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  • metabolic
  • It has been reported that mitochondrial metabolic and biophysical parameters are associated with degenerative diseases and the aging process. (rsc.org)
  • In conclusion, our data show a shift toward glycolysis in a metastatic relative to a nonmetastatic sibling breast cancer line, demonstrating the potential of our method to identify unique metabolic phenotypes in vivo . (aacrjournals.org)
  • vivo
  • However, little is known about the effect of dietary T3 on mitochondrial function in vivo. (hindawi.com)
  • Objectives This study tested the hypothesis that 4-[ 18 F]fluorophenyltriphenylphosphonium ( 18 F-TPP) is useful for in vivo positron emission tomography (PET) measurement of mitochondrial membrane potential (ΔΨm). (onlinejacc.org)
  • In vivo measurement of ΔΨm has potential value in the assessment of heart failure pathophysiology and therapy as well as assessment of myocardial viability and so may be a very useful clinical tool. (onlinejacc.org)
  • cell
  • Overall, the compounds showed potent proapoptotic effects on the two different cancer cell lines, suggesting that the compounds deserve more extensive investigation of their potential medicinal applications. (mdpi.com)
  • Chen JC, Zhang X, Singleton TP, Kiechle FL (2004) Mitochondrial membrane potential change induced by Hoechst 33342 in myelogenous leukemia cell line HL-60. (springer.com)
  • ΔΨM is an important parameter of mitochondrial function and has been used as an indicator of cell health. (creativebiomart.net)
  • Tetraphenylphosphonium was shown to be a useful chemical indicator of the mitochondrial membrane potential (ΔΨm) in 1969 ( 1 ) and has been used for in vitro studies of myocardial metabolism ( 2-7 ) and tumor imaging in which differences between normal and malignant cell ΔΨm are exploited to facilitate tumor identification ( 8 ). (onlinejacc.org)
  • Valinomycin is highly selective for potassium ions over sodium ions within the cell membrane. (wikipedia.org)