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  • SCAMP1
  • Mammalian genomes contain five SCAMP genes SCAMP1-SCAMP5 that regulate membrane dynamics, most prominently membrane-depolarization and Ca 2+ -induced regulated secretion, a key mechanism for neuronal and neuroendocrine signaling. (frontiersin.org)
  • SCAMP2
  • A deletion mutant of SCAMP2 lacking this region (SCAMP2/Delta184-208) bound weakly to NHE7, but caused a significant fraction of NHE7 and wild-type SCAMP2 to redistribute to a pool of scattered recycling vesicles without noticeably affecting the location of other resident TGN (syntaxin 6) or Golgi cisternae (GM130) proteins. (sigmaaldrich.com)
  • substrates
  • Feeding barley seedlings with [14C]-biotin revealed that the vitamin is not degraded into respiratory substrates by the plant, but is specifically incorporated into biotin carboxyl carrier protein. (forskningsdatabasen.dk)
  • Defects of mitochondrial carriers that supply mitochondria with the substrates of oxidative phosphorylation, inorganic phosphate and ADP, are responsible for diseases characterized by defective energy production. (wikipedia.org)
  • In a symporter, two substrates are transported in the same direction across the membrane. (wikipedia.org)
  • SCAMPs
  • Although the involvement of SCAMPs in activity-dependent dendritic targeting has not been tested, SCAMPs' proposed role in Ca 2+ - and depolarization-induced membrane fusion and docking makes this possibility intriguing ( Diering and Numata, 2014 ). (frontiersin.org)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • All carriers contain a common sequence, referred to as the MCF motif, in each repeated region, with some variation in one or two signature sequences. (wikipedia.org)
  • residues
  • The proteins are of fairly uniform size of about 300 residues. (wikipedia.org)
  • Most MC proteins contain a primary structure exhibiting three repeats, each of about 100 amino acyl residues in length, and both the N and C termini face the intermembrane space. (wikipedia.org)
  • It forms a dimer of two identical subunits and consists of a basket shaped structure with six transmembrane helices that are tilted with respect to the membrane, 3 of them "kinked" due to the presence of prolyl residues. (wikipedia.org)
  • substances
  • In this mechanism, the proteins normally assume a V shape that blocks the passage of materials, but the shape can change to accommodate certain substances. (seattlepi.com)
  • Each carrier protein is designed to recognize only one substance or one group of very similar substances. (wikipedia.org)
  • translocase
  • Surprisingly, the import pore formed by the translocase of the outer membrane complex appears not to be required for the insertion process. (rupress.org)
  • chloride
  • Apical membrane chloride/base exchange activity was sharply reduced, and the luminal content was more acidic in SLC26A3-null mouse colon. (wikipedia.org)
  • family
  • Distant homologues of DASS family proteins may include members of the Ars (arsenite exporter) (TC# 3.A.4) family as well as the NhaB (TC #2.A.34) and NhaC (TC #2.A.35) Na+/H+ antiporter families. (wikipedia.org)
  • Names of individual SLC members have the following format: SLCnXm where: SLC is the root name (SoLute Carrier) n = an integer representing a family (e.g., 1-52) X = a single letter (A, B, C, ...) denoting a subfamily m = an integer representing an individual family member (isoform). (wikipedia.org)