• This receptor was cloned in 1991 by two separate groups and it was reported its expression in undifferentiated stem/progenitor cells and its absent expression on the majority of differentiated hemopoietic cells. (hindawi.com)
  • The activation of this protein is dependent upon the binding of cytokines to their receptors. (thermofisher.com)
  • LIF can be up-regulated by pro-inflammatory cytokines such as TNF alpha and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. (fishersci.co.uk)
  • IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. (miltenyibiotec.com)
  • The development of the genetic studies on acute myeloid leukemias (AMLs) has led to the identification of some recurrent genetic abnormalities. (hindawi.com)
  • High levels of WT FLT3-expression have been observed in various hematological malignancies including the majority of acute myelogenous leukemias (AMLs) and B-cell acute lymphoblastic leukemias (ALLs). (hindawi.com)
  • The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. (bioportfolio.com)
  • RNA polymerase (Pol) I is a 14-subunit enzyme that solely transcribes pre-ribosomal RNA. (bioportfolio.com)
  • It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. (wikipedia.org)
  • Membrane-Bound Transcription Factor Site-1 Protease in PF429242 Bound State: Computational Kinetics and Dynamics of Reversible Binding. (bioportfolio.com)
  • The activation and nuclear translocation of these transcription factors subsequently induce the production of type I IFNs, namely, IFN-α and IFN-β, which induce the expression of ISGs and inhibit the replication of virus ( 2 - 4 ). (asm.org)