Membrane of leukocytes. Medical search. Frequent questions

β-Cells depend on the islet basement membrane (BM). (nature.com)
For metastasis to occur, cancer cells detach from the primary tumor, invade through the basement membrane, and intravasate into the peripheral circulation as circulating tumor cells (CTCs) (2). (aiche.org)
Goodpasture's name has been used in a more specific clinical condition known as Goodpasture disease, which is the pulmonary renal syndrome specifically associated with anti-glomerular basement membrane (anti-GBM) antibodies. (medscape.com)
The pathogenesis of anti-glomerular basement membrane (anti-GBM) disease (Goodpasture disease) is linked to the presence of autoantibodies that react with the alveolus in the lung and the basement membrane of the glomerulus in the kidney. (medscape.com)
These autoantibodies are believed to cross-react with the alveolar basement membrane and cause similar damage. (medscape.com)
The degree of cross-linking of the α3NC1 hexamer subunits is approximately 3 times greater in the alveolar basement membrane than in the GBM. (medscape.com)
Renal biopsy revealed membranoproliferative glomerulonephritis, with lobulated glomerular tufts, endocapillary proliferation, thickened basement membrane, and glomerular hyaline thrombi suggestive of cryoglobulin deposits. (who.int)
Immunofluorescence showed diffuse deposition of glomerular basement membrane immunoglobulin (Ig)M and complement component C3, with mesangial IgG, but negative for C4, fibrin and IgA. (who.int)

The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. (sigmaaldrich.com)
CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. (biolegend.com)

Leukocytes, trophoblast and mesenchymal cells were identified using immunohistochemistry for CD45, cytokeratin-7 and vimentin, respectively. (nih.gov)
Leukocytes present in the chorion and amnion were labelled XX, indicating maternal origin, and these cells were immunoreactive for the leukocyte marker CD45 but not for vimentin or cytokeratin-7. (nih.gov)
The CD45 molecules are single chain integral membrane proteins comprising at least five isoforms ranging from 180 to 220 kDa. (beckman.com)
The non-restricted CD45, Leucocyte Common Antigen (LCA) consists of an extracellular sequence, proximal to the membrane, which is common to all CD45 isoforms. (beckman.com)
CD45 is a major component of the lymphocyte membrane. (beckman.com)
CD45 antibodies react with leucocyte progenitors in bone marrow. (beckman.com)

Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1 . (medscape.com)
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space). (wikipedia.org)
Since mature mammalian red blood cells lack both nuclei and cytoplasmic organelles, the plasma membrane is the only lipid-containing structure in the cell. (wikipedia.org)
The ratio of the surface area of water covered by the extracted lipid to the surface area calculated for the red blood cells from which the lipid was 2:1(approx) and they concluded that the plasma membrane contains a lipid bilayer. (wikipedia.org)
CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following monoclonal antibody treatment. (thermofisher.com)
It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. (biolegend.com)

Leukocyte adhesion deficiency type 1 is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. (medlineplus.gov)
Starting from birth, people with leukocyte adhesion deficiency type 1 develop serious bacterial and fungal infections. (medlineplus.gov)
One of the first signs of leukocyte adhesion deficiency type 1 is a delay in the detachment of the umbilical cord stump after birth. (medlineplus.gov)
but, in infants with leukocyte adhesion deficiency type 1, this separation usually occurs at three weeks or later. (medlineplus.gov)
In leukocyte adhesion deficiency type 1, bacterial and fungal infections most commonly occur on the skin and mucous membranes such as the moist lining of the nose and mouth. (medlineplus.gov)
A hallmark of leukocyte adhesion deficiency type 1 is the lack of pus formation at the sites of infection. (medlineplus.gov)
Life expectancy in individuals with leukocyte adhesion deficiency type 1 is often severely shortened. (medlineplus.gov)
Leukocyte adhesion deficiency type 1 is estimated to occur in 1 per million people worldwide. (medlineplus.gov)
Mutations in the ITGB2 gene cause leukocyte adhesion deficiency type 1. (medlineplus.gov)
ITGB2 gene mutations that cause leukocyte adhesion deficiency type 1 lead to the production of a β2 subunit that cannot bind with other subunits to form β2 integrins. (medlineplus.gov)
Cox DP, Weathers DR. Leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. (medlineplus.gov)

The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. (sigmaaldrich.com)
An association between Human Leukocyte Histocompatibility Antigen B-27 (HLA-B27) and major arthritis syndromes such as Ankylosing Spondylitis and Reactive Arthritis is well documented (Khan et al. (cdc.gov)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)

Here we review evidence showing that apicobasal polarity regulates the inflammatory response: various polarized epithelia asymmetrically secrete chemotactic mediators and polarize adhesion receptors that dictate the route of leukocyte migration within the parenchyma. (hindawi.com)
The LTB4 receptors on a partially purified PMN membrane were characterized. (aspetjournals.org)
Adenosine can act at 4 different 7-transmembrane, G-protein-coupled receptors present on the surfaces of both infiltrating leukocytes and resident parenchymal cells. (jci.org)

F. tularensis can infect humans through the skin, mucous membranes, gastrointestinal tract, and lungs. (cdc.gov)
Untreated, bacilli inoculated into skin or mucous membranes multiply, spread to regional lymph nodes and further multiply, and then may disseminate to organs throughout the body. (cdc.gov)

In addition, cell membranes are involved in a variety of cellular processes such as cell adhesion, ion conductivity, and cell signalling and serve as the attachment surface for several extracellular structures, including the cell wall and the carbohydrate layer called the glycocalyx, as well as the intracellular network of protein fibers called the cytoskeleton. (wikipedia.org)
Recent work published in The EMBO Journal and EMBO Reports reveals a novel role for the protein TECPR1 as a sensor for stressed membranes and regulator of lysosomal membrane repair. (babraham.ac.uk)
In non-canonical Atg8-family protein lipidation they become conjugated to single membranes. (babraham.ac.uk)
Apart from being an acidic medium containing an assortment of antimicrobial molecules including antibodies (IgA and IgG), mucins, β-defensins, secretory leucocyte protease inhibitor (SLPI), neutrophil gelatinase-associated lipocalin (NGAL), surfactant protein etc. (frontiersin.org)
Is It Useful to Measure C-Reactive Protein and Leukocytes in Patients with Prelabor Rupture of Membranes? (thieme-connect.com)
Pre-embedding immunogold labeling to optimize protein localization at subcellular compartments and membrane microdomains of leukocytes. (harvard.edu)
Apart from testing the static protein resistance of both membrane systems, the antifouling ability in dynamic conditions which is the primary focus of this study were also challenged. (ncl.edu.tw)
Integral membrane protein. (lu.se)

The M17/4 antibody reacts with the 180 kDa αL chain of LFA-1 (CD11a/CD18, αLβ2 integrin), a heterodimeric surface glycoprotein expressed on almost all leukocytes. (bdbiosciences.com)
Leukocyte rolling in postcapillary venules of inflamed tissues is reduced in L-selectin-deficient mice and mice treated with L-selectin blocking antibodies, but the glycoprotein ligand for L-selectin in inflamed venules is unknown. (rupress.org)

This agent decreases inflammation by stabilizing lysosomal membranes, inhibiting polymorphonuclear leukocyte and mast cell degranulation. (medscape.com)

PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells. (harvard.edu)

Leukotriene B4 induces formation of inositol phosphates in rat peritoneal polymorphonuclear leukocytes. (aspetjournals.org)
Leukotriene B4 (LTB4) induced rapid breakdown of prelabeled inositol phospholipids in rat peritoneal polymorphonuclear leukocytes (PMNs). (aspetjournals.org)
This interaction results in complement activation with glomerular infiltration of polymorphonuclear leukocytes (PMNs) and monocytes. (medscape.com)
The initial tissue reaction to infection is a focal, intensely suppurative necrosis consisting largely of accumulations of polymorphonuclear leukocytes, followed by invasion of macrophages, epithelioid cells, and lymphocytes. (cdc.gov)

We also discuss recent findings showing that the loss of apicobasal polarity increases leukocyte adhesion to epithelial cells and the consequences that this could have for the inflammatory response towards damaged, infected or transformed epithelial cells. (hindawi.com)
LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. (sigmaaldrich.com)

The aim of this study was to determine the maternal or fetal origin of inflammatory leukocytes in fetal membranes from cases of chorioamnionitis. (nih.gov)
The results indicated that maternal leukocytes invade the amnion and chorion in chorioamnionitis and we suggest that this is part of the maternal inflammatory response to intrauterine infection. (nih.gov)
Leukocyte recruitment into the inflamed parenchyma requires successive interactions with cellular and stromal barriers that establish mechanical, chemotactic and haptotactic gradients to guide immune cells towards the inflammatory focus. (hindawi.com)
On the one hand, similar to endothelial cells, parenchymal epithelia must guide leukocytes to traverse them in order to reach a localized inflammatory focus, for example, in the lung or intestinal mucosa. (hindawi.com)
On the other hand, these barriers contain damaged or infected cells that are part of the inflammatory focus and the endpoint of the leukocyte migratory journey, so some sort of footprint, which is not completely understood, must exist in these cells to promote a preferential adhesion with infiltrated leukocytes. (hindawi.com)
So far, most of the in vivo and in vitro approaches to study leukocyte migration across the tissue parenchyma have addressed the role of each single tissue barrier that immune cells encounter in their journey to the inflammatory focus. (hindawi.com)
We believe that successfully combining our current knowledge about leukocyte extravasation, three-dimensional migration through the stroma and the sequential interactions with parenchymal cell barriers, which include adopting unified experimental models, will help shed light on the entire migratory route of each immune cell type and on the specificity of the innate inflammatory responses in each type of tissue. (hindawi.com)
Endothelial and epithelial barriers determine the different stages of leukocyte migration in its journey towards the inflammatory focus in complex tissues. (hindawi.com)
Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. (fishersci.com)
It is believed that adhesive interactions between selectins on the blood vessel wall and selectin ligands on the CTC surface facilitate metastatic progression, in a manner similar to the leukocyte adhesion cascade essential in the inflammatory response (3). (aiche.org)

Additionally, there is concomitant production of mucins, immunoglobulins (secretory IgA and IgG), secretory leucocyte protease inhibitor (SLPI), neutrophil gelatinase-associated lipocalin (NGAL), and β-defensins, and other antimicrobial proteins, which all together provide a formidable first line of defense against infection. (frontiersin.org)

It was not until later studies with osmosis and permeability that cell membranes gained more recognition. (wikipedia.org)
The effects of colchicine on phosgene (75445) induced changes in alveolar/capillary membrane permeability were studied in rats. (cdc.gov)
Changes in alveolar/capillary membrane permeability were determined from the amounts of I-125 activity recovered in the lavagate. (cdc.gov)
Phosgene also caused significant increases in alveolar/capillary membrane permeability immediately after exposure and significant increases in pulmonary surfactant secretion 24 to 26 hours postexposure. (cdc.gov)

Additionally, biocompatible materials such as amphiphilic/zwitterionic polymers can also be explored as coating materials for use in leukapheresis membranes for enhanced hemocompatibility. (marketsandmarkets.com)
The next part dealt with the evaluation of the hemocompatibility of UF-LIPS membranes as it was intended for blood-contacting uses. (ncl.edu.tw)

Leukocytes that lack these integrins cannot attach to the blood vessel wall or cross the vessel wall to contribute to the immune response. (medlineplus.gov)
The first stage of this immune steeplechase, the leukocyte transendothelial migration, is a multi-step cascade of interactions that have been extensively studied in recent years in different vascular beds and experimental models, and some comprehensive reviews on this topic can be found in this special issue [ 1 - 5 ]. (hindawi.com)
The peri-islet membrane, which encapsulates the islets, separates the endocrine cells from the exocrine pancreas and serves as a barrier from immune cell infiltration to the islets. (nature.com)
They produce human alpha-2-leukocyte interferon, strengthens the human immune system. (kalinka-store.com)
We also detected changes in energy utilization and immune responses in leukocytes from older cows. (biomedcentral.com)

The membrane also contains membrane proteins, including integral proteins that span the membrane and serve as membrane transporters, and peripheral proteins that loosely attach to the outer (peripheral) side of the cell membrane, acting as enzymes to facilitate interaction with the cell's environment. (wikipedia.org)
The instrument could resolve thicknesses that depended on pH measurements and the presence of membrane proteins that ranged from 8.6 to 23.2 nm, with the lower measurements supporting the lipid bilayer hypothesis. (wikipedia.org)
However, the Atg8 family of proteins are not found solely attached to double-membrane autophagosomes. (babraham.ac.uk)
We have shown that this process is triggered by recruitment of ATG16L1 by the vacuolar-type H-translocating ATPase (V-ATPase) proton pump, suggesting a role for pH sensing in recruitment of Atg8-family proteins to single membranes. (babraham.ac.uk)

The aim of this study was to investigate the impact of the adjunct of leukocyte- and platelet-rich fibrin (LPRF) to root-end surgery (RES) on the patients ' quality of life during the first week post RES. (bvsalud.org)
The events that follow leukocyte extravasation are perhaps less well characterized, although significant advances have been made with the advent of high-resolution intravital microscopy and the development of more sophisticated culture systems to investigate leukocyte migration and interactions in three dimensions. (hindawi.com)
To investigate whether leukocyte-expressed PSGL-1 is mediating L-selectin-dependent rolling, we reconstituted lethally irradiated wild-type mice with PSGL-1 −/− bone marrow cells. (rupress.org)

ATP is sequentially dephosphorylated by a series of membrane-bound and soluble ectonucleotidases to produce adenosine. (jci.org)
CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. (fishersci.com)

The cell membrane consists of a lipid bilayer, made up of two layers of phospholipids with cholesterols (a lipid component) interspersed between them, maintaining appropriate membrane fluidity at various temperatures. (wikipedia.org)

Oncolytic vesicular stomatitis virus (VSV) can be delivered intravenously to target primary and metastatic lesions, but the interaction between human peripheral blood leukocytes (PBLs) and VSV remains poorly understood. (karger.com)

The cell membrane controls the movement of substances in and out of a cell, being selectively permeable to ions and organic molecules. (wikipedia.org)
Vitamin E-bonded cellulose membrane and hemodialysis bioincompatibility: Absence of an acute benefit on expression of leukocyte surface molecules. (ugent.be)
Citrate anticoagulation does not correct cuprophane bioincompatibility as evaluated by the expression of leukocyte surface molecules. (ugent.be)

Complement, a complex system of enzymes and regulators endowed with multiple biological activities (opsonisation, chemoattraction of leukocytes, cell lysis, cell activation), is a major component of innate defence against pathogens. (europa.eu)

Fetal membranes were collected from male preterm infants and chorioamnionitis was diagnosed histologically. (nih.gov)

A Membrane System for the Leukocyte Selective Recruitment. (uni-trier.de)

Thus, human endocrine cells are not in direct contact with the vascular BM components but with the invaginated peri-islet membrane. (nature.com)
stimulated human leukocytes. (sigmaaldrich.com)
Here, we describe a novel approach to functionalize human and murine leukocytes with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on their surface, along with E-selectin (ES), to capture and induce cancer cell apoptosis both in vitro in human blood and in vivo in mouse circulation. (aiche.org)
To determine leukocyte functionalization with ES/TRAIL, fluorescent (FL) liposomes were exposed to human blood under shear flow, and leukocytes were isolated and analyzed for ES/TRAIL attachment using FC and confocal microscopy. (aiche.org)
Upon exposure to shear flow, ES/TRAIL liposomes in human blood were functionalized to the surface of leukocytes, as confirmed by confocal microscopy (Fig. 1A) and FC. (aiche.org)
We have shown that leukocytes functionalized with ES/TRAIL can capture and induce cancer cell apoptosis in vitro in human blood and in vivo in mouse experiments. (aiche.org)
Leukocytes were labeled with BD IMag™ Anti-Human CD8 Magnetic Particles - DM (Cat. (bdbiosciences.com)

Signaling through the β2 integrins triggers the transport of the attached leukocyte across the blood vessel wall to the site of infection or injury. (medlineplus.gov)
Penetrating through the wall of the gastrointestinal tract, interferon enters the blood stream, after which protects cell membranes from infection by viruses. (kalinka-store.com)
In an upper respiratory infection (URI), the swollen nasal mucous membrane obstructs the ostium of a paranasal sinus, and the oxygen in the sinus is absorbed into the blood vessels of the mucous membrane. (merckmanuals.com)

Exposure of functionalized ES/TRAIL leukocytes into cancer cell-spiked blood successfully targeted and killed cancer cells under shear flow, compared to controls (Fig. 1B). (aiche.org)
Results demonstrate that PVDF membranes were successfully prepared with a facile approach. (ncl.edu.tw)

Also, blood cells (thrombocytes, erythrocytes, and leukocytes) attachment was investigated by means of SEM and confocal microscopy. (ncl.edu.tw)

The parenchymal three-dimensional organization contributes to establish an haptotactic and chemotactic gradient (1) Leukocyte adhesion and transendothelial migration or diapedesis. (hindawi.com)

In the field of synthetic biology, cell membranes can be artificially reassembled. (wikipedia.org)
While Robert Hooke's discovery of cells in 1665 led to the proposal of the cell theory, Hooke misled the cell membrane theory that all cells contained a hard cell wall since only plant cells could be observed at the time. (wikipedia.org)
By the second half of the 19th century, microscopy was still not advanced enough to make a distinction between cell membranes and cell walls. (wikipedia.org)
However, some microscopists correctly identified at this time that while invisible, it could be inferred that cell membranes existed in animal cells due to intracellular movement of components internally but not externally and that membranes were not the equivalent of a plant cell wall. (wikipedia.org)
It was also inferred that cell membranes were not vital components to all cells. (wikipedia.org)
Many refuted the existence of a cell membrane still towards the end of the 19th century. (wikipedia.org)
In 1890, an update to the Cell Theory stated that cell membranes existed, but were merely secondary structures. (wikipedia.org)
In 1895, Ernest Overton proposed that cell membranes were made of lipids. (wikipedia.org)
The lipid bilayer hypothesis, proposed in 1925 by Gorter and Grendel, created speculation in the description of the cell membrane bilayer structure based on crystallographic studies and soap bubble observations. (wikipedia.org)
In 1925 it was determined by Fricke that the thickness of erythrocyte and yeast cell membranes ranged between 3.3 and 4 nm, a thickness compatible with a lipid monolayer. (wikipedia.org)
Leukocytes can be identified by the brown labeling of their cell membranes. (bdbiosciences.com)

On the other hand, PS-b-PEGMA-4 VIPS membranes, exhibited exceptionally high permeate flux and rejection ratio of more than 97.7% that suggests efficient harvesting of microalgae. (ncl.edu.tw)

Consequently, all of the lipids extracted from the cells can be assumed to have resided in the cells' plasma membranes. (wikipedia.org)
Khz cytotoxicity was measured using an MTT assay and the mitochondrial membrane potential (MMP)-related, calcium-induced generation of reactive oxygen species (ROS) in A549 cells was measured by flow cytometry. (springer.com)
Particular attention has been paid to elucidating how leukocytes can migrate through the stroma, the way these cells remodel their morphology and sense cues that guide them towards dysfunctional tissue areas. (hindawi.com)
Cancer cells lodged within the mouse lung were apoptotic after treatment with ES/TRAIL leukocytes, as determined by multiphoton microscopy. (aiche.org)

It is also emerging as an important factor in atherosclerosis: complement activation, and formation of the terminal C5b-9 membrane attack complex of complement were shown to occur in atherosclerotic lesions. (europa.eu)

Root-end surgery with leucocyte- and platelet-rich fibrin and an occlusive membrane: a randomized controlled clinical trial on patients' quality of life. (bvsalud.org)

This binding leads to linkage (adhesion) of the leukocyte to the blood vessel wall. (medlineplus.gov)
According to a 2021 study published in the Royal Society of Chemistry, further research needs to take place on interfacial chemistries between the blood and the membrane materials it interacts with. (marketsandmarkets.com)
Therefore, PS-b-PEGMA/PVDF membranes with integrated antifouling property, blood compatibility, high permeate flux provided wide variety of specific applications for instance hemodialysis and microalgae recovery. (ncl.edu.tw)

Anatomy59

Organisms14

Diseases5

Chemicals and Drugs89

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes54

Disciplines and Occupations3

Technology, Industry, Agriculture8

Information Science4

Health Care1

Basement Membrane8

Type I membrane glycoprotein2

CD456

Plasma membrane6

Adhesion deficiency11

Antigen3

Receptors3

Mucous membranes2

Protein8

Glycoprotein2

Lysosomal1

Antibodies1

Polymorphonuclear leukocytes4

Epithelial cells2

Inflammatory10

SLPI1

Permeability4

Hemocompatibility2

Immune5

Proteins4

Investigate3

Soluble2

Phospholipids1

Peripheral1

Molecules3

Enzymes1

Infants1

Recruitment1

Human7

Infection3

Successfully2

Confocal microscopy1

Parenchymal1

Cell11

Ratio1

Cells4

Complement activation1

Patients1

Blood3