• The larger form of this antigen (185-255 kD) occurs in the developing nervous system and is present in membranes of nerve growth cones, as determined by analysis of a growth cone particle fraction. (rupress.org)
  • Background While CD40L is normally a membrane glycoprotein expressed on activated T cells and platelets that binds and activates CD40 on the top on antigen presenting cells, a soluble derivative (sCD40L) that seems to retain its biological activity after cleavage from cell membrane also exists. (biomedigs.org)
  • CD40 is present on surface on antigen showing cells (APCs) such as B cells, monocytes, macrophages and dendritic cells, as well as within the membrane of various nonimmune cells, such as endothelial and epithelial cells [16]. (biomedigs.org)
  • A number of laboratories have observed that membrane glycoprotein plasma cell antigen 1 (PC-1) [ ectonucleotide pyrophosphatase phosphodiesterase 1] is either overexpressed or overactive in muscle, adipose tissue, fibroblasts, and other tissues of insulin-resistant individuals, both nondiabetic and diabetic. (cnr.it)
  • Gaoxin Li , Ling Ding , Xiaojing Ma , Qiliang Cai , Tianlei Ying , Fang Wei , 2019: Establishment of Novel Monoclonal Fabs Specific for Epstein-Barr Virus Encoded Latent Membrane Protein 1, Virologica Sinica, 34, 467-470. (virosin.org)
  • 孙怀昌 , LindaK.Dixon , R.M.EParkhouse , 1999: Com puter-Based Prediction and Experim ental Confirm ation of the jSR Membrane Protein of African Swine Fever Viru, Virologica Sinica, 14, 236-243. (virosin.org)
  • Among these glycoproteins, gB is thought to be the protein that executes fusion. (uic.edu)
  • Type I membrane protein. (lu.se)
  • and spike glycoprotein or spike protein (red, tall spike). (medlineplus.gov)
  • Rather, it suggests that one or more receptors localized to the ER membrane may mediate the selective transport of membrane glycoproteins out of the ER to the Golgi apparatus. (johnshopkins.edu)
  • VWF binds to receptors on the platelet surface membrane (glycoprotein Ib/IX). (msdmanuals.com)
  • Platelet receptors for ADP include the P2Y12 receptor, which sends signals to suppress adenylate cyclase, decreases cyclic adenosine monophosphate (cAMP) levels, and promotes activation of the glycoprotein IIb/IIIa receptor (assembled on the activated platelet surface membrane from glycoproteins IIb and IIIa). (msdmanuals.com)
  • Platelet Glycoprotein GPIIb-IIIa Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Harvard Catalyst Profiles by year, and whether "Platelet Glycoprotein GPIIb-IIIa Complex" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Profiles. (harvard.edu)
  • Exploratory Use of Glycoprotein IIb/IIIa Inhibition in Prevention of Blalock-Taussig Shunt Thrombosis. (harvard.edu)
  • Fibrinogen binds to the glycoprotein IIb/IIIa complexes of adjacent platelets, connecting them into aggregates. (msdmanuals.com)
  • Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin . (online-medical-dictionary.org)
  • The viral entry of SARS-CoV-2 depends on an interaction between the receptor-binding domain of its trimeric spike glycoprotein and the human angiotensin-converting enzyme 2 (ACE2) receptor. (usuhs.edu)
  • also known as IL-6 signal transducer, IL-6 receptor beta, oncostatin-M alpha subunit) is a ubiquitously expressed, 130 kDa type I transmembrane glycoprotein and member of the type II subfamily, type I cytokine receptor family. (rndsystems.com)
  • CD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein that is also known as the LPS receptor. (biolegend.com)
  • Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury . (online-medical-dictionary.org)
  • Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. (harvard.edu)
  • Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion. (ox.ac.uk)
  • The envelope contains viral glycoproteins ( 3 ). (cdc.gov)
  • The spike glycoprotein helps the virus latch onto and gain entry into the host cell, so that the virus can infect the cell. (medlineplus.gov)
  • The transmembrane (TM) domains in P-glycoprotein (P-gp) contain the drug binding sites and undergo conformational changes driven by nucleotide catalysis to effect translocation. (aston.ac.uk)
  • Integrin alpha 2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. (rndsystems.com)
  • Addgene: Improving cell-free glycoprotein synthesis by characterizing and enriching native membrane vesicles. (addgene.org)
  • In this study, we assessed the functional kinetics of transport mediated by Pgp that is physiologically expressed in normal tissue by using human placental brush-border membrane vesicles (BBMVs). (elsevierpure.com)
  • Thus the plate assay was used to investigate the role of the glycan component of the glycoproteins in pathogen binding, by assessing bacterial binding before and after treatment of membranes from human epithelial lung cells with glycosidases. (edu.au)
  • This allows the generation of a model to describe the orientation of the glycan with respect to the membrane. (dundee.ac.uk)
  • This shows that the glycan exists in an extended configuration along the plane of the membrane and spans an area of 600 Å 2 , which is similar to the cross-sectional area of a monomeric N-terminal VSG domain. (dundee.ac.uk)
  • The present study was aimed to evaluate the oxidants, enzymatic and nonenzymatic antioxidants, glycoproteins and membrane adenosine triphosphatases (ATPases). (scialert.net)
  • Our data is inconsistent with a passive membrane flow mechanism for the intracellular transport of membrane glycoproteins. (johnshopkins.edu)
  • High-Resolution Description of the Hantavirus Surface Glycoprotein Lattice and Its Membrane Fusion Control Mechanism. (cienciavida.org)
  • The average solution conformation of the glycosylphosphatidylinositol (GPI) membrane anchor of Trypanosoma brucei variant surface glycoprotein (VSG) has been determined by using a combination of two-dimensional 1 H- 1 H NMR methods together with molecular orbital calculations and restrained molecular dynamics simulations. (dundee.ac.uk)
  • The intracellular transport of two closely related membrane glycoproteins was studied in the murine B cell lymphoma line, AKTB-1b. (johnshopkins.edu)
  • MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy. (amrita.edu)
  • Home Publications MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy. (amrita.edu)
  • 2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)
  • Radioactive galactose, covalently bound to cell surface glycoconjugates on mouse macrophage cells, P388D1, was used as a membrane marker to study the composition, and the kinetics of exchange, of plasma membrane-derived constituents in the membrane of secondary lysosomes. (rupress.org)
  • We hypothesized lysosome-associated membrane glycoprotein 1 (LAMP1, CD107a) to be a marker for fratricide in TCR transgenic CD8 + T cells. (oncotarget.com)
  • The recognized glycoprotein is a specific membrane marker of glandular carcinomas. (abcam.com)
  • CD97 overexpression upregulated membrane-bound but not cytoplasmic or nuclear beta-catenin and reduced phospho-beta-catenin, labeled for degradation. (nih.gov)
  • The Epstein-Barr virus (EBV) glycoprotein B cytoplasmic C-terminal tail domain regulates the energy requirement for EBV-induced membrane fusion. (uic.edu)
  • To further characterize the function of the EBV gB cytoplasmic C-terminal tail domain (CTD) in fusion, we used a previously constructed CTD truncation mutant and studied its fusion activity in the context of other EBV glycoprotein mutants. (uic.edu)
  • Williams, DB, Swiedler, SJ & Hart, GW 1985, ' Intracellular transport of membrane glycoproteins: Two closely related histocompatibility antigens differ in their rates of transit to the cell surface ', Journal of Cell Biology , vol. 101, no. 3, pp. 725-734. (johnshopkins.edu)
  • A structural classification of the variant surface glycoproteins of the African trypanosome. (wroc.pl)
  • Here, we investigated the degree of cooperativity of ACE2 within both the SARS-CoV-2 and the closely related SARS-CoV-1 membrane-bound S glycoproteins. (usuhs.edu)
  • Akin to other phleboviruses, SFTSV relies on a viral glycoprotein, Gc, to catalyze the merger of endosomal host and viral membranes during cell entry. (ox.ac.uk)
  • Proteínas de la matriz viral presentes en las especies de virus de la familia CORONAVIRIDAE. (bvsalud.org)
  • In this thesis, methods were developed to study the binding of bacteria to human epithelial membrane glycoproteins by Pseudomonas aeruginosa, a common respiratory pathogen of individuals with cystic fibrosis (CF). A plate assay was developed and revealed differences between the adhesion of clinical strains isolated from four CF patient sputum samples, and a laboratory prototype of P. aeruginosa, to epithelial mucins. (edu.au)
  • gB843 can rescue the fusion function of other glycoprotein mutants that have null or decreased fusion activity in epithelial and B cells. (uic.edu)
  • As analyzed by NaDodSO4 PAGE, labeled molecules of Mr 160-190 kD were depleted and of Mr 100-120 kD were enriched in lysosome membrane compared with the relative composition of label on the cell surface. (rupress.org)
  • These carbohydrates not only provide a means to identify mouse M-cells by LM but may also contribute to the occurrence of specific interactions between microorganisms and the M-cell apical membrane. (nih.gov)
  • Fang Wei , Qing Zhu , Ling Ding , Qing Liang , Qiliang Cai , 2016: Manipulation of the host cell membrane by human γ-herpesviruses EBV and KSHV for pathogenesis, Virologica Sinica, 31, 395-405. (virosin.org)
  • Qingxiu Chen , Hong Guo , Fuxian Zhang , Qin Fang , 2018: N-Terminal Myristoylated VP5 is Required for Penetrating Cell Membrane and Promoting Infectivity in Aquareoviruses, Virologica Sinica, 33, 287-290. (virosin.org)
  • As an enveloped virus, EBV must fuse with a host cell membrane for entry and infection by using glycoproteins gH/gL, gB, and gp42. (uic.edu)
  • 2002). However, during aging an oxidant challenge exceeds the capacity of the cell s defense system, membrane damage may occur. (scialert.net)
  • Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
  • Limited and selective transfer of plasma membrane glycoproteins to membrane of secondary lysosomes. (rupress.org)
  • The results indicate that endocytosis-derived transfer of plasma membrane constituents to secondary lysosomes is a limited and selective process, and that only approximately 1% of internalized membrane is recycled via a membrane pool of secondary lysosomes. (rupress.org)
  • In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)
  • ab3924 reacts with 80 kDa human secretory component glycoprotein (both free and bound in secretory IgA). (abcam.com)
  • The entry of enveloped viruses into host cells is preceded by membrane fusion, which in Epstein-Barr virus (EBV) is thought to be mediated by the refolding of glycoprotein B (gB) from a prefusion to a postfusion state. (uic.edu)
  • Secondary lysosomes were separated from endosomes and plasma membrane on self-forming Percoll density gradients. (rupress.org)
  • Concurrently, the fraction of plasma membrane-derived label in secondary lysosomes increased by first order kinetics (k = [56 min]-1) from less than 0.1% (background level) to a steady-state level of approximately 2.5% of the total label. (rupress.org)
  • Functionally, it is responsible for transduction of the IL-6 signal across the plasma membrane (1). (rndsystems.com)
  • The Rh antigens appear to exist as a multisubunit complex of CD47 (MIM 601028), LW (MIM 111250), glycophorin B (MIM 111740), and play a critical role in the Rh50 glycoprotein. (novusbio.com)
  • Shu-ling Zhao , Xue-juan Dai , Jian-sheng Liang , Chang-yong Liang , 2012: Surface Display of Rice Stripe Virus NSvc2 and Analysis of Its Membrane Fusion Activity, Virologica Sinica, 27, 100-108. (virosin.org)
  • P-Glycoprotein (Pgp) plays an important role in drug disposition and excretion in various tissues such as the brain, intestine, and kidney. (elsevierpure.com)
  • Moreover, we have demonstrated that Pgp is expressed on the brush-border membranes of trophoblast cells in the placenta and restricts drug transfer from the maternal circulation to the fetus. (elsevierpure.com)