• Here recent studies that highlight the utility of these complementary approaches will be reviewed with a focus on the well-characterized influenza virus hemagglutinin fusion glycoprotein system. (mdpi.com)
  • There is only limited knowledge about the organization of the viral particles and in particular, about the hantavirus membrane fusion glycoprotein Gc, the function of which is essential for virus entry. (pasteur.fr)
  • One of these was a novel gene encoding a membrane glycoprotein containing a leucine-rich repeat (LRR), a C2-type Ig-like domain, and a fibronectin (FN) type III domain, and the transcript of which was specifically expressed in the retina. (jneurosci.org)
  • The genome of Pneumocystis, which causes life-threatening pneumonia in immunosuppressed patients, contains a multicopy gene family that encodes the major surface glycoprotein (Msg). (nih.gov)
  • This transmembrane glycoprotein complex is composed of four subunits: GPIbα, GPIbβ, GPV and GPIX. (wikipedia.org)
  • Many viral fusion proteins are tight complexes of two glycoprotein subunits that confer binding as well as fusion activity, and many are made as larger precursors which require proteolytic activation of their fusogenic potential ( 16 ). (asm.org)
  • The virus genome is negative-stranded and encodes for seven structural and regulatory proteins ( 3 , 4 ), including a surface glycoprotein (Gp) that is synthesized as a precursor molecule and then cleaved into two subunits ( 5 , 6 ), Gp1 and Gp2, the latter of which is anchored in the membrane. (pnas.org)
  • The data support a viral entry mechanism dependent on binding to the lysosome-resident receptor LAMP1 and further dissociation of the membrane-distal GP1 subunits. (nih.gov)
  • The mature Env spike results from cleavage of a trimeric glycoprotein precursor, gp160, into three gp120 and three gp41 subunits. (elsevier.com)
  • In contrast to the murine lens, the 35 k peptide could not be detected in rabbit lens membranes. (arvojournals.org)
  • They are composed of one or two type I integral membrane glycoproteins, contain extended ectodomains carrying N-linked carbohydrates, form higher-order oligomers, are present on the viral membrane at high surface density, and contain a fusion peptide in a membrane-anchored subunit. (asm.org)
  • In general, it is suggested that a triggered conformational change exposes a previously cryptic fusion peptide, which is then able to insert into the lipid bilayer and thus initiate the fusion reaction by disturbing the membrane integrity. (asm.org)
  • The ectodomain of the Ebola virus Gp2 glycoprotein was solubilized with a trimeric, isoleucine zipper derived from GCN4 (pIIGCN4) in place of the hydrophobic fusion peptide at the N terminus. (pnas.org)
  • This structural organization that places the membrane anchor in close proximity to the hydrophobic fusion peptide, at the same end of a long rod-shaped molecule, was proposed to facilitate the membrane fusion process ( 17 ) and thus viral entry. (pnas.org)
  • The 58-amino-acid stable signal peptide (SSP) is myristoylated and spans the membrane twice, with both the N and C termini in the cytosol ( 3 ). (asm.org)
  • Instead, a novel O-linked trisaccharide substituent, not previously found as a constituent of glycoproteins, is present within a peptide spanning amino acid residues 45 to 73 of the PilE molecule. (nih.gov)
  • A comparison of composition revealed that the major glycoprotein had 77% carbohydrate and 23% peptide, and the minor one had 27% carbohydrate and 73% peptide. (elsevier.com)
  • The interactions with P-glycoprotein of two novel hydrophobic peptide chemosensitizers (reversins 121 and 205) have been studied in model systems in vitro, and in a variety of MDR1-expressing intact tumor cells. (elsevier.com)
  • When [ 14 C] fucose and [ 3 H]N-acetylmannosamine, a sialic acid precursor, were injected following an acute dose of ethanol, minimal effects on fucose and a slight reduction of sialic acid incorporation into the total pool of hepatic membrane glycoproteins were observed. (nebraska.edu)
  • In this report, we describe for the first time the flagellar membrane components of vegetative C. moewusii. (biologists.org)
  • In both membrane vesicles and reconstituted proteoliposomes, 1-2 μM reversins were more effective than cyclosporin A at blocking colchicine transport. (elsevier.com)
  • Virus mutants lacking glycoprotein gB, gD, gH, or gL are unable to penetrate target cells, a defect which can be at least partially overcome by treatment with an artificial fusogen, polyethylene glycol, indicating that these proteins are involved in the fusion process (reviewed in references 27 and 37 ). (asm.org)
  • Calnexin interaction with N-glycosylation mutants of a polytopic membrane glycoprotein, the human erythrocyte anion exchanger 1 (band 3). (semanticscholar.org)