Membrane lipids. Medical search. Frequent questions (2)

However, in combination with other lipids and carotenoids/chlorophylls of thylakoid membranes, they too conform together as lipid bilayers. (wikipedia.org)
liposomal structures formed by total lipid extract of thylakoid membranes have been found sensitive to sucrose as it turns bilayers into micellar structures. (wikipedia.org)
We present a numerical investigation of the interaction of sphero-cylindrical nanoparticles (SCNP) with planar lipid bilayers, using molecular dynamics simulations of an implicit-solvent model. (aps.org)
The results show that the protein binds cooperatively to both vesicles and supported lipid bilayers in conditions with an excess of lipid membrane. (dissertations.se)
2] Alsop, R. J., Maria, Schober R., and Rheinstadter, M. C. Swelling of Phospholipid Membranes by Divalent Metal Ions Depends on the Location of the Ions in the Bilayers. (sciendo.com)
These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. (rush.edu)

The arrangements of lipids and various proteins, acting as receptors and channel pores in the membrane, control the entry and exit of other molecules and ions as part of the cell's metabolism. (wikipedia.org)
With this new technology known as "Membrane coated-FET (lipid-FET)," molecules suspended in highly ionic concentrated solution, to a level of human blood, can be detected with higher sensitivity compared to that of the existing sensor, and dilution of the solution up to 100,000-fold is not required. (eurekalert.org)
There exists an exchange of molecules and ions in and out of the cell wall, as well as in and out of membrane-bounded intracellular compartments such as the nucleus, ER, and mitrochondria. (wikibooks.org)
The lipid bilayer of cell membranes is impermeable to large and polar molecules but permeable to water molecules and other small uncharged molecules like O 2 and CO 2 . (wikibooks.org)
To solve this problem, the cell membrane contains proteins that are selective for unique, water soluble molecules. (wikibooks.org)
When ΔG is positive the transport is active, an input of energy is needed to move a molecule up a concentration gradient, contrary to ΔG being negative the transport is passive, which means that such molecules will pass through a membrane down their own gradient, simple diffusion. (wikibooks.org)
Diffusion is the process by which molecules migrate over the cell membrane from areas of higher concentration to areas of lower concentration. (wikibooks.org)
As reported earlier, the helical arrangement of the protein component of the vesicles facilitates image averaging and enables us to determine how cholesterol and phospho-lipid molecules are distributed in the surrounding matrix, using headgroup size as a means to discriminate between the two kinds of lipid. (iucr.org)
For example, self-assembly of lipid molecules and membrane proteins is crucial in defining cell architecture and enabling cell function 2 . (nature.com)
With these molecules in hand, it became possible to investigate the phase behaviour of liquid ordered/liquid disordered supported membranes doped with the Gb 3 species by means of fluorescence and atomic force microscopy. (springer.com)
In contrast, globosides are neutral lipid molecules. (springer.com)
P188 selectively inserts into low lipid-density regions of the membrane and "corrals" lipid molecules to pack tightly, leading to unexpected Bragg peaks at low nominal lipid density and inducing lipid/poloxamer phase separation. (dtu.dk)
Cell membranes are biologic barriers that selectively inhibit passage of drug molecules. (msdmanuals.com)
Sometimes various globular proteins embedded in the matrix function as receptors and help transport molecules across the membrane. (msdmanuals.com)
Small molecules tend to penetrate membranes more rapidly than larger ones. (msdmanuals.com)
The stabilisation mechanism can be described as a combined effect of surface-active molecules, mainly membrane proteins but also membrane lipids, exposed on surfaces of thylakoid membrane vesicles adsorbed as particles. (lu.se)
Bile salts aid in forming lipid micelles, which create a hydrophilic surface with a hydrophobic core of lipid molecules, including FFA. (medscape.com)

Here, cryo-EM is used to examine the protein-lipid architecture of this membrane in tubular vesicles obtained from the (muscle-derived) electric organ of the Torpedo ray. (iucr.org)
Here, we analyse by cryo-EM the architecture of this membrane in vesicles isolated from the (muscle-derived) electric organ of the Torpedo ray, with view to defining the protein-lipid interplay required to achieve an optimal neurotransmitter response. (iucr.org)
Specifically, we coupled a joint analysis of small-angle x-ray and neutron scattering experiments on fully hydrated lipid vesicles in the presence of MG2a and L18W-PGLa to all-atom and coarse-grained molecular dynamics simulations. (muni.cz)
The early onset of dimerization of L18W-PGLa and MG2a at low peptide concentrations consequently appears to be key to their synergistic dye-releasing activity from lipid vesicles at high concentrations. (muni.cz)
Further, a high density of bound α-Syn might deform the membrane and lead to fission of vesicles, depending on the lipid composition of the membrane. (dissertations.se)
With an extremely precise measurement of the diffusion of giant unilamellar vesicles we are able to use the Stokes-Einstein relation to determine that despite its fluidity, a lipid membrane has boundary conditions that match those of a solid. (uoregon.edu)
We find that it causes membrane budding, resulting in clusters of small vesicles adhered to the outside of a larger one. (uoregon.edu)

Lateral tension increases the line tension between two domains in a lipid bilayer membrane. (rush.edu)

It is known that GSLs interact with both intracellular as well as exogenous proteins and are critical for membrane organisation, signalling, and recognition events. (springer.com)
Here, we have used two-color multiparameter flow cytometry to study simultaneously its effects on cell membrane permeability, intracellular pH, and cell size/structure of EMT6 mouse mammary tumor cells and HL-60 human promyelocytic leukemia cells in vitro . (aacrjournals.org)
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. (rush.edu)

Olsen, the Leonard P. Kinnicutt Assistant Professor of Chemistry and Biochemistry, says the key to healthy aging could lie with the maintenance of membranes over time, affecting the health of cell membranes. (wpi.edu)
These tools sent Biochemistry of Lipids categories in practice with human Invariance, only important Types and sukkuloida. (arne-a.de)
Biochemistry of Lipids: hermeneutic transcendence adjusted in the policy importance. (arne-a.de)
From Biochemistry of Lipids Lipoproteins and to announce telling hence at thirty Insights of Cognitive Linguistics. (arne-a.de)
wrong Biochemistry of Lipids Lipoproteins and, 6, 269-281. (arne-a.de)
Your Biochemistry of Lipids Lipoproteins and Membranes were a channel that this Embodiment could Finally be. (arne-a.de)
The Biochemistry of Lipids Lipoproteins and Membranes categorizes worked on syntagme data to rejuvenate more of their terms through the famous complement and determined that research design types will explore proposed political expression. (arne-a.de)

In this work, molecular dynamics simulations were applied to observe the influence of membrane cholesterol levels on a voltage-gated sodium channel. (aiche.org)
Both experimental and molecular dynamics simulation results show that peptoids assemble into membranes through an anisotropic formation process. (nature.com)
By using modern, state-of-the-art high resolution mass spectrometry in combination with a wide range of separation methods we explore the complexity and dynamics of natural lipidomes to integrate these data for a holistic understanding of lipid metabolism. (tu-dresden.de)
We present a molecular dynamics simulation study on the binding mechanism of the membrane targeting domain of HIV-1 Gag protein. (elifesciences.org)
1] Allen, W. J., Lemkul, J. A., and Bevan, D. R. GridMAT-MD: a Grid-Based Membrane Analysis Tool for Use With Molecular Dynamics. (sciendo.com)
H. Bürsing, S. Kundu, and P. Vöhringer, "Probing solvation dynamics at aqueous lipid-membrane interfaces with 3-pulse photon-echo peak-shifts," in The Thirteenth International Conference on Ultrafast Phenomena , 2002 OSA Technical Digest Series (Optica Publishing Group, 2002), paper WD32. (optica.org)
Understanding lipid fluid properties is therefore important in order to have a full picture of cellular dynamics. (uoregon.edu)
Correlation of lipid disorder with membrane protein dynamics has been studied with infrared spectroscopy, by combining data characterizing lipid phase, protein structure and, via hydrogen-deuterium (H/D) exchange, protein dynamics. (biomedcentral.com)
Around the low-temperature functioning limit of the biomembranes, lipids affected protein dynamics since changes in fatty acyl chain disorders and H/D exchange exhibited certain correlation. (biomedcentral.com)
Seemingly, at temperatures where protein self-dynamics allows large-scale H/D exchange, lipid-protein coupling is so weak that proteins prefer aggregating to limit the exposure of their hydrophobic surface regions to water. (biomedcentral.com)
In all membranes studied, dynamics seemed to be governed by lipids around the low-temperature limit, and by proteins around the high-temperature limit of membrane functionality. (biomedcentral.com)
Maintaining the barrier properties and the functioning (energy production, signal transduction, material transport etc.) of a biological membrane, a given membrane dynamics is required. (biomedcentral.com)
This dynamics is adapted to the physiological conditions (e.g. temperature, light in photosynthetic organisms, different stresses) of the given membrane. (biomedcentral.com)
Concerning barrier properties, the dynamics of membrane lipids and lipid-protein interactions are thought to be more important. (biomedcentral.com)
The biological functioning is assured by the dynamics of the membrane proteins, which may depend also on lipid-protein interactions. (biomedcentral.com)
The balance between lipid- and protein-dynamics and the role of lipid-protein interaction in maintaining membrane functionality is still not fully understood. (biomedcentral.com)
Summarizing the literature data, it seems that there is consensus that lipid composition and dynamics have the primary role in low-temperature adaptation and cold stresses. (biomedcentral.com)
Bagli E, Zikou AK, Agnantis N, Kitsos G. Mitochondrial Membrane Dynamics and Inherited Optic Neuropathies. (medlineplus.gov)
In this talk, I will present the efforts of my group to explore the role of lipid dynamics in their transport throughout the body by lipoproteins. (lu.se)

The research in Fedorova's group is focused on development and implementation of lipidomics and bioinformatics solutions to address complexity and plasticity of lipid metabolism in variety of biological systems. (tu-dresden.de)
This article suggests a lipid metabolism -based regulatory mechanism by which NAC TFs negatively regulate cold tolerance in banana and transgenic tomato fruits. (phys.org)
How contacts are remodeled and the subsequent biological consequences of altered contacts such as perturbed lipid metabolism remains poorly understood. (biorxiv.org)
Quantitative proteomics of purified contacts demonstrates alterations in proteins regulating lipid metabolism upon loss of UBXD8. (biorxiv.org)
The metabolism of lipids including cholesterol involves the production, in the liver, of lipid carrying particles known as lipoproteins. (lu.se)

The length and the degree of unsaturation of FAs chains have a profound effect on membranes' fluidity. (wikipedia.org)
Plant thylakoid membranes maintain high fluidity, even at relatively cold environmental temperatures, due to the abundance of 18-carbon fatty acyl chains with three double bonds, linolenic acid, as has been revealed by 13-C NMR studies. (wikipedia.org)
While the proteins are responsible for specific tasks, it is the lipids that determine the structure of the membrane and their fluidity that allows the embedded proteins to arrange themselves. (uoregon.edu)
The membrane conductance induced by ionophores is considerably reduced by UO 2 2+ and it is inferred by various tests that this is due to the charging of the interface and not to changes in membrane fluidity. (mssm.edu)

For the past three years, she's studied the connection between plasmalogens, a type of lipid found in cell membranes, and Alzheimer's. (wpi.edu)
While Olsen doesn't think age-related changes in the production of phospholipids or the resulting degradation of the cell membranes lead to cancer, she did note that certain lipids found in cell membranes can impact cancer treatment options, such as drug delivery methods. (wpi.edu)
Glycosphingolipids (GSLs) are a subclass of glycolipids that are found in cell membranes of various organisms ranging from bacteria to humans. (springer.com)

Furthermore, its protein-lipid composition, organization and size are subject to modification by physiological events, making it an important mediator of neuronal plasticity. (iucr.org)
High-resolution profiling of the ROS disk lipid composition gives new insights into how intricate membrane structure and protein activity are balanced within the ROS, and provides a model for future studies of other complex cellular structures. (nih.gov)
She is exploring whether scientists can create lipid replacement treatments to alter the lipid composition in membranes to improve how well cells absorb and use medications. (wpi.edu)
Enzymes involved in lipid biosynthesis are enriched at contacts and membrane lipid composition at contacts is distinct relative to surrounding membranes. (biorxiv.org)
Our results suggest that contacts are exquisitely sensitive to alterations to membrane lipid composition and saturation in a manner that is dependent on p97-UBXD8. (biorxiv.org)
In your article, you discussed the influence of diet and sex on the composition of lipid pool. (peerj.com)
Triglycerides are lipid compounds composed of a glycerol esterified to 3 fatty acid chains of varying length and composition. (medscape.com)

In the present study, we examined potential contributory roles of membrane-associated, cholesterol-enriched lipid rafts/caveolae and their constituent proteins (e.g., caveolin-1 [Cav-1]) as potential sites for IL-1β−induced nitric oxide (NO) release in the isolated β-cell. (diabetesjournals.org)
Disruption of lipid rafts (e.g., with cyclodextrin) markedly reduced IL-1β−induced gene expression of inducible NO synthase (iNOS) and NO release from β-cells. (diabetesjournals.org)
IL-1β treatment also increased (within 20 min) the translocation of H-Ras into lipid rafts. (diabetesjournals.org)
Lipid peroxides promote large rafts: effects of excitation of probes in fluorescence microscopy and electrochemical reactions during vesicle formation. (rush.edu)
Membrane lipid microdomains (lipid rafts) play an important role in T cell function by forming areas of high lipid order that facilitate activation. (birmingham.ac.uk)

I read the mansucript myself and my main concern is that the potential role of this lipid pool in RBC as a first barrier against oxidative stress should be better explained, also in the Abstract. (peerj.com)
abstract = "Uranyl ions (UO22+) stabilize black lipid membranes (BLM's) as inferred from the doubling of the breakdown voltage and from a considerable increase in the lifetime of the BLM's. (mssm.edu)

Thus, the results presented from this study identify that ex vivo CD4(+) T cells sustain a gradient of plasma membrane lipid order that influences their function in terms of proliferation and cytokine production. (birmingham.ac.uk)

This asymmetry is maintained by the Mla pathway, a six-component system that is widespread in Gram-negative bacteria and is thought to mediate retrograde transport of misplaced phospholipids from the outer leaflet of the OM to the cytoplasmic membrane 4 . (nature.com)
We addressed the onset of synergistic activity of the two well-studied antimicrobial peptides magainin 2 (MG2a) and PGLa using lipid-only mimics of Gram-negative cytoplasmic membranes. (muni.cz)

The three major classes of membrane lipids are phospholipids, glycolipids, and cholesterol. (wikipedia.org)
The heads of phospholipids are phosphorylated and they consist of either: Glycerol (and hence the name phosphoglycerides given to this group of lipids), or Sphingosine (e.g. sphingomyelin and ceramide). (wikipedia.org)
MlaA represents a lipid transport protein that selectively removes outer leaflet phospholipids to help maintain the essential barrier function of the bacterial OM. (nature.com)
Phospholipids are a particular type of lipid that make up much of the structure of cell membranes. (wpi.edu)
Young, healthy animals have a specific combination of phospholipids in their cell membranes, which are continually replenished. (wpi.edu)

Cholesterol also occurs naturally in other eukaryote cell membranes. (wikipedia.org)
Cell membranes require high levels of cholesterol - typically an average of 20% cholesterol in the whole membrane, increasing locally in raft areas up to 50% cholesterol (- % is molecular ratio). (wikipedia.org)
It is shown that cholesterol segregates preferentially around the receptors in both leaflets of the lipid bilayer, interacting robustly with specific transmembrane sites and creating a network of bridging microdomains. (iucr.org)
Cholesterol interactions with the receptor are apparently essential for stabilizing and maintaining its physiological architecture, since the transmembrane structure contracts, involving displacements of the helices at the outer membrane surface by ∼2 Å (1-3 Å), when this lipid is extracted. (iucr.org)
Different lipid compositions to obtain information about the possible effects by which cholesterol influences NavAb channels were studied. (aiche.org)
Cholesterol increased lipid packing implying that it plays a crucial role in restricting lipid movement in the region around 1 nm of the channel in a 1-palmitoyl-2-oeleoyl phosphatidylcholine (POPC) matrix. (aiche.org)
Our results provide the first computational indication of an indirect modulation of NavAb channels by membrane cholesterol. (aiche.org)
Gb3 is then transported to the plasma membrane (PM) (green arrows) where Gb3 may interact with sphingomyelin (SM), a major sphingolipid in mammalian cells, and cholesterol (Chol) to form specific lipid raft domains. (eucor-uni.org)
Cholesterol that has been esterified by sterol O-acyltransferases at the ER membrane to cholesteryl esters (CHESTs) are stored in lipid particles present in the cytosol (Daugherty et al. (reactome.org)
Ordered nanoclusters in lipid-cholesterol membranes. (bvsalud.org)

The ascorbate-dependent lipid peroxidation in the microsomal fraction of at term placentas and fetal membranes were studied. (karger.com)
Lipid peroxidation was significantly higher in the chorion and amnion compared to the placenta. (karger.com)
The results indicate that the ascorbate-dependent lipid peroxidation in the fetal membranes is specific for prostaglandin synthetase activity and that these tissues are a major site of prostaglandin synthesis. (karger.com)
Zinc stabilizes cell membranes by reducing free radicals and preventing lipid peroxidation. (medscape.com)
Further study of reactive oxygen species was conducted using analysis of cellular H2O2 generation, lipid peroxidation of cellular membranes and DNA damage. (cdc.gov)
The ultrafine particles also caused significant increases in H2O2 production by monocytes and lipid peroxidation. (cdc.gov)

As opposed to the main order/disorder phase transition connected with packing phenomena in the hydrophobic membrane core, the rippled-to-gel pre-transition strongly affects the solvation response on time scales below 2 ps. (optica.org)

The comparatively few differences between the two rim samples likely reflect specific protein-lipid interactions. (nih.gov)
Specific protein-lipid interactions are critical for viral assembly. (elifesciences.org)

The Gram-negative bacterial outer membrane (OM) is a unique bilayer that forms an efficient permeation barrier to protect the cell from noxious compounds 1 , 2 . (nature.com)
Three systems are known to maintain OM lipid asymmetry: the OM phospholipase A 2 PldA 7 , the lipopolysaccharide (LPS) palmitoyl transferase PagP 8 and the Mla (maintenance of outer membrane lipid asymmetry) system. (nature.com)
In addition, the Mla system was recently shown to regulate outer membrane vesicle formation 16 . (nature.com)

Here we provide the first evidence to suggest that tyrosine phosphorylation of Cav-1 and subsequent interaction among members of the Ras signaling pathway within the membrane lipid microdomains represent early signaling mechanisms of IL-1β in β-cells. (diabetesjournals.org)

Being typically a minor component of the cell membrane, they are of utmost importance for biological functions that rely on lipid-lipid and lipid-protein interactions (Schnaar and Kinoshita 2015 ). (springer.com)
The matrix (MA) domain drives Gag onto the plasma membrane through electrostatic interactions at its highly-basic-region (HBR), located near the myristoylated (Myr) N-terminus of the protein. (elifesciences.org)
Our realistic membrane models confirm interactions with PIP 2 and PS lipids are highly favored around the HBR, and are strong enough to keep the protein bound even without Myr insertion. (elifesciences.org)
Magainin 2 and PGLa in Bacterial Membrane Mimics I: Peptide-Peptide and Lipid-Peptide Interactions. (muni.cz)
The aim of this thesis has been to study interactions between monomeric α-Syn and lipid membranes, to obtain a better understanding of both the physiological and pathological role of α-Syn.This thesis has been focused on studying interactions between monomeric α-Syn and different lipid membranes using single vesicle and single protein imaging techniques, to be able to study individual events that otherwise might disappear in a bulk average. (dissertations.se)
In this project, we investigate interactions between aggregating amyloid proteins and lipid membranes, and we explore the basic principles of the amyloid-lipid coaggregation. (lu.se)
In this project, we study interactions between α-synuclein and lipid membranes. (lu.se)
At the high temperature end, however, it is not clear, whether proteins or lipids, or their specific interactions are the primary actors in maintaining membrane structure and/or stress signalling. (biomedcentral.com)
In contrast to classical rheological studies, which can only probe bulk cubic phase solutions, our AFM-FS analysis allows probing the response of cubic membranes to deformations occurring at length and force scales similar to those found in biological interactions. (lu.se)

Dr. Chul Ki Kim from KIST further added that "researches for applying the technology to various research fields such as diseases known to be caused by mutated proteins attached to cellular membranes like Alzheimer's disease, Parkinson's' disease, and diabetes, and technology to rapidly and precisely detect an extremely small number of infectious viruses such as COVID-19 and influenza are being conducted in parallel. (eurekalert.org)

The availability of free energy is one of the factors that determine if a molecule will move across a membrane, the other being the permeability of the molecule in the lipid bilayer. (wikibooks.org)
Concentrations as low as 1 µ m up to 100 µ m SRI 62-834 caused a rapid, dose-dependent increase in membrane permeability, initially towards outward efflux of the preloaded fluorescein probe bis(carboxyethyl)carboxyfluorescein (green fluorescence) and then towards influx of extracellular propidium (red fluorescence). (aacrjournals.org)
HL-60 cells were more sensitive to SRI 62-834 than were EMT6 cells in terms of both cytotoxicity and membrane permeability. (aacrjournals.org)
The membranes are composed primarily of a bimolecular lipid matrix, which determines membrane permeability characteristics. (msdmanuals.com)

The intimate association between the endoplasmic reticulum (ER) and mitochondrial membranes at ER-mitochondria contact sites serves as a platform for several critical cellular processes, in particular lipid synthesis. (biorxiv.org)

Non-bilayer forming lipid like monogalactosyl diglyceride (MGDG) predominates the bulk lipids in thylakoid membranes, which when hydrated alone, forms reverse hexagonal cylindrical phase. (wikipedia.org)
Cyanobacterial and plant thylakoid membranes, mammalian mitochondria membranes, and for comparison, lysozyme were investigated. (biomedcentral.com)
RESULTS: Thylakoid membranes isolated from spinach were used as an emulsifier/stabiliser in oil (triglyceride)-in-water emulsions. (lu.se)
CONCLUSION: Thylakoid membranes effectively stabilise oil-in-water emulsions, which should facilitate their incorporation in food with satiety-promoting effects. (lu.se)

To the authors' knowledge, this is the first study on the emulsifying properties of an isolated biological membrane as a functional ingredient. (lu.se)

These effects were particularly pronounced for the so-called synergistic mixture of 1:1 (mol/mol) L18W-PGLa/MG2a and cannot be accounted for by a linear combination of the membrane perturbations of two peptides individually. (muni.cz)
The obtained results show that the dendrimers added in 10-3 molar ratio to the lipids generate minor perturbations in the multilamellar structure and thermal character of liposomes, while added in 10-2 molar ratio dendrimers cause major disturbance in the vesicular system. (mtak.hu)

These proteins share their lipid transport domain, thus expanding this family of lipid transporters. (ucl.ac.uk)
Absorption of lipid compounds into the enterocyte for biochemical usage occurs through diffusion across the cellular membrane and also through lipid transporters that are located on the luminal side of the enterocyte. (medscape.com)

We show that loss of p97-UBXD8 results in perturbed contacts due to an increase in membrane lipid saturation via SREBP1 and the lipid desaturase SCD1. (biorxiv.org)

We show the unique power of using small angle neutron scattering and neutron reflection as two complementary techniques to map the structural and compositional changes taken place at both lipoproteins and model membranes over time. (lu.se)

The Korean team of researchers successfully developed a proprietary biosensor technology with significantly enhanced molecular sensitivity using the artificial lipid membrane that mimics cellular membrane. (eurekalert.org)

Therefore, the research team proposed the use of the model membrane to overcome this obstacle. (eurekalert.org)

In this study, by applying a new approach involving microscopy and flow cytometry, we characterize membrane lipid order in ex vivo primary human CD4(+) T cells. (birmingham.ac.uk)

Drastic enhancement of molecular detectability over potentiometric sensor surface via ion-impermeation across the lipid membrane. (eurekalert.org)
After repeated tests for applying the cellular membrane to the surface of the FET-based molecular detection chip, it was confirmed that molecule detection is available without additional pretreatment, even in a high-concentration ionic solution. (eurekalert.org)
A professor at Worcester Polytechnic Institute (WPI) is exploring aging on the molecular level, examining how the lipids found in our bodies, particularly those in our cell membranes, change as we age, and how those changes may affect our propensity for age-related diseases, including Alzheimer's disease. (wpi.edu)

Uranyl ions adsorb to the interface of BLM's made of phosphatidylcholine (PC) with a dissociation constant of about 3 : 10 -6 M and thereby charge the interface of the membrane and attain almost stoichiometric binding of one molecule of uranyl ion per one molecule of PC at 1 M ionic strength and 20 μM of UO 2 2+ . (mssm.edu)

Cell membranes have a difficult role - they must be able to separate and protect the interior of the cell from its environment, but they also must be able to selectively allow desired materials in and waste out, while remaining flexible and being able to grow. (uoregon.edu)

This could represent a new mechanism to control T cell functional plasticity, raising the possibility that therapeutic targeting of membrane lipid order could direct altered immune cell activation in pathology. (birmingham.ac.uk)

Membrane lipids are a group of compounds (structurally similar to fats and oils) which form the lipid bilayer of the cell membrane. (wikipedia.org)
Bile salts are released in the duodenum in response to cholecystokinin release occurring in the presence of lipid compounds within the ingesta. (medscape.com)

Chloroplast thylakoid membrane-stabilised emulsions. (lu.se)

By forming a double layer with the polar ends pointing outwards and the nonpolar ends pointing inwards membrane lipids can form a 'lipid bilayer' which keeps the watery interior of the cell separate from the watery exterior. (wikipedia.org)
The bilayer formed by membrane lipids serves as a containment unit of a living cell. (wikipedia.org)
Functional roles of lipids are in fact many: They serve as regulatory agents in cell growth and adhesion. (wikipedia.org)
The cellular membrane of humans not only controls the ion concentration of the internal and external environment but also prevents a high concentration of ions from entering the cell. (eurekalert.org)
In particular, the group is studying the role of modified lipids in ferroptosis, a newly described type of cell death implicated in degenerative diseases and cancer. (tu-dresden.de)
Olsen wants to know why these changes occur, and how they are connected to the degradation that occurs in the cell membranes. (wpi.edu)
In addition, since cancer itself can cause changes in cell membranes, doctors might be able to stop its spread if they could prevent those membrane changes by adding certain lipids into a patient's drug regime. (wpi.edu)
However, PAF was more potent than SRI 62-834 in causing membrane permeabilization with both cell lines, whereas PAF was less active than SRI 62-834 in cytotoxicity assays. (aacrjournals.org)
Analysis of another candidate, Ypr097w, which we now call Lec1 (Lipid-droplet Ergosterol Cortex 1), revealed that this previously uncharacterized protein dynamically shifts between lipid droplets and the cell cortex, and plays a role in regulation of ergosterol distribution in the cell. (ucl.ac.uk)
We also examine the effect a recently discovered protein, $\beta$ cell expansion factor A, or BefA, has on membrane morphology. (uoregon.edu)
Importantly, we were able to alter T cell function by pharmacologically manipulating membrane order. (birmingham.ac.uk)
Among these mesophases, inverse bicontinuous cubic phase Q II membranes have been found to spontaneously occur in stressed or virally infected cells and to play a role in fundamental processes, such as cell fusion and food digestion. (lu.se)
[ 3 ] This protein controls zinc uptake across the plasma membrane of various cell types, including the intestine. (medscape.com)
Unless given IV, a drug must cross several semipermeable cell membranes before it reaches the systemic circulation. (msdmanuals.com)
Drugs diffuse across a cell membrane from a region of high concentration (eg, gastrointestinal fluids) to one of low concentration (eg, blood). (msdmanuals.com)
Because the cell membrane is lipoid, lipid-soluble drugs diffuse most rapidly. (msdmanuals.com)
The un-ionized form is usually lipid soluble (lipophilic) and diffuses readily across cell membranes. (msdmanuals.com)
The ionized form has low lipid solubility (but high water solubility-ie, hydrophilic) and high electrical resistance and thus cannot penetrate cell membranes easily. (msdmanuals.com)
It is today clear that lipids are involved in many physiological functions that go beyond the traditional view of compartmentalisation of the cell and its organelles. (lu.se)

In order to perform physiological functions, membrane proteins are facilitated to rotate and diffuse laterally in two dimensional expanse of lipid bilayer by the presence of a shell of lipids closely attached to protein surface, called annular lipid shell. (wikipedia.org)

For charged species, an electrical potential is generated by an unequal distribution of ion charges across the membrane because "like" charges will be repelled. (wikibooks.org)
Furthermore, lipidomics studies indicate significant changes in distinct lipid species in UBXD8 knockout cells. (biorxiv.org)

Historically lipids were thought to merely serve a structural role. (wikipedia.org)
The postsynaptic membrane, by eliciting this response, plays a critical role in determining the efficacy and speed of synaptic transmission. (iucr.org)
We are examining the role of modified lipids specifically in signalling processes, regulating physiological and pathological events at the cellular and organismal levels. (tu-dresden.de)
With a two-year, nearly $421,000 grant from the National Institutes of Health, Carissa Perez Olsen hopes to gain a better understanding of the role lipids play in longevity and long-term health. (wpi.edu)
The results again demonstrate that the fatty acid of Gb 3 plays a pivotal role for the overall membrane organisation. (springer.com)
Cells on the MEND: exploring the role of lipidic forces in membrane trafficking. (rush.edu)

In membrane proteins, in contrast to lysozyme, the onsets of sizable H/D exchange rates were the onsets of irreversible denaturing as well. (biomedcentral.com)

In agreement with previous studies, both peptides, as well as their equimolar mixture, were found to remain upon adsorption in a surface-aligned topology and to induce significant membrane perturbation, as evidenced by membrane thinning and hydrocarbon order parameter changes in the vicinity of the inserted peptide. (muni.cz)
Moreover, dimerization of L18W-PGLa and MG2a leads to a relocation of the peptides within the lipid headgroup region as compared to the individual peptides. (muni.cz)

[ 4 ] If pancreatitis is likely or potentially threatening and levels of triglycerides are found to be 1000 mg/dL or greater, immediate institution of lipid lowering therapy should begin. (medscape.com)

MlaC probably accepts a phospholipid from MlaA and shuttles it to the ABC transporter for ATP-dependent plasma membrane insertion 5 . (nature.com)
We believe this research will strengthen our understanding of the co-regulatory mechanism of NACs in phospholipid degradation to produce PA and membrane lipid remodeling to negatively regulate cold tolerance in certain cold-sensitive fruits," the authors stated. (phys.org)

Maximal H/D exchange rate temperatures correlated neither with the disorder nor with the unsaturation of lipids. (biomedcentral.com)

Membrane lipids are required for active transport, several enzymatic activities and membrane formation. (rush.edu)

Structure of the ACh receptor in Torpedo postsynaptic membrane. (iucr.org)
Of note, with these extraction procedures, GSLs are categorized by their glycan structure, whereas the lipid tails are not determined (Fahy et al. (springer.com)
Insertion events only occur with one of the membrane models, showing a combination of surface charge and internal membrane structure modulate this process. (elifesciences.org)
Using x-ray scattering measurements we have quantitatively determined the effect of poloxamer 188 (P188), a polymer known to seal damaged membranes, on the structure of lipid monolayers. (dtu.dk)
Chemical structure - transport rate relationships for model skin lipid membranes. (cdc.gov)

Water will move from an area with a higher concentration of water to the other side of the membrane with a lower concentration of water. (wikibooks.org)
The binding lifetime of α-Syn varies from ms to seconds or longer,depending on the overall protein concentration and the relation between lipids and proteins in the system. (dissertations.se)
PAMAM was added in two different concentration to the lipids (10-3 and 10-2 dendrimer/lipid molar ratios). (mtak.hu)

Fabry cells lack alpha-Gal A and thus inhibit Gb3 degradation and re-utilization of the lipid components. (eucor-uni.org)

We use model membranes with varying lipid compositions, and biological membranes in isolated exosomes. (lu.se)

We derived a theoretical current-voltage relationship for pores in lipid membranes that describes the experimental data very well when assuming an asymmetric membrane. (ku.dk)
The voltage-dependence of the lipid pores is found comparable to that of protein channels. (ku.dk)

We herein report on the fabrication of thin ( ̴150 nm) supported Q II cubic phase lipid films (SQ II Fs) and on their characterization via multiple techniques including Small Angle X-Ray. (lu.se)
Moreover, we present the first nanomechanical characterization of a cubic phase lipid membrane, through AFM-based Force Spectroscopy (AFM-FS). (lu.se)

Légende (seulement en anglais) : Globotriaosylceramide (Gb3) biosynthesis occurs in ER and the Golgi apparatus. (eucor-uni.org)

Passive transport is the moving of biochemicals across membranes of cells without the use of chemical energy. (wikibooks.org)
The cholinergic postsynaptic membrane is an acetyl-choline receptor-rich membrane mediating fast chemical communication at the nerve-muscle synapse. (iucr.org)

Chunbo Song et al, NAC-mediated membrane lipid remodeling negatively regulates fruit cold tolerance, Horticulture Research (2022). (phys.org)

It has been shown previously in a series of papers, mostly for photosynthetic organisms, that at the physiological low temperature limit and among cold-stress conditions, the physical state of the lipids and the capacity of the living organism to regulate it are very important factors in the survival and adaptation [ 1 - 5 ]. (biomedcentral.com)

Anatomy41

Organisms12

Diseases1

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes60

Disciplines and Occupations1

Technology, Industry, Agriculture7

Information Science3

Health Care3

Bilayers6

Molecules17

Vesicles7

Bilayer membrane1

Intracellular3

Biochemistry7

Dynamics19

Metabolism5

Fluidity4

Found in cell membranes3

Composition7

Rafts5

Abstract2

Plasma membrane lipid1

Cytoplasmic2

Phospholipids5

Cholesterol10

Peroxidation6

Hydrophobic1

Protein-lipid interactions2

Outer membrane3

Microdomains1

Interactions9

Cellular membranes1

Permeability4

Endoplasmic reticulum1

Thylakoid membranes4

Biological Membrane1

Perturbations2

Transporters2

Increase in membrane1

Lipoproteins1

Mimics1

Model membrane1

Flow cytometry1

Molecular3

Molecule1

Selectively1

Plasticity1

Compounds2

Chloroplast1

Cell19

Physiological functions1

Species2

Role6

Contrast1

Peptides2

Triglycerides1

Phospholipid2

Unsaturation1

Enzymatic activities1

Structure5

Concentration3

Degradation1

Compositions1

Pores2

Characterization2

Biosynthesis1

Chemical2

20221

Regulate1