Membrane mucin. Medical search. Frequent questions

The Mucin 1 (MUC1) gene encodes a membrane bound glycosylated phosphoprotein, belonging to the family of mucins which are heavily glycosylated proteins. (sigmaaldrich.com)
New research from Stanford reveals how a class of particularly bushy proteins in this forest, called mucins, could hinder the flu's progression. (phys.org)
Radicioni G, Cao R, Carpenter J , Ford AA, Wang T, Li L, Kesimer M. The innate immune properties of airway mucosal surfaces are regulated by dynamic interactions between mucins and interacting proteins: the mucin interactome . (unc.edu)
To investigate that question, Ribbeck and her colleagues observed the behavior of Pseudomonas aeruginosa bacteria in a growth medium that contained soluble purified mucins - long proteins with many sugar molecules attached. (mit.edu)
molecule 1 (CEACAM1) (9,C12), and Testosterone levels cell immunoglobulin and mucin domain-containing proteins 3 (Tim-3) (4, 12,C14) lead to Testosterone levels cell tiredness, reducing harmful potentially, constant Testosterone levels cell account activation. (exposed-skin-care.net)
Mucins are glycoproteins that are expressed in cells of different types and fulfill multiple functions that determine participation of these proteins in such processes as signal transduction, regulation of gene expression, cell proliferation, embryogenesis, cell differentiation, immunity, apoptosis and cancer development. (benthambooks.com)
On the other hand, the treatment of enamel surface with human saliva presents differences in this process, as it contains proteins such as mucin, which is deposited on the surface and may hamper the remineralization process 15 . (bvsalud.org)

Mucins belong to a heterogeneous group of large O-glycoproteins that can be either secreted or membrane-bound. (amrita.edu)
Mucus comprises water, glycoproteins (mucins), and ions. (bmj.com)
VWF mediates the adhesion of platelets to sites of vascular damage by binding to specific platelet membrane glycoproteins and to constituents of exposed connective tissue. (embl.de)
Mammalian mucins, glycoproteins that are major constituents of the glycocalyx that covers mucosal epithelium. (embl.de)

Mucin short variant S1, also called polymorphic epithelial mucin (PEM) or epithelial membrane antigen (EMA), is a mucin encoded by the MUC1 gene in humans. (wikipedia.org)
MUC1 is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. (wikipedia.org)
Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages. (bvsalud.org)
Mucin 1 (Muc1) exhibits protective action by binding to pathogens and is also associated with cell signaling capacity. (sigmaaldrich.com)
Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
Cancer antigen 27-29 (or CA 27-29) is an epitope of a large transmembrane mucin glycoprotein named MUC1 that is expressed on the cell surfaces of most glandular epithelia. (medscape.com)

To evaluate the effect of multipurpose contact lens care solutions (MPSs) on membrane-associated mucins (Muc 1 & 16) expressions in the cornea using SV40 transformed Human corneal epithelial Cells (HCET) and Rat cornea tissue sections. (arvojournals.org)
Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. (wikipedia.org)
Muc in animals ) is a transmembrane mucin glycoprotein expressed in mucosal epithelial cells and hematopoietic cells . (bvsalud.org)
Embedded in these epithelial cells are a very important cell type called mucin-producing cells that are vital for keeping the epithelial surface moisturized and healthy, and they secrete mucin to protect the surface of the airways. (medindia.net)
HAVCR1 is a type I trans-membrane structural glycoprotein located in the renal proximal tubule epithelial cells. (prospecbio.com)
A family of small peptides expressed primarily by MUCOUS MEMBRANE EPITHELIAL CELLS in vertebrates. (bvsalud.org)

1, 2 This review approaches the role of mucin degrading enzymes from the potential interaction of micro-organisms with the cervical mucus barrier, and discusses the contribution that mucin degrading enzymes may make to microbial colonisation of the reproductive tract. (bmj.com)
Mucin coatings may help prevent biofilm formation on medical devices and could also find applications in personal hygiene: Incorporating them into products such as toothpaste or mouthwash may supplement the body's own defenses, especially in people whose natural mucus has been depleted, Ribbeck says. (mit.edu)

[ 1 ] This protein, also known as polymorphic epithelial mucin or epithelial membrane antigen, has a large extracellular region, a transmembrane sequence, and a cytosolic domain. (medscape.com)

Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. (wikipedia.org)
Aberrant expression and glycosylation of mucins contribute to tumour survival and proliferation in many cancers, which in turn activates numerous signalling pathways such as NF-kB, ERα, HIF, MAPK, p53, c-Src, Wnt and JAK-STAT, etc. (amrita.edu)
The mucin region undergoes extensive O-linked glycosylation. (rndsystems.com)
The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. (nih.gov)

These antibodies are predominantly secretory and are found mixed with the mucous secretion of the membrane concerned. (wordinfo.info)

An inflammation localized to a mucous membrane. (wordinfo.info)
Referring to the mucous membrane lining the cheek. (wordinfo.info)
Candidiasis (Mucocutaneous) Candidiasis is skin and mucous membrane infection with Candida species, most commonly Candida albicans . (msdmanuals.com)

Production of mucin is normally tightly controlled, but too much of it can be damaging," he said. (medindia.net)
This, in turn, leads to massive production of mucin in the airways, eventually clogging them up. (medindia.net)
Research shows that it protects the mucous membranes lining the digestive tract by increasing production of mucin, a substance that protects against stomach acid and other harmful substances. (totalhealthmagazine.com)

Dermatopathology archives were then searched for any corresponding biopsies consistent with dermatomyositis, and those identified were assessed for eosinophils, adnexal involvement, epidermal atrophy, dermal mucin, and basement membrane thickening. (iasp-pain.org)
Dermal mucin deposition and adnexal interface dermatitis were noted in 72% (n = 28) and 44% (n = 17) of biopsy specimens, respectively. (iasp-pain.org)
However, the presence of changes in the basement membrane, periadnexal lymphocytic infiltration, and dermal mucin are very rare. (medscape.com)

It is believed that dysfunction in the expression of mucins and aberrant expression of some lncRNAs are associated with the occurrence and development of CRC. (sabanciuniv.edu)
This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)

We have previously demonstrated that MUC17 is anchored to the apical membrane domain via an interaction with the scaffolding protein PDZK1. (scilifelab.se)
Using Caco-2 cells as a model system, we found that induction of an inflammatory state by long-term stimulation with the proinflammatory cytokine TNFα resulted in an increase of MUC17 protein levels and enhanced insertion of MUC17 and its two phospho-variants into apical membranes. (scilifelab.se)
Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains. (embl.de)
One of the key features of asthma is an overproduction of a highly sticky protein secreted by the mucous membranes of airways in the lungs, called mucin, which leads to plugging up the small airways and stopping air from traveling in and out of them. (medindia.net)
Central to their findings was the identification of T helper cells that communicate with mucin-producing cells in the lungs through a small protein called interleukin 9 (IL-9). (medindia.net)
Fractalkine, also known as CX3CL1, is a cytokine protein containing a CX3C chemokine motif atop a mucin stalk. (irvinesci.com)
The RMT2-26 monoclonal antibody specifically recognizes T cell immunoglobulin and mucin domain-2 (TIM-2) which is also known as T-cell membrane protein 2, TIMD-2, or Tim2. (bdbiosciences.com)
Hepatitis A virus cellular receptor 1 homolog, HAVcr-1, Kidney injury molecule 1, KIM-1, T cell immunoglobulin and mucin domain-containing protein 1, TIMD-1, T cell membrane protein 1, T-cell immunoglobulin mucin receptor 1, TIM-1. (prospecbio.com)

The nucleus of each columnar cell is located close to the basement membrane. (iarc.fr)

The columnar epithelium is composed of a single layer of tall columnar cells that secrete mucin, which helps in the lubrication of the cervix and the vagina. (iarc.fr)

The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane. (scilifelab.se)
Transmembrane mucin MUC17 is an integral part of the glycocalyx as it covers the brush border membrane of small intestinal enterocytes and presents an extended O-glycosylated mucin domain to the intestinal lumen. (scilifelab.se)
Overexpression and increased presentation at the plasma membrane of wild-type MUC17 and its phosphodeficient variant MUC17 S-4492A protected Caco-2 cells against adhesion of enteropathogenic Escherichia coli, indicating that C-terminal phosphorylation of MUC17 may play a functional role in epithelial cell protection. (scilifelab.se)
namely, MUC3, MUC4, MUC12, MUC13, and the recently described mucin MUC17, which share a C-terminal structural domain that consists of two or three epithelial growth factor (EGF)-like regions, a transmembrane segment, and a short cytoplasmic tail. (bmj.com)
Characterization of human mucin MUC17. (nih.gov)

Mucinases are enzymes capable of degrading mucins (the complex high molecular weight molecules that are the major non-aqueous components of mucous gels). (bmj.com)
Partial or complete degradation of mucin molecules by microbial enzymes is often a fundamental step in disruption of defensive mucosal barriers, as these constitute direct interfaces between internal and external environments. (bmj.com)
Mucins are represented by two types of molecules: secreted mucins and membrane-bound (receptor) mucins. (benthambooks.com)

MUC4 is a heterodimeric membrane mucin composed of a mucin subunit ASGP-1 (MUC4α) and a transmembrane subunit ASGP-2 (MUC4β) which has been implicated in the safety of epithelial cell surfaces. (healthanddietblog.info)
Intro Rat Muc4/SMC (sialomucin complex) is definitely a heterodimeric membrane mucin composed of a mucin subunit ASGP-1 (called MUC4α in human being) and a transmembrane subunit ASGP-2 (MUC4β in human being) (Sherblom and Carraway 1980 Carraway et al. (healthanddietblog.info)
Transmembrane mucins have previously been shown to play a role in the prevention of bacterial colonization by acting as sheddable decoys for encroaching bacteria. (scilifelab.se)
TIM-2 is an ~55 kDa type I transmembrane glycoprotein that is encoded by Timd2 (T cell immunoglobulin and mucin domain containing 2) which belongs to the immunoglobulin gene superfamily. (bdbiosciences.com)
TIM-2 contains extracellular IgV and mucin domains and a cytoplasmic region with a conserved tyrosine phosphorylation motif which is involved in transmembrane signaling. (bdbiosciences.com)

In the new study, the researchers found that mucins block bacterial cluster formation by preventing them from adhering, which is necessary for them to clump together. (mit.edu)

Chronic HIV infection results in a loss of HIV-specific Compact disc8+ Capital t cell effector function, termed exhaustion, which is definitely mediated, in part, by the membrane coinhibitory receptor Capital t cell immunoglobulin mucin domain-3 (Tim-3). (exposed-skin-care.net)

Moreover, BF-30 exerted antibacterial acitivities through enhancing the permeability of cytoplasmic membrane which is superior to the common antibiotics [ 2 ]. (jcancer.org)

Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. (wikipedia.org)
CA 27-29 represents a sequence of mucins on the extracellular region of this glycoprotein. (medscape.com)

1990 QX 314 chloride A second cleavage happens at a similar time in some cells to release a soluble form of the mucin (Komatsu et al. (healthanddietblog.info)
The soluble form of the mucin may aid this protecting function by loose adsorption to the membrane mucin (McNeer et al. (healthanddietblog.info)
This volume introduces readers to the general properties of mucins, followed by chapters on specific variants of gel-forming and soluble mucins. (benthambooks.com)

A major impediment to this process is the mucosal barrier, which exists in a secreted or membrane bound form. (bmj.com)

Hepatitis A virus cellular receptor 1 (HAVCR1) is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. (prospecbio.com)

One advantage of using mucins as antimicrobial coatings is that the substance disarms pathogenic bacteria without killing them. (mit.edu)

2002 The membrane mucin may lengthen more than a micron from your cell surface. (healthanddietblog.info)
Though it can protect epithelia from invasion it also may disrupt normal cell-cell relationships if the mucin is definitely overproduced. (healthanddietblog.info)
Mitochondrial carriers catalyse the translocation of numerous metabolites across the inner mitochondrial membrane, playing a key role in different cell functions. (cancerindex.org)
A precursor of a mucin-secreting cell. (wordinfo.info)
The pair recognized their shared interest in how mucins on cell membranes affect viral infection. (phys.org)
Second, mucins often contain a specific sugar, called sialic acid, that could tether the virus to a cell and help position it to bind to receptors on the cell surface . (phys.org)
Once a virus is successfully bound, the cell membrane folds back on itself to swallow the virus, along with the mucins and other cell surface sugars in the vicinity, to make a small bubble inside the cell, called an endosome. (phys.org)
Further experiments showed that when there is ample space between them, mucins of various lengths can relax on themselves and settle atop the cell surface resulting in a thin mucin coat. (phys.org)
gain access to the cell membrane to initiate invasion ( 9, 10). (researchgate.net)
As a component of tissue , glucosamine plays a role in the maintenance of the cell membrane lining, collagen, growing bone and bone matrix. (marnys.com)
Cell-membrane-bound fractalkine, which is induced on activated endothelial cells, promotes leukocyte adhesion. (irvinesci.com)
This E-book series on mucins presents critical reviews on modern data concerning structures and functions of mucins, their roles in cell physiology and pathology as well as molecular aspects of therapy of mucin-associated diseases. (benthambooks.com)
Moreover, LBF-14 was proved to inhibit the proliferation of B16F10 melanoma cell by disrupting the cytoplasmic membrane and binding to genomic DNA to prevent transcription. (jcancer.org)
Importantly, we observed that loss of N-myristoylation resulted in greatly reduced infectivity of assembled mature virus particles, characterized by significantly reduced host cell entry and a decline in membrane fusion activity of progeny virus. (cdc.gov)

Epithelial mucins can be classified into two distinct families: secretory (gel forming) and membrane bound. (bmj.com)
Carpenter J , Kesimer M. Membrane-bound mucins of the airway mucosal surfaces are densely decorated with keratan sulfate: revisiting their role in the Lung's innate defense . (unc.edu)

Cornea sections and lysates were prepared from the eyes of the treated rats and used for the immunohistochemistry and Western blot analysis of membrane-associated mucins expressions. (arvojournals.org)
Immunohistochemistry analysis of membrane-associated mucins expressions confirmed the results of the Western blot analysis. (arvojournals.org)

The cytoplasmic tail is then inserted into the mitochondrial outer membrane. (wikipedia.org)
previously demonstrated that native BF-30 may selectively inhibit the proliferation of melanoma cells via in vitro permeabilization of cytoplasmic membrane and DNA-binding, and exerted the outstanding anti-cancer effects in B16F10-bearing mice [ 4 ]. (jcancer.org)

Capable of bringing about the hydrolysis (splitting of a compound into fragments by the addition of water) of mucin, as by a mucinase (an enzyme that acts upon mucin). (wordinfo.info)

Conclusion: The current experiment revealed changes in expression level of mucin genes and lncRNAs in CRC and its different stages, showing that they can be considered as biomarkers for diagnosis of this cancer. (sabanciuniv.edu)

The researchers hope that their method and findings will help in tackling other viruses that infect individuals through places like the lungs and respiratory tracts, which have mucin-rich mucous coatings. (phys.org)

New study has discovered the role of IL-9 gene super-enhancers in the overproduction of mucin. (medindia.net)

Chemical inhibitors were used to stop this assembly of IL-9 gene super-enhancers to prevent the production of IL-9, which in turn reduces mucin production in asthma patients. (medindia.net)
Clinical aspects of mucins, such as their role as diagnostic markers as well as possible applications in mucin-based immuno- and gene-therapies are also discussed. (benthambooks.com)

They found that increasing the density of mucins on the surface inhibited two major steps of influenza A infection. (phys.org)
Combined with previous research, this finding supports a theory that cells make more mucins in response to infection to make a thicker barrier that impedes the flu virus during binding and fusion. (phys.org)
The possible contribution of mucin degrading enzymes to the pathogenesis of infection is, therefore, not to be underestimated. (bmj.com)

The researchers wanted to deconvolute the ways that the length of mucins, their density on the surface, and the amount of sialic acid could each help or inhibit membrane binding and fusion. (phys.org)
Membrane-tethered mucin-like polypeptides sterically inhibit binding and slow fusion kinetics of influenza A virus, Proceedings of the National Academy of Sciences (2020). (phys.org)
Sub-objective 1A: Reduce the incidence of Campylobacter in preharvest poultry by selecting probiotics that utilize mucin for growth and competitively inhibit Campylobacter colonization in broiler chickens. (usda.gov)

2002 To avoid this problem cells must have stringent mechanisms for controlling membrane mucin production. (healthanddietblog.info)
First, when cells are infected with viruses, they often begin making a lot more mucins. (phys.org)
The mucins have the ability to suppress virulence by keeping the cells separate. (mit.edu)
Cells developing into the synovial membrane of a joint. (diagnose-me.com)

Presence of mucin in the urine, suggesting vaginal contamination. (wordinfo.info)

They open to the surface of the epithelium to discharge mucin, and the openings are called crypt openings. (iarc.fr)

2. The presence of mucin in blood, a condition that may occur in metastatic malignancies of the gastrointestinal tract or the ovaries. (wordinfo.info)
Chapters in each volume demonstrate the central role of mucins as connectors and regulators of different signaling pathways and their participation metastatic processes. (benthambooks.com)

They then planted them sparsely or densely on their membrane mimics and introduced the flu virus to watch binding and fusion separately. (phys.org)

Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)

Glucosamine is also involved in the production of lubricants and protective agents such as mucin and mucous secretions. (marnys.com)

1. Presence of, or accumulation of, mucin in the blood. (wordinfo.info)

With increasing interest on mucins as diagnostic and therapeutic targets in cancers and other diseases, it is becoming imperative to characterize novel mucins and investigate their biological significance. (nih.gov)

2002 Several functions have been attributed to membrane mucins. (healthanddietblog.info)
The volume concludes with information on the functions of secreted mucins. (benthambooks.com)

viscous, slippery secretion of mucous membranes and glands. (freezingblue.com)

This e-book series represents a unique attempt to describe the molecular nature of mucin multifunctionality in separate volumes. (benthambooks.com)

Anatomy16

Organisms1

Diseases4

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes9

Technology, Industry, Agriculture4

Information Science2

Proteins7

Glycoproteins4

MUC18

Epithelial cells6

Mucus2

Polymorphic epithelial mucin1

Glycosylation4

Mixed with the1

Mucous membrane3

Production of mucin3

Dermal mucin3

Expression of mucins2

Protein8

Basement membrane1

Secrete mucin1

MUC175

Molecules3

Transmembrane5

Bacterial1

Immunoglobulin1

Antibacterial1

Extracellular2

Soluble3

Secreted or membrane-bound1

Receptor1

Antimicrobial1

Cell14

Bound2

Immunohistochemistry2

Cytoplasmic2

Hydrolysis1

Genes1

Lungs1

Overproduction1

Gene2

Infection3

Inhibit3

Cells4

Urine1

Discharge1

Metastatic2

Densely1

Clinical1

Protective1

Presence1

Diseases1

Functions2

Slippery1

Molecular1