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  • metabolism
  • The different tools/approaches used for lipid analysis will also be discussed in relation to the studies to be carried out on lipid metabolism and function. (springer.com)
  • During periods with the highest rate of metabolism, the content of polyunsaturated, mainly trienoic fatty acids increase in membrane lipids. (springer.com)
  • In: Freysz L., Dreyfus H., Massarelli R., Gatt S. (eds) Enzymes of Lipid Metabolism II. (springer.com)
  • Here, we show that synaptic activity, one of the most important inducers of neurite growth, transcriptionally regulates the expression of neuronal glucose transporter Glut3 and rate‐limiting enzymes of glycolysis, resulting in enhanced glucose uptake and metabolism that is partly used for lipid synthesis. (embopress.org)
  • Alterations of membrane lipids and in gene expression of ganglioside metabolism in different brain structures in a mouse model of mucopolysaccharidosis type I (MPS I). (sigmaaldrich.com)
  • enzyme
  • Specifically, they were seeing that when they modified the composition of lipids in a cell membrane, the activity of an enzyme named FAAH increased. (gpugrid.net)
  • Through simulations performed here on GPUGRID we discovered that, contrary to expectations, the lipids modified the function of the enzyme by directly interacting with it and its endogenous ligand. (gpugrid.net)
  • FAAH (fatty acid amide hydrolase) is a membrane-bound enzyme that is responsible for the intracellular hydrolysis of the bioactive lipid AEA (anandamide or N -arachidonoylethanolamine) and other congeners known as eCBs (endocannabinoids) [ 1 ]. (biochemj.org)
  • The membrane-bound Na + /K + -ATPase, a ubiquitous enzyme of animal cells, is known as the sodium pump and is responsible for maintenance of this Na + gradient. (biologists.org)
  • phospholipid
  • Phospholipid molecular species and headgroup compositions were determined for sarcoplasmic reticular and microsomal membranes in two species of Sonoran desert cyprinid fish ( Agosia chrysogaster Girard and Notropis lutrensis Girard) trapped in an isolated pool of a desert stream. (biologists.org)
  • nanodomains
  • In more complex membrane models containing also sphingomyelin, with liquid disordered (ld)/ liquid ordered (lo) phases coexistence, mimicking domains in the external leaflet of human plasma membrane, all compounds were able to affect nanodomains lateral organization. (ovid.com)
  • Molecular
  • Recently, stimulated-emission-depletion (STED) nanoscopy ( 21 , 22 ), delivering subdiffraction resolution in live cells, provided direct evidence that certain lipids are transiently trapped in cholesterol-assisted molecular complexes ( 23 , 24 ). (pnas.org)
  • Nikaido, H. Molecular basis of bacterial outer membrane permeability revisited. (nature.com)
  • 1983
  • Macala LJ, Yo RK, Ando S (1983) Analysis of brain lipids by high performance TLC and densitometry. (springer.com)
  • role
  • Since their proposal, the question of the existence and functional role of such cholesterol-mediated lipid assemblies has caused much controversy ( 13 - 16 ). (pnas.org)
  • However, many questions remain regarding the synthesis and physiological role of some of the more complex archaeal lipids. (pnas.org)
  • The collected structural information has identified the catalytic mechanism of FAAH, but a role for the surrounding membrane lipids in controlling the enzyme's activity remains as yet unknown. (biochemj.org)
  • article{osti_1389231, title = {A Central Role for Triacylglycerol in Membrane Lipid Breakdown, Fatty Acid β -Oxidation, and Plant Survival under Extended Darkness}, author = {Fan, Jilian and Yu, Linhui and Xu, Changcheng}, abstractNote = {Triacylglycerol is a key intermediate in membrane lipid breakdown and fatty acid β-oxidation, and blocking triacylglycerol hydrolysis reduces oxidative stress and enhances plant survival under extended darkness. (osti.gov)
  • cells
  • The results support previous STED nanoscopy measurements and suggest that, at least for nontreated cells, the transient interaction of a single lipid is confined to macromolecular dimensions. (pnas.org)
  • Nanoscale trapping of fluorescent lipid analogs in the plasma membrane of living cells is revealed and is consistent with the previous STED-FCS data. (pnas.org)
  • Scaffolding proteins play important roles in supporting the plasma membrane (sarcolemma) of muscle cells. (cea.fr)
  • Lagerholm BC, Andrade DM, Clausen MP, Eggeling C (2017) Convergence of lateral dynamic measurements in the plasma membrane of live cells from single particle tracking and STED-FCS. (springer.com)
  • integral
  • Structural evidence for dimerization-regulated activation of an integral membrane phospholipase. (nature.com)
  • Finally, our strategy opens up new possibilities for structure determination of peripheral and integral membrane proteins not compatible with different high-resolution structural methods. (cea.fr)
  • survival
  • Many researchers have related membrane lipid with survival success after cryopreservation or cold shock. (hindawi.com)
  • Triacylglycerol is a key intermediate in membrane lipid breakdown and fatty acid β-oxidation, and blocking triacylglycerol hydrolysis reduces oxidative stress and enhances plant survival under extended darkness. (osti.gov)
  • bound
  • The results show that specific structural lipids remain bound in the gas phase and can be counted. (sciencemag.org)
  • From these studies, we report an all-atom model of R1-3 that highlights the opening of the R1 coiled-coil repeat when bound to the membrane lipids. (cea.fr)