this subject? (bvsalud.org)
Membrane trafficking is crucial for cell proliferation, differentiation and apoptosis, especially tumorigenesis and development. (bvsalud.org)
EHD2 overexpression suppressed cell invasion and proliferation, but enhanced cell apoptosis and cell cycle arrest in vitro. (bvsalud.org)
In a different study, in which researchers systematically analyzed mutations identical to those found in patients with Darier disease, mutant SERCA2 protein aggregates were found to cause stress to the endoplasmic reticulum, subsequently inducing cell apoptosis. (medscape.com)
Uncoated CloisNa caused membrane damage, inflammasome activation, and apoptosis in epithelial and macrophage cells, with minimal response observed in incinerated ONC-exposed cells. (cdc.gov)

Furthermore, proteins involved in epithelial-mesenchymal transition (EMT) were strongly altered, which plays a central role in metastasis. (spandidos-publications.com)
During EMT, cells will undergo transformation from epithelial phenotype to mesenchymal phenotype ( 14 ) and many characteristics of cells will change including loss of cell-cell adhesion and acquisition of aggressive and metastatic ability ( 15 ). (spandidos-publications.com)
Keratin also protects epithelial cells from damage or stress. (wikipedia.org)
They are also present in epithelial cells in general. (wikipedia.org)
For example, mouse thymic epithelial cells react with antibodies for keratin 5, keratin 8, and keratin 14. (wikipedia.org)
These antibodies are used as fluorescent markers to distinguish subsets of mouse thymic epithelial cells in genetic studies of the thymus . (wikipedia.org)
Electron microscopy reveals loss of desmosomes (epithelial intercellular junctions formed by membrane and submembrane protein complexes), breakdown of desmosome-keratin intermediate filament attachment, and perinuclear aggregates of keratin intermediate filaments. (medscape.com)

Combining X-ray crystallography and molecular dynamics simulations, they showed that APTs contain in their structure positively-charged patches that allow them to electrostatically attract the lipid bilayer of a membrane. (epfl.ch)
16. A living cell has a protoplasm which is water based and demarcated by a lipid bilayer membrane. (pharmatutor.org)

It is estimated that about 30-35 percent of proteins in the human proteome are integral membrane proteins. (biophysics.org)

In response to certain signals, the RYR2 channel releases calcium ions from the sarcoplasmic reticulum into the surrounding cell fluid (the cytoplasm). (medlineplus.gov)
In Xp11.2 translocation-associated renal cell carcinoma (RCC), cells typically have voluminous cytoplasm, which can range from eosinophilic and granular to clear. (medscape.com)
at least focally, tumor cells often have abundant clear cytoplasm, mimicking clear cell RCC. (medscape.com)
In Xp11.2 translocation-associated renal cell carcinoma, tumor cells with abundant eosinophilic cytoplasm and high nuclear grade are often arranged in large nests with a delicate, intervening vascular stroma. (medscape.com)
If the membrane-anchor is missing or defective, Fp and Ip subunits accumulate as soluble proteins in the cytoplasm. (lu.se)

Some attach to bacterial outer membrane proteins, while others attach to appendages such as pili or flagella. (virology.ws)
In addition, mutation or altered expression of outer membrane proteins constituting porins can also contribute to cephamycin resistance. (cdc.gov)

Moreover, some studies demonstrated that LAPTM5 was highly expressed in malignant B lymphomas and involved in B cell malignancies ( 10 ), involving in negative regulation of cell surface T and B cell receptor by promoting lysosome degradation ( 6 ). (spandidos-publications.com)
In the present study, up-regulation of SOX9 was observed in both NPC tissues and different NPC cells. (cancerindex.org)
The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. (embl-heidelberg.de)
Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart. (umassmed.edu)
Using Arabidopsis thaliana , we show guard cell GABA production is necessary and sufficient to reduce stomatal opening and transpirational water loss, which improves water use efficiency and drought tolerance, via negative regulation of a stomatal guard cell tonoplast-localised anion transporter. (nature.com)
PSA has been proposed to function in a variety of processes, including metabolism of neuropeptidase, regulation of the cell cycle, and hydrolysis of proteasomal products to amino acids. (genetex.com)
Critical biomolecules of the cell are identified, engineered and harnessed for myriad applications in sessions on "Frontiers in carbohydrate synthesis and recognition," "Lipid dynamics and signals in membrane and protein structure," and "Regulation of RNA. (asbmb.org)
Additionally, this discussion expands its mandate by analyzing the function and regulation of anti-cell death in plant development. (essaywriter.org)
EHD2 proteins play an important role in the regulation of membrane trafficking in endocytosis. (bvsalud.org)
Some studies of keratosis follicularis (Darier disease) have suggested that alterations in calcium regulation may affect the synthesis, folding, or trafficking of desmosomal proteins. (medscape.com)

de Marcos-Lousa C, P Sideris D, Tokatlidis K. (2006) Translocation of mitochondrial inner-membrane proteins: conformation matters. (forth.gr)

It promotes lipid membrane association of the protein, for instance to the plasma membrane, Golgi apparatus, or inner nuclear membrane. (epfl.ch)
Previous studies have shown that the enzyme is heavily accumulated in the cell's Golgi apparatus, which is the organelle that packages new protein into vesicles before sending them off to the cell's membrane. (epfl.ch)
Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)

Taken together, our results suggested that decreased LAPTM5 inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 in BCa cells. (spandidos-publications.com)
Furthermore, previous studies suggested that knockdown of LAPTM4B , another important subtype of the LAPTM family inhibited proliferation of hepatocellular carcinoma ( 11 ), prostate ( 12 ) and breast cancer cells ( 13 ). (spandidos-publications.com)
SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling. (cancerindex.org)
Overexpression of SOX9 promoted NPC cell proliferation, migration and invasion. (cancerindex.org)
A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
The aim of our study was to investigate the role of SNHG3 in the proliferation, migration, and invasion of GC cell lines. (hindawi.com)
CCK-8 and Transwell assays were performed to detect cell proliferation, invasion, and migration abilities. (hindawi.com)
Moreover, lncRNA SNHG3 knockdown or miR-326 overexpression significantly inhibited cell proliferation, migration, and invasion of GC cell lines. (hindawi.com)
In addition, TWIST overexpression can reverse the inhibition of lncRNA SNHG3 knockdown or miR-326 overexpression on cell proliferation, migration, and invasion. (hindawi.com)

Combining structural biology, molecular simulations, mutagenesis, and in vivo assays, EPFL scientists have made the first extensive study of the mode of action of the enzyme acyl thioesterase, which regulates deacylation, one of the most critical functions of the cell. (epfl.ch)
The team also uncovered a mildly hydrophobic loop on the surface of APTs that they called the "β tongue", which allows the enzyme to perform hydrophobic interactions with the membrane. (epfl.ch)
The site allows the enzyme to be bound by ubiquitin, a protein that the cell uses to mark molecules for breakdown. (epfl.ch)
First, long-range electrostatic interactions attract the enzyme, through its positive patches, to the lipid membrane. (epfl.ch)
4F10 was against the Epstein-Barr virus (EBV) Zta protein and 311 H specifically recognized EBV DNase enzyme. (karger.com)
This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. (genetex.com)
RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)
Succinate:quinone oxidoreductase (SQR) is both a Krebs´ citric acid cycle enzyme and a component (Complex II) of the respiratory chain in aerobic cells. (lu.se)
a foreign substance, usually protein or carbohydrate substance (as a toxin or enzyme) capable of stimulating an immune response, usually the production of antibodies. (cdc.gov)

However, only a small fraction of membrane proteins, such as G-protein coupled receptors (GPCRs) and ion channels, have been considered as drug targets. (biophysics.org)
When an HIV particle lands on a suitable cell, receptors (shown as golden knob like structures) attach it to the cell surface. (rkm.com.au)
The released virus particles can now land and dock with other cells that have the appropriate receptors on their plasma membranes. (rkm.com.au)
Also acts downstream of some G-protein coupled receptors. (caslab.com)
This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
This protein is part of a family of ryanodine receptors, which form channels that transport positively charged calcium atoms (calcium ions) within cells. (medlineplus.gov)

Analysis of the changes of migration and invasion, showed significant reduced LAPTM5 suppressed cell metastasis. (spandidos-publications.com)
Breast cancer stem cells (BCSCs) play a critical role in chemoresistance, metastasis, and poor prognosis of breast cancer. (hindawi.com)
is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
reported that miR-326 is abnormally expressed in metastasis and nonmetastasis tissues in non-small-cell lung cancer, providing an experimental basis for exploring the mechanism of non-small cell lung cancer metastasis and molecular diagnosis and treatment [ 16 ]. (hindawi.com)
EHD2 overexpression may inhibit tumorigenesis in colon cancer through the modulation of E-cadherin, the critical marker of EMT which is closely related to invasion and distant metastasis of tumor cells. (bvsalud.org)

GSE76211) ( 3 , 4 ), revealing a significantly upregulated gene in BCa tissues, the lysosomal-associated protein multispanning transmembrane 5 (LAPTM5). (spandidos-publications.com)
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
In contrast, the thermally sensitive population exhibited higher basal levels of heat shock proteins and had three times fewer changes in gene expression overall. (frontiersin.org)
Endophilin-A2, SH3 domain protein 2B or SH3 Domain-Containing GRB2-Like Protein 1 is encoded by the gene Sh3gl1 and a member of the endophilin family of Src homology 3 domain-containing proteins. (antibodiesinc.com)
This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. (nih.gov)
Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. (nih.gov)
Mutations of PTCH1 gene in two pedigrees with bifid rib-basal cell nevus-jaw cyst syndrome. (nih.gov)
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
This was studied by using the CtrA gene, which encodes for an important cell cycle regulatory protein. (kenyon.edu)
The RYR2 gene provides instructions for making a protein called ryanodine receptor 2. (medlineplus.gov)
Almost all of the RYR2 gene mutations involved in CPVT change single protein building blocks (amino acids) in the ryanodine receptor 2 protein. (medlineplus.gov)
The RYR2 gene mutations responsible for ARVC change single amino acids in the ryanodine receptor 2 protein. (medlineplus.gov)
Translocation carcinoma is a renal cell carcinoma (RCC) subtype that harbors a translocation involving a member of the microphthalmia transcription factor gene family. (medscape.com)

A single polypeptide motif of gp210 is responsible for sorting to nuclear membrane, and indicate the carboxyl tail of the protein is oriented toward the cytoplasmic side of the membrane. (wikipedia.org)
In experimental electrophysiological studies, this can be relatively easily controlled via electrodes in the aqueous solutions on each side of the membrane. (biophysics.org)

Protein translocation across membranes. (lu.se)
Translocation-associated renal cell carcinomas (RCCs) arise from the proximal tubule epithelium, similar to conventional clear cell and papillary RCCs. (medscape.com)
Xp11.2 translocation-associated renal cell carcinomas are generally cortical or subcapsular, well-circumscribed lesions with yellow-tan, variegated cut surfaces. (medscape.com)
Xp11.2 translocation-associated renal cell carcinomas (RCCs) may have well-developed papillae, mimicking papillary RCCs. (medscape.com)
The nests of tumor cells in Xp11.2 translocation-associated renal cell carcinomas may become centrally discohesive, giving rise to a pseudoalveolar growth pattern. (medscape.com)

This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
It was found that the C . crescentus genome encodes for more two-component signal transduction proteins that assist in cell cycle progression than any other bacterial genome sequenced so far. (kenyon.edu)
Caulobacter also uses DNA methylation as a regulatory mechanism in cell cycle progression. (kenyon.edu)
Several two-component signal transduction proteins are involved in the cell cycle progression by accumulating at one or both poles "in a spatial and temporal pattern that is reproduced during each cycle" (Jacobs-Wagner 2003). (kenyon.edu)

Hatzis P, Kyrmizi I, Talianidis I. (2006) Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression. (forth.gr)
Due to their efficient mechanisms for lethal membrane disruption, these proteins are gaining interest in many fields, including the medical, food, biotechnological, and pharmaceutical fields. (edu.au)

Endophilin-A2 is involved in endocytosis and is thought to recruit other proteins to the membrane. (antibodiesinc.com)

Finally, the scientists brought their data together to work out how APT2 actually binds lipid membranes, which is essential to its capacity to perform its function in the cell. (epfl.ch)
What they found was that APT2 binds membranes in a three-step process. (epfl.ch)
In the interaction with proteins, lead binds with virtually every available functional group, including sulfhydryl, amine, phosphate, and carboxyl groups, with sulfhydryl having the highest affinity. (cdc.gov)

LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
Finally, the interaction between HNK and two HNK-targets regulating the cell cycle was analyzed using molecular docking analysis. (hindawi.com)
The function of this domain is not yet known but in analogy with the LIM domain it could be involved in protein-protein interaction and be important for the assembly or activity of multicomponent complexes involved in transcriptional activation or repression. (embl-heidelberg.de)
Besides, Protein Disulfide Isomerase A3 (PDIA3) has been identified as an interactor of PSA, thus a binding ELISA assay was conducted to detect the interaction of recombinant human PSA and recombinant human PDIA3. (genetex.com)
The ribosome-membrane interaction depends not only on the developmental stage of the cell but also on light. (rupress.org)
For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)

Viruses that infect eukaryotic cells typically bind to a plasma membrane receptor to initiate the reproduction cycle. (virology.ws)
The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses. (virology.ws)
Adenosine A1 and A2A receptor effects on G-protein cycling in beta-adrenergic stimulated ventricular membranes. (umassmed.edu)
Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. (umassmed.edu)
The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. (nih.gov)
Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. (nih.gov)
set the stage for the still ongoing debate on the role of bulk flow versus receptor-mediated transport of cargo molecules through the secretory pathway of eukaryotic cells. (biologists.com)
Channels made with the ryanodine receptor 2 protein are found in heart (cardiac) muscle cells called myocytes. (medlineplus.gov)

The BD IntraSure™ kit is a reagent kit designed to fix and permeabilize cells prior to intracellular immunofluorescence staining with monoclonal antibodies. (bdbiosciences.com)
Abcam: antibodies, proteins, kits. (abcam.com)
in the case of SARS-CoV-2, there is effectively one external protein that antibodies can target, providing a natural focus for vaccine development. (emergingscholars.org)

Like most biochemical processes in the cell, protein S-acylation is reversible to regulate the functions of acylated proteins. (epfl.ch)
Cell wall proteomics, as well as numerous genetic or biochemical studies, have revealed the high diversity of CWPs, among which proteins acting on polysaccharides, proteases, oxido-reductases, lipid-related proteins and structural proteins. (mdpi.com)
[ 7 ] Thus, diverse biochemical mechanisms are responsible for altered protein function. (medscape.com)

Evidently, it has been established from the above outline that cell death plays a pivotal role in the innate responses in both animals and plants. (essaywriter.org)
In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)

Genome-wide acetylation modification of H3K27ac in bovine rumen cell following butyrate exposure. (usda.gov)
The viral RNA genome is converted to DNA in the cell. (rkm.com.au)
The integrated viral genome (or provirus) instructs the cell to produce new viral gemomes (RNA) and new viral proteins. (rkm.com.au)
Internally, those cells have a nucleus and mitochondria (with a separate genome) and other organelles, just like our cells. (emergingscholars.org)

He added that it could be a key enabler to make "electrobiosynthesis" possible, the idea of using electricity to directly power the synthesis of useful chemicals by cells. (singularityhub.com)
In the light, when there is an increase in the chlorophyll content and synthesis of thylakoid membrane proteins, about 20-30% of the chloroplast ribosomes are bound to the thylakoid membranes. (rupress.org)

ATP2A2, located on 12q23-24.1, encodes the sarcoplasmic/endoplasmic reticulum Ca 2+ -ATP isoform 2 protein (SERCA2), which is a calcium pump. (medscape.com)

The viral envelope joins the plasma membrane of the cell and the viral matrix proteins (bluish) and the viral core (purple) are thrust into the interior of the cell. (rkm.com.au)
The new viral particles push out the cell surface (plasma membrane) and bud from the cell. (rkm.com.au)
Also involved in promoting the localization of EPOR to the plasma membrane. (caslab.com)
Plasma membrane-associated small GTPase which cycles between an active GTP-bond and inactive GDP-bound state. (lu.se)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
After serial passage, 8 of 10 strains developed cefoxitin resistance, none developed promoter or attenuator mutations, 6 lost both the OmpC and OmpF porin proteins, and 1 showed decreased production of both. (cdc.gov)
The mechanisms by which specific ATP2A2 mutations impact the function of the ATP2A2 protein have been investigated using an in vitro model. (medscape.com)
[ 22 ] Investigators transfected a fibroblast cell line with 51 different mutations seen in keratosis follicularis (Darier disease) pedigrees. (medscape.com)

During eukaryotic mitosis the nuclear envelope disintegrates into vesicles dispersing nuclear lamina proteins and nuclear pore complexes. (wikipedia.org)

Attachment of bacteriophages to bacterial cells is more diverse. (virology.ws)
The North Carolina-based scientists tested the potential of their blueberry and green tea-enriched protein complex using viral and bacterial challenges to the serum from athletes because it would have been unethical to infect the athletes directly. (nutraingredients-usa.com)
Holins and spanins are bacteriophage-encoded membrane proteins that control bacterial cell lysis in the final stage of the bacteriophage reproductive cycle. (edu.au)
However, investigating these lethal proteins is challenging due to their toxicity in bacterial expression systems and the resultant low protein yields have hindered their analysis compared to other cell lytic proteins. (edu.au)

Gp-210 anchors the pore complex to the nuclear membrane. (wikipedia.org)
The viral DNA enters the nucleus through a nuclear pore and integrates (joins) with the DNA of the host cell. (rkm.com.au)

However, the molecular mechanisms of action of HNK in BCSCs, as well as its effects on the cell cycle, remain unclear. (hindawi.com)
This study aimed to explore the potential targets and molecular mechanisms of HNK on metastatic BCSC (mBCSC)-cell cycle arrest and the impact of the TME. (hindawi.com)
Caulobacter crescentus is a single-celled, small bacterium that divides asymmetrically producing cells that differ in structure and function - it is an ideal model system for the mechanisms of asymmetric cell division and has been studied thoroughly. (kenyon.edu)
In order to analyze the cell cycle regulatory mechanisms and other mechanisms of Caulobacter , many mutant strains have been made and studied. (kenyon.edu)
These mechanisms include the ability of lead to inhibit or mimic the action of calcium and to interact with proteins. (cdc.gov)
[ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)

But this recharging process relies on a complex sequence of reactions involving various protein complexes embedded in the cell membrane. (singularityhub.com)

This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)

When applied to membrane proteins, the contribution to the scattering signal of the detergent molecules present in the sample is significant and needs to be dealt with. (biophysics.org)
He loved microscopes and watching the proteins and molecules that make up cells move around. (biophysics.org)
MAEBL is a chimera between two previously known molecules: AMA-1 (apical membrane antigen-1) and EBL (erythrocyte binding-like) protein. (the-scientist.com)
Transport of small molecules across membranes. (lu.se)

This Special Issue, "Plant Cell Wall Proteins and Development", will cover a selection of recent research topics in the field of cell wall biology focused on cell wall proteins and their roles during development. (mdpi.com)
The course is an optional second-cycle course for a degree of Bachelor or Master of Science in Biology. (lu.se)

It is an important process of the cell that regulates the localization and function of numerous proteins. (epfl.ch)

BPS member Martin Picard, along with a few colleagues, organized the symposium which brought together scientists from the Great Paris area to discuss the recent advances in the field of structural and functional analysis of membrane proteins. (biophysics.org)
Alternatively, the interactions could be intra-molecular and be important in maintaining the structural integrity of the protein. (embl-heidelberg.de)
Keratin ( / ˈ k ɛr ə t ɪ n / [1] [2] ) is one of a family of structural fibrous proteins also known as scleroproteins . (wikipedia.org)

Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
EBV miRNAs also inhibit the expression of viral antigens, thereby enabling infected cells to escape immune recognition. (ijbs.com)
Intriguingly, EBV miRNAs directly suppress host antiviral immunity by interfering with antigen presentation and immune cell activation. (ijbs.com)
EBV can not be completely cleared once entry into the host cells and ultimately establishes life-long latent infection in host, indicating that EBV has developed elaborate strategies to evade host immune surveillance [ 4 ]. (ijbs.com)
And since some of the P. falciparum proteins show high variability possibly to avoid immune responses, only a more conserved protein is used. (emergingscholars.org)
Incidentally, since single proteins don't generate as much of an immune response, the vaccine also includes an adjuvant-basically an immune system activating signal-called Matrix-M, a new product also being used in the Novavax vaccine for SARS-CoV-2. (emergingscholars.org)

The complete taxonomic breakdown of all proteins with PHD domain is also avaliable . (embl-heidelberg.de)

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. (cancerindex.org)

within a given tumor, cells may be variably arranged in broad sheets, nests, trabeculae, true papillae, or pseudopapillae (see the first 3 images below). (medscape.com)

J. Cell Biol. (wikipedia.org)
DNA Cell Biol. (cancerindex.org)
Mol Cell Biol. (forth.gr)
J Cell Biol (1976) 71 (2): 497-514. (rupress.org)

Artal-Sanz M, Samara C, Syntichaki P, Tavernarakis N. (2006) Lysosomal biogenesis and function is critical for necrotic cell death in Caenorhabditis elegans. (forth.gr)

Remarkably, EBV-encoded miRNAs are abundantly expressed in latently-infected cells and serve important function in viral infection and pathogenesis. (ijbs.com)
A soy protein powder enriched with blueberry and green tea polyphenols may reduce exercise-induced susceptibility to viral infection, says a new study from North Carolina. (nutraingredients-usa.com)
Cell samples from long-distance runners who ingested 40 grams per day of the polyphenol-enriched protein powder for 17 days were found to resist viral replication, report scientists from the Appalachian State University, the Dole Nutrition Research Laboratory at the North Carolina Research Campus, and North Carolina State University. (nutraingredients-usa.com)
W]e found that pre-incubation of cells with serum from [polyphenol soy protein complex]-supplemented individuals for 4 h provided significant and sustained protection against killing by VSV, whereas the addition of serum at 0 h following viral infection did not result in sustained antiviral activity during the recovery period. (nutraingredients-usa.com)
Inside the viral core the viral RNA is converted to viral DNA which is ferrie to the nucleus of the cell. (rkm.com.au)
These viral proteins and viral genomic RNA raft together just beneath the cell membrane and assemble spontaeously into new virus particles. (rkm.com.au)

In addition, phosphorylated ERK1/2 and p38, key members of mitogen-activated protein kinase (MAPK) family regulating BCa tumorigenesis, were strongly decreased. (spandidos-publications.com)

To do their work, APTs have to interact with the lipid membranes that their target proteins are bound to. (epfl.ch)
In membranes, they interact with ion channels and can be converted into bioactive eicosanoid (Harris, 2008). (cdc.gov)

The single-cell transcriptome and chromatin accessibility datasets of peripheral blood mononuclear cells in Chinese Holstein cattle. (usda.gov)
Single-cell transcriptomic and chromatin accessibility analyses of dairy cattle peripheral blood mononuclear cells and their responses to lipopolysaccharide. (usda.gov)
Flow cytometric estimation of the apoptotic marker CD95 in peripheral neutrophils, lymphocytes and monocytes was done for 18 infants with non-oedematous protein energy malnutrition (PEM) and 12 oedematous ones, on hospital admission and after supervised nutritional rehabilitation, and compared with 12 matched controls. (who.int)
SQR consists of a membrane-peripheral heterodimer domain (often called succinate dehydrogenase) which is tightly bound to a membrane-spanning anchor, which is a cytochrome with one or two heme groups depending on the organism. (lu.se)

BCSCs can develop into many cell types and repopulate heterogeneous tumors following conventional chemotherapy or radiotherapy [ 4 , 6 ]. (hindawi.com)
Psammoma bodies and scattered xanthoma cells have been described in some tumors. (medscape.com)

Esterified FA are hydrolyzed from washed RBC membranes using sequential treatment with mineral acid and base in the presence of heat. (cdc.gov)

The researchers synthesized APT2 mutants with deficient β tongues and found that they were rendered unable to bind membranes, which led them to the conclusion that the ability of APT2 (and other thioesterases by extension) to bind membranes is mediated by the ß tongue sequence. (epfl.ch)
Alternatively, after one job is complete, APT2 can relocate to another membrane, bind it, and deacylate another protein there. (epfl.ch)
In short, S-acylation on Cys-2 is essential for APT2 to be able to stably bind lipid membranes and deacylate its targets in the cell. (epfl.ch)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl-heidelberg.de)
Functional ELISA analysis of GTX00222-pro Human NPEPPS protein which can bind immobilized PDIA3 protein. (genetex.com)
Flavinylation of Fp in B. subtilis does not require the Ip subunit or the membrane anchor but depends on folding of the Fp polypeptide into a state that can bind FAD and subsequent mediate covalent binding of the FAD [3, 4]. (lu.se)

And crucially, the process works in vitro and doesn't rely on the native machinery of cells. (singularityhub.com)
Several reports suggest that it can function as a protein-protein interacton domain and it was recently demonstrated that the PHD finger of p300 can cooperate with the adjacent BROMO domain in nucleosome binding in vitro. (embl-heidelberg.de)
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. (antibodiesinc.com)
Additionally, the biological behavior of ESCC cells was investigated in vitro and in vivo. (bvsalud.org)
Assessing organomodified nanoclay pulmonary toxicity across its life cycle using integrated exposure and in vitro/in vivo approaches. (cdc.gov)
Evaluation of ONCs along their life cycle, by incorporating exposure estimates into current in vitro/in vivo comparative toxicological tiered frameworks, provides key information for prevention-by-design and material user approaches. (cdc.gov)
An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
Head and neck squamous cell carcinoma in vitro (cell culture). (medscape.com)

How APT2 interacts with the lipid membrane to deacylate proteins. (epfl.ch)
2006) Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. (forth.gr)

Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
Butyrate induces modifications of the CTCF-binding landscape in cattle cells. (usda.gov)

Kappe didn't find the homologs (those were identified later by another group), but he uncovered something else: a paralog of the Duffy protein that his group named MAEBL, for membrane antigen-1-erythrocyte binding-like protein. (the-scientist.com)

The investigators found that the resultant transfected cells showed defects in ATP2A2 protein expression (15 mutants), ATP hydrolysis (29 mutants), calcium transport (4 mutants), and calcium binding and kinetics (3 mutants). (medscape.com)
Regulated by guanine nucleotide exchange factors (GEFS) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (gaps) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. (lu.se)

Anatomy43

Organisms11

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes74

Disciplines and Occupations1

Technology, Industry, Agriculture5

Information Science3

Health Care1

Genes11

Cellular13

Apoptosis15

Epithelial7

Lipid bilayer2

Integral membrane1

Cytoplasm5

Outer membrane proteins2

Regulation10

Mitochondrial1

Golgi3

Proliferation9

Enzyme9

Receptors6

Metastasis5

Gene15

Side of the membrane2

Translocation5

Progression4

Disruption2

Involved in endocytosis1

Binds3

Interaction6

Receptor8

Antibodies3

Biochemical3

Plays a pivotal role2

Genome4

Synthesis2

Endoplasmic reticulum1

Plasma4

Mutations4

Vesicles1

Bacterial4

Nuclear2

Mechanisms6

Complexes1

Regulate1

Molecules4

Biology2

Localization1

Structural3

Immune6

Breakdown1

Neuronal1

Tumor cells1

Biol4

Lysosomal1

Viral6

Tumorigenesis1

Interact2

Peripheral4

Tumors2

Sequential1

Bind6

Vitro8

Interacts2

Induces2

Erythrocyte1

Hydrolysis2