AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceHealth Care
Membrane FluidityMembrane LipidsDiphenylhexatrieneCell MembraneFluorescence PolarizationErythrocyte MembraneMembranesBenzyl AlcoholPhospholipidsIntracellular MembranesMembranes, ArtificialLiposomesMembrane PotentialsLauratesElectron Spin Resonance SpectroscopyFatty Acids2-NaphthylamineCell Membrane PermeabilityTemperatureCholesterolLipid BilayersBiologyStearatesPhosphatidylcholinesSpin LabelsViscosityBenzyl AlcoholsSystems BiologyFatty Acids, UnsaturatedFluorescent DyesMicrovilliErythrocytesLipid PeroxidationAlcoholsBasement MembraneSpectrometry, FluorescenceCold TemperatureHexanolsLipidsNorisoprenoidsReceptors, Concanavalin ACalciumModels, BiologicalTenuazonic AcidCell LineErgosterolMicroscopy, ElectronHemolysisAnisotropyCells, CulturedNisinKineticsPyrenesDiffusionMolecular BiologyFatty Acid DesaturasesMembrane Transport ProteinsAbetalipoproteinemiaDevelopmental BiologyHydrogen-Ion ConcentrationProtein BindingEscherichia coliLipid MetabolismMicroscopy, FluorescenceMutationPhosphatidylethanolaminesMitochondrial MembranesMembrane GlycoproteinsSodium-Potassium-Exchanging ATPaseCalorimetry, Differential ScanningBacterial ProteinsSynaptic MembranesSphingomyelinsTime FactorsLysophosphatidylcholinesRabbitsbeta-Cyclodextrins1,2-DipalmitoylphosphatidylcholineAdaptation, PhysiologicalPermeabilityPhosphatidylglycerolsG(M1) Ganglioside1-ButanolConcanavalin AProtein TransportKetocholesterolsSynthetic BiologySignal TransductionMolecular Sequence DataCa(2+) Mg(2+)-ATPaseFluorescenceDimyristoylphosphatidylcholineHydrophobic and Hydrophilic InteractionsMembrane MicrodomainsStearic AcidsCytochalasin BWaterOleic AcidsCattleComputational Biology
ProteinsPhospholipidsBiochemistryBiological membranesPhospholipidNeuronalCholesterolPhenytoinPlasmaCompositionChemistryMoleculesMacromoleculesProteinVesiclesSaturated hydrocarbonModulationCell'sPathwaysDecreasesErythrocyteFluidCompositionallyTemperatureReceptorsPhysiologyDynamicsOutermostMolecularCorrelationProcessesNucleusIncreasesOuterCellsRibosomesSyntheticStructural BiologyInteractionsElectronStructureBacterialChemical biologyProbeTemperaturesSupportRoleFunctionsDynamic
Proteins33
  • Viscosity of the membrane can affect the rotation and diffusion of proteins and other bio-molecules within the membrane, there-by affecting the functions of these things. (wikipedia.org)
  • Also, a narrow annular lipid shell of membrane lipids in contact with integral membrane proteins have low fluidity compared to bulk lipids in biological membranes, as these lipid molecules stay stuck to surface of the protein macromolecules. (wikipedia.org)
  • The nucleus stores chromatin (DNA plus proteins) in a gel-like substance called the nucleoplasm.The nucleolus is a condensed region of chromatin where ribosome synthesis occurs.The boundary of the nucleus is called the nuclear envelope.It consists of two phospholipid bilayers: an outer membrane and an inner membrane.The nuclear membrane is continuous with the endoplasmic reticulum.Nuclear pores allow substances to enter and exit the nucleus. (coursehero.com)
  • Membranes and Cell Movement: Interactions of Membranes with the Proteins of the Cytoskeleton. (godman-inc.com)
  • Where are proteins located within the membrane? (sliderbase.com)
  • The cell membrane properties change rapidly over time and have remarkable effects on various phenomena like the interaction with membranes proteins, the regulation of the ion channels activity. (moflabunito.com)
  • Are you interested in structural mass spectrometry, method development ad/or membrane proteins? (peterslab.org)
  • Curcumin modulates cellular activity through interacting with membrane-bound proteins and modulating signaling cascade activity by altering the fluidity of the membrane bilayer [ 17 ]. (hindawi.com)
  • We show here that LAZY1-LIKE (LZY) family proteins involved in statocyte gravity signaling associate with amyloplasts and the proximal plasma membrane. (bvsalud.org)
  • A team of international researchers, including researchers from Kiel University, has now found indications of a possible different function of the flotillins: together with colleagues from the Universities of Groningen (the Netherlands) and Bordeaux (France), among others, the Kiel researchers were able to show that flotillin proteins apparently have a direct influence on the structure of the cell membrane and can make it more fluid under certain conditions. (uni-kiel.de)
  • Various proteins are necessary for the formation of the cell membranes and to equip them with their functions. (uni-kiel.de)
  • Until now, researchers assumed that the so-called flotillin proteins serve to contribute to the formation of the necessary functional protein complexes - for example by delimiting certain areas of the membrane. (uni-kiel.de)
  • The work now presented by Professor Marc Bramkamp's Microbial Biochemistry and Cell Biology group at the Institute of General Microbiology at Kiel University contradicts this view: "Together with a group of international colleagues, we have found evidence that the flotillin proteins have a completely different function. (uni-kiel.de)
  • However, if the researchers added a chemical substance to fluidize the membranes, the bacteria could maintain their shape even without flotillin proteins. (uni-kiel.de)
  • In further research, the researchers hope to find out what is the exact molecular mechanism between the flotillin proteins and membrane fluidity. (uni-kiel.de)
  • It is possible that the flotillin proteins are able to bind certain phospholipids that reduce fluidity and thus increase the total fluidity of the cell membrane. (uni-kiel.de)
  • The plasma membrane is made up primarily of a bilayer of phospholipids with embedded proteins carbohydrates glycolipids and glycoproteins and in animal cells cholesterol. (pages.dev)
  • What are the 2 categories of membrane proteins. (pages.dev)
  • Like all other cellular membranes the plasma membrane consists of both lipids and proteins. (pages.dev)
  • The major components of a cell membrane are phospholipids glycolipids proteins and cholesterol. (pages.dev)
  • Depending on the membranes location and role in the body lipids can make up anywhere from 20 to 80 percent of the membrane with the remainder being proteins. (pages.dev)
  • Like a mosaic the cell membrane is a complex structure made up of many different parts such as proteins phospholipids and cholesterol. (pages.dev)
  • The cell membrane is primarily composed of a mix of proteins and lipids. (pages.dev)
  • And the various proteins perform a great diversity of tasks, ranging from transmitting information to transporting molecules, across the membrane. (blogspot.com)
  • A recent study , for instance, revealed that the membrane proteins are arranged in complex patterns, ranging from what has been described as "patches" to "networks. (blogspot.com)
  • You learned about DNA and proteins in your high school biology class, but you may not remember much about the cell's membrane which is based on a dynamic, fluctuating sandwich structure. (blogspot.com)
  • The red blood cell membrane is composed of a lipid bilayer and proteins assembled in a complex manner that protects the red blood cell's integrity and allows a bidirectional flux of electrolytes, energy, and information between the cell and its environment. (medscape.com)
  • [ 4 ] To preserve the red blood cell's shape and regulate the cell's deformability and mechanical stability, the plasma membrane is tethered to a filamentous network of proteins known as the membrane skeleton. (medscape.com)
  • Acanthocytes can result from abnormalities in membrane lipids and proteins. (medscape.com)
  • However, some rare conditions have normal lipids and abnormal membrane proteins. (medscape.com)
  • While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)
  • Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
  • Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)
Phospholipids13
Biochemistry1
  • Symposium on Education in the Molecular Life Sciences, Combined 2nd Human Proteome (HUPO) & 19th International Union of Biochemistry & Molecular Biology (IUBMB) Congress. (edu.au)
Biological membranes1
  • Recent years have seen strong research efforts on the lipid component of biological membranes. (lu.se)
Phospholipid5
  • Both the inner and outer membranes of the nuclear envelope are phospholipid bilayers. (coursehero.com)
  • One approach might be the investigation of the phospholipid composition of the membrane. (uni-kiel.de)
  • Importantly the properties of phospholipid molecules allow them to spontaneously form a double-layered membrane. (pages.dev)
  • The fundamental structure of the membrane is the phospholipid bilayer which forms a stable barrier between two aqueous compartments. (pages.dev)
  • Within the membrane sandwich structure, the phospholipid tails are attracted to each other via the weakest chemical force, van der Waals interactions. (blogspot.com)
Neuronal1
  • This induces a positive feedback loop that affects membrane fluidity and impairs retromer function and neuronal function. (nih.gov)
Cholesterol8
Phenytoin3
  • Phenytoin (formerly diphenylhydantoin) "normalizes" fluidity differences in spectra derived from myotonic erythrocytes but has no significant effect on normal spectra. (uky.edu)
  • No significant differences in membrane anisotropy were noted in 3-day-old phenytoin offspring, but a reduction in anisotropy in 28-day-old phenytoin offspring hippocampal regions was observed. (elsevierpure.com)
  • The data, together with previous findings of memory impairments in phenytoin offspring, support an association between the hippocampal membrane disordering effect and functional impairments produced by prenatal phenytoin exposure. (elsevierpure.com)
Plasma10
  • Like a prokaryotic cell, a eukaryotic cell has a plasma membrane, cytoplasm, and ribosomes. (coursehero.com)
  • Other than the fact that vacuoles are somewhat larger than vesicles, there is a very subtle distinction between them: the membranes of vesicles can fuse with either the plasma membrane or other membrane systems within the cell. (coursehero.com)
  • We now understand that the plasma membrane is a very dynamic part of the cell and that is much more than just a barrier. (visionlearning.com)
  • Plasma membrane redox system (PMRS) is an electron transport chain system ubiquitously present throughout all cell types. (hindawi.com)
  • Plasma membrane redox system (PMRS) is an electron transport chain system ubiquitously present in all cell types that transfers electrons from intracellular substrates to extracellular acceptors maintaining redox homeostasis for a successful cell physiology [ 1 ]. (hindawi.com)
  • We propose a gravity-sensing mechanism by which LZY translocation to the plasma membrane signals the direction of gravity by transmitting information on the position of amyloplasts. (bvsalud.org)
  • At each of these ages half of the litters from each group were used to determine synaptic plasma membrane order in selected brain regions (cerebellum, cortex, hippocampus) by fluorescence polarization using the probe 1,6-diphenyl-1,3,5-hexatriene (DPH). (elsevierpure.com)
  • The extended-cement was stored at 5 o C. Parameters of chilled-cement quality examined were percentage of sperm motility, live sperm, and intact plasma membrane (IPM), which were evaluated every day for four days. (unsoed.ac.id)
  • The plasma membrane mediates cellular processes by regulating the materials that enter and exit the cell. (pages.dev)
  • The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane. (leibniz-fmp.de)
Composition2
  • The composition of a membrane can also affect its fluidity. (wikipedia.org)
  • Furthermore, the all-important lipid composition of the membrane strongly influences these patterns as well as the protein sequences themselves. (blogspot.com)
Chemistry3
  • Our research interests reside at the interface of synthetic organic chemistry, functional materials and chemical biology. (moflabunito.com)
  • The preparation and the investigation of emissive analogs is off importance to provide tools for deeper understanding of structural motives, specific supramolecular interactions, preferential pathways in the chemical biology and medicinal chemistry fields. (moflabunito.com)
  • Shed light and visualize how the lipids bilayers are organized and behave over time is crucial in many aspects of biology and medicinal chemistry. (moflabunito.com)
Molecules7
  • The outer layer of a cell, or a cell membrane, is a complex structure with many different kinds of molecules that are in constant motion, moving fluidly throughout the membrane. (visionlearning.com)
  • Cell membranes form selective barriers that protect the cell from the watery environment around them while letting water-insoluble molecules like oxygen, carbon dioxide and some hormones pass through. (visionlearning.com)
  • Yes, it does restrict many molecules from entering (or leaving) the cell, but it is also designed so that some molecules can very quickly move through the membrane, and thus enter or leave the cell with ease. (visionlearning.com)
  • Cell membrane is called dynamic as it is involved in transport of molecules in and out of the cell. (meritnation.com)
  • It is known as semi permeable because only some molecules can pass through cell membrane. (meritnation.com)
  • The pores allow the transport of large molecules in and out of nucleus and the membranes keep the hereditary material in contact with the rest of the cell. (pages.dev)
  • While small oily molecules are able to pass through this membrane structure, it is difficult for any water-loving molecule, including water itself, to pass through the barrier. (blogspot.com)
Macromolecules1
  • At the molecular level, most of biology happens at interfaces where water makes contact with macromolecules or molecular aggregates. (lu.se)
Protein3
  • Until now, scientists assumed that these flotillins mainly help in the formation of other functional protein complexes and confine highly ordered areas of the cell membrane. (uni-kiel.de)
  • In addition, the protein machinery that synthesises the cell wall moves dynamically through the cell membrane and this movement is significantly reduced in the absence of the flotillins. (uni-kiel.de)
  • Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)
Vesicles2
  • Vesicles and vacuoles are membrane-bound sacs that function in storage and transport. (coursehero.com)
  • We recently developed a generic method for producing polymer-supported lipid bilayers directly from cell-derived native membrane vesicles (NMVs). (lu.se)
Saturated hydrocarbon1
  • While unsaturated lipids may have more rigid individual bonds, membranes made with such lipids are more fluid because the individual lipids cannot pack as tightly as saturated lipids and thus have lower melting points: less thermal energy is required to achieve the same level of fluidity as membranes made with lipids with saturated hydrocarbon chains. (wikipedia.org)
Modulation2
  • The major focus of investigations described here is assessment in whole cell systems of modulation of cell membrane fluidity, as an indicator of adaptability and vitality. (edu.au)
  • Fluidity modulation has been observed in relation to physiological state (growth phase and glucose repression), temperature up shift and increased concentrations of ethanol. (edu.au)
Cell's3
  • Because a eukaryotic cell's nucleus is surrounded by a membrane, it is often said to have a "true nucleus. (coursehero.com)
  • Eukaryotic cells have a true nucleus, which means the cell's DNA is surrounded by a membrane. (coursehero.com)
  • This abnormality is more pronounced in patients with spur cell anemia, resulting in the alteration of the red blood cell shape and a decrease of the cell's fluidity. (medscape.com)
Pathways1
  • Once absorbed into the body, tocotrienols are readily taken up by cell membranes where they help neutralize harmful free radicals, help maintain cell membrane fluidity and support cell signaling pathways. (endur.com)
Decreases1
Erythrocyte2
  • These experiments demonstrate the applicability of biophysical methods to human erythrocyte membranes and support the concept of a membrane defect in myotonic dystrophy that does not have a primary myopathic, neuropathic, or vascular cause. (uky.edu)
  • An increase in the proteolytic activity of the erythrocyte membrane is also reported in spur cell anemia. (medscape.com)
Fluid7
  • energetic lipids move around more, arranging and rearranging randomly, making the membrane more fluid. (wikipedia.org)
  • The melting temperature T m {\displaystyle T_{m}} of a membrane is defined as the temperature across which the membrane transitions from a crystal-like to a fluid-like organization, or vice versa. (wikipedia.org)
  • T m {\displaystyle T>T_{m}} : The membrane is in the liquid-crystal phase, the membrane is less ordered and more fluid. (wikipedia.org)
  • Cell membrane is fluid in nature because lipids present in cell membrane provide fluidity. (meritnation.com)
  • Apparently, they regulate the fluidity of bacterial membranes, making them more fluid to a certain extent and thus, changing their properties," emphasises Bramkamp. (uni-kiel.de)
  • This assumption might also explain the effect that flotillins have on the synthesis of the cell wall: building blocks for the cell wall are produced inside the cells and must subsequently be "flipped" outwards, which is easier to do in a more fluid membrane. (uni-kiel.de)
  • Depending on the temperature and this degree of attraction, the sandwich structure may be like a gel or like a fluid, and this is important because the phase influences the membrane permeability and the membrane's molecular machines. (blogspot.com)
Compositionally1
  • As cell membranes are both dynamic and compositionally complex, replicating these aspects in a model membrane are essential. (lu.se)
Temperature2
  • The magnitude of the change corresponded to an approximately 3-5°C increase in temperature and to changes produced by other known membrane disordering agents, such as ethanol. (elsevierpure.com)
  • Membrane fluidity and temperature perception. (google.pl)
Receptors1
  • Slow genomic mechanisms, such as nuclear receptors, as well as fast nongenomic mechanisms, such as membrane-associated receptors and signalling cascades, mediate their effects. (vedantu.com)
Physiology1
  • Curcumin, isolated from Curcuma longa, has modulatory effects on cellular physiology due to its membrane interaction ability and antioxidant potential. (hindawi.com)
Dynamics1
  • With this Dynamics workshop, our goal is to bring together leading experts in the field of membrane dynamics, with a particular focus on neutrons and X-rays, but also complementary techniques including NMR, single molecule spectroscopy and computer modeling. (lu.se)
Outermost1
  • The nuclear envelope is a double-membrane structure that constitutes the outermost portion of the nucleus. (coursehero.com)
Molecular5
  • Advances in Enzymology and Related Areas of Molecular Biology. (godman-inc.com)
  • A molecular rotor FLIM probe reveals dynamic coupling between mitochondrial inner membrane fluidity and cellular respiration. (ncbs.res.in)
  • Describe the molecular components that make up the cell membrane. (pages.dev)
  • This cellular envelope controls what chemicals enter and exit the cell, partly due to molecular machines such as channels and pumps in the membrane, and partly due to the sandwich structure itself. (blogspot.com)
  • But the membrane permeability and the operation of the molecular machines depend on the details of the sandwich structure. (blogspot.com)
Correlation1
Processes2
  • Many different processes are regulated by the membrane fluidity, potential or by the presence of transient microdomains. (moflabunito.com)
  • The flotillins seem to have an effect on the physical structure of the membrane, conferring the correct fluidity so other membrane-bound processes can function properly"," Savietto continues. (uni-kiel.de)
Nucleus2
  • A eukaryotic cell has a true membrane-bound nucleus and has other membranous organelles that allow for compartmentalization of functions. (coursehero.com)
  • Eukaryotic cells are larger than prokaryotic cells and have a "true" nucleus, membrane-bound organelles, and rod-shaped chromosomes. (coursehero.com)
Increases2
  • The absence of double bonds increases fluidity. (wikipedia.org)
  • It maintains the fluidity and increases the stability of the membrane. (sliderbase.com)
Outer2
  • Although it was too thin for them to see with simple light microscropes, scientists called this outer wrapping a membrane (in Latin, membrana ), which means a thin layer of skin or tissue. (visionlearning.com)
  • From the 17th century until around the 1960s, the outer membrane of cells was thought to be a simple passive barrier. (visionlearning.com)
Cells8
  • Having complex cells in which the genetic material is organized into membrane-bound nuclei. (coursehero.com)
  • Although these early studies didn't directly focus on membranes or even cells , they were very important because they described the repulsion that occurs when water-insoluble fluids , such as oil, come in contact with water. (visionlearning.com)
  • a. if cells were surrounded by membranes. (visionlearning.com)
  • Like all cells, bacteria have a membrane that shields them from the outside like a skin. (uni-kiel.de)
  • My research group has been working on the function of flotillins for many years and we know that cells with altered membrane fluidity are much more sensitive to conventional antibiotics. (uni-kiel.de)
  • It might be possible to use this mechanism, for example to specifically alter the membrane of bacterial cells in such a way that they can be killed more easily with antibiotics," Bramkamp looks ahead. (uni-kiel.de)
  • Cell membranes throughout the body - from lipoproteins that travel through the blood to endothelial cells that line blood vessels - can benefit from this powerful antioxidant protection. (endur.com)
  • The membrane that surrounds and encapsulates living cells is truly amazing. (blogspot.com)
Ribosomes1
  • Mitochondria are oval-shaped, double membrane organelles that have their own ribosomes and DNA. (coursehero.com)
Synthetic2
Structural Biology1
Interactions1
  • Traction stress analysis and modeling reveal that amoeboid migration in confined spaces is accompanied by expansive forces and requires the structural integrity of the membrane-cortex interactions. (godman-inc.com)
Electron2
  • Membrane fluidity can be measured with electron spin resonance, fluorescence, atomic force microscopy-based force spectroscopy, or deuterium nuclear magnetic resonance spectroscopy. (wikipedia.org)
  • Electron spin resonance spectroscopy was used to substantiate the presence of a membrane defect in myotonic erythrocytes. (uky.edu)
Structure3
Bacterial3
  • We therefore assume that they take over a physical role in the bacterial membrane," emphasises Abigail Savietto, PhD student in Bramkamp's group at Kiel University. (uni-kiel.de)
  • The new hypothesis of the Kiel research team thus also holds promising perspectives for application: in the future, it might be possible to specifically influence the physical properties of bacterial cell membranes by disrupting the flotillin function. (uni-kiel.de)
  • Furthermore, we detected effects on cell membranes of process additives that may potentially be toxic or membrane-active, in both yeast and bacterial systems. (edu.au)
Chemical biology1
Probe1
  • Membrane fluidity is determined by fluorescence Polarization and Generalized Polarization of the membrane-localising probe 6-lauroyl-2-dimethylamino naphthalene (laurdan). (edu.au)
Temperatures2
  • At low temperatures, the lipids are laterally ordered and organized in the membrane, and the lipid chains are mostly in the all-trans configuration and pack well together. (wikipedia.org)
  • 2010).]]This hydrocarbon might be produced to help maintain membrane fluidity during the winter because Lake Oneida reaches freezing temperatures for many months. (kenyon.edu)
Support1
  • rather, they are condensed regions of peritoneal membrane that support the liver1. (blogspot.com)
Role1
Functions1
  • The biological analogue, 'lipid raft', is hypothesized to exist in cell membranes and perform biological functions. (wikipedia.org)
Dynamic2
  • Cell membranes is a dynamic non-homogenous systems more complex than how it is usually depicted. (moflabunito.com)
  • In my talk, I will show you some examples how such biological cues influence the dynamic properties of membranes. (lu.se)